Amino acid dipepetide frequency for Tuhoko virus 3

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.077AlaAla: 5.077 ± 1.124
0.203AlaCys: 0.203 ± 0.31
2.843AlaAsp: 2.843 ± 0.56
4.265AlaGlu: 4.265 ± 1.126
2.843AlaPhe: 2.843 ± 0.824
3.046AlaGly: 3.046 ± 1.31
1.219AlaHis: 1.219 ± 0.569
3.656AlaIle: 3.656 ± 0.911
3.046AlaLys: 3.046 ± 1.265
6.093AlaLeu: 6.093 ± 1.448
1.422AlaMet: 1.422 ± 0.835
4.062AlaAsn: 4.062 ± 1.146
3.859AlaPro: 3.859 ± 1.923
2.843AlaGln: 2.843 ± 0.96
3.046AlaArg: 3.046 ± 1.066
7.92AlaSer: 7.92 ± 1.329
4.468AlaThr: 4.468 ± 2.142
3.452AlaVal: 3.452 ± 1.555
0.609AlaTrp: 0.609 ± 0.382
1.625AlaTyr: 1.625 ± 0.769
0.0AlaXaa: 0.0 ± 0.0
Cys
1.422CysAla: 1.422 ± 0.48
0.406CysCys: 0.406 ± 0.284
1.625CysAsp: 1.625 ± 0.41
0.812CysGlu: 0.812 ± 0.39
0.609CysPhe: 0.609 ± 0.3
1.015CysGly: 1.015 ± 0.774
0.406CysHis: 0.406 ± 0.284
1.015CysIle: 1.015 ± 0.293
0.812CysLys: 0.812 ± 0.489
2.031CysLeu: 2.031 ± 0.538
0.812CysMet: 0.812 ± 0.444
1.015CysAsn: 1.015 ± 0.58
0.812CysPro: 0.812 ± 0.436
0.609CysGln: 0.609 ± 0.275
1.219CysArg: 1.219 ± 0.516
1.828CysSer: 1.828 ± 1.055
2.234CysThr: 2.234 ± 1.024
1.015CysVal: 1.015 ± 0.583
0.0CysTrp: 0.0 ± 0.0
1.219CysTyr: 1.219 ± 0.528
0.0CysXaa: 0.0 ± 0.0
Asp
3.452AspAla: 3.452 ± 0.62
1.219AspCys: 1.219 ± 0.63
2.437AspAsp: 2.437 ± 0.772
2.843AspGlu: 2.843 ± 0.819
1.828AspPhe: 1.828 ± 0.412
1.015AspGly: 1.015 ± 0.476
1.015AspHis: 1.015 ± 0.472
4.265AspIle: 4.265 ± 0.928
3.249AspLys: 3.249 ± 1.143
5.077AspLeu: 5.077 ± 1.227
1.219AspMet: 1.219 ± 0.42
3.656AspAsn: 3.656 ± 1.237
3.452AspPro: 3.452 ± 0.998
2.031AspGln: 2.031 ± 1.293
2.234AspArg: 2.234 ± 0.57
3.249AspSer: 3.249 ± 1.326
1.828AspThr: 1.828 ± 0.568
1.219AspVal: 1.219 ± 0.306
0.609AspTrp: 0.609 ± 0.371
1.422AspTyr: 1.422 ± 0.381
0.0AspXaa: 0.0 ± 0.0
Glu
3.249GluAla: 3.249 ± 0.986
1.625GluCys: 1.625 ± 0.4
3.046GluAsp: 3.046 ± 1.056
3.656GluGlu: 3.656 ± 1.84
1.422GluPhe: 1.422 ± 0.515
2.64GluGly: 2.64 ± 0.577
0.609GluHis: 0.609 ± 0.309
4.671GluIle: 4.671 ± 0.898
2.64GluLys: 2.64 ± 0.407
5.483GluLeu: 5.483 ± 1.518
2.031GluMet: 2.031 ± 0.926
3.452GluAsn: 3.452 ± 1.23
2.031GluPro: 2.031 ± 1.252
3.046GluGln: 3.046 ± 0.974
2.437GluArg: 2.437 ± 1.501
4.062GluSer: 4.062 ± 0.575
3.249GluThr: 3.249 ± 1.084
2.843GluVal: 2.843 ± 0.745
0.812GluTrp: 0.812 ± 0.371
