Amino acid dipepetide frequency for Aspergillus uvarum CBS 121591

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.981AlaAla: 9.981 ± 0.066	1.179AlaCys: 1.179 ± 0.014	4.405AlaAsp: 4.405 ± 0.028	5.231AlaGlu: 5.231 ± 0.034	3.194AlaPhe: 3.194 ± 0.028	6.151AlaGly: 6.151 ± 0.043	1.994AlaHis: 1.994 ± 0.021	4.306AlaIle: 4.306 ± 0.035	3.513AlaLys: 3.513 ± 0.032	8.295AlaLeu: 8.295 ± 0.045	1.983AlaMet: 1.983 ± 0.021	2.785AlaAsn: 2.785 ± 0.022	4.811AlaPro: 4.811 ± 0.038	3.612AlaGln: 3.612 ± 0.031	5.322AlaArg: 5.322 ± 0.037	7.375AlaSer: 7.375 ± 0.045	5.718AlaThr: 5.718 ± 0.039	5.788AlaVal: 5.788 ± 0.037	1.272AlaTrp: 1.272 ± 0.019	2.299AlaTyr: 2.299 ± 0.021	0.0AlaXaa: 0.0 ± 0.0
Cys	1.056CysAla: 1.056 ± 0.014	0.28CysCys: 0.28 ± 0.008	0.711CysAsp: 0.711 ± 0.013	0.623CysGlu: 0.623 ± 0.009	0.572CysPhe: 0.572 ± 0.01	0.986CysGly: 0.986 ± 0.016	0.37CysHis: 0.37 ± 0.008	0.737CysIle: 0.737 ± 0.013	0.455CysLys: 0.455 ± 0.009	1.436CysLeu: 1.436 ± 0.018	0.305CysMet: 0.305 ± 0.008	0.419CysAsn: 0.419 ± 0.009	0.71CysPro: 0.71 ± 0.015	0.503CysGln: 0.503 ± 0.01	0.867CysArg: 0.867 ± 0.016	1.008CysSer: 1.008 ± 0.014	0.774CysThr: 0.774 ± 0.013	0.888CysVal: 0.888 ± 0.014	0.218CysTrp: 0.218 ± 0.006	0.388CysTyr: 0.388 ± 0.007	0.0CysXaa: 0.0 ± 0.0
Asp	4.724AspAla: 4.724 ± 0.029	0.67AspCys: 0.67 ± 0.011	3.843AspAsp: 3.843 ± 0.038	4.171AspGlu: 4.171 ± 0.03	2.11AspPhe: 2.11 ± 0.021	3.839AspGly: 3.839 ± 0.028	1.356AspHis: 1.356 ± 0.014	2.783AspIle: 2.783 ± 0.025	1.961AspLys: 1.961 ± 0.022	5.233AspLeu: 5.233 ± 0.03	1.121AspMet: 1.121 ± 0.015	1.713AspAsn: 1.713 ± 0.02	3.377AspPro: 3.377 ± 0.026	1.914AspGln: 1.914 ± 0.018	3.199AspArg: 3.199 ± 0.032	3.956AspSer: 3.956 ± 0.033	2.894AspThr: 2.894 ± 0.022	3.475AspVal: 3.475 ± 0.025	0.905AspTrp: 0.905 ± 0.014	1.653AspTyr: 1.653 ± 0.017	0.0AspXaa: 0.0 ± 0.0
Glu	5.339GluAla: 5.339 ± 0.036	0.633GluCys: 0.633 ± 0.012	3.916GluAsp: 3.916 ± 0.032	5.343GluGlu: 5.343 ± 0.059	1.907GluPhe: 1.907 ± 0.02	3.761GluGly: 3.761 ± 0.025	1.404GluHis: 1.404 ± 0.017	2.976GluIle: 2.976 ± 0.024	3.178GluLys: 3.178 ± 0.033	5.155GluLeu: 5.155 ± 0.035	1.415GluMet: 1.415 ± 0.017	2.05GluAsn: 2.05 ± 0.021	2.738GluPro: 2.738 ± 0.039	2.528GluGln: 2.528 ± 0.023	3.864GluArg: 3.864 ± 0.032	4.139GluSer: 4.139 ± 0.034	3.515GluThr: 3.515 ± 0.025	3.617GluVal: 3.617 ± 0.027	0.878GluTrp: 0.878 ± 0.014	1.656GluTyr: 1.656 ± 0.019	0.0GluXaa: 0.0 ± 0.0
Phe	3.155PheAla: 3.155 ± 0.028	0.608PheCys: 0.608 ± 0.011	2.216PheAsp: 2.216 ± 0.021	2.045PheGlu: 2.045 ± 0.02	1.672PhePhe: 1.672 ± 0.02	2.752PheGly: 2.752 ± 0.029	0.98PheHis: 0.98 ± 0.014	1.742PheIle: 1.742 ± 0.02	1.276PheLys: 1.276 ± 0.018	3.688PheLeu: 3.688 ± 0.031	0.754PheMet: 0.754 ± 0.013	1.299PheAsn: 1.299 ± 0.018	2.026PhePro: 2.026 ± 0.019	1.447PheGln: 1.447 ± 0.016	2.059PheArg: 2.059 ± 0.02	2.937PheSer: 2.937 ± 0.025	2.188PheThr: 2.188 ± 0.02	2.452PheVal: 2.452 ± 0.022	0.68PheTrp: 0.68 ± 0.011	1.146PheTyr: 1.146 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	5.509GlyAla: 5.509 ± 0.042	0.973GlyCys: 0.973 ± 0.015	3.523GlyAsp: 3.523 ± 0.025	3.622GlyGlu: 3.622 ± 0.03	2.824GlyPhe: 2.824 ± 0.028	5.762GlyGly: 5.762 ± 0.05	1.691GlyHis: 1.691 ± 0.021	3.372GlyIle: 3.372 ± 0.028	2.981GlyLys: 2.981 ± 0.029	6.388GlyLeu: 6.388 ± 0.037	1.538GlyMet: 1.538 ± 0.018	2.297GlyAsn: 2.297 ± 0.025	3.335GlyPro: 3.335 ± 0.026	2.579GlyGln: 2.579 ± 0.027	4.189GlyArg: 4.189 ± 0.032	5.647GlySer: 5.647 ± 0.038	3.938GlyThr: 3.938 ± 0.031	4.599GlyVal: 4.599 ± 0.034	1.226GlyTrp: 1.226 ± 0.018	2.195GlyTyr: 2.195 ± 0.026	0.0GlyXaa: 0.0 ± 0.0
His	2.043HisAla: 2.043 ± 0.021	0.367HisCys: 0.367 ± 0.008	1.379HisAsp: 1.379 ± 0.016	1.394HisGlu: 1.394 ± 0.016	0.955HisPhe: 0.955 ± 0.012	1.796HisGly: 1.796 ± 0.019	1.041HisHis: 1.041 ± 0.02	1.212HisIle: 1.212 ± 0.017	0.809HisLys: 0.809 ± 0.012	2.511HisLeu: 2.511 ± 0.023	0.497HisMet: 0.497 ± 0.011	0.851HisAsn: 0.851 ± 0.014	1.876HisPro: 1.876 ± 0.02	1.099HisGln: 1.099 ± 0.017	1.725HisArg: 1.725 ± 0.022	1.868HisSer: 1.868 ± 0.022	1.358HisThr: 1.358 ± 0.018	1.477HisVal: 1.477 ± 0.016	0.377HisTrp: 0.377 ± 0.008	0.76HisTyr: 0.76 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	4.17IleAla: 4.17 ± 0.032	0.784IleCys: 0.784 ± 0.014	2.709IleAsp: 2.709 ± 0.02	2.652IleGlu: 2.652 ± 0.023	1.982IlePhe: 1.982 ± 0.02	3.052IleGly: 3.052 ± 0.031	1.284IleHis: 1.284 ± 0.017	2.416IleIle: 2.416 ± 0.023	1.85IleLys: 1.85 ± 0.021	4.714IleLeu: 4.714 ± 0.032	0.927IleMet: 0.927 ± 0.014	1.652IleAsn: 1.652 ± 0.02	3.135IlePro: 3.135 ± 0.023	1.903IleGln: 1.903 ± 0.019	2.81IleArg: 2.81 ± 0.023	3.687IleSer: 3.687 ± 0.027	2.834IleThr: 2.834 ± 0.027	3.121IleVal: 3.121 ± 0.027	0.711IleTrp: 0.711 ± 0.012	1.462IleTyr: 1.462 ± 0.019	0.0IleXaa: 0.0 ± 0.0
Lys	3.69LysAla: 3.69 ± 0.027	0.474LysCys: 0.474 ± 0.011	2.301LysAsp: 2.301 ± 0.023	2.848LysGlu: 2.848 ± 0.03	1.225LysPhe: 1.225 ± 0.015	2.585LysGly: 2.585 ± 0.022	1.017LysHis: 1.017 ± 0.016	1.942LysIle: 1.942 ± 0.02	2.62LysLys: 2.62 ± 0.038	3.657LysLeu: 3.657 ± 0.033	0.847LysMet: 0.847 ± 0.012	1.449LysAsn: 1.449 ± 0.02	2.421LysPro: 2.421 ± 0.027	1.693LysGln: 1.693 ± 0.02	3.013LysArg: 3.013 ± 0.027	3.039LysSer: 3.039 ± 0.028	2.437LysThr: 2.437 ± 0.023	2.543LysVal: 2.543 ± 0.026	0.578LysTrp: 0.578 ± 0.011	1.205LysTyr: 1.205 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	8.43LeuAla: 8.43 ± 0.05	1.332LeuCys: 1.332 ± 0.017	5.24LeuAsp: 5.24 ± 0.033	5.574LeuGlu: 5.574 ± 0.036	3.471LeuPhe: 3.471 ± 0.03	6.221LeuGly: 6.221 ± 0.039	2.476LeuHis: 2.476 ± 0.023	4.07LeuIle: 4.07 ± 0.032	3.752LeuLys: 3.752 ± 0.032	9.093LeuLeu: 9.093 ± 0.057	1.853LeuMet: 1.853 ± 0.018	3.133LeuAsn: 3.133 ± 0.025	5.733LeuPro: 5.733 ± 0.035	4.088LeuGln: 4.088 ± 0.032	6.189LeuArg: 6.189 ± 0.034	7.55LeuSer: 7.55 ± 0.045	5.234LeuThr: 5.234 ± 0.034	5.811LeuVal: 5.811 ± 0.039	1.296LeuTrp: 1.296 ± 0.014	2.565LeuTyr: 2.565 ± 0.025	0.0LeuXaa: 0.0 ± 0.0
Met	2.125MetAla: 2.125 ± 0.019	0.253MetCys: 0.253 ± 0.007	1.155MetAsp: 1.155 ± 0.015	1.21MetGlu: 1.21 ± 0.015	0.716MetPhe: 0.716 ± 0.012	1.419MetGly: 1.419 ± 0.017	0.486MetHis: 0.486 ± 0.01	1.01MetIle: 1.01 ± 0.015	0.874MetLys: 0.874 ± 0.012	1.888MetLeu: 1.888 ± 0.019	0.555MetMet: 0.555 ± 0.01	0.753MetAsn: 0.753 ± 0.012	1.171MetPro: 1.171 ± 0.015	0.886MetGln: 0.886 ± 0.016	1.263MetArg: 1.263 ± 0.014	1.777MetSer: 1.777 ± 0.019	1.312MetThr: 1.312 ± 0.014	1.36MetVal: 1.36 ± 0.017	0.254MetTrp: 0.254 ± 0.006	0.514MetTyr: 0.514 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	2.977AsnAla: 2.977 ± 0.023	0.448AsnCys: 0.448 ± 0.01	1.758AsnAsp: 1.758 ± 0.02	1.837AsnGlu: 1.837 ± 0.02	1.244AsnPhe: 1.244 ± 0.017	2.583AsnGly: 2.583 ± 0.027	0.866AsnHis: 0.866 ± 0.013	1.806AsnIle: 1.806 ± 0.02	1.28AsnLys: 1.28 ± 0.017	3.186AsnLeu: 3.186 ± 0.023	0.737AsnMet: 0.737 ± 0.012	1.397AsnAsn: 1.397 ± 0.025	2.425AsnPro: 2.425 ± 0.022	1.266AsnGln: 1.266 ± 0.018	1.905AsnArg: 1.905 ± 0.017	2.495AsnSer: 2.495 ± 0.027	2.059AsnThr: 2.059 ± 0.024	2.198AsnVal: 2.198 ± 0.021	0.531AsnTrp: 0.531 ± 0.01	1.024AsnTyr: 1.024 ± 0.016	0.0AsnXaa: 0.0 ± 0.0
Pro	5.615ProAla: 5.615 ± 0.047	0.613ProCys: 0.613 ± 0.012	3.188ProAsp: 3.188 ± 0.025	3.773ProGlu: 3.773 ± 0.034	2.086ProPhe: 2.086 ± 0.021	3.952ProGly: 3.952 ± 0.028	1.442ProHis: 1.442 ± 0.016	2.465ProIle: 2.465 ± 0.02	2.262ProLys: 2.262 ± 0.026	4.91ProLeu: 4.91 ± 0.033	1.033ProMet: 1.033 ± 0.014	2.005ProAsn: 2.005 ± 0.023	4.996ProPro: 4.996 ± 0.064	2.502ProGln: 2.502 ± 0.027	3.586ProArg: 3.586 ± 0.028	6.003ProSer: 6.003 ± 0.044	4.193ProThr: 4.193 ± 0.034	3.723ProVal: 3.723 ± 0.033	0.813ProTrp: 0.813 ± 0.013	1.558ProTyr: 1.558 ± 0.018	0.0ProXaa: 0.0 ± 0.0
Gln	3.628GlnAla: 3.628 ± 0.031	0.505GlnCys: 0.505 ± 0.011	2.026GlnAsp: 2.026 ± 0.02	2.425GlnGlu: 2.425 ± 0.025	1.331GlnPhe: 1.331 ± 0.013	2.469GlnGly: 2.469 ± 0.022	1.158GlnHis: 1.158 ± 0.019	1.934GlnIle: 1.934 ± 0.016	1.799GlnLys: 1.799 ± 0.02	3.673GlnLeu: 3.673 ± 0.031	0.889GlnMet: 0.889 ± 0.013	1.425GlnAsn: 1.425 ± 0.017	2.69GlnPro: 2.69 ± 0.029	2.704GlnGln: 2.704 ± 0.046	2.762GlnArg: 2.762 ± 0.019	3.174GlnSer: 3.174 ± 0.031	2.457GlnThr: 2.457 ± 0.023	2.29GlnVal: 2.29 ± 0.022	0.606GlnTrp: 0.606 ± 0.011	1.194GlnTyr: 1.194 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	5.062ArgAla: 5.062 ± 0.035	0.819ArgCys: 0.819 ± 0.013	3.35ArgAsp: 3.35 ± 0.028	3.871ArgGlu: 3.871 ± 0.036	2.297ArgPhe: 2.297 ± 0.023	3.801ArgGly: 3.801 ± 0.034	1.659ArgHis: 1.659 ± 0.021	2.887ArgIle: 2.887 ± 0.023	3.204ArgLys: 3.204 ± 0.028	5.947ArgLeu: 5.947 ± 0.034	1.329ArgMet: 1.329 ± 0.018	2.142ArgAsn: 2.142 ± 0.018	3.599ArgPro: 3.599 ± 0.033	2.704ArgGln: 2.704 ± 0.023	5.239ArgArg: 5.239 ± 0.044	4.864ArgSer: 4.864 ± 0.038	3.45ArgThr: 3.45 ± 0.031	3.694ArgVal: 3.694 ± 0.026	1.029ArgTrp: 1.029 ± 0.015	1.765ArgTyr: 1.765 ± 0.018	0.0ArgXaa: 0.0 ± 0.0
Ser	6.878SerAla: 6.878 ± 0.035	0.957SerCys: 0.957 ± 0.013	4.063SerAsp: 4.063 ± 0.032	3.995SerGlu: 3.995 ± 0.032	3.019SerPhe: 3.019 ± 0.024	5.465SerGly: 5.465 ± 0.045	2.048SerHis: 2.048 ± 0.023	3.866SerIle: 3.866 ± 0.03	3.181SerLys: 3.181 ± 0.028	7.519SerLeu: 7.519 ± 0.046	1.652SerMet: 1.652 ± 0.019	2.748SerAsn: 2.748 ± 0.024	5.473SerPro: 5.473 ± 0.049	3.264SerGln: 3.264 ± 0.03	4.957SerArg: 4.957 ± 0.041	8.991SerSer: 8.991 ± 0.082	5.72SerThr: 5.72 ± 0.046	4.666SerVal: 4.666 ± 0.03	1.155SerTrp: 1.155 ± 0.014	2.094SerTyr: 2.094 ± 0.022	0.0SerXaa: 0.0 ± 0.0
Thr	5.724ThrAla: 5.724 ± 0.037	0.821ThrCys: 0.821 ± 0.012	2.891ThrAsp: 2.891 ± 0.022	3.132ThrGlu: 3.132 ± 0.024	2.23ThrPhe: 2.23 ± 0.02	4.352ThrGly: 4.352 ± 0.032	1.401ThrHis: 1.401 ± 0.015	3.101ThrIle: 3.101 ± 0.027	2.297ThrLys: 2.297 ± 0.024	5.565ThrLeu: 5.565 ± 0.034	1.186ThrMet: 1.186 ± 0.014	2.039ThrAsn: 2.039 ± 0.02	4.335ThrPro: 4.335 ± 0.033	2.216ThrGln: 2.216 ± 0.023	3.282ThrArg: 3.282 ± 0.025	5.292ThrSer: 5.292 ± 0.043	4.95ThrThr: 4.95 ± 0.05	4.025ThrVal: 4.025 ± 0.029	0.9ThrTrp: 0.9 ± 0.013	1.698ThrTyr: 1.698 ± 0.019	0.0ThrXaa: 0.0 ± 0.0
Val	5.599ValAla: 5.599 ± 0.034	0.932ValCys: 0.932 ± 0.012	3.709ValAsp: 3.709 ± 0.025	3.855ValGlu: 3.855 ± 0.032	2.519ValPhe: 2.519 ± 0.025	4.196ValGly: 4.196 ± 0.034	1.524ValHis: 1.524 ± 0.018	3.019ValIle: 3.019 ± 0.025	2.552ValLys: 2.552 ± 0.022	5.919ValLeu: 5.919 ± 0.045	1.345ValMet: 1.345 ± 0.014	2.134ValAsn: 2.134 ± 0.017	3.649ValPro: 3.649 ± 0.025	2.493ValGln: 2.493 ± 0.024	3.706ValArg: 3.706 ± 0.028	4.724ValSer: 4.724 ± 0.033	3.696ValThr: 3.696 ± 0.03	4.614ValVal: 4.614 ± 0.032	0.93ValTrp: 0.93 ± 0.013	1.856ValTyr: 1.856 ± 0.022	0.0ValXaa: 0.0 ± 0.0
Trp	1.214TrpAla: 1.214 ± 0.015	0.206TrpCys: 0.206 ± 0.006	0.897TrpAsp: 0.897 ± 0.013	0.88TrpGlu: 0.88 ± 0.014	0.567TrpPhe: 0.567 ± 0.012	0.957TrpGly: 0.957 ± 0.015	0.376TrpHis: 0.376 ± 0.009	0.762TrpIle: 0.762 ± 0.012	0.748TrpLys: 0.748 ± 0.011	1.436TrpLeu: 1.436 ± 0.017	0.384TrpMet: 0.384 ± 0.009	0.636TrpAsn: 0.636 ± 0.012	0.645TrpPro: 0.645 ± 0.013	0.594TrpGln: 0.594 ± 0.011	1.01TrpArg: 1.01 ± 0.015	1.119TrpSer: 1.119 ± 0.015	0.987TrpThr: 0.987 ± 0.013	0.963TrpVal: 0.963 ± 0.015	0.306TrpTrp: 0.306 ± 0.008	0.45TrpTyr: 0.45 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.294TyrAla: 2.294 ± 0.019	0.451TyrCys: 0.451 ± 0.01	1.62TyrAsp: 1.62 ± 0.019	1.532TyrGlu: 1.532 ± 0.017	1.197TyrPhe: 1.197 ± 0.016	2.09TyrGly: 2.09 ± 0.025	0.824TyrHis: 0.824 ± 0.013	1.448TyrIle: 1.448 ± 0.019	0.989TyrLys: 0.989 ± 0.015	2.897TyrLeu: 2.897 ± 0.027	0.628TyrMet: 0.628 ± 0.011	1.097TyrAsn: 1.097 ± 0.014	1.575TyrPro: 1.575 ± 0.022	1.144TyrGln: 1.144 ± 0.015	1.766TyrArg: 1.766 ± 0.021	2.066TyrSer: 2.066 ± 0.023	1.724TyrThr: 1.724 ± 0.019	1.667TyrVal: 1.667 ± 0.019	0.473TyrTrp: 0.473 ± 0.011	1.005TyrTyr: 1.005 ± 0.018	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 12014 proteins (5616582 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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