Amino acid dipepetide frequency for Apis mellifera associated microvirus 18

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.346AlaAla: 11.346 ± 3.142
0.756AlaCys: 0.756 ± 1.084
4.539AlaAsp: 4.539 ± 1.084
7.564AlaGlu: 7.564 ± 4.48
2.269AlaPhe: 2.269 ± 1.039
3.026AlaGly: 3.026 ± 1.864
3.026AlaHis: 3.026 ± 1.085
4.539AlaIle: 4.539 ± 2.231
1.513AlaLys: 1.513 ± 1.245
9.077AlaLeu: 9.077 ± 3.463
2.269AlaMet: 2.269 ± 1.215
3.782AlaAsn: 3.782 ± 0.962
6.051AlaPro: 6.051 ± 2.133
5.295AlaGln: 5.295 ± 1.184
10.59AlaArg: 10.59 ± 2.056
7.564AlaSer: 7.564 ± 1.755
10.59AlaThr: 10.59 ± 2.776
8.321AlaVal: 8.321 ± 1.982
0.756AlaTrp: 0.756 ± 1.053
3.026AlaTyr: 3.026 ± 1.305
0.0AlaXaa: 0.0 ± 0.0
Cys
1.513CysAla: 1.513 ± 0.634
0.0CysCys: 0.0 ± 0.0
0.756CysAsp: 0.756 ± 0.501
0.0CysGlu: 0.0 ± 0.0
0.0CysPhe: 0.0 ± 0.0
0.756CysGly: 0.756 ± 0.782
0.0CysHis: 0.0 ± 0.0
2.269CysIle: 2.269 ± 1.39
0.0CysLys: 0.0 ± 0.0
0.756CysLeu: 0.756 ± 0.782
0.0CysMet: 0.0 ± 0.0
0.756CysAsn: 0.756 ± 1.084
0.0CysPro: 0.0 ± 0.0
0.756CysGln: 0.756 ± 1.053
0.756CysArg: 0.756 ± 1.084
0.756CysSer: 0.756 ± 0.782
0.0CysThr: 0.0 ± 0.0
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
8.321AspAla: 8.321 ± 3.684
0.0AspCys: 0.0 ± 0.0
4.539AspAsp: 4.539 ± 1.842
2.269AspGlu: 2.269 ± 1.274
6.051AspPhe: 6.051 ± 1.939
3.782AspGly: 3.782 ± 1.154
2.269AspHis: 2.269 ± 1.066
0.756AspIle: 0.756 ± 0.501
3.026AspLys: 3.026 ± 0.95
3.026AspLeu: 3.026 ± 1.337
1.513AspMet: 1.513 ± 1.359
3.026AspAsn: 3.026 ± 1.337
5.295AspPro: 5.295 ± 2.672
2.269AspGln: 2.269 ± 1.39
3.026AspArg: 3.026 ± 1.568
4.539AspSer: 4.539 ± 1.779
1.513AspThr: 1.513 ± 1.002
6.051AspVal: 6.051 ± 1.496
0.0AspTrp: 0.0 ± 0.0
1.513AspTyr: 1.513 ± 1.002
0.0AspXaa: 0.0 ± 0.0
Glu
10.59GluAla: 10.59 ± 3.281
0.756GluCys: 0.756 ± 1.053
3.782GluAsp: 3.782 ± 0.962
1.513GluGlu: 1.513 ± 1.336
0.756GluPhe: 0.756 ± 1.084
1.513GluGly: 1.513 ± 1.245
1.513GluHis: 1.513 ± 0.692
3.782GluIle: 3.782 ± 1.108
3.782GluLys: 3.782 ± 2.099
1.513GluLeu: 1.513 ± 0.9
0.756GluMet: 0.756 ± 0.782
1.513GluAsn: 1.513 ± 1.336
0.756GluPro: 0.756 ± 0.501
2.269GluGln: 2.269 ± 1.104
3.782GluArg: 3.782 ± 1.109
2.269GluSer: 2.269 ± 1.066
1.513GluThr: 1.513 ± 1.453
2.269GluVal: 2.269 ± 1.789
1.513GluTrp: 1.513 ± 1.002
3.782GluTyr: 3.782 ± 1.109
