Amino acid dipepetide frequency for Silicibacter phage DSS3phi2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.987AlaAla: 7.987 ± 0.816
0.695AlaCys: 0.695 ± 0.226
4.688AlaAsp: 4.688 ± 0.475
6.381AlaGlu: 6.381 ± 0.662
2.387AlaPhe: 2.387 ± 0.342
6.164AlaGly: 6.164 ± 0.642
1.085AlaHis: 1.085 ± 0.25
4.167AlaIle: 4.167 ± 0.484
4.862AlaLys: 4.862 ± 0.515
5.99AlaLeu: 5.99 ± 0.552
2.691AlaMet: 2.691 ± 0.321
4.037AlaAsn: 4.037 ± 0.449
2.908AlaPro: 2.908 ± 0.315
2.908AlaGln: 2.908 ± 0.394
3.994AlaArg: 3.994 ± 0.487
4.949AlaSer: 4.949 ± 0.448
4.341AlaThr: 4.341 ± 0.665
5.904AlaVal: 5.904 ± 0.708
1.215AlaTrp: 1.215 ± 0.236
2.431AlaTyr: 2.431 ± 0.274
0.0AlaXaa: 0.0 ± 0.0
Cys
0.521CysAla: 0.521 ± 0.184
0.174CysCys: 0.174 ± 0.135
0.391CysAsp: 0.391 ± 0.149
0.564CysGlu: 0.564 ± 0.169
0.434CysPhe: 0.434 ± 0.152
0.608CysGly: 0.608 ± 0.221
0.217CysHis: 0.217 ± 0.102
0.26CysIle: 0.26 ± 0.132
0.651CysLys: 0.651 ± 0.234
0.521CysLeu: 0.521 ± 0.172
0.347CysMet: 0.347 ± 0.141
0.217CysAsn: 0.217 ± 0.121
0.564CysPro: 0.564 ± 0.192
0.521CysGln: 0.521 ± 0.17
0.477CysArg: 0.477 ± 0.178
0.391CysSer: 0.391 ± 0.144
0.695CysThr: 0.695 ± 0.226
0.477CysVal: 0.477 ± 0.219
0.087CysTrp: 0.087 ± 0.06
0.217CysTyr: 0.217 ± 0.08
0.0CysXaa: 0.0 ± 0.0
Asp
4.645AspAla: 4.645 ± 0.438
0.521AspCys: 0.521 ± 0.159
3.69AspAsp: 3.69 ± 0.459
4.037AspGlu: 4.037 ± 0.536
3.039AspPhe: 3.039 ± 0.391
4.732AspGly: 4.732 ± 0.446
1.042AspHis: 1.042 ± 0.193
4.558AspIle: 4.558 ± 0.46
2.865AspLys: 2.865 ± 0.465
6.077AspLeu: 6.077 ± 0.428
1.867AspMet: 1.867 ± 0.288
2.691AspAsn: 2.691 ± 0.372
4.037AspPro: 4.037 ± 0.455
2.691AspGln: 2.691 ± 0.375
3.256AspArg: 3.256 ± 0.344
3.429AspSer: 3.429 ± 0.387
3.473AspThr: 3.473 ± 0.447
5.079AspVal: 5.079 ± 0.532
1.302AspTrp: 1.302 ± 0.195
2.04AspTyr: 2.04 ± 0.322
0.0AspXaa: 0.0 ± 0.0
Glu
5.035GluAla: 5.035 ± 0.586
0.391GluCys: 0.391 ± 0.178
4.167GluAsp: 4.167 ± 0.395
6.164GluGlu: 6.164 ± 0.673
3.386GluPhe: 3.386 ± 0.428
4.688GluGly: 4.688 ± 0.677
1.085GluHis: 1.085 ± 0.264
3.994GluIle: 3.994 ± 0.291
3.69GluLys: 3.69 ± 0.479
5.252GluLeu: 5.252 ± 0.502
2.908GluMet: 2.908 ± 0.413
2.908GluAsn: 2.908 ± 0.324
1.693GluPro: 1.693 ± 0.301
2.865GluGln: 2.865 ± 0.43
3.863GluArg: 3.863 ± 0.365
4.254GluSer: 4.254 ± 0.41
3.907GluThr: 3.907 ± 0.502
5.383GluVal: 5.383 ± 0.504
0.608GluTrp: 0.608 ± 0.236
1.91GluTyr: 1.91 ± 0.245
0.0GluXaa: 0.0 ± 0.0
Phe
2.735PheAla: 2.735 ± 0.306
0.217PheCys: 0.217 ± 0.142
2.648PheAsp: 2.648 ± 0.327
2.387PheGlu: 2.387 ± 0.297
1.693PhePhe: 1.693 ± 0.331
2.908PheGly: 2.908 ± 0.338
0.912PheHis: 0.912 ± 0.255
2.605PheIle: 2.605 ± 0.381
2.605PheLys: 2.605 ± 0.353
2.691PheLeu: 2.691 ± 0.361
1.476PheMet: 1.476 ± 0.33
2.431PheAsn: 2.431 ± 0.333
1.476PhePro: 1.476 ± 0.202
1.693PheGln: 1.693 ± 0.247
2.04PheArg: 2.04 ± 0.266
2.952PheSer: 2.952 ± 0.278
2.344PheThr: 2.344 ± 0.331
2.17PheVal: 2.17 ± 0.285
0.304PheTrp: 0.304 ± 0.113
1.389PheTyr: 1.389 ± 0.276
0.0PheXaa: 0.0 ± 0.0
Gly
5.73GlyAla: 5.73 ± 0.537
0.304GlyCys: 0.304 ± 0.167
4.297GlyAsp: 4.297 ± 0.457
4.428GlyGlu: 4.428 ± 0.377
3.299GlyPhe: 3.299 ± 0.307
5.99GlyGly: 5.99 ± 0.791
1.476GlyHis: 1.476 ± 0.293
3.473GlyIle: 3.473 ± 0.414
4.08GlyLys: 4.08 ± 0.554
6.511GlyLeu: 6.511 ± 0.661
2.387GlyMet: 2.387 ± 0.317
3.646GlyAsn: 3.646 ± 0.453
2.387GlyPro: 2.387 ± 0.41
2.908GlyGln: 2.908 ± 0.407
3.342GlyArg: 3.342 ± 0.518
5.296GlySer: 5.296 ± 0.584
4.514GlyThr: 4.514 ± 0.433
4.862GlyVal: 4.862 ± 0.495
1.085GlyTrp: 1.085 ± 0.275
2.778GlyTyr: 2.778 ± 0.309
0.0GlyXaa: 0.0 ± 0.0
His
1.129HisAla: 1.129 ± 0.225
0.217HisCys: 0.217 ± 0.108
1.215HisAsp: 1.215 ± 0.274
1.129HisGlu: 1.129 ± 0.245
0.781HisPhe: 0.781 ± 0.215
1.519HisGly: 1.519 ± 0.362
0.651HisHis: 0.651 ± 0.237
1.215HisIle: 1.215 ± 0.218
1.476HisLys: 1.476 ± 0.379
1.867HisLeu: 1.867 ± 0.289
0.608HisMet: 0.608 ± 0.151
0.998HisAsn: 0.998 ± 0.228
0.912HisPro: 0.912 ± 0.202
0.564HisGln: 0.564 ± 0.127
1.129HisArg: 1.129 ± 0.281
1.215HisSer: 1.215 ± 0.268
0.651HisThr: 0.651 ± 0.226
0.998HisVal: 0.998 ± 0.28
0.174HisTrp: 0.174 ± 0.103
0.825HisTyr: 0.825 ± 0.302
0.0HisXaa: 0.0 ± 0.0
Ile
4.905IleAla: 4.905 ± 0.6
0.608IleCys: 0.608 ± 0.212
3.516IleAsp: 3.516 ± 0.338
3.907IleGlu: 3.907 ± 0.42
2.431IlePhe: 2.431 ± 0.404
3.516IleGly: 3.516 ± 0.403
1.302IleHis: 1.302 ± 0.3
3.212IleIle: 3.212 ± 0.389
2.691IleLys: 2.691 ± 0.391
4.558IleLeu: 4.558 ± 0.421
1.302IleMet: 1.302 ± 0.249
3.212IleAsn: 3.212 ± 0.292
3.169IlePro: 3.169 ± 0.374
2.084IleGln: 2.084 ± 0.358
2.995IleArg: 2.995 ± 0.36
3.559IleSer: 3.559 ± 0.335
3.603IleThr: 3.603 ± 0.386
3.039IleVal: 3.039 ± 0.424
0.955IleTrp: 0.955 ± 0.262
2.127IleTyr: 2.127 ± 0.353
0.0IleXaa: 0.0 ± 0.0
Lys
5.209LysAla: 5.209 ± 0.677
0.521LysCys: 0.521 ± 0.153
3.559LysAsp: 3.559 ± 0.487
4.471LysGlu: 4.471 ± 0.427
1.606LysPhe: 1.606 ± 0.297
3.125LysGly: 3.125 ± 0.379
0.912LysHis: 0.912 ± 0.274
2.561LysIle: 2.561 ± 0.302
3.473LysLys: 3.473 ± 0.545
4.992LysLeu: 4.992 ± 0.702
2.084LysMet: 2.084 ± 0.291
2.474LysAsn: 2.474 ± 0.345
2.387LysPro: 2.387 ± 0.395
2.605LysGln: 2.605 ± 0.378
2.648LysArg: 2.648 ± 0.297
2.822LysSer: 2.822 ± 0.482
3.082LysThr: 3.082 ± 0.534
3.299LysVal: 3.299 ± 0.417
0.738LysTrp: 0.738 ± 0.176
1.78LysTyr: 1.78 ± 0.251
0.0LysXaa: 0.0 ± 0.0
Leu
6.164LeuAla: 6.164 ± 0.683
0.955LeuCys: 0.955 ± 0.258
5.296LeuAsp: 5.296 ± 0.48
5.296LeuGlu: 5.296 ± 0.45
2.778LeuPhe: 2.778 ± 0.363
4.992LeuGly: 4.992 ± 0.477
1.519LeuHis: 1.519 ± 0.37
4.08LeuIle: 4.08 ± 0.44
4.905LeuLys: 4.905 ± 0.516
5.035LeuLeu: 5.035 ± 0.538
2.214LeuMet: 2.214 ± 0.289
5.252LeuAsn: 5.252 ± 0.466
3.863LeuPro: 3.863 ± 0.492
3.559LeuGln: 3.559 ± 0.37
4.037LeuArg: 4.037 ± 0.337
5.209LeuSer: 5.209 ± 0.462
5.383LeuThr: 5.383 ± 0.371
4.905LeuVal: 4.905 ± 0.474
0.998LeuTrp: 0.998 ± 0.214
2.474LeuTyr: 2.474 ± 0.443
0.0LeuXaa: 0.0 ± 0.0
Met
3.169MetAla: 3.169 ± 0.335
0.347MetCys: 0.347 ± 0.16
2.04MetAsp: 2.04 ± 0.236
1.563MetGlu: 1.563 ± 0.288
1.085MetPhe: 1.085 ± 0.185
2.214MetGly: 2.214 ± 0.283
0.217MetHis: 0.217 ± 0.1
1.823MetIle: 1.823 ± 0.303
1.606MetLys: 1.606 ± 0.249
2.822MetLeu: 2.822 ± 0.358
0.825MetMet: 0.825 ± 0.202
1.997MetAsn: 1.997 ± 0.347
1.823MetPro: 1.823 ± 0.286
1.823MetGln: 1.823 ± 0.262
1.65MetArg: 1.65 ± 0.354
2.301MetSer: 2.301 ± 0.314
2.648MetThr: 2.648 ± 0.33
2.04MetVal: 2.04 ± 0.388
0.304MetTrp: 0.304 ± 0.128
0.608MetTyr: 0.608 ± 0.17
0.0MetXaa: 0.0 ± 0.0
Asn
4.384AsnAla: 4.384 ± 0.458
0.391AsnCys: 0.391 ± 0.15
3.646AsnAsp: 3.646 ± 0.344
3.299AsnGlu: 3.299 ± 0.467
2.561AsnPhe: 2.561 ± 0.342
3.777AsnGly: 3.777 ± 0.407
1.302AsnHis: 1.302 ± 0.232
2.518AsnIle: 2.518 ± 0.405
2.518AsnLys: 2.518 ± 0.483
4.124AsnLeu: 4.124 ± 0.479
1.389AsnMet: 1.389 ± 0.208
2.561AsnAsn: 2.561 ± 0.39
3.039AsnPro: 3.039 ± 0.367
2.865AsnGln: 2.865 ± 0.336
2.518AsnArg: 2.518 ± 0.275
2.908AsnSer: 2.908 ± 0.367
2.778AsnThr: 2.778 ± 0.363
3.429AsnVal: 3.429 ± 0.46
0.738AsnTrp: 0.738 ± 0.264
1.78AsnTyr: 1.78 ± 0.308
0.0AsnXaa: 0.0 ± 0.0
Pro
3.256ProAla: 3.256 ± 0.514
0.347ProCys: 0.347 ± 0.148
3.646ProAsp: 3.646 ± 0.372
3.733ProGlu: 3.733 ± 0.393
2.04ProPhe: 2.04 ± 0.282
2.127ProGly: 2.127 ± 0.267
0.868ProHis: 0.868 ± 0.183
1.997ProIle: 1.997 ± 0.372
2.084ProLys: 2.084 ± 0.375
3.082ProLeu: 3.082 ± 0.417
1.302ProMet: 1.302 ± 0.249
2.387ProAsn: 2.387 ± 0.348
1.736ProPro: 1.736 ± 0.317
2.127ProGln: 2.127 ± 0.27
1.867ProArg: 1.867 ± 0.26
2.865ProSer: 2.865 ± 0.386
2.952ProThr: 2.952 ± 0.336
3.559ProVal: 3.559 ± 0.421
0.651ProTrp: 0.651 ± 0.208
0.868ProTyr: 0.868 ± 0.19
0.0ProXaa: 0.0 ± 0.0
Gln
3.603GlnAla: 3.603 ± 0.517
0.217GlnCys: 0.217 ± 0.113
2.865GlnAsp: 2.865 ± 0.307
2.648GlnGlu: 2.648 ± 0.308
1.519GlnPhe: 1.519 ± 0.29
2.995GlnGly: 2.995 ± 0.382
0.998GlnHis: 0.998 ± 0.205
3.082GlnIle: 3.082 ± 0.412
2.561GlnLys: 2.561 ± 0.317
3.212GlnLeu: 3.212 ± 0.51
1.519GlnMet: 1.519 ± 0.271
2.344GlnAsn: 2.344 ± 0.468
1.65GlnPro: 1.65 ± 0.372
2.344GlnGln: 2.344 ± 0.327
2.561GlnArg: 2.561 ± 0.388
2.04GlnSer: 2.04 ± 0.345
3.125GlnThr: 3.125 ± 0.361
2.344GlnVal: 2.344 ± 0.264
0.608GlnTrp: 0.608 ± 0.157
1.346GlnTyr: 1.346 ± 0.265
0.0GlnXaa: 0.0 ± 0.0
Arg
3.169ArgAla: 3.169 ± 0.41
0.651ArgCys: 0.651 ± 0.222
2.778ArgAsp: 2.778 ± 0.32
3.516ArgGlu: 3.516 ± 0.601
2.214ArgPhe: 2.214 ± 0.459
3.386ArgGly: 3.386 ± 0.394
0.477ArgHis: 0.477 ± 0.125
3.169ArgIle: 3.169 ± 0.334
2.648ArgLys: 2.648 ± 0.363
4.341ArgLeu: 4.341 ± 0.473
2.214ArgMet: 2.214 ± 0.268
2.648ArgAsn: 2.648 ± 0.398
1.823ArgPro: 1.823 ± 0.257
2.431ArgGln: 2.431 ± 0.354
2.387ArgArg: 2.387 ± 0.326
2.995ArgSer: 2.995 ± 0.326
3.299ArgThr: 3.299 ± 0.455
3.603ArgVal: 3.603 ± 0.391
0.651ArgTrp: 0.651 ± 0.18
1.867ArgTyr: 1.867 ± 0.289
0.0ArgXaa: 0.0 ± 0.0
Ser
3.863SerAla: 3.863 ± 0.493
0.434SerCys: 0.434 ± 0.149
4.384SerAsp: 4.384 ± 0.608
3.777SerGlu: 3.777 ± 0.409
2.518SerPhe: 2.518 ± 0.394
6.424SerGly: 6.424 ± 0.607
1.042SerHis: 1.042 ± 0.274
3.125SerIle: 3.125 ± 0.293
3.473SerLys: 3.473 ± 0.413
4.254SerLeu: 4.254 ± 0.369
1.91SerMet: 1.91 ± 0.295
2.995SerAsn: 2.995 ± 0.347
2.691SerPro: 2.691 ± 0.372
2.084SerGln: 2.084 ± 0.331
2.518SerArg: 2.518 ± 0.289
3.516SerSer: 3.516 ± 0.407
4.471SerThr: 4.471 ± 0.373
4.992SerVal: 4.992 ± 0.65
0.391SerTrp: 0.391 ± 0.112
1.823SerTyr: 1.823 ± 0.368
0.0SerXaa: 0.0 ± 0.0
Thr
4.992ThrAla: 4.992 ± 0.501
0.304ThrCys: 0.304 ± 0.157
4.601ThrAsp: 4.601 ± 0.504
3.429ThrGlu: 3.429 ± 0.521
1.91ThrPhe: 1.91 ± 0.367
6.251ThrGly: 6.251 ± 0.431
1.563ThrHis: 1.563 ± 0.226
3.907ThrIle: 3.907 ± 0.472
3.863ThrLys: 3.863 ± 0.418
4.124ThrLeu: 4.124 ± 0.371
1.953ThrMet: 1.953 ± 0.318
3.386ThrAsn: 3.386 ± 0.44
2.995ThrPro: 2.995 ± 0.336
2.605ThrGln: 2.605 ± 0.349
3.342ThrArg: 3.342 ± 0.459
2.865ThrSer: 2.865 ± 0.268
3.299ThrThr: 3.299 ± 0.42
3.559ThrVal: 3.559 ± 0.454
0.955ThrTrp: 0.955 ± 0.242
1.91ThrTyr: 1.91 ± 0.264
0.0ThrXaa: 0.0 ± 0.0
Val
5.513ValAla: 5.513 ± 0.512
0.477ValCys: 0.477 ± 0.169
3.994ValAsp: 3.994 ± 0.424
3.95ValGlu: 3.95 ± 0.429
2.561ValPhe: 2.561 ± 0.342
4.514ValGly: 4.514 ± 0.475
1.432ValHis: 1.432 ± 0.316
3.863ValIle: 3.863 ± 0.435
2.518ValLys: 2.518 ± 0.342
5.99ValLeu: 5.99 ± 0.633
2.431ValMet: 2.431 ± 0.351
3.82ValAsn: 3.82 ± 0.429
2.995ValPro: 2.995 ± 0.393
2.561ValGln: 2.561 ± 0.348
3.473ValArg: 3.473 ± 0.463
4.688ValSer: 4.688 ± 0.516
4.775ValThr: 4.775 ± 0.489
3.69ValVal: 3.69 ± 0.473
0.781ValTrp: 0.781 ± 0.232
2.084ValTyr: 2.084 ± 0.268
0.0ValXaa: 0.0 ± 0.0
Trp
0.998TrpAla: 0.998 ± 0.186
0.087TrpCys: 0.087 ± 0.074
1.215TrpAsp: 1.215 ± 0.235
1.042TrpGlu: 1.042 ± 0.268
0.521TrpPhe: 0.521 ± 0.152
1.042TrpGly: 1.042 ± 0.26
0.434TrpHis: 0.434 ± 0.165
1.259TrpIle: 1.259 ± 0.269
0.608TrpLys: 0.608 ± 0.196
1.215TrpLeu: 1.215 ± 0.248
0.651TrpMet: 0.651 ± 0.162
0.477TrpAsn: 0.477 ± 0.166
0.087TrpPro: 0.087 ± 0.067
0.825TrpGln: 0.825 ± 0.17
0.477TrpArg: 0.477 ± 0.159
0.477TrpSer: 0.477 ± 0.153
1.042TrpThr: 1.042 ± 0.289
0.781TrpVal: 0.781 ± 0.221
0.564TrpTrp: 0.564 ± 0.209
0.217TrpTyr: 0.217 ± 0.115
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.778TyrAla: 2.778 ± 0.265
0.477TyrCys: 0.477 ± 0.155
2.431TyrAsp: 2.431 ± 0.446
2.474TyrGlu: 2.474 ± 0.372
0.912TyrPhe: 0.912 ± 0.18
1.823TyrGly: 1.823 ± 0.273
0.738TyrHis: 0.738 ± 0.175
1.823TyrIle: 1.823 ± 0.281
1.172TyrLys: 1.172 ± 0.224
2.257TyrLeu: 2.257 ± 0.448
0.781TyrMet: 0.781 ± 0.164
2.04TyrAsn: 2.04 ± 0.35
1.259TyrPro: 1.259 ± 0.272
1.519TyrGln: 1.519 ± 0.293
1.693TyrArg: 1.693 ± 0.32
1.953TyrSer: 1.953 ± 0.266
1.432TyrThr: 1.432 ± 0.252
1.997TyrVal: 1.997 ± 0.383
0.912TyrTrp: 0.912 ± 0.27
1.085TyrTyr: 1.085 ± 0.185
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 81 proteins (23038 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski