Amino acid dipepetide frequency for [Clostridium] methylpentosum DSM 5476

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.798AlaAla: 8.798 ± 0.136	1.138AlaCys: 1.138 ± 0.038	4.798AlaAsp: 4.798 ± 0.079	5.64AlaGlu: 5.64 ± 0.083	3.167AlaPhe: 3.167 ± 0.061	6.33AlaGly: 6.33 ± 0.077	1.261AlaHis: 1.261 ± 0.04	4.762AlaIle: 4.762 ± 0.073	4.676AlaLys: 4.676 ± 0.081	8.003AlaLeu: 8.003 ± 0.107	2.085AlaMet: 2.085 ± 0.046	2.939AlaAsn: 2.939 ± 0.063	2.707AlaPro: 2.707 ± 0.061	3.61AlaGln: 3.61 ± 0.068	3.379AlaArg: 3.379 ± 0.071	4.676AlaSer: 4.676 ± 0.073	3.897AlaThr: 3.897 ± 0.087	7.198AlaVal: 7.198 ± 0.102	0.731AlaTrp: 0.731 ± 0.03	2.692AlaTyr: 2.692 ± 0.063	0.0AlaXaa: 0.0 ± 0.0
Cys	1.25CysAla: 1.25 ± 0.035	0.368CysCys: 0.368 ± 0.019	0.819CysAsp: 0.819 ± 0.033	0.923CysGlu: 0.923 ± 0.033	0.733CysPhe: 0.733 ± 0.033	1.458CysGly: 1.458 ± 0.042	0.286CysHis: 0.286 ± 0.018	0.998CysIle: 0.998 ± 0.036	0.787CysLys: 0.787 ± 0.031	1.289CysLeu: 1.289 ± 0.039	0.384CysMet: 0.384 ± 0.02	0.496CysAsn: 0.496 ± 0.024	0.781CysPro: 0.781 ± 0.034	0.449CysGln: 0.449 ± 0.021	0.846CysArg: 0.846 ± 0.034	1.097CysSer: 1.097 ± 0.037	0.749CysThr: 0.749 ± 0.03	0.915CysVal: 0.915 ± 0.036	0.145CysTrp: 0.145 ± 0.012	0.546CysTyr: 0.546 ± 0.026	0.0CysXaa: 0.0 ± 0.0
Asp	4.59AspAla: 4.59 ± 0.094	0.905AspCys: 0.905 ± 0.034	2.671AspAsp: 2.671 ± 0.058	3.911AspGlu: 3.911 ± 0.077	2.528AspPhe: 2.528 ± 0.055	4.598AspGly: 4.598 ± 0.094	0.866AspHis: 0.866 ± 0.029	3.68AspIle: 3.68 ± 0.073	3.249AspLys: 3.249 ± 0.066	4.904AspLeu: 4.904 ± 0.07	1.259AspMet: 1.259 ± 0.04	2.373AspAsn: 2.373 ± 0.068	2.25AspPro: 2.25 ± 0.056	1.983AspGln: 1.983 ± 0.046	2.631AspArg: 2.631 ± 0.054	3.513AspSer: 3.513 ± 0.072	3.174AspThr: 3.174 ± 0.072	3.457AspVal: 3.457 ± 0.068	0.67AspTrp: 0.67 ± 0.027	2.593AspTyr: 2.593 ± 0.059	0.0AspXaa: 0.0 ± 0.0
Glu	4.984GluAla: 4.984 ± 0.08	0.688GluCys: 0.688 ± 0.025	3.336GluAsp: 3.336 ± 0.07	4.989GluGlu: 4.989 ± 0.089	2.6GluPhe: 2.6 ± 0.056	4.037GluGly: 4.037 ± 0.075	1.25GluHis: 1.25 ± 0.039	4.958GluIle: 4.958 ± 0.076	4.293GluLys: 4.293 ± 0.07	6.501GluLeu: 6.501 ± 0.091	2.022GluMet: 2.022 ± 0.043	3.428GluAsn: 3.428 ± 0.06	2.028GluPro: 2.028 ± 0.047	3.675GluGln: 3.675 ± 0.072	3.462GluArg: 3.462 ± 0.081	3.415GluSer: 3.415 ± 0.066	3.665GluThr: 3.665 ± 0.06	3.951GluVal: 3.951 ± 0.071	0.645GluTrp: 0.645 ± 0.029	2.579GluTyr: 2.579 ± 0.054	0.0GluXaa: 0.0 ± 0.0
Phe	3.363PheAla: 3.363 ± 0.067	0.892PheCys: 0.892 ± 0.034	2.827PheAsp: 2.827 ± 0.055	2.817PheGlu: 2.817 ± 0.051	2.073PhePhe: 2.073 ± 0.063	3.101PheGly: 3.101 ± 0.06	0.876PheHis: 0.876 ± 0.032	2.289PheIle: 2.289 ± 0.058	1.808PheLys: 1.808 ± 0.047	4.018PheLeu: 4.018 ± 0.084	0.89PheMet: 0.89 ± 0.03	1.672PheAsn: 1.672 ± 0.042	1.508PhePro: 1.508 ± 0.04	1.521PheGln: 1.521 ± 0.041	1.806PheArg: 1.806 ± 0.052	3.41PheSer: 3.41 ± 0.075	2.56PheThr: 2.56 ± 0.056	3.005PheVal: 3.005 ± 0.064	0.482PheTrp: 0.482 ± 0.019	1.663PheTyr: 1.663 ± 0.044	0.0PheXaa: 0.0 ± 0.0
Gly	5.351GlyAla: 5.351 ± 0.097	1.237GlyCys: 1.237 ± 0.038	3.931GlyAsp: 3.931 ± 0.072	5.101GlyGlu: 5.101 ± 0.073	3.29GlyPhe: 3.29 ± 0.06	5.13GlyGly: 5.13 ± 0.074	1.082GlyHis: 1.082 ± 0.036	5.046GlyIle: 5.046 ± 0.081	4.505GlyLys: 4.505 ± 0.071	5.891GlyLeu: 5.891 ± 0.094	2.182GlyMet: 2.182 ± 0.046	2.984GlyAsn: 2.984 ± 0.072	1.566GlyPro: 1.566 ± 0.051	2.624GlyGln: 2.624 ± 0.056	3.388GlyArg: 3.388 ± 0.072	4.552GlySer: 4.552 ± 0.078	4.155GlyThr: 4.155 ± 0.064	5.159GlyVal: 5.159 ± 0.073	0.881GlyTrp: 0.881 ± 0.04	3.098GlyTyr: 3.098 ± 0.065	0.0GlyXaa: 0.0 ± 0.0
His	1.205HisAla: 1.205 ± 0.036	0.38HisCys: 0.38 ± 0.021	0.781HisAsp: 0.781 ± 0.028	0.853HisGlu: 0.853 ± 0.031	0.887HisPhe: 0.887 ± 0.033	1.197HisGly: 1.197 ± 0.031	0.362HisHis: 0.362 ± 0.019	1.156HisIle: 1.156 ± 0.032	1.004HisLys: 1.004 ± 0.026	1.597HisLeu: 1.597 ± 0.054	0.44HisMet: 0.44 ± 0.021	0.771HisAsn: 0.771 ± 0.029	1.022HisPro: 1.022 ± 0.038	0.659HisGln: 0.659 ± 0.025	1.006HisArg: 1.006 ± 0.034	1.209HisSer: 1.209 ± 0.034	1.007HisThr: 1.007 ± 0.029	0.855HisVal: 0.855 ± 0.029	0.2HisTrp: 0.2 ± 0.017	0.729HisTyr: 0.729 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	5.394IleAla: 5.394 ± 0.088	1.087IleCys: 1.087 ± 0.035	4.14IleAsp: 4.14 ± 0.072	4.16IleGlu: 4.16 ± 0.078	2.407IlePhe: 2.407 ± 0.059	4.439IleGly: 4.439 ± 0.086	1.235IleHis: 1.235 ± 0.038	3.563IleIle: 3.563 ± 0.085	3.3IleLys: 3.3 ± 0.073	6.362IleLeu: 6.362 ± 0.104	1.299IleMet: 1.299 ± 0.039	2.589IleAsn: 2.589 ± 0.049	2.931IlePro: 2.931 ± 0.057	2.443IleGln: 2.443 ± 0.048	3.146IleArg: 3.146 ± 0.058	4.565IleSer: 4.565 ± 0.067	3.865IleThr: 3.865 ± 0.065	4.263IleVal: 4.263 ± 0.072	0.569IleTrp: 0.569 ± 0.022	2.098IleTyr: 2.098 ± 0.051	0.0IleXaa: 0.0 ± 0.0
Lys	4.457LysAla: 4.457 ± 0.078	0.577LysCys: 0.577 ± 0.029	2.698LysAsp: 2.698 ± 0.054	4.197LysGlu: 4.197 ± 0.075	1.724LysPhe: 1.724 ± 0.044	3.489LysGly: 3.489 ± 0.066	0.909LysHis: 0.909 ± 0.03	3.774LysIle: 3.774 ± 0.066	4.158LysLys: 4.158 ± 0.08	5.276LysLeu: 5.276 ± 0.084	1.703LysMet: 1.703 ± 0.037	2.774LysAsn: 2.774 ± 0.056	2.098LysPro: 2.098 ± 0.048	2.714LysGln: 2.714 ± 0.056	3.302LysArg: 3.302 ± 0.064	3.275LysSer: 3.275 ± 0.053	3.646LysThr: 3.646 ± 0.061	3.4LysVal: 3.4 ± 0.06	0.485LysTrp: 0.485 ± 0.021	1.966LysTyr: 1.966 ± 0.048	0.0LysXaa: 0.0 ± 0.0
Leu	7.508LeuAla: 7.508 ± 0.099	1.799LeuCys: 1.799 ± 0.047	5.342LeuAsp: 5.342 ± 0.084	5.726LeuGlu: 5.726 ± 0.094	4.609LeuPhe: 4.609 ± 0.104	6.04LeuGly: 6.04 ± 0.086	1.725LeuHis: 1.725 ± 0.045	5.734LeuIle: 5.734 ± 0.106	5.233LeuLys: 5.233 ± 0.076	9.815LeuLeu: 9.815 ± 0.162	2.293LeuMet: 2.293 ± 0.044	3.867LeuAsn: 3.867 ± 0.053	4.137LeuPro: 4.137 ± 0.067	3.23LeuGln: 3.23 ± 0.056	4.523LeuArg: 4.523 ± 0.094	7.456LeuSer: 7.456 ± 0.113	5.663LeuThr: 5.663 ± 0.08	5.71LeuVal: 5.71 ± 0.08	0.828LeuTrp: 0.828 ± 0.035	3.345LeuTyr: 3.345 ± 0.06	0.0LeuXaa: 0.0 ± 0.0
Met	2.021MetAla: 2.021 ± 0.047	0.302MetCys: 0.302 ± 0.02	1.327MetAsp: 1.327 ± 0.037	1.732MetGlu: 1.732 ± 0.047	0.87MetPhe: 0.87 ± 0.03	1.744MetGly: 1.744 ± 0.044	0.415MetHis: 0.415 ± 0.022	1.669MetIle: 1.669 ± 0.044	1.939MetLys: 1.939 ± 0.047	2.653MetLeu: 2.653 ± 0.057	0.698MetMet: 0.698 ± 0.028	1.294MetAsn: 1.294 ± 0.036	1.019MetPro: 1.019 ± 0.033	1.115MetGln: 1.115 ± 0.033	1.226MetArg: 1.226 ± 0.035	1.503MetSer: 1.503 ± 0.041	1.47MetThr: 1.47 ± 0.039	1.59MetVal: 1.59 ± 0.043	0.205MetTrp: 0.205 ± 0.017	0.714MetTyr: 0.714 ± 0.029	0.0MetXaa: 0.0 ± 0.0
Asn	3.485AsnAla: 3.485 ± 0.075	0.647AsnCys: 0.647 ± 0.025	2.085AsnAsp: 2.085 ± 0.052	2.382AsnGlu: 2.382 ± 0.049	1.624AsnPhe: 1.624 ± 0.049	3.527AsnGly: 3.527 ± 0.072	0.796AsnHis: 0.796 ± 0.03	2.73AsnIle: 2.73 ± 0.057	2.259AsnLys: 2.259 ± 0.058	3.834AsnLeu: 3.834 ± 0.057	1.036AsnMet: 1.036 ± 0.035	1.806AsnAsn: 1.806 ± 0.052	2.313AsnPro: 2.313 ± 0.051	1.764AsnGln: 1.764 ± 0.043	2.216AsnArg: 2.216 ± 0.055	2.616AsnSer: 2.616 ± 0.056	2.47AsnThr: 2.47 ± 0.047	2.404AsnVal: 2.404 ± 0.051	0.509AsnTrp: 0.509 ± 0.023	1.839AsnTyr: 1.839 ± 0.056	0.0AsnXaa: 0.0 ± 0.0
Pro	3.366ProAla: 3.366 ± 0.065	0.561ProCys: 0.561 ± 0.027	2.687ProAsp: 2.687 ± 0.057	3.103ProGlu: 3.103 ± 0.053	1.721ProPhe: 1.721 ± 0.045	2.577ProGly: 2.577 ± 0.052	0.742ProHis: 0.742 ± 0.031	2.209ProIle: 2.209 ± 0.049	1.915ProLys: 1.915 ± 0.042	3.278ProLeu: 3.278 ± 0.065	0.864ProMet: 0.864 ± 0.028	1.519ProAsn: 1.519 ± 0.037	1.41ProPro: 1.41 ± 0.049	1.527ProGln: 1.527 ± 0.039	1.328ProArg: 1.328 ± 0.043	2.472ProSer: 2.472 ± 0.053	1.996ProThr: 1.996 ± 0.053	3.307ProVal: 3.307 ± 0.069	0.358ProTrp: 0.358 ± 0.019	1.511ProTyr: 1.511 ± 0.042	0.0ProXaa: 0.0 ± 0.0
Gln	3.534GlnAla: 3.534 ± 0.069	0.391GlnCys: 0.391 ± 0.02	1.9GlnAsp: 1.9 ± 0.04	2.651GlnGlu: 2.651 ± 0.057	1.418GlnPhe: 1.418 ± 0.038	2.506GlnGly: 2.506 ± 0.056	0.627GlnHis: 0.627 ± 0.025	2.81GlnIle: 2.81 ± 0.049	2.674GlnLys: 2.674 ± 0.054	3.818GlnLeu: 3.818 ± 0.07	1.244GlnMet: 1.244 ± 0.038	2.005GlnAsn: 2.005 ± 0.042	1.572GlnPro: 1.572 ± 0.045	2.23GlnGln: 2.23 ± 0.058	2.026GlnArg: 2.026 ± 0.048	2.5GlnSer: 2.5 ± 0.048	2.358GlnThr: 2.358 ± 0.052	2.528GlnVal: 2.528 ± 0.054	0.4GlnTrp: 0.4 ± 0.023	1.471GlnTyr: 1.471 ± 0.046	0.0GlnXaa: 0.0 ± 0.0
Arg	3.497ArgAla: 3.497 ± 0.07	0.778ArgCys: 0.778 ± 0.036	2.278ArgAsp: 2.278 ± 0.054	3.577ArgGlu: 3.577 ± 0.076	2.204ArgPhe: 2.204 ± 0.049	3.009ArgGly: 3.009 ± 0.063	0.874ArgHis: 0.874 ± 0.029	3.403ArgIle: 3.403 ± 0.072	2.864ArgLys: 2.864 ± 0.067	4.647ArgLeu: 4.647 ± 0.093	1.562ArgMet: 1.562 ± 0.042	1.864ArgAsn: 1.864 ± 0.043	1.665ArgPro: 1.665 ± 0.042	2.108ArgGln: 2.108 ± 0.052	2.944ArgArg: 2.944 ± 0.075	2.739ArgSer: 2.739 ± 0.058	2.529ArgThr: 2.529 ± 0.054	2.984ArgVal: 2.984 ± 0.056	0.501ArgTrp: 0.501 ± 0.02	2.007ArgTyr: 2.007 ± 0.048	0.0ArgXaa: 0.0 ± 0.0
Ser	5.395SerAla: 5.395 ± 0.086	1.008SerCys: 1.008 ± 0.036	3.555SerAsp: 3.555 ± 0.071	3.975SerGlu: 3.975 ± 0.072	3.272SerPhe: 3.272 ± 0.054	5.286SerGly: 5.286 ± 0.082	1.13SerHis: 1.13 ± 0.033	4.155SerIle: 4.155 ± 0.064	3.245SerLys: 3.245 ± 0.063	6.187SerLeu: 6.187 ± 0.086	1.578SerMet: 1.578 ± 0.041	2.49SerAsn: 2.49 ± 0.052	2.513SerPro: 2.513 ± 0.051	2.262SerGln: 2.262 ± 0.05	2.938SerArg: 2.938 ± 0.066	4.701SerSer: 4.701 ± 0.092	3.355SerThr: 3.355 ± 0.061	4.807SerVal: 4.807 ± 0.075	0.773SerTrp: 0.773 ± 0.03	2.728SerTyr: 2.728 ± 0.065	0.0SerXaa: 0.0 ± 0.0
Thr	5.521ThrAla: 5.521 ± 0.103	0.646ThrCys: 0.646 ± 0.027	3.343ThrAsp: 3.343 ± 0.071	3.523ThrGlu: 3.523 ± 0.064	2.197ThrPhe: 2.197 ± 0.047	5.066ThrGly: 5.066 ± 0.098	0.862ThrHis: 0.862 ± 0.026	3.742ThrIle: 3.742 ± 0.062	2.675ThrLys: 2.675 ± 0.062	5.259ThrLeu: 5.259 ± 0.073	1.361ThrMet: 1.361 ± 0.035	2.061ThrAsn: 2.061 ± 0.048	2.674ThrPro: 2.674 ± 0.052	2.044ThrGln: 2.044 ± 0.043	2.223ThrArg: 2.223 ± 0.054	3.476ThrSer: 3.476 ± 0.068	3.32ThrThr: 3.32 ± 0.083	4.819ThrVal: 4.819 ± 0.092	0.505ThrTrp: 0.505 ± 0.027	2.002ThrTyr: 2.002 ± 0.049	0.0ThrXaa: 0.0 ± 0.0
Val	5.251ValAla: 5.251 ± 0.079	1.156ValCys: 1.156 ± 0.042	4.168ValAsp: 4.168 ± 0.073	4.357ValGlu: 4.357 ± 0.074	3.071ValPhe: 3.071 ± 0.067	4.27ValGly: 4.27 ± 0.08	1.08ValHis: 1.08 ± 0.035	4.343ValIle: 4.343 ± 0.072	3.614ValLys: 3.614 ± 0.068	6.683ValLeu: 6.683 ± 0.08	1.498ValMet: 1.498 ± 0.039	2.885ValAsn: 2.885 ± 0.064	2.528ValPro: 2.528 ± 0.053	2.519ValGln: 2.519 ± 0.05	3.102ValArg: 3.102 ± 0.064	5.072ValSer: 5.072 ± 0.079	4.264ValThr: 4.264 ± 0.083	4.97ValVal: 4.97 ± 0.086	0.661ValTrp: 0.661 ± 0.027	2.452ValTyr: 2.452 ± 0.054	0.0ValXaa: 0.0 ± 0.0
Trp	0.691TrpAla: 0.691 ± 0.028	0.19TrpCys: 0.19 ± 0.013	0.648TrpAsp: 0.648 ± 0.026	0.655TrpGlu: 0.655 ± 0.027	0.442TrpPhe: 0.442 ± 0.021	0.69TrpGly: 0.69 ± 0.03	0.191TrpHis: 0.191 ± 0.013	0.626TrpIle: 0.626 ± 0.024	0.625TrpLys: 0.625 ± 0.026	0.95TrpLeu: 0.95 ± 0.035	0.308TrpMet: 0.308 ± 0.017	0.626TrpAsn: 0.626 ± 0.029	0.282TrpPro: 0.282 ± 0.018	0.461TrpGln: 0.461 ± 0.022	0.394TrpArg: 0.394 ± 0.022	0.626TrpSer: 0.626 ± 0.029	0.628TrpThr: 0.628 ± 0.035	0.557TrpVal: 0.557 ± 0.025	0.162TrpTrp: 0.162 ± 0.014	0.374TrpTyr: 0.374 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.824TyrAla: 2.824 ± 0.06	0.573TyrCys: 0.573 ± 0.026	2.471TyrAsp: 2.471 ± 0.058	2.23TyrGlu: 2.23 ± 0.049	1.744TyrPhe: 1.744 ± 0.047	2.661TyrGly: 2.661 ± 0.059	0.749TyrHis: 0.749 ± 0.03	2.206TyrIle: 2.206 ± 0.043	1.8TyrLys: 1.8 ± 0.039	3.617TyrLeu: 3.617 ± 0.066	0.801TyrMet: 0.801 ± 0.029	1.9TyrAsn: 1.9 ± 0.052	1.447TyrPro: 1.447 ± 0.035	1.724TyrGln: 1.724 ± 0.052	2.147TyrArg: 2.147 ± 0.045	2.48TyrSer: 2.48 ± 0.049	2.548TyrThr: 2.548 ± 0.067	2.065TyrVal: 2.065 ± 0.043	0.42TyrTrp: 0.42 ± 0.023	1.623TyrTyr: 1.623 ± 0.048	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3907 proteins (988130 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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