0.0GluXaa: 0.0 ± 0.0
Phe
4.539PheAla: 4.539 ± 2.229
0.756PheCys: 0.756 ± 1.084
3.026PheAsp: 3.026 ± 1.219
2.269PheGlu: 2.269 ± 1.104
3.026PhePhe: 3.026 ± 1.169
3.782PheGly: 3.782 ± 0.993
1.513PheHis: 1.513 ± 1.255
0.756PheIle: 0.756 ± 0.501
0.756PheLys: 0.756 ± 1.053
3.026PheLeu: 3.026 ± 0.994
2.269PheMet: 2.269 ± 1.471
3.782PheAsn: 3.782 ± 1.497
0.756PhePro: 0.756 ± 0.679
3.026PheGln: 3.026 ± 0.95
3.026PheArg: 3.026 ± 1.337
3.782PheSer: 3.782 ± 0.667
4.539PheThr: 4.539 ± 2.633
2.269PheVal: 2.269 ± 0.935
0.0PheTrp: 0.0 ± 0.0
1.513PheTyr: 1.513 ± 0.692
0.0PheXaa: 0.0 ± 0.0
Gly
6.051GlyAla: 6.051 ± 0.891
0.756GlyCys: 0.756 ± 0.782
5.295GlyAsp: 5.295 ± 1.447
5.295GlyGlu: 5.295 ± 1.807
2.269GlyPhe: 2.269 ± 1.215
8.321GlyGly: 8.321 ± 3.391
2.269GlyHis: 2.269 ± 1.39
3.026GlyIle: 3.026 ± 0.652
3.782GlyLys: 3.782 ± 1.815
6.051GlyLeu: 6.051 ± 2.213
0.0GlyMet: 0.0 ± 0.0
3.026GlyAsn: 3.026 ± 0.652
2.269GlyPro: 2.269 ± 0.921
3.026GlyGln: 3.026 ± 1.252
2.269GlyArg: 2.269 ± 1.39
6.051GlySer: 6.051 ± 2.087
4.539GlyThr: 4.539 ± 1.852
1.513GlyVal: 1.513 ± 1.002
0.756GlyTrp: 0.756 ± 0.501
2.269GlyTyr: 2.269 ± 1.503
0.0GlyXaa: 0.0 ± 0.0
His
1.513HisAla: 1.513 ± 1.002
2.269HisCys: 2.269 ± 1.39
1.513HisAsp: 1.513 ± 0.634
1.513HisGlu: 1.513 ± 1.565
3.026HisPhe: 3.026 ± 1.311
1.513HisGly: 1.513 ± 0.634
0.756HisHis: 0.756 ± 1.053
1.513HisIle: 1.513 ± 0.692
0.756HisLys: 0.756 ± 1.053
1.513HisLeu: 1.513 ± 0.918
1.513HisMet: 1.513 ± 0.634
0.0HisAsn: 0.0 ± 0.0
2.269HisPro: 2.269 ± 2.212
1.513HisGln: 1.513 ± 0.9
2.269HisArg: 2.269 ± 1.215
2.269HisSer: 2.269 ± 0.919
0.0HisThr: 0.0 ± 0.0
0.756HisVal: 0.756 ± 0.782
0.756HisTrp: 0.756 ± 0.782
1.513HisTyr: 1.513 ± 1.565
0.0HisXaa: 0.0 ± 0.0
Ile
4.539IleAla: 4.539 ± 1.735
0.0IleCys: 0.0 ± 0.0
3.026IleAsp: 3.026 ± 0.95
1.513IleGlu: 1.513 ± 1.255
2.269IlePhe: 2.269 ± 1.215
9.077IleGly: 9.077 ± 1.734
0.756IleHis: 0.756 ± 0.679
1.513IleIle: 1.513 ± 1.002
0.756IleLys: 0.756 ± 0.782
2.269IleLeu: 2.269 ± 0.605
0.756IleMet: 0.756 ± 0.911
3.026IleAsn: 3.026 ± 2.004
1.513IlePro: 1.513 ± 1.002
0.756IleGln: 0.756 ± 0.501
3.026IleArg: 3.026 ± 1.268
0.756IleSer: 0.756 ± 0.501
1.513IleThr: 1.513 ± 0.692
2.269IleVal: 2.269 ± 0.935
0.756IleTrp: 0.756 ± 0.501
1.513IleTyr: 1.513 ± 0.692