1.015GluTyr: 1.015 ± 0.275
0.0GluXaa: 0.0 ± 0.0
Phe
2.234PheAla: 2.234 ± 0.774
0.609PheCys: 0.609 ± 0.275
2.031PheAsp: 2.031 ± 0.64
2.031PheGlu: 2.031 ± 0.515
1.828PhePhe: 1.828 ± 0.685
1.625PheGly: 1.625 ± 0.539
0.406PheHis: 0.406 ± 0.284
3.046PheIle: 3.046 ± 0.85
1.828PheLys: 1.828 ± 0.998
4.874PheLeu: 4.874 ± 1.016
1.015PheMet: 1.015 ± 0.465
0.812PheAsn: 0.812 ± 0.495
2.64PhePro: 2.64 ± 0.936
0.406PheGln: 0.406 ± 0.222
1.422PheArg: 1.422 ± 0.855
2.437PheSer: 2.437 ± 0.39
2.031PheThr: 2.031 ± 0.614
1.422PheVal: 1.422 ± 0.363
0.203PheTrp: 0.203 ± 0.31
2.031PheTyr: 2.031 ± 0.597
0.0PheXaa: 0.0 ± 0.0
Gly
2.843GlyAla: 2.843 ± 0.803
1.015GlyCys: 1.015 ± 0.666
3.452GlyAsp: 3.452 ± 0.728
3.452GlyGlu: 3.452 ± 0.745
2.234GlyPhe: 2.234 ± 0.343
2.031GlyGly: 2.031 ± 0.643
1.219GlyHis: 1.219 ± 0.358
4.062GlyIle: 4.062 ± 1.112
3.859GlyLys: 3.859 ± 1.046
6.702GlyLeu: 6.702 ± 0.761
0.609GlyMet: 0.609 ± 0.309
2.437GlyAsn: 2.437 ± 0.938
2.031GlyPro: 2.031 ± 0.875
1.625GlyGln: 1.625 ± 0.688
3.046GlyArg: 3.046 ± 0.879
3.859GlySer: 3.859 ± 1.063
1.015GlyThr: 1.015 ± 0.504
2.64GlyVal: 2.64 ± 0.497
0.406GlyTrp: 0.406 ± 0.284
1.828GlyTyr: 1.828 ± 0.498
0.0GlyXaa: 0.0 ± 0.0
His
0.812HisAla: 0.812 ± 0.376
0.406HisCys: 0.406 ± 0.4
0.609HisAsp: 0.609 ± 0.275
0.609HisGlu: 0.609 ± 0.251
0.812HisPhe: 0.812 ± 0.575
1.422HisGly: 1.422 ± 0.66
1.422HisHis: 1.422 ± 0.866
1.219HisIle: 1.219 ± 0.366
1.422HisLys: 1.422 ± 0.544
2.843HisLeu: 2.843 ± 0.959
0.609HisMet: 0.609 ± 0.264
0.812HisAsn: 0.812 ± 0.348
2.437HisPro: 2.437 ± 0.701
0.812HisGln: 0.812 ± 0.47
1.219HisArg: 1.219 ± 0.553
1.422HisSer: 1.422 ± 0.676
1.422HisThr: 1.422 ± 0.337
0.812HisVal: 0.812 ± 0.495
0.203HisTrp: 0.203 ± 0.124
0.812HisTyr: 0.812 ± 0.303
0.0HisXaa: 0.0 ± 0.0
Ile
5.686IleAla: 5.686 ± 0.981
1.422IleCys: 1.422 ± 0.522
2.64IleAsp: 2.64 ± 0.629
5.89IleGlu: 5.89 ± 0.979
3.452IlePhe: 3.452 ± 0.986
4.671IleGly: 4.671 ± 1.116
0.609IleHis: 0.609 ± 0.251
6.296IleIle: 6.296 ± 1.783
4.671IleLys: 4.671 ± 0.543
5.686IleLeu: 5.686 ± 1.427
2.843IleMet: 2.843 ± 0.498
5.686IleAsn: 5.686 ± 1.038
4.874IlePro: 4.874 ± 0.486
3.656IleGln: 3.656 ± 0.814
3.656IleArg: 3.656 ± 1.38
5.077IleSer: 5.077 ± 0.868
4.265IleThr: 4.265 ± 0.9
4.062IleVal: 4.062 ± 0.93
1.015IleTrp: 1.015 ± 0.581
1.625IleTyr: 1.625 ± 0.41
0.0IleXaa: 0.0 ± 0.0
Lys
2.843LysAla: 2.843 ± 0.624
0.609LysCys: 0.609 ± 0.309
1.828LysAsp: 1.828 ± 0.55
2.843LysGlu: 2.843 ± 0.732
1.828LysPhe: 1.828 ± 0.456
1.828LysGly: 1.828 ± 0.696
1.828LysHis: 1.828 ± 0.558
4.062LysIle: 4.062 ± 0.795
2.64LysLys: 2.64 ± 0.6
6.093LysLeu: 6.093 ± 1.615
1.219LysMet: 1.219 ± 0.439
1.625LysAsn: 1.625 ± 0.851
1.219LysPro: 1.219 ± 0.89
2.031LysGln: 2.031 ± 0.564
3.656LysArg: 3.656 ± 1.542
3.046LysSer: 3.046 ± 0.575
2.437LysThr: 2.437 ± 0.874
4.874LysVal: 4.874 ± 1.506
0.406LysTrp: 0.406 ± 0.314
1.422LysTyr: 1.422 ± 0.655
0.0LysXaa: 0.0 ± 0.0
Leu
6.093LeuAla: 6.093 ± 1.461
2.437LeuCys: 2.437 ± 0.509
5.686LeuAsp: 5.686 ± 1.769
6.499LeuGlu: 6.499 ± 1.147
2.64LeuPhe: 2.64 ± 0.653
5.483LeuGly: 5.483 ± 0.866
1.422LeuHis: 1.422 ± 0.866
9.139LeuIle: 9.139 ± 1.412
3.656LeuLys: 3.656 ± 1.121
8.733LeuLeu: 8.733 ± 2.25
2.64LeuMet: 2.64 ± 0.646
6.499LeuAsn: 6.499 ± 1.267
4.062LeuPro: 4.062 ± 0.662
4.468LeuGln: 4.468 ± 1.229
4.671LeuArg: 4.671 ± 0.967
10.357LeuSer: 10.357 ± 2.674
8.123LeuThr: 8.123 ± 1.073
6.702LeuVal: 6.702 ± 0.974
1.219LeuTrp: 1.219 ± 0.306
4.062LeuTyr: 4.062 ± 1.87
0.0LeuXaa: 0.0 ± 0.0
Met
3.046MetAla: 3.046 ± 1.293
0.609MetCys: 0.609 ± 0.275
2.64MetAsp: 2.64 ± 0.694
1.219MetGlu: 1.219 ± 0.555
0.406MetPhe: 0.406 ± 0.247
1.828MetGly: 1.828 ± 0.723
0.406MetHis: 0.406 ± 0.4
1.422MetIle: 1.422 ± 0.591
1.015MetLys: 1.015 ± 0.472
2.234MetLeu: 2.234 ± 0.601
1.422MetMet: 1.422 ± 0.855
1.219MetAsn: 1.219 ± 0.649
1.422MetPro: 1.422 ± 0.679
0.609MetGln: 0.609 ± 0.251
1.828MetArg: 1.828 ± 0.731
2.64MetSer: 2.64 ± 0.776
3.249MetThr: 3.249 ± 0.657
1.219MetVal: 1.219 ± 0.418
0.406MetTrp: 0.406 ± 0.247
0.609MetTyr: 0.609 ± 0.264
0.0MetXaa: 0.0 ± 0.0
Asn
4.265AsnAla: 4.265 ± 1.066
0.609AsnCys: 0.609 ± 0.559
1.422AsnAsp: 1.422 ± 0.441
2.64AsnGlu: 2.64 ± 0.892
2.64AsnPhe: 2.64 ± 0.505
2.234AsnGly: 2.234 ± 0.636
1.828AsnHis: 1.828 ± 0.52
2.843AsnIle: 2.843 ± 0.694
1.422AsnLys: 1.422 ± 0.445
6.499AsnLeu: 6.499 ± 1.278
1.828AsnMet: 1.828 ± 0.587
1.828AsnAsn: 1.828 ± 0.673
3.452AsnPro: 3.452 ± 0.886
3.249AsnGln: 3.249 ± 0.714
1.828AsnArg: 1.828 ± 0.618
5.28AsnSer: 5.28 ± 0.98
2.437AsnThr: 2.437 ± 0.549
2.843AsnVal: 2.843 ± 0.672
0.812AsnTrp: 0.812 ± 0.495
1.219AsnTyr: 1.219 ± 0.424
0.0AsnXaa: 0.0 ± 0.0
Pro
1.828ProAla: 1.828 ± 1.215
1.015ProCys: 1.015 ± 0.699
2.843ProAsp: 2.843 ± 0.623
2.843ProGlu: 2.843 ± 0.959
1.015ProPhe: 1.015 ± 0.876
3.656ProGly: 3.656 ± 1.36
1.828ProHis: 1.828 ± 0.489
4.671ProIle: 4.671 ± 1.125
2.437ProLys: 2.437 ± 0.745
4.671ProLeu: 4.671 ± 0.672
1.625ProMet: 1.625 ± 0.531
1.625ProAsn: 1.625 ± 0.621
3.859ProPro: 3.859 ± 0.71
2.437ProGln: 2.437 ± 1.511
2.64ProArg: 2.64 ± 0.775
5.89ProSer: 5.89 ± 1.827
4.874ProThr: 4.874 ± 1.704
2.64ProVal: 2.64 ± 1.189
0.203ProTrp: 0.203 ± 0.124
1.828ProTyr: 1.828 ± 0.719
0.0ProXaa: 0.0 ± 0.0
Gln
3.859GlnAla: 3.859 ± 2.152
1.422GlnCys: 1.422 ± 1.077
1.422GlnAsp: 1.422 ± 0.883
2.234GlnGlu: 2.234 ± 0.614
1.422GlnPhe: 1.422 ± 0.635
2.437GlnGly: 2.437 ± 1.287
1.015GlnHis: 1.015 ± 0.352
4.062GlnIle: 4.062 ± 0.7
2.234GlnLys: 2.234 ± 0.423
4.874GlnLeu: 4.874 ± 0.724
1.219GlnMet: 1.219 ± 0.42
2.437GlnAsn: 2.437 ± 0.755
4.265GlnPro: 4.265 ± 2.118
2.843GlnGln: 2.843 ± 1.606
1.422GlnArg: 1.422 ± 0.438
5.28GlnSer: 5.28 ± 1.629
1.422GlnThr: 1.422 ± 0.45
2.234GlnVal: 2.234 ± 0.731
0.203GlnTrp: 0.203 ± 0.124
0.203GlnTyr: 0.203 ± 0.227
0.0GlnXaa: 0.0 ± 0.0
Arg
2.031ArgAla: 2.031 ± 0.758
1.219ArgCys: 1.219 ± 0.724
1.422ArgAsp: 1.422 ± 0.235
2.234ArgGlu: 2.234 ± 0.855
1.828ArgPhe: 1.828 ± 0.781
2.843ArgGly: 2.843 ± 1.112
1.219ArgHis: 1.219 ± 0.42
4.062ArgIle: 4.062 ± 0.865
2.234ArgLys: 2.234 ± 0.857
6.905ArgLeu: 6.905 ± 1.422
1.015ArgMet: 1.015 ± 0.345
2.234ArgAsn: 2.234 ± 0.592
2.437ArgPro: 2.437 ± 0.517
1.828ArgGln: 1.828 ± 0.723
4.265ArgArg: 4.265 ± 1.451
3.249ArgSer: 3.249 ± 0.43
3.046ArgThr: 3.046 ± 0.707
3.859ArgVal: 3.859 ± 0.637
0.609ArgTrp: 0.609 ± 0.421
1.422ArgTyr: 1.422 ± 0.408
0.0ArgXaa: 0.0 ± 0.0
Ser
6.905SerAla: 6.905 ± 1.354
2.234SerCys: 2.234 ± 0.712
4.062SerAsp: 4.062 ± 0.588
3.452SerGlu: 3.452 ± 0.642
2.843SerPhe: 2.843 ± 0.449
4.265SerGly: 4.265 ± 0.452
1.828SerHis: 1.828 ± 0.934
7.108SerIle: 7.108 ± 1.738
3.249SerLys: 3.249 ± 1.122
9.748SerLeu: 9.748 ± 0.951
2.843SerMet: 2.843 ± 0.626
4.874SerAsn: 4.874 ± 0.606
3.656SerPro: 3.656 ± 0.619
5.483SerGln: 5.483 ± 1.88
2.64SerArg: 2.64 ± 0.958
9.342SerSer: 9.342 ± 2.759
4.874SerThr: 4.874 ± 1.235
5.28SerVal: 5.28 ± 1.124
0.812SerTrp: 0.812 ± 0.348
2.031SerTyr: 2.031 ± 0.323
0.0SerXaa: 0.0 ± 0.0
Thr
3.452ThrAla: 3.452 ± 1.675
1.219ThrCys: 1.219 ± 0.967
3.249ThrAsp: 3.249 ± 1.159
3.656ThrGlu: 3.656 ± 0.477
1.422ThrPhe: 1.422 ± 0.448
3.249ThrGly: 3.249 ± 0.999
1.625ThrHis: 1.625 ± 0.4
6.296ThrIle: 6.296 ± 0.934
4.062ThrLys: 4.062 ± 0.721
4.671ThrLeu: 4.671 ± 0.873
1.828ThrMet: 1.828 ± 0.646
2.843ThrAsn: 2.843 ± 1.512
3.656ThrPro: 3.656 ± 1.338
3.046ThrGln: 3.046 ± 1.338
3.249ThrArg: 3.249 ± 0.608
5.483ThrSer: 5.483 ± 1.771
3.859ThrThr: 3.859 ± 0.889
2.437ThrVal: 2.437 ± 0.436
0.406ThrTrp: 0.406 ± 0.247
1.422ThrTyr: 1.422 ± 0.669
0.0ThrXaa: 0.0 ± 0.0
Val
4.062ValAla: 4.062 ± 0.866
1.422ValCys: 1.422 ± 0.928
3.046ValAsp: 3.046 ± 0.851
1.625ValGlu: 1.625 ± 0.52
2.64ValPhe: 2.64 ± 1.031
2.437ValGly: 2.437 ± 1.116
1.625ValHis: 1.625 ± 0.344
3.046ValIle: 3.046 ± 0.841
2.234ValLys: 2.234 ± 1.266
5.28ValLeu: 5.28 ± 0.819
2.234ValMet: 2.234 ± 0.55
2.234ValAsn: 2.234 ± 0.524
2.437ValPro: 2.437 ± 0.554
3.249ValGln: 3.249 ± 0.76
3.656ValArg: 3.656 ± 0.495
4.062ValSer: 4.062 ± 1.341
4.062ValThr: 4.062 ± 0.608
2.64ValVal: 2.64 ± 0.788
0.812ValTrp: 0.812 ± 0.405
1.625ValTyr: 1.625 ± 0.435
0.0ValXaa: 0.0 ± 0.0
Trp
0.609TrpAla: 0.609 ± 0.309
0.406TrpCys: 0.406 ± 0.406
0.0TrpAsp: 0.0 ± 0.0
0.203TrpGlu: 0.203 ± 0.124
0.609TrpPhe: 0.609 ± 0.309
1.015TrpGly: 1.015 ± 0.391
0.0TrpHis: 0.0 ± 0.0
1.219TrpIle: 1.219 ± 0.402
0.812TrpLys: 0.812 ± 0.372
0.812TrpLeu: 0.812 ± 0.444
0.406TrpMet: 0.406 ± 0.284
0.609TrpAsn: 0.609 ± 0.309
1.015TrpPro: 1.015 ± 0.353
0.0TrpGln: 0.0 ± 0.0
0.406TrpArg: 0.406 ± 0.247
0.406TrpSer: 0.406 ± 0.247
0.609TrpThr: 0.609 ± 0.264
0.406TrpVal: 0.406 ± 0.404
0.203TrpTrp: 0.203 ± 0.244
0.406TrpTyr: 0.406 ± 0.247
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.828TyrAla: 1.828 ± 0.442
0.812TyrCys: 0.812 ± 0.256
1.015TyrAsp: 1.015 ± 0.593
1.015TyrGlu: 1.015 ± 0.399
0.609TyrPhe: 0.609 ± 0.264
1.625TyrGly: 1.625 ± 0.679
0.609TyrHis: 0.609 ± 0.45
1.625TyrIle: 1.625 ± 0.485
0.812TyrLys: 0.812 ± 0.375
5.28TyrLeu: 5.28 ± 1.436
0.406TyrMet: 0.406 ± 0.222
1.422TyrAsn: 1.422 ± 0.679
0.812TyrPro: 0.812 ± 0.444
2.234TyrGln: 2.234 ± 0.712
1.422TyrArg: 1.422 ± 0.787
2.64TyrSer: 2.64 ± 0.796
1.625TyrThr: 1.625 ± 0.573
1.828TyrVal: 1.828 ± 0.792
0.203TyrTrp: 0.203 ± 0.124
1.422TyrTyr: 1.422 ± 0.531
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 7 proteins (4925 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski