Amino acid dipepetide frequency for Pseudoalteromonas piratica

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.068AlaAla: 7.068 ± 0.083	0.924AlaCys: 0.924 ± 0.033	4.274AlaAsp: 4.274 ± 0.059	5.453AlaGlu: 5.453 ± 0.084	3.715AlaPhe: 3.715 ± 0.055	5.314AlaGly: 5.314 ± 0.073	1.677AlaHis: 1.677 ± 0.035	6.148AlaIle: 6.148 ± 0.077	5.817AlaLys: 5.817 ± 0.073	9.754AlaLeu: 9.754 ± 0.111	2.338AlaMet: 2.338 ± 0.038	4.514AlaAsn: 4.514 ± 0.055	2.726AlaPro: 2.726 ± 0.048	3.69AlaGln: 3.69 ± 0.061	3.154AlaArg: 3.154 ± 0.049	5.601AlaSer: 5.601 ± 0.077	4.419AlaThr: 4.419 ± 0.058	5.419AlaVal: 5.419 ± 0.062	0.898AlaTrp: 0.898 ± 0.029	2.487AlaTyr: 2.487 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	0.747CysAla: 0.747 ± 0.027	0.148CysCys: 0.148 ± 0.01	0.625CysAsp: 0.625 ± 0.023	0.637CysGlu: 0.637 ± 0.024	0.506CysPhe: 0.506 ± 0.02	0.756CysGly: 0.756 ± 0.031	0.323CysHis: 0.323 ± 0.017	0.584CysIle: 0.584 ± 0.024	0.488CysLys: 0.488 ± 0.02	0.958CysLeu: 0.958 ± 0.026	0.206CysMet: 0.206 ± 0.013	0.415CysAsn: 0.415 ± 0.017	0.369CysPro: 0.369 ± 0.017	0.472CysGln: 0.472 ± 0.017	0.363CysArg: 0.363 ± 0.017	0.677CysSer: 0.677 ± 0.025	0.429CysThr: 0.429 ± 0.016	0.595CysVal: 0.595 ± 0.023	0.098CysTrp: 0.098 ± 0.009	0.356CysTyr: 0.356 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	4.599AspAla: 4.599 ± 0.058	0.468AspCys: 0.468 ± 0.021	3.217AspAsp: 3.217 ± 0.059	3.974AspGlu: 3.974 ± 0.067	2.767AspPhe: 2.767 ± 0.045	3.546AspGly: 3.546 ± 0.064	0.988AspHis: 0.988 ± 0.026	4.148AspIle: 4.148 ± 0.058	3.662AspLys: 3.662 ± 0.049	5.248AspLeu: 5.248 ± 0.064	1.294AspMet: 1.294 ± 0.039	2.885AspAsn: 2.885 ± 0.056	1.772AspPro: 1.772 ± 0.038	1.677AspGln: 1.677 ± 0.037	1.738AspArg: 1.738 ± 0.039	3.377AspSer: 3.377 ± 0.052	2.852AspThr: 2.852 ± 0.052	3.918AspVal: 3.918 ± 0.058	0.8AspTrp: 0.8 ± 0.023	2.334AspTyr: 2.334 ± 0.046	0.0AspXaa: 0.0 ± 0.0
Glu	4.803GluAla: 4.803 ± 0.08	0.47GluCys: 0.47 ± 0.022	2.743GluAsp: 2.743 ± 0.055	3.474GluGlu: 3.474 ± 0.071	2.861GluPhe: 2.861 ± 0.049	3.243GluGly: 3.243 ± 0.054	1.597GluHis: 1.597 ± 0.034	4.169GluIle: 4.169 ± 0.06	4.519GluLys: 4.519 ± 0.064	7.309GluLeu: 7.309 ± 0.077	1.573GluMet: 1.573 ± 0.038	3.333GluAsn: 3.333 ± 0.048	1.84GluPro: 1.84 ± 0.04	4.463GluGln: 4.463 ± 0.063	3.033GluArg: 3.033 ± 0.056	3.804GluSer: 3.804 ± 0.056	3.071GluThr: 3.071 ± 0.05	4.21GluVal: 4.21 ± 0.058	0.609GluTrp: 0.609 ± 0.023	1.932GluTyr: 1.932 ± 0.042	0.0GluXaa: 0.0 ± 0.0