0.0IleXaa: 0.0 ± 0.0
Lys
5.295LysAla: 5.295 ± 3.369
0.756LysCys: 0.756 ± 0.501
1.513LysAsp: 1.513 ± 1.336
2.269LysGlu: 2.269 ± 2.275
2.269LysPhe: 2.269 ± 0.919
1.513LysGly: 1.513 ± 0.918
3.026LysHis: 3.026 ± 1.602
2.269LysIle: 2.269 ± 1.365
4.539LysLys: 4.539 ± 2.614
6.051LysLeu: 6.051 ± 1.178
0.756LysMet: 0.756 ± 0.834
3.026LysAsn: 3.026 ± 1.649
3.026LysPro: 3.026 ± 0.652
0.0LysGln: 0.0 ± 0.0
4.539LysArg: 4.539 ± 2.074
1.513LysSer: 1.513 ± 0.634
3.026LysThr: 3.026 ± 1.169
1.513LysVal: 1.513 ± 2.169
0.0LysTrp: 0.0 ± 0.0
1.513LysTyr: 1.513 ± 2.106
0.0LysXaa: 0.0 ± 0.0
Leu
7.564LeuAla: 7.564 ± 2.455
0.756LeuCys: 0.756 ± 0.679
3.026LeuAsp: 3.026 ± 1.169
3.026LeuGlu: 3.026 ± 1.628
3.782LeuPhe: 3.782 ± 1.413
4.539LeuGly: 4.539 ± 1.779
0.756LeuHis: 0.756 ± 0.501
5.295LeuIle: 5.295 ± 2.432
5.295LeuLys: 5.295 ± 1.263
4.539LeuLeu: 4.539 ± 1.211
0.756LeuMet: 0.756 ± 0.501
4.539LeuAsn: 4.539 ± 1.532
6.808LeuPro: 6.808 ± 3.699
4.539LeuGln: 4.539 ± 1.084
6.051LeuArg: 6.051 ± 1.8
5.295LeuSer: 5.295 ± 1.512
4.539LeuThr: 4.539 ± 1.842
3.026LeuVal: 3.026 ± 1.348
0.0LeuTrp: 0.0 ± 0.0
1.513LeuTyr: 1.513 ± 1.002
0.0LeuXaa: 0.0 ± 0.0
Met
0.756MetAla: 0.756 ± 1.084
0.0MetCys: 0.0 ± 0.0
0.756MetAsp: 0.756 ± 0.501
0.0MetGlu: 0.0 ± 0.0
1.513MetPhe: 1.513 ± 0.634
2.269MetGly: 2.269 ± 1.215
0.756MetHis: 0.756 ± 0.782
0.0MetIle: 0.0 ± 0.0
0.756MetLys: 0.756 ± 0.782
0.0MetLeu: 0.0 ± 0.0
0.756MetMet: 0.756 ± 1.084
0.0MetAsn: 0.0 ± 0.0
0.756MetPro: 0.756 ± 0.501
0.756MetGln: 0.756 ± 0.501
2.269MetArg: 2.269 ± 1.39
3.782MetSer: 3.782 ± 1.953
2.269MetThr: 2.269 ± 1.039
1.513MetVal: 1.513 ± 0.634
1.513MetTrp: 1.513 ± 0.634
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
1.513AsnAla: 1.513 ± 0.9
0.0AsnCys: 0.0 ± 0.0
1.513AsnAsp: 1.513 ± 1.453
0.756AsnGlu: 0.756 ± 0.501
0.756AsnPhe: 0.756 ± 0.501
3.026AsnGly: 3.026 ± 0.652
1.513AsnHis: 1.513 ± 0.692
0.0AsnIle: 0.0 ± 0.0
1.513AsnLys: 1.513 ± 1.205
7.564AsnLeu: 7.564 ± 2.678
0.0AsnMet: 0.0 ± 0.0
0.756AsnAsn: 0.756 ± 1.084
5.295AsnPro: 5.295 ± 1.76
2.269AsnGln: 2.269 ± 0.919
3.026AsnArg: 3.026 ± 0.894
0.756AsnSer: 0.756 ± 0.782
1.513AsnThr: 1.513 ± 0.634
3.026AsnVal: 3.026 ± 0.652
0.756AsnTrp: 0.756 ± 0.501
1.513AsnTyr: 1.513 ± 1.002
0.0AsnXaa: 0.0 ± 0.0
Pro
6.051ProAla: 6.051 ± 3.69
0.0ProCys: 0.0 ± 0.0
4.539ProAsp: 4.539 ± 1.186
1.513ProGlu: 1.513 ± 0.692
2.269ProPhe: 2.269 ± 1.126
3.026ProGly: 3.026 ± 1.169
1.513ProHis: 1.513 ± 0.692
6.808ProIle: 6.808 ± 3.13
5.295ProLys: 5.295 ± 1.196
3.782ProLeu: 3.782 ± 1.491
2.269ProMet: 2.269 ± 0.919
0.756ProAsn: 0.756 ± 1.053
4.539ProPro: 4.539 ± 0.908
3.782ProGln: 3.782 ± 1.798
6.808ProArg: 6.808 ± 2.299
7.564ProSer: 7.564 ± 3.658
1.513ProThr: 1.513 ± 0.918
3.782ProVal: 3.782 ± 1.798
0.756ProTrp: 0.756 ± 0.501
1.513ProTyr: 1.513 ± 0.9
0.0ProXaa: 0.0 ± 0.0
Gln
3.782GlnAla: 3.782 ± 1.202
0.0GlnCys: 0.0 ± 0.0
3.026GlnAsp: 3.026 ± 1.311
4.539GlnGlu: 4.539 ± 0.699
0.0GlnPhe: 0.0 ± 0.0
4.539GlnGly: 4.539 ± 1.084
1.513GlnHis: 1.513 ± 0.692
1.513GlnIle: 1.513 ± 1.565
3.026GlnLys: 3.026 ± 1.219
2.269GlnLeu: 2.269 ± 1.039
0.756GlnMet: 0.756 ± 0.501
1.513GlnAsn: 1.513 ± 0.918
1.513GlnPro: 1.513 ± 1.245
1.513GlnGln: 1.513 ± 0.692
3.026GlnArg: 3.026 ± 1.085
0.756GlnSer: 0.756 ± 1.084
3.782GlnThr: 3.782 ± 1.109
0.756GlnVal: 0.756 ± 0.679
0.0GlnTrp: 0.0 ± 0.0
0.756GlnTyr: 0.756 ± 0.501
0.0GlnXaa: 0.0 ± 0.0
Arg
6.051ArgAla: 6.051 ± 1.486
0.0ArgCys: 0.0 ± 0.0
3.782ArgAsp: 3.782 ± 1.108
4.539ArgGlu: 4.539 ± 1.501
3.026ArgPhe: 3.026 ± 1.628
2.269ArgGly: 2.269 ± 0.921
0.756ArgHis: 0.756 ± 0.501
1.513ArgIle: 1.513 ± 1.205
2.269ArgLys: 2.269 ± 1.543
6.808ArgLeu: 6.808 ± 1.568
2.269ArgMet: 2.269 ± 1.136
2.269ArgAsn: 2.269 ± 0.935
6.808ArgPro: 6.808 ± 1.552
0.756ArgGln: 0.756 ± 0.679
4.539ArgArg: 4.539 ± 3.059
9.834ArgSer: 9.834 ± 2.261
2.269ArgThr: 2.269 ± 2.295
6.051ArgVal: 6.051 ± 2.032
0.0ArgTrp: 0.0 ± 0.0
4.539ArgTyr: 4.539 ± 1.431
0.0ArgXaa: 0.0 ± 0.0
Ser
9.077SerAla: 9.077 ± 1.798
0.756SerCys: 0.756 ± 0.782
6.051SerAsp: 6.051 ± 1.661
3.782SerGlu: 3.782 ± 0.993
3.026SerPhe: 3.026 ± 0.994
6.051SerGly: 6.051 ± 2.536
3.782SerHis: 3.782 ± 1.798
1.513SerIle: 1.513 ± 1.359
3.026SerLys: 3.026 ± 2.217
8.321SerLeu: 8.321 ± 2.123
0.756SerMet: 0.756 ± 1.227
1.513SerAsn: 1.513 ± 1.002
3.782SerPro: 3.782 ± 2.364
0.756SerGln: 0.756 ± 0.679
4.539SerArg: 4.539 ± 2.152
6.808SerSer: 6.808 ± 3.686
5.295SerThr: 5.295 ± 2.108
3.782SerVal: 3.782 ± 1.468
0.756SerTrp: 0.756 ± 1.084
0.756SerTyr: 0.756 ± 1.053
0.0SerXaa: 0.0 ± 0.0
Thr
6.051ThrAla: 6.051 ± 2.536
0.0ThrCys: 0.0 ± 0.0
