Amino acid dipepetide frequency for Streptacidiphilus bronchialis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	24.502AlaAla: 24.502 ± 0.203	1.108AlaCys: 1.108 ± 0.027	8.914AlaAsp: 8.914 ± 0.081	9.327AlaGlu: 9.327 ± 0.102	3.523AlaPhe: 3.523 ± 0.043	13.466AlaGly: 13.466 ± 0.1	2.887AlaHis: 2.887 ± 0.045	3.269AlaIle: 3.269 ± 0.047	2.473AlaLys: 2.473 ± 0.049	15.204AlaLeu: 15.204 ± 0.123	2.448AlaMet: 2.448 ± 0.039	1.829AlaAsn: 1.829 ± 0.037	7.729AlaPro: 7.729 ± 0.085	3.78AlaGln: 3.78 ± 0.049	10.626AlaArg: 10.626 ± 0.103	5.785AlaSer: 5.785 ± 0.062	7.234AlaThr: 7.234 ± 0.076	13.417AlaVal: 13.417 ± 0.113	1.891AlaTrp: 1.891 ± 0.035	2.57AlaTyr: 2.57 ± 0.037	0.0AlaXaa: 0.0 ± 0.0
Cys	1.131CysAla: 1.131 ± 0.027	0.118CysCys: 0.118 ± 0.009	0.5CysAsp: 0.5 ± 0.015	0.37CysGlu: 0.37 ± 0.016	0.247CysPhe: 0.247 ± 0.012	0.993CysGly: 0.993 ± 0.024	0.201CysHis: 0.201 ± 0.01	0.201CysIle: 0.201 ± 0.011	0.101CysLys: 0.101 ± 0.008	0.782CysLeu: 0.782 ± 0.022	0.117CysMet: 0.117 ± 0.007	0.142CysAsn: 0.142 ± 0.01	0.531CysPro: 0.531 ± 0.017	0.165CysGln: 0.165 ± 0.009	0.7CysArg: 0.7 ± 0.019	0.466CysSer: 0.466 ± 0.016	0.597CysThr: 0.597 ± 0.018	0.571CysVal: 0.571 ± 0.015	0.159CysTrp: 0.159 ± 0.009	0.155CysTyr: 0.155 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	7.579AspAla: 7.579 ± 0.065	0.427AspCys: 0.427 ± 0.018	3.24AspAsp: 3.24 ± 0.05	3.276AspGlu: 3.276 ± 0.043	1.558AspPhe: 1.558 ± 0.028	6.37AspGly: 6.37 ± 0.066	1.504AspHis: 1.504 ± 0.028	1.759AspIle: 1.759 ± 0.032	0.845AspLys: 0.845 ± 0.031	6.516AspLeu: 6.516 ± 0.065	0.681AspMet: 0.681 ± 0.022	0.803AspAsn: 0.803 ± 0.028	4.955AspPro: 4.955 ± 0.058	1.674AspGln: 1.674 ± 0.032	5.466AspArg: 5.466 ± 0.063	2.472AspSer: 2.472 ± 0.037	3.022AspThr: 3.022 ± 0.043	3.965AspVal: 3.965 ± 0.045	0.973AspTrp: 0.973 ± 0.023	1.111AspTyr: 1.111 ± 0.026	0.0AspXaa: 0.0 ± 0.0
Glu	7.386GluAla: 7.386 ± 0.081	0.369GluCys: 0.369 ± 0.014	2.472GluAsp: 2.472 ± 0.033	3.334GluGlu: 3.334 ± 0.05	1.294GluPhe: 1.294 ± 0.029	3.93GluGly: 3.93 ± 0.053	1.364GluHis: 1.364 ± 0.032	1.98GluIle: 1.98 ± 0.036	1.098GluLys: 1.098 ± 0.03	6.618GluLeu: 6.618 ± 0.077	0.767GluMet: 0.767 ± 0.02	0.867GluAsn: 0.867 ± 0.022	3.35GluPro: 3.35 ± 0.048	2.505GluGln: 2.505 ± 0.048	5.154GluArg: 5.154 ± 0.059	2.395GluSer: 2.395 ± 0.033	2.684GluThr: 2.684 ± 0.046	4.749GluVal: 4.749 ± 0.054	0.73GluTrp: 0.73 ± 0.019	1.081GluTyr: 1.081 ± 0.022	0.0GluXaa: 0.0 ± 0.0
Phe	3.622PheAla: 3.622 ± 0.046	0.267PheCys: 0.267 ± 0.013	1.869PheAsp: 1.869 ± 0.033	1.287PheGlu: 1.287 ± 0.026	0.836PhePhe: 0.836 ± 0.024	2.947PheGly: 2.947 ± 0.039	0.651PheHis: 0.651 ± 0.018	0.683PheIle: 0.683 ± 0.019	0.422PheLys: 0.422 ± 0.016	2.416PheLeu: 2.416 ± 0.039	0.338PheMet: 0.338 ± 0.014	0.538PheAsn: 0.538 ± 0.02	1.369PhePro: 1.369 ± 0.024	0.71PheGln: 0.71 ± 0.019	1.828PheArg: 1.828 ± 0.032	1.424PheSer: 1.424 ± 0.028	2.03PheThr: 2.03 ± 0.034	1.903PheVal: 1.903 ± 0.033	0.407PheTrp: 0.407 ± 0.013	0.499PheTyr: 0.499 ± 0.018	0.0PheXaa: 0.0 ± 0.0
Gly	11.328GlyAla: 11.328 ± 0.096	0.952GlyCys: 0.952 ± 0.022	5.076GlyAsp: 5.076 ± 0.051	4.862GlyGlu: 4.862 ± 0.058	2.824GlyPhe: 2.824 ± 0.039	9.588GlyGly: 9.588 ± 0.106	2.332GlyHis: 2.332 ± 0.042	3.292GlyIle: 3.292 ± 0.046	2.02GlyLys: 2.02 ± 0.042	9.819GlyLeu: 9.819 ± 0.084	1.987GlyMet: 1.987 ± 0.033	1.693GlyAsn: 1.693 ± 0.038	5.661GlyPro: 5.661 ± 0.072	2.708GlyGln: 2.708 ± 0.038	8.601GlyArg: 8.601 ± 0.074	5.811GlySer: 5.811 ± 0.073	6.378GlyThr: 6.378 ± 0.075	7.497GlyVal: 7.497 ± 0.086	1.813GlyTrp: 1.813 ± 0.036	2.271GlyTyr: 2.271 ± 0.036	0.0GlyXaa: 0.0 ± 0.0
His	2.746HisAla: 2.746 ± 0.046	0.219HisCys: 0.219 ± 0.009	1.258HisAsp: 1.258 ± 0.026	1.041HisGlu: 1.041 ± 0.022	0.619HisPhe: 0.619 ± 0.016	2.582HisGly: 2.582 ± 0.04	0.738HisHis: 0.738 ± 0.023	0.672HisIle: 0.672 ± 0.02	0.278HisLys: 0.278 ± 0.013	2.607HisLeu: 2.607 ± 0.04	0.287HisMet: 0.287 ± 0.013	0.333HisAsn: 0.333 ± 0.015	2.083HisPro: 2.083 ± 0.039	0.722HisGln: 0.722 ± 0.02	2.38HisArg: 2.38 ± 0.039	1.058HisSer: 1.058 ± 0.025	1.322HisThr: 1.322 ± 0.025	1.476HisVal: 1.476 ± 0.029	0.383HisTrp: 0.383 ± 0.015	0.449HisTyr: 0.449 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	4.607IleAla: 4.607 ± 0.061	0.285IleCys: 0.285 ± 0.013	2.096IleAsp: 2.096 ± 0.04	1.742IleGlu: 1.742 ± 0.031	0.665IlePhe: 0.665 ± 0.02	3.366IleGly: 3.366 ± 0.042	0.627IleHis: 0.627 ± 0.019	0.763IleIle: 0.763 ± 0.02	0.624IleLys: 0.624 ± 0.021	2.251IleLeu: 2.251 ± 0.039	0.375IleMet: 0.375 ± 0.014	0.633IleAsn: 0.633 ± 0.018	1.773IlePro: 1.773 ± 0.033	0.704IleGln: 0.704 ± 0.022	2.251IleArg: 2.251 ± 0.033	1.621IleSer: 1.621 ± 0.029	2.061IleThr: 2.061 ± 0.039	2.421IleVal: 2.421 ± 0.042	0.356IleTrp: 0.356 ± 0.016	0.459IleTyr: 0.459 ± 0.018	0.0IleXaa: 0.0 ± 0.0
Lys	2.494LysAla: 2.494 ± 0.046	0.087LysCys: 0.087 ± 0.006	1.038LysAsp: 1.038 ± 0.034	0.945LysGlu: 0.945 ± 0.026	0.365LysPhe: 0.365 ± 0.016	1.47LysGly: 1.47 ± 0.031	0.39LysHis: 0.39 ± 0.015	0.658LysIle: 0.658 ± 0.022	0.559LysLys: 0.559 ± 0.026	1.671LysLeu: 1.671 ± 0.039	0.264LysMet: 0.264 ± 0.012	0.369LysAsn: 0.369 ± 0.017	1.094LysPro: 1.094 ± 0.029	0.613LysGln: 0.613 ± 0.021	1.176LysArg: 1.176 ± 0.025	0.957LysSer: 0.957 ± 0.026	1.029LysThr: 1.029 ± 0.031	1.591LysVal: 1.591 ± 0.037	0.204LysTrp: 0.204 ± 0.011	0.372LysTyr: 0.372 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	16.175LeuAla: 16.175 ± 0.119	0.889LeuCys: 0.889 ± 0.023	6.801LeuAsp: 6.801 ± 0.066	4.883LeuGlu: 4.883 ± 0.056	2.443LeuPhe: 2.443 ± 0.045	9.756LeuGly: 9.756 ± 0.087	2.609LeuHis: 2.609 ± 0.04	3.099LeuIle: 3.099 ± 0.052	1.698LeuLys: 1.698 ± 0.04	12.375LeuLeu: 12.375 ± 0.104	1.511LeuMet: 1.511 ± 0.029	1.588LeuAsn: 1.588 ± 0.03	7.059LeuPro: 7.059 ± 0.071	2.192LeuGln: 2.192 ± 0.038	9.238LeuArg: 9.238 ± 0.08	5.242LeuSer: 5.242 ± 0.051	6.477LeuThr: 6.477 ± 0.069	8.98LeuVal: 8.98 ± 0.076	1.298LeuTrp: 1.298 ± 0.032	1.846LeuTyr: 1.846 ± 0.039	0.0LeuXaa: 0.0 ± 0.0
Met	2.235MetAla: 2.235 ± 0.033	0.13MetCys: 0.13 ± 0.009	0.836MetAsp: 0.836 ± 0.021	0.682MetGlu: 0.682 ± 0.019	0.39MetPhe: 0.39 ± 0.014	1.267MetGly: 1.267 ± 0.029	0.339MetHis: 0.339 ± 0.014	0.493MetIle: 0.493 ± 0.017	0.301MetLys: 0.301 ± 0.014	1.621MetLeu: 1.621 ± 0.035	0.27MetMet: 0.27 ± 0.013	0.324MetAsn: 0.324 ± 0.012	1.055MetPro: 1.055 ± 0.023	0.446MetGln: 0.446 ± 0.013	1.355MetArg: 1.355 ± 0.026	1.139MetSer: 1.139 ± 0.024	1.342MetThr: 1.342 ± 0.032	1.341MetVal: 1.341 ± 0.029	0.177MetTrp: 0.177 ± 0.009	0.301MetTyr: 0.301 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	2.12AsnAla: 2.12 ± 0.036	0.149AsnCys: 0.149 ± 0.009	0.817AsnAsp: 0.817 ± 0.022	0.651AsnGlu: 0.651 ± 0.021	0.442AsnPhe: 0.442 ± 0.016	1.793AsnGly: 1.793 ± 0.04	0.371AsnHis: 0.371 ± 0.013	0.551AsnIle: 0.551 ± 0.019	0.296AsnLys: 0.296 ± 0.013	1.669AsnLeu: 1.669 ± 0.034	0.257AsnMet: 0.257 ± 0.011	0.358AsnAsn: 0.358 ± 0.018	1.326AsnPro: 1.326 ± 0.031	0.549AsnGln: 0.549 ± 0.018	1.236AsnArg: 1.236 ± 0.021	0.813AsnSer: 0.813 ± 0.025	1.029AsnThr: 1.029 ± 0.027	1.22AsnVal: 1.22 ± 0.028	0.253AsnTrp: 0.253 ± 0.011	0.365AsnTyr: 0.365 ± 0.016	0.0AsnXaa: 0.0 ± 0.0
Pro	9.693ProAla: 9.693 ± 0.099	0.367ProCys: 0.367 ± 0.014	4.616ProAsp: 4.616 ± 0.049	4.465ProGlu: 4.465 ± 0.055	1.468ProPhe: 1.468 ± 0.027	7.444ProGly: 7.444 ± 0.091	1.411ProHis: 1.411 ± 0.024	1.36ProIle: 1.36 ± 0.031	0.965ProLys: 0.965 ± 0.024	5.593ProLeu: 5.593 ± 0.067	0.958ProMet: 0.958 ± 0.024	0.852ProAsn: 0.852 ± 0.023	4.228ProPro: 4.228 ± 0.088	2.076ProGln: 2.076 ± 0.041	4.124ProArg: 4.124 ± 0.057	3.272ProSer: 3.272 ± 0.048	3.509ProThr: 3.509 ± 0.051	5.732ProVal: 5.732 ± 0.064	0.954ProTrp: 0.954 ± 0.024	1.401ProTyr: 1.401 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	4.062GlnAla: 4.062 ± 0.048	0.179GlnCys: 0.179 ± 0.009	1.467GlnAsp: 1.467 ± 0.026	1.389GlnGlu: 1.389 ± 0.031	0.605GlnPhe: 0.605 ± 0.019	2.484GlnGly: 2.484 ± 0.036	0.684GlnHis: 0.684 ± 0.019	1.005GlnIle: 1.005 ± 0.028	0.489GlnLys: 0.489 ± 0.019	3.231GlnLeu: 3.231 ± 0.04	0.409GlnMet: 0.409 ± 0.014	0.492GlnAsn: 0.492 ± 0.018	1.963GlnPro: 1.963 ± 0.039	1.59GlnGln: 1.59 ± 0.039	2.64GlnArg: 2.64 ± 0.038	1.31GlnSer: 1.31 ± 0.031	1.355GlnThr: 1.355 ± 0.027	2.636GlnVal: 2.636 ± 0.042	0.451GlnTrp: 0.451 ± 0.015	0.618GlnTyr: 0.618 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	10.178ArgAla: 10.178 ± 0.096	0.708ArgCys: 0.708 ± 0.019	4.267ArgAsp: 4.267 ± 0.055	4.511ArgGlu: 4.511 ± 0.053	2.317ArgPhe: 2.317 ± 0.032	5.819ArgGly: 5.819 ± 0.06	2.237ArgHis: 2.237 ± 0.035	3.403ArgIle: 3.403 ± 0.043	1.373ArgLys: 1.373 ± 0.028	9.675ArgLeu: 9.675 ± 0.084	1.789ArgMet: 1.789 ± 0.03	1.335ArgAsn: 1.335 ± 0.026	5.665ArgPro: 5.665 ± 0.071	2.561ArgGln: 2.561 ± 0.035	8.471ArgArg: 8.471 ± 0.087	4.393ArgSer: 4.393 ± 0.052	5.436ArgThr: 5.436 ± 0.059	5.964ArgVal: 5.964 ± 0.054	1.443ArgTrp: 1.443 ± 0.027	1.882ArgTyr: 1.882 ± 0.033	0.0ArgXaa: 0.0 ± 0.0
Ser	6.959SerAla: 6.959 ± 0.072	0.434SerCys: 0.434 ± 0.012	2.583SerAsp: 2.583 ± 0.039	2.223SerGlu: 2.223 ± 0.035	1.509SerPhe: 1.509 ± 0.029	6.306SerGly: 6.306 ± 0.069	1.023SerHis: 1.023 ± 0.023	1.415SerIle: 1.415 ± 0.029	0.804SerLys: 0.804 ± 0.023	4.807SerLeu: 4.807 ± 0.059	0.954SerMet: 0.954 ± 0.023	0.842SerAsn: 0.842 ± 0.024	3.304SerPro: 3.304 ± 0.045	1.226SerGln: 1.226 ± 0.026	3.698SerArg: 3.698 ± 0.049	2.903SerSer: 2.903 ± 0.047	3.078SerThr: 3.078 ± 0.048	4.051SerVal: 4.051 ± 0.047	0.962SerTrp: 0.962 ± 0.024	1.2SerTyr: 1.2 ± 0.026	0.0SerXaa: 0.0 ± 0.0
Thr	9.828ThrAla: 9.828 ± 0.087	0.426ThrCys: 0.426 ± 0.016	3.258ThrAsp: 3.258 ± 0.044	2.865ThrGlu: 2.865 ± 0.035	1.509ThrPhe: 1.509 ± 0.031	6.908ThrGly: 6.908 ± 0.079	1.065ThrHis: 1.065 ± 0.024	1.454ThrIle: 1.454 ± 0.035	0.868ThrLys: 0.868 ± 0.024	5.695ThrLeu: 5.695 ± 0.048	0.839ThrMet: 0.839 ± 0.023	0.904ThrAsn: 0.904 ± 0.025	4.142ThrPro: 4.142 ± 0.05	1.224ThrGln: 1.224 ± 0.029	3.919ThrArg: 3.919 ± 0.047	3.022ThrSer: 3.022 ± 0.042	3.807ThrThr: 3.807 ± 0.067	6.115ThrVal: 6.115 ± 0.064	0.834ThrTrp: 0.834 ± 0.026	1.129ThrTyr: 1.129 ± 0.029	0.0ThrXaa: 0.0 ± 0.0
Val	11.029ValAla: 11.029 ± 0.083	0.793ValCys: 0.793 ± 0.022	4.936ValAsp: 4.936 ± 0.059	4.584ValGlu: 4.584 ± 0.06	2.339ValPhe: 2.339 ± 0.039	6.686ValGly: 6.686 ± 0.068	2.064ValHis: 2.064 ± 0.033	2.659ValIle: 2.659 ± 0.042	1.53ValLys: 1.53 ± 0.039	9.652ValLeu: 9.652 ± 0.09	1.297ValMet: 1.297 ± 0.028	1.573ValAsn: 1.573 ± 0.03	5.268ValPro: 5.268 ± 0.062	2.288ValGln: 2.288 ± 0.038	7.337ValArg: 7.337 ± 0.071	4.26ValSer: 4.26 ± 0.059	5.183ValThr: 5.183 ± 0.061	7.985ValVal: 7.985 ± 0.073	1.077ValTrp: 1.077 ± 0.026	1.505ValTyr: 1.505 ± 0.03	0.0ValXaa: 0.0 ± 0.0
Trp	1.691TrpAla: 1.691 ± 0.033	0.158TrpCys: 0.158 ± 0.008	0.767TrpAsp: 0.767 ± 0.023	0.701TrpGlu: 0.701 ± 0.02	0.495TrpPhe: 0.495 ± 0.017	1.07TrpGly: 1.07 ± 0.027	0.364TrpHis: 0.364 ± 0.015	0.499TrpIle: 0.499 ± 0.014	0.303TrpLys: 0.303 ± 0.013	1.772TrpLeu: 1.772 ± 0.034	0.28TrpMet: 0.28 ± 0.012	0.379TrpAsn: 0.379 ± 0.017	0.799TrpPro: 0.799 ± 0.024	0.658TrpGln: 0.658 ± 0.019	1.361TrpArg: 1.361 ± 0.032	0.978TrpSer: 0.978 ± 0.024	1.052TrpThr: 1.052 ± 0.026	1.026TrpVal: 1.026 ± 0.02	0.301TrpTrp: 0.301 ± 0.015	0.368TrpTyr: 0.368 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.617TyrAla: 2.617 ± 0.038	0.183TyrCys: 0.183 ± 0.01	1.386TyrAsp: 1.386 ± 0.031	0.988TyrGlu: 0.988 ± 0.026	0.597TyrPhe: 0.597 ± 0.018	2.269TyrGly: 2.269 ± 0.04	0.39TyrHis: 0.39 ± 0.013	0.465TyrIle: 0.465 ± 0.017	0.3TyrLys: 0.3 ± 0.014	2.186TyrLeu: 2.186 ± 0.035	0.217TyrMet: 0.217 ± 0.011	0.41TyrAsn: 0.41 ± 0.015	1.134TyrPro: 1.134 ± 0.022	0.672TyrGln: 0.672 ± 0.02	1.865TyrArg: 1.865 ± 0.036	0.959TyrSer: 0.959 ± 0.025	1.183TyrThr: 1.183 ± 0.028	1.402TyrVal: 1.402 ± 0.025	0.358TyrTrp: 0.358 ± 0.014	0.425TyrTyr: 0.425 ± 0.018	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5673 proteins (1967069 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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