Phe	4.087PheAla: 4.087 ± 0.056	0.546PheCys: 0.546 ± 0.021	3.22PheAsp: 3.22 ± 0.058	2.94PheGlu: 2.94 ± 0.045	1.819PhePhe: 1.819 ± 0.045	2.949PheGly: 2.949 ± 0.054	0.76PheHis: 0.76 ± 0.024	3.221PheIle: 3.221 ± 0.055	2.618PheLys: 2.618 ± 0.045	3.581PheLeu: 3.581 ± 0.058	0.947PheMet: 0.947 ± 0.028	2.745PheAsn: 2.745 ± 0.042	1.302PhePro: 1.302 ± 0.03	1.201PheGln: 1.201 ± 0.028	1.391PheArg: 1.391 ± 0.035	3.82PheSer: 3.82 ± 0.063	2.55PheThr: 2.55 ± 0.051	2.997PheVal: 2.997 ± 0.048	0.487PheTrp: 0.487 ± 0.023	1.652PheTyr: 1.652 ± 0.042	0.0PheXaa: 0.0 ± 0.0
Gly	4.799GlyAla: 4.799 ± 0.068	0.772GlyCys: 0.772 ± 0.026	3.583GlyAsp: 3.583 ± 0.065	4.313GlyGlu: 4.313 ± 0.057	3.443GlyPhe: 3.443 ± 0.053	4.148GlyGly: 4.148 ± 0.074	1.364GlyHis: 1.364 ± 0.036	4.269GlyIle: 4.269 ± 0.063	3.97GlyLys: 3.97 ± 0.064	6.394GlyLeu: 6.394 ± 0.086	1.544GlyMet: 1.544 ± 0.031	2.771GlyAsn: 2.771 ± 0.052	1.477GlyPro: 1.477 ± 0.034	2.541GlyGln: 2.541 ± 0.042	2.545GlyArg: 2.545 ± 0.051	3.784GlySer: 3.784 ± 0.051	3.111GlyThr: 3.111 ± 0.058	4.657GlyVal: 4.657 ± 0.067	0.784GlyTrp: 0.784 ± 0.025	2.403GlyTyr: 2.403 ± 0.044	0.0GlyXaa: 0.0 ± 0.0
His	1.549HisAla: 1.549 ± 0.035	0.307HisCys: 0.307 ± 0.015	1.116HisAsp: 1.116 ± 0.03	1.032HisGlu: 1.032 ± 0.031	1.211HisPhe: 1.211 ± 0.033	1.436HisGly: 1.436 ± 0.037	0.705HisHis: 0.705 ± 0.024	1.605HisIle: 1.605 ± 0.035	1.147HisLys: 1.147 ± 0.031	2.243HisLeu: 2.243 ± 0.042	0.413HisMet: 0.413 ± 0.017	1.066HisAsn: 1.066 ± 0.03	0.981HisPro: 0.981 ± 0.029	1.198HisGln: 1.198 ± 0.031	0.83HisArg: 0.83 ± 0.027	1.455HisSer: 1.455 ± 0.031	1.15HisThr: 1.15 ± 0.03	1.204HisVal: 1.204 ± 0.032	0.293HisTrp: 0.293 ± 0.014	0.955HisTyr: 0.955 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	6.655IleAla: 6.655 ± 0.069	0.701IleCys: 0.701 ± 0.025	4.522IleAsp: 4.522 ± 0.067	5.108IleGlu: 5.108 ± 0.064	2.441IlePhe: 2.441 ± 0.05	4.251IleGly: 4.251 ± 0.068	1.122IleHis: 1.122 ± 0.026	3.735IleIle: 3.735 ± 0.064	4.098IleLys: 4.098 ± 0.053	5.263IleLeu: 5.263 ± 0.068	1.221IleMet: 1.221 ± 0.034	3.915IleAsn: 3.915 ± 0.058	2.326IlePro: 2.326 ± 0.046	2.055IleGln: 2.055 ± 0.043	2.539IleArg: 2.539 ± 0.047	5.088IleSer: 5.088 ± 0.065	4.008IleThr: 4.008 ± 0.055	4.04IleVal: 4.04 ± 0.065	0.643IleTrp: 0.643 ± 0.024	1.884IleTyr: 1.884 ± 0.041	0.0IleXaa: 0.0 ± 0.0
Lys	5.311LysAla: 5.311 ± 0.072	0.381LysCys: 0.381 ± 0.021	2.973LysAsp: 2.973 ± 0.047	3.701LysGlu: 3.701 ± 0.061	1.889LysPhe: 1.889 ± 0.04	3.506LysGly: 3.506 ± 0.056	1.629LysHis: 1.629 ± 0.041	3.274LysIle: 3.274 ± 0.054	3.514LysLys: 3.514 ± 0.069	6.505LysLeu: 6.505 ± 0.077	1.32LysMet: 1.32 ± 0.034	2.614LysAsn: 2.614 ± 0.049	2.46LysPro: 2.46 ± 0.047	3.979LysGln: 3.979 ± 0.06	3.039LysArg: 3.039 ± 0.053	3.777LysSer: 3.777 ± 0.054	3.215LysThr: 3.215 ± 0.052	4.266LysVal: 4.266 ± 0.058	0.579LysTrp: 0.579 ± 0.02	1.666LysTyr: 1.666 ± 0.039	0.0LysXaa: 0.0 ± 0.0
Leu	10.305LeuAla: 10.305 ± 0.083	1.017LeuCys: 1.017 ± 0.03	5.754LeuAsp: 5.754 ± 0.078	6.308LeuGlu: 6.308 ± 0.081	4.507LeuPhe: 4.507 ± 0.059	6.366LeuGly: 6.366 ± 0.078	1.879LeuHis: 1.879 ± 0.042	6.755LeuIle: 6.755 ± 0.086	6.17LeuLys: 6.17 ± 0.087	10.579LeuLeu: 10.579 ± 0.133	2.408LeuMet: 2.408 ± 0.041	5.583LeuAsn: 5.583 ± 0.071	4.426LeuPro: 4.426 ± 0.072	3.523LeuGln: 3.523 ± 0.063	3.613LeuArg: 3.613 ± 0.054	8.224LeuSer: 8.224 ± 0.085	6.357LeuThr: 6.357 ± 0.068	7.039LeuVal: 7.039 ± 0.072	0.933LeuTrp: 0.933 ± 0.029	2.81LeuTyr: 2.81 ± 0.047	0.0LeuXaa: 0.0 ± 0.0
Met	2.293MetAla: 2.293 ± 0.046	0.182MetCys: 0.182 ± 0.014	1.055MetAsp: 1.055 ± 0.031	1.073MetGlu: 1.073 ± 0.027	0.833MetPhe: 0.833 ± 0.026	1.421MetGly: 1.421 ± 0.036	0.481MetHis: 0.481 ± 0.02	1.268MetIle: 1.268 ± 0.033	1.359MetLys: 1.359 ± 0.036	2.498MetLeu: 2.498 ± 0.049	0.612MetMet: 0.612 ± 0.023	0.986MetAsn: 0.986 ± 0.029	1.124MetPro: 1.124 ± 0.028	1.128MetGln: 1.128 ± 0.028	1.12MetArg: 1.12 ± 0.033	1.709MetSer: 1.709 ± 0.036	1.394MetThr: 1.394 ± 0.037	1.464MetVal: 1.464 ± 0.035	0.185MetTrp: 0.185 ± 0.011	0.527MetTyr: 0.527 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	4.359AsnAla: 4.359 ± 0.061	0.505AsnCys: 0.505 ± 0.02	2.892AsnAsp: 2.892 ± 0.06	3.142AsnGlu: 3.142 ± 0.054	1.908AsnPhe: 1.908 ± 0.04	3.319AsnGly: 3.319 ± 0.06	1.114AsnHis: 1.114 ± 0.031	3.197AsnIle: 3.197 ± 0.047	3.093AsnLys: 3.093 ± 0.046	4.748AsnLeu: 4.748 ± 0.075	1.097AsnMet: 1.097 ± 0.031	2.94AsnAsn: 2.94 ± 0.061	2.018AsnPro: 2.018 ± 0.048	2.698AsnGln: 2.698 ± 0.051	2.004AsnArg: 2.004 ± 0.041	3.235AsnSer: 3.235 ± 0.051	3.017AsnThr: 3.017 ± 0.051	3.011AsnVal: 3.011 ± 0.054	0.686AsnTrp: 0.686 ± 0.023	1.837AsnTyr: 1.837 ± 0.044	0.0AsnXaa: 0.0 ± 0.0
Pro	2.648ProAla: 2.648 ± 0.048	0.286ProCys: 0.286 ± 0.015	2.043ProAsp: 2.043 ± 0.042	2.885ProGlu: 2.885 ± 0.051	1.736ProPhe: 1.736 ± 0.037	2.037ProGly: 2.037 ± 0.044	0.81ProHis: 0.81 ± 0.024	2.476ProIle: 2.476 ± 0.042	1.996ProLys: 1.996 ± 0.042	3.678ProLeu: 3.678 ± 0.048	0.83ProMet: 0.83 ± 0.027	2.004ProAsn: 2.004 ± 0.047	0.873ProPro: 0.873 ± 0.03	1.336ProGln: 1.336 ± 0.032	1.092ProArg: 1.092 ± 0.035	2.491ProSer: 2.491 ± 0.047	1.93ProThr: 1.93 ± 0.042	2.563ProVal: 2.563 ± 0.041	0.454ProTrp: 0.454 ± 0.018	1.184ProTyr: 1.184 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	4.121GlnAla: 4.121 ± 0.06	0.361GlnCys: 0.361 ± 0.017	2.11GlnAsp: 2.11 ± 0.04	2.28GlnGlu: 2.28 ± 0.041	2.108GlnPhe: 2.108 ± 0.037	2.949GlnGly: 2.949 ± 0.055	1.233GlnHis: 1.233 ± 0.033	2.782GlnIle: 2.782 ± 0.049	2.391GlnLys: 2.391 ± 0.048	5.596GlnLeu: 5.596 ± 0.086	0.983GlnMet: 0.983 ± 0.029	2.136GlnAsn: 2.136 ± 0.039	1.493GlnPro: 1.493 ± 0.042	3.237GlnGln: 3.237 ± 0.08	1.788GlnArg: 1.788 ± 0.036	3.06GlnSer: 3.06 ± 0.053	2.496GlnThr: 2.496 ± 0.042	3.179GlnVal: 3.179 ± 0.044	0.516GlnTrp: 0.516 ± 0.022	1.397GlnTyr: 1.397 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	3.096ArgAla: 3.096 ± 0.051	0.348ArgCys: 0.348 ± 0.016	2.202ArgAsp: 2.202 ± 0.04	2.576ArgGlu: 2.576 ± 0.054	2.274ArgPhe: 2.274 ± 0.04	2.228ArgGly: 2.228 ± 0.042	0.919ArgHis: 0.919 ± 0.025	2.868ArgIle: 2.868 ± 0.045	2.223ArgLys: 2.223 ± 0.045	4.298ArgLeu: 4.298 ± 0.071	0.938ArgMet: 0.938 ± 0.028	1.813ArgAsn: 1.813 ± 0.036	1.241ArgPro: 1.241 ± 0.033	1.674ArgGln: 1.674 ± 0.037	1.703ArgArg: 1.703 ± 0.043	2.205ArgSer: 2.205 ± 0.043	1.913ArgThr: 1.913 ± 0.038	2.763ArgVal: 2.763 ± 0.048	0.433ArgTrp: 0.433 ± 0.021	1.638ArgTyr: 1.638 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	5.411SerAla: 5.411 ± 0.055	0.643SerCys: 0.643 ± 0.026	4.029SerAsp: 4.029 ± 0.063	4.536SerGlu: 4.536 ± 0.063	3.248SerPhe: 3.248 ± 0.047	4.671SerGly: 4.671 ± 0.074	1.64SerHis: 1.64 ± 0.036	4.38SerIle: 4.38 ± 0.074	3.73SerLys: 3.73 ± 0.055	7.677SerLeu: 7.677 ± 0.082	1.415SerMet: 1.415 ± 0.035	3.385SerAsn: 3.385 ± 0.058	2.352SerPro: 2.352 ± 0.039	3.305SerGln: 3.305 ± 0.05	2.557SerArg: 2.557 ± 0.038	4.659SerSer: 4.659 ± 0.077	3.211SerThr: 3.211 ± 0.055	4.523SerVal: 4.523 ± 0.068	0.811SerTrp: 0.811 ± 0.024	2.342SerTyr: 2.342 ± 0.044	0.0SerXaa: 0.0 ± 0.0
Thr	4.439ThrAla: 4.439 ± 0.063	0.457ThrCys: 0.457 ± 0.018	2.785ThrAsp: 2.785 ± 0.051	3.141ThrGlu: 3.141 ± 0.047	2.334ThrPhe: 2.334 ± 0.049	3.769ThrGly: 3.769 ± 0.054	1.308ThrHis: 1.308 ± 0.033	3.541ThrIle: 3.541 ± 0.06	2.814ThrLys: 2.814 ± 0.046	6.424ThrLeu: 6.424 ± 0.073	1.014ThrMet: 1.014 ± 0.032	2.517ThrAsn: 2.517 ± 0.05	2.595ThrPro: 2.595 ± 0.044	2.557ThrGln: 2.557 ± 0.047	2.069ThrArg: 2.069 ± 0.036	3.581ThrSer: 3.581 ± 0.06	2.919ThrThr: 2.919 ± 0.054	3.621ThrVal: 3.621 ± 0.06	0.608ThrTrp: 0.608 ± 0.021	1.545ThrTyr: 1.545 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	5.989ValAla: 5.989 ± 0.078	0.73ValCys: 0.73 ± 0.023	3.86ValAsp: 3.86 ± 0.053	4.496ValGlu: 4.496 ± 0.068	2.96ValPhe: 2.96 ± 0.042	3.991ValGly: 3.991 ± 0.062	1.141ValHis: 1.141 ± 0.031	4.737ValIle: 4.737 ± 0.059	4.012ValLys: 4.012 ± 0.058	6.515ValLeu: 6.515 ± 0.083	1.671ValMet: 1.671 ± 0.036	3.415ValAsn: 3.415 ± 0.049	2.295ValPro: 2.295 ± 0.046	1.953ValGln: 1.953 ± 0.042	2.5ValArg: 2.5 ± 0.044	5.058ValSer: 5.058 ± 0.065	3.996ValThr: 3.996 ± 0.074	4.73ValVal: 4.73 ± 0.07	0.688ValTrp: 0.688 ± 0.025	2.003ValTyr: 2.003 ± 0.042	0.0ValXaa: 0.0 ± 0.0
Trp	0.684TrpAla: 0.684 ± 0.022	0.128TrpCys: 0.128 ± 0.01	0.496TrpAsp: 0.496 ± 0.022	0.41TrpGlu: 0.41 ± 0.022	0.547TrpPhe: 0.547 ± 0.022	0.655TrpGly: 0.655 ± 0.026	0.402TrpHis: 0.402 ± 0.02	0.502TrpIle: 0.502 ± 0.018	0.341TrpLys: 0.341 ± 0.016	1.622TrpLeu: 1.622 ± 0.036	0.279TrpMet: 0.279 ± 0.012	0.392TrpAsn: 0.392 ± 0.019	0.432TrpPro: 0.432 ± 0.019	1.334TrpGln: 1.334 ± 0.034	0.616TrpArg: 0.616 ± 0.022	0.637TrpSer: 0.637 ± 0.023	0.397TrpThr: 0.397 ± 0.018	0.694TrpVal: 0.694 ± 0.023	0.159TrpTrp: 0.159 ± 0.012	0.381TrpTyr: 0.381 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.427TyrAla: 2.427 ± 0.041	0.377TyrCys: 0.377 ± 0.016	1.765TyrAsp: 1.765 ± 0.044	1.577TyrGlu: 1.577 ± 0.032	1.728TyrPhe: 1.728 ± 0.037	2.117TyrGly: 2.117 ± 0.039	0.805TyrHis: 0.805 ± 0.026	1.956TyrIle: 1.956 ± 0.04	1.632TyrLys: 1.632 ± 0.039	3.668TyrLeu: 3.668 ± 0.051	0.606TyrMet: 0.606 ± 0.022	1.391TyrAsn: 1.391 ± 0.041	1.254TyrPro: 1.254 ± 0.031	2.195TyrGln: 2.195 ± 0.04	1.659TyrArg: 1.659 ± 0.04	2.28TyrSer: 2.28 ± 0.046	1.601TyrThr: 1.601 ± 0.033	1.848TyrVal: 1.848 ± 0.041	0.444TyrTrp: 0.444 ± 0.017	1.187TyrTyr: 1.187 ± 0.032	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3997 proteins (1331845 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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