4.539ThrAsp: 4.539 ± 1.698
3.782ThrGlu: 3.782 ± 1.758
6.051ThrPhe: 6.051 ± 2.64
5.295ThrGly: 5.295 ± 0.722
0.756ThrHis: 0.756 ± 0.782
3.026ThrIle: 3.026 ± 1.01
3.782ThrLys: 3.782 ± 3.019
3.782ThrLeu: 3.782 ± 1.413
2.269ThrMet: 2.269 ± 0.605
0.0ThrAsn: 0.0 ± 0.0
5.295ThrPro: 5.295 ± 1.9
0.756ThrGln: 0.756 ± 0.679
1.513ThrArg: 1.513 ± 1.002
4.539ThrSer: 4.539 ± 3.006
3.782ThrThr: 3.782 ± 2.505
1.513ThrVal: 1.513 ± 1.097
0.0ThrTrp: 0.0 ± 0.0
0.756ThrTyr: 0.756 ± 0.782
0.0ThrXaa: 0.0 ± 0.0
Val
6.808ValAla: 6.808 ± 2.159
0.0ValCys: 0.0 ± 0.0
1.513ValAsp: 1.513 ± 1.002
2.269ValGlu: 2.269 ± 1.538
3.782ValPhe: 3.782 ± 1.126
2.269ValGly: 2.269 ± 1.215
0.756ValHis: 0.756 ± 0.501
1.513ValIle: 1.513 ± 1.002
1.513ValLys: 1.513 ± 1.565
3.782ValLeu: 3.782 ± 0.962
0.0ValMet: 0.0 ± 0.0
1.513ValAsn: 1.513 ± 0.918
7.564ValPro: 7.564 ± 1.721
1.513ValGln: 1.513 ± 1.002
3.782ValArg: 3.782 ± 4.211
3.026ValSer: 3.026 ± 1.693
4.539ValThr: 4.539 ± 1.146
0.756ValVal: 0.756 ± 0.782
2.269ValTrp: 2.269 ± 0.921
2.269ValTyr: 2.269 ± 1.104
0.0ValXaa: 0.0 ± 0.0
Trp
1.513TrpAla: 1.513 ± 0.918
0.0TrpCys: 0.0 ± 0.0
0.756TrpAsp: 0.756 ± 0.501
1.513TrpGlu: 1.513 ± 1.097
0.756TrpPhe: 0.756 ± 0.501
0.756TrpGly: 0.756 ± 0.782
0.756TrpHis: 0.756 ± 0.501
0.0TrpIle: 0.0 ± 0.0
0.756TrpLys: 0.756 ± 0.679
0.0TrpLeu: 0.0 ± 0.0
0.0TrpMet: 0.0 ± 0.0
0.756TrpAsn: 0.756 ± 0.501
2.269TrpPro: 2.269 ± 1.503
0.0TrpGln: 0.0 ± 0.0
0.0TrpArg: 0.0 ± 0.0
0.756TrpSer: 0.756 ± 0.501
0.0TrpThr: 0.0 ± 0.0
0.0TrpVal: 0.0 ± 0.0
0.0TrpTrp: 0.0 ± 0.0
0.756TrpTyr: 0.756 ± 0.782
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.026TyrAla: 3.026 ± 1.663
1.513TyrCys: 1.513 ± 0.692
5.295TyrAsp: 5.295 ± 1.662
0.0TyrGlu: 0.0 ± 0.0
1.513TyrPhe: 1.513 ± 1.002
1.513TyrGly: 1.513 ± 1.336
0.756TyrHis: 0.756 ± 0.782
0.0TyrIle: 0.0 ± 0.0
2.269TyrLys: 2.269 ± 0.921
1.513TyrLeu: 1.513 ± 1.002
0.0TyrMet: 0.0 ± 0.0
1.513TyrAsn: 1.513 ± 1.002
1.513TyrPro: 1.513 ± 0.9
3.026TyrGln: 3.026 ± 0.994
1.513TyrArg: 1.513 ± 0.918
2.269TyrSer: 2.269 ± 0.921
0.756TyrThr: 0.756 ± 0.501
2.269TyrVal: 2.269 ± 2.347
0.756TyrTrp: 0.756 ± 0.501
0.756TyrTyr: 0.756 ± 0.501
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5 proteins (1323 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski