Amino acid dipepetide frequency for Halomonas sp. PA5

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.749AlaAla: 11.749 ± 0.124	1.217AlaCys: 1.217 ± 0.034	5.28AlaAsp: 5.28 ± 0.067	7.277AlaGlu: 7.277 ± 0.092	4.037AlaPhe: 4.037 ± 0.07	8.954AlaGly: 8.954 ± 0.1	2.308AlaHis: 2.308 ± 0.048	5.788AlaIle: 5.788 ± 0.081	2.823AlaLys: 2.823 ± 0.062	14.18AlaLeu: 14.18 ± 0.135	3.413AlaMet: 3.413 ± 0.052	2.717AlaAsn: 2.717 ± 0.056	4.637AlaPro: 4.637 ± 0.074	4.273AlaGln: 4.273 ± 0.077	8.133AlaArg: 8.133 ± 0.091	6.683AlaSer: 6.683 ± 0.09	5.227AlaThr: 5.227 ± 0.074	7.203AlaVal: 7.203 ± 0.088	1.765AlaTrp: 1.765 ± 0.044	2.379AlaTyr: 2.379 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	0.917CysAla: 0.917 ± 0.03	0.146CysCys: 0.146 ± 0.012	0.582CysAsp: 0.582 ± 0.024	0.557CysGlu: 0.557 ± 0.023	0.339CysPhe: 0.339 ± 0.019	0.927CysGly: 0.927 ± 0.029	0.335CysHis: 0.335 ± 0.018	0.417CysIle: 0.417 ± 0.02	0.226CysLys: 0.226 ± 0.014	1.041CysLeu: 1.041 ± 0.035	0.231CysMet: 0.231 ± 0.015	0.239CysAsn: 0.239 ± 0.017	0.527CysPro: 0.527 ± 0.025	0.424CysGln: 0.424 ± 0.019	0.712CysArg: 0.712 ± 0.029	0.489CysSer: 0.489 ± 0.02	0.413CysThr: 0.413 ± 0.019	0.641CysVal: 0.641 ± 0.023	0.127CysTrp: 0.127 ± 0.011	0.256CysTyr: 0.256 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	6.173AspAla: 6.173 ± 0.085	0.454AspCys: 0.454 ± 0.022	3.545AspAsp: 3.545 ± 0.064	4.43AspGlu: 4.43 ± 0.068	2.005AspPhe: 2.005 ± 0.04	4.266AspGly: 4.266 ± 0.071	1.299AspHis: 1.299 ± 0.035	2.93AspIle: 2.93 ± 0.057	1.51AspLys: 1.51 ± 0.046	5.182AspLeu: 5.182 ± 0.067	1.317AspMet: 1.317 ± 0.034	1.579AspAsn: 1.579 ± 0.042	2.866AspPro: 2.866 ± 0.051	1.807AspGln: 1.807 ± 0.045	3.298AspArg: 3.298 ± 0.06	2.777AspSer: 2.777 ± 0.05	2.829AspThr: 2.829 ± 0.055	3.635AspVal: 3.635 ± 0.06	0.879AspTrp: 0.879 ± 0.031	1.675AspTyr: 1.675 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	8.325GluAla: 8.325 ± 0.105	0.554GluCys: 0.554 ± 0.021	2.607GluAsp: 2.607 ± 0.055	4.497GluGlu: 4.497 ± 0.083	1.768GluPhe: 1.768 ± 0.04	4.913GluGly: 4.913 ± 0.073	1.86GluHis: 1.86 ± 0.041	3.348GluIle: 3.348 ± 0.055	1.764GluLys: 1.764 ± 0.051	7.298GluLeu: 7.298 ± 0.083	1.706GluMet: 1.706 ± 0.042	1.519GluAsn: 1.519 ± 0.042	2.836GluPro: 2.836 ± 0.061	3.37GluGln: 3.37 ± 0.064	6.528GluArg: 6.528 ± 0.084	3.441GluSer: 3.441 ± 0.063	3.247GluThr: 3.247 ± 0.053	4.873GluVal: 4.873 ± 0.07	0.969GluTrp: 0.969 ± 0.03	1.375GluTyr: 1.375 ± 0.036	0.0GluXaa: 0.0 ± 0.0
Phe	3.726PheAla: 3.726 ± 0.068	0.38PheCys: 0.38 ± 0.018	2.49PheAsp: 2.49 ± 0.047	2.224PheGlu: 2.224 ± 0.043	1.345PhePhe: 1.345 ± 0.037	3.208PheGly: 3.208 ± 0.047	0.845PheHis: 0.845 ± 0.03	1.824PheIle: 1.824 ± 0.043	0.941PheLys: 0.941 ± 0.03	3.302PheLeu: 3.302 ± 0.061	0.979PheMet: 0.979 ± 0.031	1.067PheAsn: 1.067 ± 0.03	1.491PhePro: 1.491 ± 0.035	1.132PheGln: 1.132 ± 0.034	2.0PheArg: 2.0 ± 0.038	2.268PheSer: 2.268 ± 0.044	1.938PheThr: 1.938 ± 0.044	2.388PheVal: 2.388 ± 0.052	0.497PheTrp: 0.497 ± 0.02	0.969PheTyr: 0.969 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	7.504GlyAla: 7.504 ± 0.077	0.917GlyCys: 0.917 ± 0.03	4.3GlyAsp: 4.3 ± 0.072	6.049GlyGlu: 6.049 ± 0.091	3.217GlyPhe: 3.217 ± 0.057	6.527GlyGly: 6.527 ± 0.089	2.091GlyHis: 2.091 ± 0.048	4.719GlyIle: 4.719 ± 0.069	2.703GlyLys: 2.703 ± 0.053	9.216GlyLeu: 9.216 ± 0.107	2.595GlyMet: 2.595 ± 0.051	2.215GlyAsn: 2.215 ± 0.05	2.736GlyPro: 2.736 ± 0.048	3.164GlyGln: 3.164 ± 0.071	5.531GlyArg: 5.531 ± 0.08	4.41GlySer: 4.41 ± 0.065	3.742GlyThr: 3.742 ± 0.055	6.196GlyVal: 6.196 ± 0.078	1.344GlyTrp: 1.344 ± 0.036	2.402GlyTyr: 2.402 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	2.557HisAla: 2.557 ± 0.053	0.313HisCys: 0.313 ± 0.017	1.563HisAsp: 1.563 ± 0.046	1.481HisGlu: 1.481 ± 0.036	1.029HisPhe: 1.029 ± 0.031	2.351HisGly: 2.351 ± 0.053	0.789HisHis: 0.789 ± 0.031	1.031HisIle: 1.031 ± 0.032	0.519HisLys: 0.519 ± 0.02	2.66HisLeu: 2.66 ± 0.049	0.516HisMet: 0.516 ± 0.021	0.598HisAsn: 0.598 ± 0.021	1.512HisPro: 1.512 ± 0.037	0.952HisGln: 0.952 ± 0.033	1.736HisArg: 1.736 ± 0.041	1.194HisSer: 1.194 ± 0.035	1.023HisThr: 1.023 ± 0.03	1.579HisVal: 1.579 ± 0.043	0.455HisTrp: 0.455 ± 0.019	0.836HisTyr: 0.836 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	6.189IleAla: 6.189 ± 0.083	0.476IleCys: 0.476 ± 0.023	3.635IleAsp: 3.635 ± 0.058	3.931IleGlu: 3.931 ± 0.061	1.59IlePhe: 1.59 ± 0.041	4.629IleGly: 4.629 ± 0.078	1.066IleHis: 1.066 ± 0.032	2.22IleIle: 2.22 ± 0.049	1.428IleLys: 1.428 ± 0.038	4.261IleLeu: 4.261 ± 0.06	1.06IleMet: 1.06 ± 0.034	1.623IleAsn: 1.623 ± 0.044	2.293IlePro: 2.293 ± 0.048	1.462IleGln: 1.462 ± 0.036	3.13IleArg: 3.13 ± 0.059	2.929IleSer: 2.929 ± 0.054	2.71IleThr: 2.71 ± 0.051	3.607IleVal: 3.607 ± 0.061	0.512IleTrp: 0.512 ± 0.023	1.117IleTyr: 1.117 ± 0.038	0.0IleXaa: 0.0 ± 0.0
Lys	3.086LysAla: 3.086 ± 0.063	0.168LysCys: 0.168 ± 0.013	1.074LysAsp: 1.074 ± 0.038	1.548LysGlu: 1.548 ± 0.045	0.63LysPhe: 0.63 ± 0.026	2.16LysGly: 2.16 ± 0.05	0.639LysHis: 0.639 ± 0.021	1.181LysIle: 1.181 ± 0.034	0.932LysLys: 0.932 ± 0.039	2.833LysLeu: 2.833 ± 0.061	0.637LysMet: 0.637 ± 0.029	0.586LysAsn: 0.586 ± 0.027	1.497LysPro: 1.497 ± 0.039	1.173LysGln: 1.173 ± 0.036	2.604LysArg: 2.604 ± 0.047	1.57LysSer: 1.57 ± 0.04	1.31LysThr: 1.31 ± 0.036	1.992LysVal: 1.992 ± 0.053	0.241LysTrp: 0.241 ± 0.014	0.526LysTyr: 0.526 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	14.71LeuAla: 14.71 ± 0.152	1.114LeuCys: 1.114 ± 0.03	7.077LeuAsp: 7.077 ± 0.097	7.784LeuGlu: 7.784 ± 0.095	3.998LeuPhe: 3.998 ± 0.071	9.576LeuGly: 9.576 ± 0.122	2.358LeuHis: 2.358 ± 0.042	5.784LeuIle: 5.784 ± 0.077	3.353LeuLys: 3.353 ± 0.055	12.635LeuLeu: 12.635 ± 0.174	2.891LeuMet: 2.891 ± 0.052	2.979LeuAsn: 2.979 ± 0.05	6.202LeuPro: 6.202 ± 0.09	3.318LeuGln: 3.318 ± 0.061	7.074LeuArg: 7.074 ± 0.085	6.98LeuSer: 6.98 ± 0.088	5.742LeuThr: 5.742 ± 0.092	7.951LeuVal: 7.951 ± 0.098	1.523LeuTrp: 1.523 ± 0.043	2.513LeuTyr: 2.513 ± 0.045	0.0LeuXaa: 0.0 ± 0.0
Met	3.296MetAla: 3.296 ± 0.051	0.168MetCys: 0.168 ± 0.013	1.071MetAsp: 1.071 ± 0.03	1.29MetGlu: 1.29 ± 0.035	0.723MetPhe: 0.723 ± 0.03	1.977MetGly: 1.977 ± 0.045	0.549MetHis: 0.549 ± 0.024	1.42MetIle: 1.42 ± 0.039	0.792MetLys: 0.792 ± 0.025	3.125MetLeu: 3.125 ± 0.059	0.704MetMet: 0.704 ± 0.025	0.802MetAsn: 0.802 ± 0.029	1.565MetPro: 1.565 ± 0.04	1.044MetGln: 1.044 ± 0.025	1.821MetArg: 1.821 ± 0.042	1.834MetSer: 1.834 ± 0.035	1.685MetThr: 1.685 ± 0.041	1.886MetVal: 1.886 ± 0.045	0.199MetTrp: 0.199 ± 0.014	0.357MetTyr: 0.357 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	2.957AsnAla: 2.957 ± 0.054	0.237AsnCys: 0.237 ± 0.014	1.511AsnAsp: 1.511 ± 0.039	1.534AsnGlu: 1.534 ± 0.04	0.88AsnPhe: 0.88 ± 0.03	2.071AsnGly: 2.071 ± 0.045	0.619AsnHis: 0.619 ± 0.026	1.355AsnIle: 1.355 ± 0.036	0.568AsnLys: 0.568 ± 0.023	2.672AsnLeu: 2.672 ± 0.049	0.592AsnMet: 0.592 ± 0.026	0.741AsnAsn: 0.741 ± 0.029	1.64AsnPro: 1.64 ± 0.039	1.0AsnGln: 1.0 ± 0.033	1.977AsnArg: 1.977 ± 0.039	1.225AsnSer: 1.225 ± 0.035	1.292AsnThr: 1.292 ± 0.036	1.865AsnVal: 1.865 ± 0.047	0.377AsnTrp: 0.377 ± 0.016	0.687AsnTyr: 0.687 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	4.926ProAla: 4.926 ± 0.074	0.38ProCys: 0.38 ± 0.02	3.018ProAsp: 3.018 ± 0.052	3.759ProGlu: 3.759 ± 0.063	1.805ProPhe: 1.805 ± 0.04	4.28ProGly: 4.28 ± 0.063	1.235ProHis: 1.235 ± 0.037	2.103ProIle: 2.103 ± 0.045	1.149ProLys: 1.149 ± 0.038	5.792ProLeu: 5.792 ± 0.073	1.285ProMet: 1.285 ± 0.035	1.246ProAsn: 1.246 ± 0.028	2.235ProPro: 2.235 ± 0.052	1.798ProGln: 1.798 ± 0.039	3.103ProArg: 3.103 ± 0.059	2.852ProSer: 2.852 ± 0.054	2.243ProThr: 2.243 ± 0.048	3.563ProVal: 3.563 ± 0.053	0.836ProTrp: 0.836 ± 0.024	1.116ProTyr: 1.116 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	5.397GlnAla: 5.397 ± 0.098	0.304GlnCys: 0.304 ± 0.015	1.487GlnAsp: 1.487 ± 0.037	2.324GlnGlu: 2.324 ± 0.043	1.076GlnPhe: 1.076 ± 0.032	3.379GlnGly: 3.379 ± 0.063	1.001GlnHis: 1.001 ± 0.031	1.639GlnIle: 1.639 ± 0.04	0.818GlnLys: 0.818 ± 0.03	4.308GlnLeu: 4.308 ± 0.076	0.908GlnMet: 0.908 ± 0.03	0.74GlnAsn: 0.74 ± 0.028	1.921GlnPro: 1.921 ± 0.049	2.135GlnGln: 2.135 ± 0.062	3.616GlnArg: 3.616 ± 0.072	1.85GlnSer: 1.85 ± 0.042	1.653GlnThr: 1.653 ± 0.045	2.962GlnVal: 2.962 ± 0.052	0.637GlnTrp: 0.637 ± 0.024	0.74GlnTyr: 0.74 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	6.426ArgAla: 6.426 ± 0.081	0.667ArgCys: 0.667 ± 0.024	4.252ArgAsp: 4.252 ± 0.055	5.505ArgGlu: 5.505 ± 0.078	2.974ArgPhe: 2.974 ± 0.052	4.784ArgGly: 4.784 ± 0.075	2.439ArgHis: 2.439 ± 0.057	3.637ArgIle: 3.637 ± 0.058	1.824ArgLys: 1.824 ± 0.045	9.928ArgLeu: 9.928 ± 0.121	1.874ArgMet: 1.874 ± 0.04	1.725ArgAsn: 1.725 ± 0.039	3.053ArgPro: 3.053 ± 0.064	3.572ArgGln: 3.572 ± 0.072	5.669ArgArg: 5.669 ± 0.095	3.389ArgSer: 3.389 ± 0.05	2.9ArgThr: 2.9 ± 0.048	4.842ArgVal: 4.842 ± 0.074	1.123ArgTrp: 1.123 ± 0.035	2.142ArgTyr: 2.142 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	5.696SerAla: 5.696 ± 0.075	0.492SerCys: 0.492 ± 0.023	3.047SerAsp: 3.047 ± 0.054	3.405SerGlu: 3.405 ± 0.064	1.999SerPhe: 1.999 ± 0.046	5.221SerGly: 5.221 ± 0.077	1.436SerHis: 1.436 ± 0.038	2.559SerIle: 2.559 ± 0.046	1.29SerLys: 1.29 ± 0.034	6.925SerLeu: 6.925 ± 0.089	1.513SerMet: 1.513 ± 0.045	1.409SerAsn: 1.409 ± 0.043	2.952SerPro: 2.952 ± 0.054	2.24SerGln: 2.24 ± 0.047	4.441SerArg: 4.441 ± 0.065	3.242SerSer: 3.242 ± 0.058	2.58SerThr: 2.58 ± 0.043	3.87SerVal: 3.87 ± 0.062	0.813SerTrp: 0.813 ± 0.031	1.222SerTyr: 1.222 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	4.876ThrAla: 4.876 ± 0.07	0.449ThrCys: 0.449 ± 0.02	2.23ThrAsp: 2.23 ± 0.051	2.358ThrGlu: 2.358 ± 0.049	1.806ThrPhe: 1.806 ± 0.036	4.112ThrGly: 4.112 ± 0.059	1.262ThrHis: 1.262 ± 0.035	2.175ThrIle: 2.175 ± 0.043	0.913ThrLys: 0.913 ± 0.029	7.362ThrLeu: 7.362 ± 0.08	1.062ThrMet: 1.062 ± 0.029	1.12ThrAsn: 1.12 ± 0.032	3.37ThrPro: 3.37 ± 0.057	1.888ThrGln: 1.888 ± 0.047	3.512ThrArg: 3.512 ± 0.056	2.771ThrSer: 2.771 ± 0.054	2.482ThrThr: 2.482 ± 0.054	3.209ThrVal: 3.209 ± 0.057	0.65ThrTrp: 0.65 ± 0.026	1.076ThrTyr: 1.076 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	8.043ValAla: 8.043 ± 0.088	0.669ValCys: 0.669 ± 0.024	3.827ValAsp: 3.827 ± 0.063	4.916ValGlu: 4.916 ± 0.068	2.379ValPhe: 2.379 ± 0.053	5.298ValGly: 5.298 ± 0.085	1.457ValHis: 1.457 ± 0.037	4.14ValIle: 4.14 ± 0.071	1.954ValLys: 1.954 ± 0.047	7.53ValLeu: 7.53 ± 0.088	2.137ValMet: 2.137 ± 0.047	1.95ValAsn: 1.95 ± 0.042	3.346ValPro: 3.346 ± 0.059	2.118ValGln: 2.118 ± 0.043	4.353ValArg: 4.353 ± 0.065	4.316ValSer: 4.316 ± 0.071	3.966ValThr: 3.966 ± 0.061	5.576ValVal: 5.576 ± 0.079	0.808ValTrp: 0.808 ± 0.028	1.486ValTyr: 1.486 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	1.133TrpAla: 1.133 ± 0.034	0.177TrpCys: 0.177 ± 0.012	0.536TrpAsp: 0.536 ± 0.021	0.721TrpGlu: 0.721 ± 0.029	0.496TrpPhe: 0.496 ± 0.022	0.865TrpGly: 0.865 ± 0.027	0.447TrpHis: 0.447 ± 0.021	0.638TrpIle: 0.638 ± 0.026	0.37TrpLys: 0.37 ± 0.02	2.374TrpLeu: 2.374 ± 0.057	0.414TrpMet: 0.414 ± 0.022	0.373TrpAsn: 0.373 ± 0.019	0.731TrpPro: 0.731 ± 0.023	0.975TrpGln: 0.975 ± 0.031	1.272TrpArg: 1.272 ± 0.035	0.853TrpSer: 0.853 ± 0.032	0.561TrpThr: 0.561 ± 0.026	0.899TrpVal: 0.899 ± 0.027	0.278TrpTrp: 0.278 ± 0.021	0.306TrpTyr: 0.306 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.354TyrAla: 2.354 ± 0.051	0.265TyrCys: 0.265 ± 0.016	1.324TyrAsp: 1.324 ± 0.037	1.208TyrGlu: 1.208 ± 0.034	0.917TyrPhe: 0.917 ± 0.032	2.082TyrGly: 2.082 ± 0.042	0.66TyrHis: 0.66 ± 0.025	0.959TyrIle: 0.959 ± 0.031	0.511TyrLys: 0.511 ± 0.02	2.938TyrLeu: 2.938 ± 0.058	0.471TyrMet: 0.471 ± 0.02	0.571TyrAsn: 0.571 ± 0.025	1.316TyrPro: 1.316 ± 0.035	1.05TyrGln: 1.05 ± 0.031	2.214TyrArg: 2.214 ± 0.047	1.282TyrSer: 1.282 ± 0.032	1.136TyrThr: 1.136 ± 0.032	1.532TyrVal: 1.532 ± 0.038	0.387TyrTrp: 0.387 ± 0.019	0.698TyrTyr: 0.698 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3407 proteins (1107370 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---