Amino acid dipepetide frequency for Streptococcus phage Javan350

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.187AlaAla: 3.187 ± 1.053
0.336AlaCys: 0.336 ± 0.158
5.2AlaAsp: 5.2 ± 0.921
4.446AlaGlu: 4.446 ± 0.695
2.684AlaPhe: 2.684 ± 0.499
3.439AlaGly: 3.439 ± 0.691
0.671AlaHis: 0.671 ± 0.193
4.697AlaIle: 4.697 ± 0.941
5.62AlaLys: 5.62 ± 1.025
7.046AlaLeu: 7.046 ± 0.786
1.929AlaMet: 1.929 ± 0.383
3.439AlaAsn: 3.439 ± 0.523
1.761AlaPro: 1.761 ± 0.343
2.684AlaGln: 2.684 ± 0.6
3.355AlaArg: 3.355 ± 0.61
5.033AlaSer: 5.033 ± 1.013
3.858AlaThr: 3.858 ± 0.577
3.775AlaVal: 3.775 ± 0.816
1.09AlaTrp: 1.09 ± 0.321
1.761AlaTyr: 1.761 ± 0.414
0.0AlaXaa: 0.0 ± 0.0
Cys
0.252CysAla: 0.252 ± 0.142
0.084CysCys: 0.084 ± 0.087
0.252CysAsp: 0.252 ± 0.14
0.755CysGlu: 0.755 ± 0.241
0.336CysPhe: 0.336 ± 0.149
0.336CysGly: 0.336 ± 0.196
0.252CysHis: 0.252 ± 0.145
0.503CysIle: 0.503 ± 0.218
0.839CysLys: 0.839 ± 0.269
0.587CysLeu: 0.587 ± 0.295
0.0CysMet: 0.0 ± 0.0
0.168CysAsn: 0.168 ± 0.113
0.168CysPro: 0.168 ± 0.113
0.0CysGln: 0.0 ± 0.0
0.252CysArg: 0.252 ± 0.142
0.336CysSer: 0.336 ± 0.19
0.084CysThr: 0.084 ± 0.084
0.336CysVal: 0.336 ± 0.171
0.084CysTrp: 0.084 ± 0.082
0.419CysTyr: 0.419 ± 0.184
0.0CysXaa: 0.0 ± 0.0
Asp
3.775AspAla: 3.775 ± 0.662
0.671AspCys: 0.671 ± 0.358
4.446AspAsp: 4.446 ± 0.773
4.781AspGlu: 4.781 ± 0.663
3.607AspPhe: 3.607 ± 0.675
5.704AspGly: 5.704 ± 1.26
0.923AspHis: 0.923 ± 0.354
5.117AspIle: 5.117 ± 0.655
5.284AspLys: 5.284 ± 0.585
4.278AspLeu: 4.278 ± 0.626
2.265AspMet: 2.265 ± 0.327
3.523AspAsn: 3.523 ± 0.512
1.174AspPro: 1.174 ± 0.275
1.594AspGln: 1.594 ± 0.442
2.684AspArg: 2.684 ± 0.512
4.11AspSer: 4.11 ± 0.572
3.355AspThr: 3.355 ± 0.741
4.613AspVal: 4.613 ± 0.609
0.671AspTrp: 0.671 ± 0.224
2.936AspTyr: 2.936 ± 0.564
0.0AspXaa: 0.0 ± 0.0
Glu
4.446GluAla: 4.446 ± 0.75
0.419GluCys: 0.419 ± 0.22
4.446GluAsp: 4.446 ± 0.726
5.704GluGlu: 5.704 ± 0.931
3.942GluPhe: 3.942 ± 0.618
3.104GluGly: 3.104 ± 0.558
0.587GluHis: 0.587 ± 0.193
5.871GluIle: 5.871 ± 0.686
8.22GluLys: 8.22 ± 0.981
7.885GluLeu: 7.885 ± 0.875
2.013GluMet: 2.013 ± 0.483
4.781GluAsn: 4.781 ± 0.69
1.929GluPro: 1.929 ± 0.382
3.775GluGln: 3.775 ± 0.591
3.271GluArg: 3.271 ± 0.384
4.362GluSer: 4.362 ± 0.475
2.936GluThr: 2.936 ± 0.586
4.781GluVal: 4.781 ± 0.71
1.426GluTrp: 1.426 ± 0.324
2.349GluTyr: 2.349 ± 0.433
0.0GluXaa: 0.0 ± 0.0
Phe
3.187PheAla: 3.187 ± 0.456
0.252PheCys: 0.252 ± 0.122
3.775PheAsp: 3.775 ± 0.597
3.104PheGlu: 3.104 ± 0.535
1.174PhePhe: 1.174 ± 0.367
2.684PheGly: 2.684 ± 0.479
1.007PheHis: 1.007 ± 0.302
3.271PheIle: 3.271 ± 0.514
3.775PheLys: 3.775 ± 0.515
3.775PheLeu: 3.775 ± 0.736
1.342PheMet: 1.342 ± 0.394
2.936PheAsn: 2.936 ± 0.543
1.09PhePro: 1.09 ± 0.38
1.258PheGln: 1.258 ± 0.399
1.761PheArg: 1.761 ± 0.386
2.684PheSer: 2.684 ± 0.437
2.684PheThr: 2.684 ± 0.491
2.684PheVal: 2.684 ± 0.516
0.419PheTrp: 0.419 ± 0.176
1.929PheTyr: 1.929 ± 0.568
0.0PheXaa: 0.0 ± 0.0
Gly
3.607GlyAla: 3.607 ± 0.505
0.084GlyCys: 0.084 ± 0.077
3.942GlyAsp: 3.942 ± 0.54
3.607GlyGlu: 3.607 ± 0.419
3.942GlyPhe: 3.942 ± 0.858
3.523GlyGly: 3.523 ± 0.561
0.587GlyHis: 0.587 ± 0.273
4.194GlyIle: 4.194 ± 0.609
6.626GlyLys: 6.626 ± 0.624
6.794GlyLeu: 6.794 ± 0.849
1.51GlyMet: 1.51 ± 0.32
3.271GlyAsn: 3.271 ± 0.701
1.09GlyPro: 1.09 ± 0.465
2.684GlyGln: 2.684 ± 0.497
2.936GlyArg: 2.936 ± 0.54
4.697GlySer: 4.697 ± 0.833
4.026GlyThr: 4.026 ± 0.597
3.942GlyVal: 3.942 ± 0.453
1.007GlyTrp: 1.007 ± 0.484
2.013GlyTyr: 2.013 ± 0.676
0.0GlyXaa: 0.0 ± 0.0
His
1.258HisAla: 1.258 ± 0.327
0.168HisCys: 0.168 ± 0.106
1.007HisAsp: 1.007 ± 0.312
0.755HisGlu: 0.755 ± 0.263
0.839HisPhe: 0.839 ± 0.271
1.09HisGly: 1.09 ± 0.27
0.252HisHis: 0.252 ± 0.15
1.007HisIle: 1.007 ± 0.315
1.09HisLys: 1.09 ± 0.268
1.761HisLeu: 1.761 ± 0.406
0.419HisMet: 0.419 ± 0.161
1.007HisAsn: 1.007 ± 0.31
0.671HisPro: 0.671 ± 0.178
0.755HisGln: 0.755 ± 0.201
0.252HisArg: 0.252 ± 0.135
0.923HisSer: 0.923 ± 0.32
1.09HisThr: 1.09 ± 0.342
0.503HisVal: 0.503 ± 0.24
0.084HisTrp: 0.084 ± 0.088
0.252HisTyr: 0.252 ± 0.148
0.0HisXaa: 0.0 ± 0.0
Ile
4.529IleAla: 4.529 ± 0.639
0.336IleCys: 0.336 ± 0.158
5.452IleAsp: 5.452 ± 0.628
6.123IleGlu: 6.123 ± 0.841
3.355IlePhe: 3.355 ± 0.525
4.11IleGly: 4.11 ± 0.519
0.839IleHis: 0.839 ± 0.252
4.278IleIle: 4.278 ± 0.648
5.62IleLys: 5.62 ± 0.787
4.613IleLeu: 4.613 ± 0.94
1.426IleMet: 1.426 ± 0.464
2.936IleAsn: 2.936 ± 0.504
2.768IlePro: 2.768 ± 0.513
2.6IleGln: 2.6 ± 0.484
3.104IleArg: 3.104 ± 0.47
4.278IleSer: 4.278 ± 0.552
3.607IleThr: 3.607 ± 0.411
3.607IleVal: 3.607 ± 0.4
0.252IleTrp: 0.252 ± 0.168
2.181IleTyr: 2.181 ± 0.382
0.0IleXaa: 0.0 ± 0.0
Lys
6.794LysAla: 6.794 ± 1.107
0.336LysCys: 0.336 ± 0.165
4.529LysAsp: 4.529 ± 0.562
7.968LysGlu: 7.968 ± 0.815
3.104LysPhe: 3.104 ± 0.476
5.284LysGly: 5.284 ± 0.728
1.426LysHis: 1.426 ± 0.382
5.62LysIle: 5.62 ± 0.723
6.039LysLys: 6.039 ± 0.881
6.626LysLeu: 6.626 ± 0.692
2.432LysMet: 2.432 ± 0.327
5.452LysAsn: 5.452 ± 0.485
2.349LysPro: 2.349 ± 0.345
3.439LysGln: 3.439 ± 0.59
4.362LysArg: 4.362 ± 0.641
5.62LysSer: 5.62 ± 0.798
5.536LysThr: 5.536 ± 0.764
5.704LysVal: 5.704 ± 0.713
1.09LysTrp: 1.09 ± 0.403
2.936LysTyr: 2.936 ± 0.435
0.0LysXaa: 0.0 ± 0.0
Leu
6.626LeuAla: 6.626 ± 0.758
0.336LeuCys: 0.336 ± 0.203
5.871LeuAsp: 5.871 ± 0.887
7.381LeuGlu: 7.381 ± 0.938
3.775LeuPhe: 3.775 ± 0.676
5.033LeuGly: 5.033 ± 0.843
1.678LeuHis: 1.678 ± 0.404
5.033LeuIle: 5.033 ± 0.673
8.639LeuLys: 8.639 ± 0.919
6.039LeuLeu: 6.039 ± 0.83
2.013LeuMet: 2.013 ± 0.406
4.949LeuAsn: 4.949 ± 0.638
2.181LeuPro: 2.181 ± 0.384
2.684LeuGln: 2.684 ± 0.478
3.355LeuArg: 3.355 ± 0.453
6.039LeuSer: 6.039 ± 0.875
5.955LeuThr: 5.955 ± 1.004
4.613LeuVal: 4.613 ± 0.559
0.336LeuTrp: 0.336 ± 0.168
3.775LeuTyr: 3.775 ± 0.627
0.0LeuXaa: 0.0 ± 0.0
Met
1.929MetAla: 1.929 ± 0.33
0.0MetCys: 0.0 ± 0.0
1.594MetAsp: 1.594 ± 0.397
1.342MetGlu: 1.342 ± 0.361
1.258MetPhe: 1.258 ± 0.359
1.258MetGly: 1.258 ± 0.339
0.084MetHis: 0.084 ± 0.076
1.678MetIle: 1.678 ± 0.405
2.013MetLys: 2.013 ± 0.402
1.342MetLeu: 1.342 ± 0.385
0.755MetMet: 0.755 ± 0.231
1.258MetAsn: 1.258 ± 0.34
1.09MetPro: 1.09 ± 0.321
1.09MetGln: 1.09 ± 0.239
1.007MetArg: 1.007 ± 0.325
2.097MetSer: 2.097 ± 0.47
2.265MetThr: 2.265 ± 0.406
2.181MetVal: 2.181 ± 0.515
0.084MetTrp: 0.084 ± 0.076
0.503MetTyr: 0.503 ± 0.184
0.0MetXaa: 0.0 ± 0.0
Asn
3.355AsnAla: 3.355 ± 0.754
0.336AsnCys: 0.336 ± 0.168
2.6AsnAsp: 2.6 ± 0.471
4.362AsnGlu: 4.362 ± 0.586
2.516AsnPhe: 2.516 ± 0.425
5.955AsnGly: 5.955 ± 0.949
0.839AsnHis: 0.839 ± 0.3
3.355AsnIle: 3.355 ± 0.424
4.362AsnLys: 4.362 ± 0.626
5.788AsnLeu: 5.788 ± 0.658
0.419AsnMet: 0.419 ± 0.182
3.439AsnAsn: 3.439 ± 0.594
2.516AsnPro: 2.516 ± 0.448
2.265AsnGln: 2.265 ± 0.403
1.929AsnArg: 1.929 ± 0.393
3.691AsnSer: 3.691 ± 0.518
2.516AsnThr: 2.516 ± 0.32
3.439AsnVal: 3.439 ± 0.382
0.419AsnTrp: 0.419 ± 0.189
1.929AsnTyr: 1.929 ± 0.396
0.0AsnXaa: 0.0 ± 0.0
Pro
2.181ProAla: 2.181 ± 0.436
0.252ProCys: 0.252 ± 0.152
1.761ProAsp: 1.761 ± 0.388
2.181ProGlu: 2.181 ± 0.483
0.839ProPhe: 0.839 ± 0.255
1.51ProGly: 1.51 ± 0.391
0.839ProHis: 0.839 ± 0.231
1.594ProIle: 1.594 ± 0.43
3.02ProLys: 3.02 ± 0.399
2.013ProLeu: 2.013 ± 0.399
0.587ProMet: 0.587 ± 0.225
1.174ProAsn: 1.174 ± 0.292
0.503ProPro: 0.503 ± 0.171
1.174ProGln: 1.174 ± 0.333
1.09ProArg: 1.09 ± 0.257
1.929ProSer: 1.929 ± 0.366
1.51ProThr: 1.51 ± 0.382
1.594ProVal: 1.594 ± 0.304
0.587ProTrp: 0.587 ± 0.199
1.007ProTyr: 1.007 ± 0.281
0.0ProXaa: 0.0 ± 0.0
Gln
3.104GlnAla: 3.104 ± 0.766
0.084GlnCys: 0.084 ± 0.077
1.51GlnAsp: 1.51 ± 0.414
3.187GlnGlu: 3.187 ± 0.466
2.097GlnPhe: 2.097 ± 0.366
2.432GlnGly: 2.432 ± 0.681
0.671GlnHis: 0.671 ± 0.245
2.265GlnIle: 2.265 ± 0.316
3.104GlnLys: 3.104 ± 0.388
4.278GlnLeu: 4.278 ± 0.535
0.839GlnMet: 0.839 ± 0.295
1.929GlnAsn: 1.929 ± 0.392
0.587GlnPro: 0.587 ± 0.201
1.678GlnGln: 1.678 ± 0.397
1.761GlnArg: 1.761 ± 0.391
2.349GlnSer: 2.349 ± 0.353
2.013GlnThr: 2.013 ± 0.427
2.852GlnVal: 2.852 ± 0.553
0.168GlnTrp: 0.168 ± 0.106
1.594GlnTyr: 1.594 ± 0.256
0.0GlnXaa: 0.0 ± 0.0
Arg
2.349ArgAla: 2.349 ± 0.416
0.336ArgCys: 0.336 ± 0.211
3.104ArgAsp: 3.104 ± 0.429
2.852ArgGlu: 2.852 ± 0.562
1.426ArgPhe: 1.426 ± 0.338
2.516ArgGly: 2.516 ± 0.454
0.755ArgHis: 0.755 ± 0.208
1.845ArgIle: 1.845 ± 0.389
2.349ArgLys: 2.349 ± 0.489
3.775ArgLeu: 3.775 ± 0.618
1.174ArgMet: 1.174 ± 0.314
2.768ArgAsn: 2.768 ± 0.432
1.594ArgPro: 1.594 ± 0.359
1.594ArgGln: 1.594 ± 0.368
1.342ArgArg: 1.342 ± 0.324
2.684ArgSer: 2.684 ± 0.401
2.684ArgThr: 2.684 ± 0.544
1.594ArgVal: 1.594 ± 0.367
1.426ArgTrp: 1.426 ± 0.384
2.6ArgTyr: 2.6 ± 0.44
0.0ArgXaa: 0.0 ± 0.0
Ser
4.362SerAla: 4.362 ± 0.66
0.336SerCys: 0.336 ± 0.168
5.033SerAsp: 5.033 ± 0.662
5.62SerGlu: 5.62 ± 0.645
3.523SerPhe: 3.523 ± 0.518
5.033SerGly: 5.033 ± 0.738
1.007SerHis: 1.007 ± 0.282
3.691SerIle: 3.691 ± 0.684
5.536SerLys: 5.536 ± 0.835
5.368SerLeu: 5.368 ± 0.884
2.013SerMet: 2.013 ± 0.331
3.942SerAsn: 3.942 ± 0.489
1.258SerPro: 1.258 ± 0.331
2.349SerGln: 2.349 ± 0.604
2.097SerArg: 2.097 ± 0.383
4.781SerSer: 4.781 ± 0.728
3.355SerThr: 3.355 ± 0.504
4.026SerVal: 4.026 ± 0.57
1.258SerTrp: 1.258 ± 0.347
2.013SerTyr: 2.013 ± 0.392
0.0SerXaa: 0.0 ± 0.0
Thr
4.697ThrAla: 4.697 ± 1.338
0.252ThrCys: 0.252 ± 0.142
3.942ThrAsp: 3.942 ± 0.542
3.439ThrGlu: 3.439 ± 0.59
2.265ThrPhe: 2.265 ± 0.363
4.613ThrGly: 4.613 ± 0.629
0.923ThrHis: 0.923 ± 0.266
4.529ThrIle: 4.529 ± 0.772
4.865ThrLys: 4.865 ± 0.547
4.697ThrLeu: 4.697 ± 0.667
1.174ThrMet: 1.174 ± 0.21
3.02ThrAsn: 3.02 ± 0.488
1.342ThrPro: 1.342 ± 0.308
1.845ThrGln: 1.845 ± 0.32
2.265ThrArg: 2.265 ± 0.522
3.942ThrSer: 3.942 ± 0.625
4.278ThrThr: 4.278 ± 0.767
3.523ThrVal: 3.523 ± 0.721
0.923ThrTrp: 0.923 ± 0.238
2.013ThrTyr: 2.013 ± 0.397
0.0ThrXaa: 0.0 ± 0.0
Val
3.942ValAla: 3.942 ± 0.549
0.336ValCys: 0.336 ± 0.161
3.858ValAsp: 3.858 ± 0.518
5.033ValGlu: 5.033 ± 0.851
2.265ValPhe: 2.265 ± 0.561
3.775ValGly: 3.775 ± 0.465
0.923ValHis: 0.923 ± 0.293
3.607ValIle: 3.607 ± 0.53
5.955ValLys: 5.955 ± 0.66
4.781ValLeu: 4.781 ± 0.602
1.258ValMet: 1.258 ± 0.329
3.187ValAsn: 3.187 ± 0.504
1.594ValPro: 1.594 ± 0.315
2.349ValGln: 2.349 ± 0.461
1.929ValArg: 1.929 ± 0.327
4.362ValSer: 4.362 ± 0.561
4.194ValThr: 4.194 ± 0.665
3.523ValVal: 3.523 ± 0.535
0.923ValTrp: 0.923 ± 0.398
2.265ValTyr: 2.265 ± 0.399
0.0ValXaa: 0.0 ± 0.0
Trp
0.587TrpAla: 0.587 ± 0.159
0.084TrpCys: 0.084 ± 0.088
0.839TrpAsp: 0.839 ± 0.268
0.755TrpGlu: 0.755 ± 0.248
0.336TrpPhe: 0.336 ± 0.149
0.419TrpGly: 0.419 ± 0.163
0.084TrpHis: 0.084 ± 0.088
1.09TrpIle: 1.09 ± 0.281
1.426TrpLys: 1.426 ± 0.366
1.174TrpLeu: 1.174 ± 0.281
0.503TrpMet: 0.503 ± 0.213
0.587TrpAsn: 0.587 ± 0.314
0.252TrpPro: 0.252 ± 0.133
0.587TrpGln: 0.587 ± 0.234
0.671TrpArg: 0.671 ± 0.263
0.755TrpSer: 0.755 ± 0.234
0.755TrpThr: 0.755 ± 0.4
0.839TrpVal: 0.839 ± 0.311
0.168TrpTrp: 0.168 ± 0.195
0.923TrpTyr: 0.923 ± 0.627
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.845TyrAla: 1.845 ± 0.41
1.007TyrCys: 1.007 ± 0.295
2.349TyrAsp: 2.349 ± 0.393
2.852TyrGlu: 2.852 ± 0.597
1.51TyrPhe: 1.51 ± 0.364
2.265TyrGly: 2.265 ± 0.46
0.839TyrHis: 0.839 ± 0.332
2.768TyrIle: 2.768 ± 0.519
2.349TyrLys: 2.349 ± 0.421
3.691TyrLeu: 3.691 ± 0.787
0.671TyrMet: 0.671 ± 0.252
2.265TyrAsn: 2.265 ± 0.389
1.426TyrPro: 1.426 ± 0.363
2.097TyrGln: 2.097 ± 0.415
1.342TyrArg: 1.342 ± 0.377
1.929TyrSer: 1.929 ± 0.598
1.845TyrThr: 1.845 ± 0.345
1.929TyrVal: 1.929 ± 0.438
0.419TyrTrp: 0.419 ± 0.163
2.265TyrTyr: 2.265 ± 0.929
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 58 proteins (11923 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski