Amino acid dipepetide frequency for Pseudoxanthomonas indica

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.675AlaAla: 16.675 ± 0.199	1.145AlaCys: 1.145 ± 0.031	7.14AlaAsp: 7.14 ± 0.083	6.715AlaGlu: 6.715 ± 0.1	3.903AlaPhe: 3.903 ± 0.06	10.829AlaGly: 10.829 ± 0.143	2.537AlaHis: 2.537 ± 0.055	5.382AlaIle: 5.382 ± 0.08	3.497AlaLys: 3.497 ± 0.082	14.28AlaLeu: 14.28 ± 0.143	3.188AlaMet: 3.188 ± 0.049	3.094AlaAsn: 3.094 ± 0.069	6.028AlaPro: 6.028 ± 0.098	5.664AlaGln: 5.664 ± 0.078	9.262AlaArg: 9.262 ± 0.111	7.077AlaSer: 7.077 ± 0.082	6.284AlaThr: 6.284 ± 0.083	8.427AlaVal: 8.427 ± 0.099	2.159AlaTrp: 2.159 ± 0.05	2.569AlaTyr: 2.569 ± 0.053	0.0AlaXaa: 0.0 ± 0.0
Cys	0.936CysAla: 0.936 ± 0.033	0.098CysCys: 0.098 ± 0.01	0.451CysAsp: 0.451 ± 0.021	0.41CysGlu: 0.41 ± 0.021	0.271CysPhe: 0.271 ± 0.016	0.782CysGly: 0.782 ± 0.029	0.219CysHis: 0.219 ± 0.014	0.309CysIle: 0.309 ± 0.017	0.19CysLys: 0.19 ± 0.011	0.85CysLeu: 0.85 ± 0.027	0.135CysMet: 0.135 ± 0.011	0.206CysAsn: 0.206 ± 0.012	0.374CysPro: 0.374 ± 0.019	0.247CysGln: 0.247 ± 0.014	0.518CysArg: 0.518 ± 0.02	0.437CysSer: 0.437 ± 0.02	0.406CysThr: 0.406 ± 0.019	0.632CysVal: 0.632 ± 0.024	0.123CysTrp: 0.123 ± 0.008	0.205CysTyr: 0.205 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	7.99AspAla: 7.99 ± 0.089	0.429AspCys: 0.429 ± 0.02	3.411AspAsp: 3.411 ± 0.055	3.293AspGlu: 3.293 ± 0.058	2.134AspPhe: 2.134 ± 0.051	5.501AspGly: 5.501 ± 0.084	1.2AspHis: 1.2 ± 0.029	2.459AspIle: 2.459 ± 0.048	1.716AspLys: 1.716 ± 0.046	5.814AspLeu: 5.814 ± 0.069	1.071AspMet: 1.071 ± 0.032	1.477AspAsn: 1.477 ± 0.041	3.146AspPro: 3.146 ± 0.055	1.882AspGln: 1.882 ± 0.04	3.985AspArg: 3.985 ± 0.059	2.849AspSer: 2.849 ± 0.055	2.769AspThr: 2.769 ± 0.047	4.261AspVal: 4.261 ± 0.062	1.163AspTrp: 1.163 ± 0.034	1.77AspTyr: 1.77 ± 0.045	0.0AspXaa: 0.0 ± 0.0
Glu	6.673GluAla: 6.673 ± 0.1	0.306GluCys: 0.306 ± 0.017	2.578GluAsp: 2.578 ± 0.056	2.607GluGlu: 2.607 ± 0.058	1.916GluPhe: 1.916 ± 0.045	4.068GluGly: 4.068 ± 0.065	1.367GluHis: 1.367 ± 0.041	2.389GluIle: 2.389 ± 0.058	1.584GluLys: 1.584 ± 0.042	5.9GluLeu: 5.9 ± 0.076	1.097GluMet: 1.097 ± 0.036	1.301GluAsn: 1.301 ± 0.035	2.486GluPro: 2.486 ± 0.049	2.898GluGln: 2.898 ± 0.055	4.778GluArg: 4.778 ± 0.075	2.797GluSer: 2.797 ± 0.047	2.539GluThr: 2.539 ± 0.053	3.974GluVal: 3.974 ± 0.07	0.787GluTrp: 0.787 ± 0.027	1.238GluTyr: 1.238 ± 0.034	0.0GluXaa: 0.0 ± 0.0
Phe	4.295PheAla: 4.295 ± 0.065	0.322PheCys: 0.322 ± 0.016	2.605PheAsp: 2.605 ± 0.051	1.916PheGlu: 1.916 ± 0.046	1.191PhePhe: 1.191 ± 0.04	3.352PheGly: 3.352 ± 0.063	0.806PheHis: 0.806 ± 0.025	1.245PheIle: 1.245 ± 0.031	0.999PheLys: 0.999 ± 0.035	3.075PheLeu: 3.075 ± 0.064	0.614PheMet: 0.614 ± 0.022	1.224PheAsn: 1.224 ± 0.037	1.438PhePro: 1.438 ± 0.032	1.072PheGln: 1.072 ± 0.029	2.189PheArg: 2.189 ± 0.046	2.034PheSer: 2.034 ± 0.045	1.701PheThr: 1.701 ± 0.048	2.637PheVal: 2.637 ± 0.05	0.54PheTrp: 0.54 ± 0.024	0.871PheTyr: 0.871 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	8.722GlyAla: 8.722 ± 0.121	0.71GlyCys: 0.71 ± 0.029	4.802GlyAsp: 4.802 ± 0.067	4.918GlyGlu: 4.918 ± 0.068	3.325GlyPhe: 3.325 ± 0.056	7.265GlyGly: 7.265 ± 0.151	2.032GlyHis: 2.032 ± 0.048	3.856GlyIle: 3.856 ± 0.067	3.279GlyLys: 3.279 ± 0.064	8.546GlyLeu: 8.546 ± 0.093	2.261GlyMet: 2.261 ± 0.041	2.546GlyAsn: 2.546 ± 0.073	2.974GlyPro: 2.974 ± 0.055	3.691GlyGln: 3.691 ± 0.062	5.712GlyArg: 5.712 ± 0.074	4.917GlySer: 4.917 ± 0.115	4.375GlyThr: 4.375 ± 0.15	6.512GlyVal: 6.512 ± 0.088	1.695GlyTrp: 1.695 ± 0.038	2.553GlyTyr: 2.553 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	2.993HisAla: 2.993 ± 0.052	0.215HisCys: 0.215 ± 0.015	1.35HisAsp: 1.35 ± 0.029	1.164HisGlu: 1.164 ± 0.031	0.853HisPhe: 0.853 ± 0.031	2.197HisGly: 2.197 ± 0.048	0.623HisHis: 0.623 ± 0.024	0.779HisIle: 0.779 ± 0.028	0.467HisLys: 0.467 ± 0.019	2.252HisLeu: 2.252 ± 0.045	0.429HisMet: 0.429 ± 0.018	0.507HisAsn: 0.507 ± 0.022	1.381HisPro: 1.381 ± 0.04	0.685HisGln: 0.685 ± 0.025	1.663HisArg: 1.663 ± 0.043	1.025HisSer: 1.025 ± 0.033	0.929HisThr: 0.929 ± 0.026	1.574HisVal: 1.574 ± 0.035	0.486HisTrp: 0.486 ± 0.02	0.686HisTyr: 0.686 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	6.159IleAla: 6.159 ± 0.066	0.389IleCys: 0.389 ± 0.017	3.176IleAsp: 3.176 ± 0.05	2.883IleGlu: 2.883 ± 0.057	1.2IlePhe: 1.2 ± 0.037	4.201IleGly: 4.201 ± 0.059	0.839IleHis: 0.839 ± 0.028	1.479IleIle: 1.479 ± 0.037	1.24IleLys: 1.24 ± 0.037	3.201IleLeu: 3.201 ± 0.056	0.507IleMet: 0.507 ± 0.019	1.426IleAsn: 1.426 ± 0.036	2.049IlePro: 2.049 ± 0.038	1.241IleGln: 1.241 ± 0.032	2.616IleArg: 2.616 ± 0.044	2.414IleSer: 2.414 ± 0.055	2.388IleThr: 2.388 ± 0.047	3.109IleVal: 3.109 ± 0.058	0.51IleTrp: 0.51 ± 0.022	0.927IleTyr: 0.927 ± 0.026	0.0IleXaa: 0.0 ± 0.0
Lys	3.381LysAla: 3.381 ± 0.076	0.152LysCys: 0.152 ± 0.011	1.554LysAsp: 1.554 ± 0.042	1.262LysGlu: 1.262 ± 0.038	0.852LysPhe: 0.852 ± 0.032	2.045LysGly: 2.045 ± 0.054	0.631LysHis: 0.631 ± 0.022	1.227LysIle: 1.227 ± 0.04	1.144LysLys: 1.144 ± 0.056	3.231LysLeu: 3.231 ± 0.065	0.628LysMet: 0.628 ± 0.027	0.767LysAsn: 0.767 ± 0.029	2.013LysPro: 2.013 ± 0.054	1.425LysGln: 1.425 ± 0.04	2.3LysArg: 2.3 ± 0.045	1.554LysSer: 1.554 ± 0.038	1.557LysThr: 1.557 ± 0.036	2.271LysVal: 2.271 ± 0.049	0.336LysTrp: 0.336 ± 0.016	0.673LysTyr: 0.673 ± 0.027	0.0LysXaa: 0.0 ± 0.0
Leu	14.512LeuAla: 14.512 ± 0.163	0.881LeuCys: 0.881 ± 0.03	6.481LeuAsp: 6.481 ± 0.077	5.356LeuGlu: 5.356 ± 0.082	3.413LeuPhe: 3.413 ± 0.061	8.617LeuGly: 8.617 ± 0.113	2.411LeuHis: 2.411 ± 0.052	4.35LeuIle: 4.35 ± 0.068	3.186LeuLys: 3.186 ± 0.056	11.872LeuLeu: 11.872 ± 0.146	2.147LeuMet: 2.147 ± 0.048	2.499LeuAsn: 2.499 ± 0.046	6.523LeuPro: 6.523 ± 0.089	4.374LeuGln: 4.374 ± 0.07	8.518LeuArg: 8.518 ± 0.114	6.226LeuSer: 6.226 ± 0.078	5.118LeuThr: 5.118 ± 0.081	7.315LeuVal: 7.315 ± 0.09	1.473LeuTrp: 1.473 ± 0.04	2.142LeuTyr: 2.142 ± 0.045	0.0LeuXaa: 0.0 ± 0.0
Met	2.709MetAla: 2.709 ± 0.051	0.129MetCys: 0.129 ± 0.012	1.122MetAsp: 1.122 ± 0.037	0.927MetGlu: 0.927 ± 0.027	0.623MetPhe: 0.623 ± 0.025	1.565MetGly: 1.565 ± 0.043	0.452MetHis: 0.452 ± 0.019	0.842MetIle: 0.842 ± 0.027	0.83MetLys: 0.83 ± 0.027	2.198MetLeu: 2.198 ± 0.048	0.482MetMet: 0.482 ± 0.021	0.666MetAsn: 0.666 ± 0.023	1.351MetPro: 1.351 ± 0.039	0.948MetGln: 0.948 ± 0.027	1.689MetArg: 1.689 ± 0.04	1.605MetSer: 1.605 ± 0.035	1.362MetThr: 1.362 ± 0.033	1.382MetVal: 1.382 ± 0.036	0.209MetTrp: 0.209 ± 0.013	0.382MetTyr: 0.382 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.4AsnAla: 3.4 ± 0.072	0.195AsnCys: 0.195 ± 0.016	1.507AsnAsp: 1.507 ± 0.035	1.423AsnGlu: 1.423 ± 0.04	0.991AsnPhe: 0.991 ± 0.032	2.557AsnGly: 2.557 ± 0.082	0.509AsnHis: 0.509 ± 0.022	1.114AsnIle: 1.114 ± 0.033	0.652AsnLys: 0.652 ± 0.026	2.773AsnLeu: 2.773 ± 0.053	0.414AsnMet: 0.414 ± 0.018	0.831AsnAsn: 0.831 ± 0.049	1.855AsnPro: 1.855 ± 0.045	0.961AsnGln: 0.961 ± 0.032	1.779AsnArg: 1.779 ± 0.041	1.375AsnSer: 1.375 ± 0.045	1.457AsnThr: 1.457 ± 0.046	2.0AsnVal: 2.0 ± 0.045	0.446AsnTrp: 0.446 ± 0.021	0.735AsnTyr: 0.735 ± 0.031	0.0AsnXaa: 0.0 ± 0.0
Pro	7.103ProAla: 7.103 ± 0.104	0.303ProCys: 0.303 ± 0.017	3.309ProAsp: 3.309 ± 0.057	3.161ProGlu: 3.161 ± 0.054	1.585ProPhe: 1.585 ± 0.04	4.518ProGly: 4.518 ± 0.073	1.111ProHis: 1.111 ± 0.032	1.941ProIle: 1.941 ± 0.038	1.367ProLys: 1.367 ± 0.039	5.354ProLeu: 5.354 ± 0.082	1.301ProMet: 1.301 ± 0.033	1.305ProAsn: 1.305 ± 0.034	2.809ProPro: 2.809 ± 0.076	2.13ProGln: 2.13 ± 0.048	3.327ProArg: 3.327 ± 0.062	2.653ProSer: 2.653 ± 0.05	2.566ProThr: 2.566 ± 0.05	4.07ProVal: 4.07 ± 0.062	0.882ProTrp: 0.882 ± 0.03	1.251ProTyr: 1.251 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	6.123GlnAla: 6.123 ± 0.087	0.244GlnCys: 0.244 ± 0.015	1.845GlnAsp: 1.845 ± 0.041	1.67GlnGlu: 1.67 ± 0.04	1.281GlnPhe: 1.281 ± 0.029	3.158GlnGly: 3.158 ± 0.061	0.928GlnHis: 0.928 ± 0.029	1.672GlnIle: 1.672 ± 0.043	1.033GlnLys: 1.033 ± 0.032	4.546GlnLeu: 4.546 ± 0.068	0.897GlnMet: 0.897 ± 0.03	0.886GlnAsn: 0.886 ± 0.03	2.276GlnPro: 2.276 ± 0.051	2.124GlnGln: 2.124 ± 0.045	3.852GlnArg: 3.852 ± 0.065	2.04GlnSer: 2.04 ± 0.041	1.801GlnThr: 1.801 ± 0.041	3.289GlnVal: 3.289 ± 0.055	0.703GlnTrp: 0.703 ± 0.028	0.846GlnTyr: 0.846 ± 0.03	0.0GlnXaa: 0.0 ± 0.0
Arg	8.089ArgAla: 8.089 ± 0.091	0.523ArgCys: 0.523 ± 0.025	4.445ArgAsp: 4.445 ± 0.072	4.684ArgGlu: 4.684 ± 0.072	2.862ArgPhe: 2.862 ± 0.051	5.233ArgGly: 5.233 ± 0.074	1.851ArgHis: 1.851 ± 0.047	3.702ArgIle: 3.702 ± 0.061	2.17ArgLys: 2.17 ± 0.044	8.16ArgLeu: 8.16 ± 0.121	1.872ArgMet: 1.872 ± 0.045	2.099ArgAsn: 2.099 ± 0.045	3.186ArgPro: 3.186 ± 0.062	3.246ArgGln: 3.246 ± 0.048	5.572ArgArg: 5.572 ± 0.08	3.757ArgSer: 3.757 ± 0.062	3.235ArgThr: 3.235 ± 0.056	5.357ArgVal: 5.357 ± 0.073	1.514ArgTrp: 1.514 ± 0.039	2.217ArgTyr: 2.217 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	6.686SerAla: 6.686 ± 0.078	0.393SerCys: 0.393 ± 0.019	2.961SerAsp: 2.961 ± 0.048	2.726SerGlu: 2.726 ± 0.048	2.019SerPhe: 2.019 ± 0.039	5.19SerGly: 5.19 ± 0.111	1.233SerHis: 1.233 ± 0.037	2.214SerIle: 2.214 ± 0.048	1.539SerLys: 1.539 ± 0.044	6.105SerLeu: 6.105 ± 0.081	1.147SerMet: 1.147 ± 0.032	1.597SerAsn: 1.597 ± 0.048	2.94SerPro: 2.94 ± 0.051	2.146SerGln: 2.146 ± 0.046	3.87SerArg: 3.87 ± 0.061	3.137SerSer: 3.137 ± 0.059	2.964SerThr: 2.964 ± 0.069	4.111SerVal: 4.111 ± 0.061	0.851SerTrp: 0.851 ± 0.034	1.447SerTyr: 1.447 ± 0.044	0.0SerXaa: 0.0 ± 0.0
Thr	5.935ThrAla: 5.935 ± 0.082	0.392ThrCys: 0.392 ± 0.02	2.75ThrAsp: 2.75 ± 0.062	2.185ThrGlu: 2.185 ± 0.043	1.594ThrPhe: 1.594 ± 0.035	4.682ThrGly: 4.682 ± 0.1	1.089ThrHis: 1.089 ± 0.031	2.054ThrIle: 2.054 ± 0.047	1.011ThrLys: 1.011 ± 0.033	6.138ThrLeu: 6.138 ± 0.117	0.845ThrMet: 0.845 ± 0.026	1.184ThrAsn: 1.184 ± 0.048	3.53ThrPro: 3.53 ± 0.064	1.898ThrGln: 1.898 ± 0.049	3.486ThrArg: 3.486 ± 0.051	2.634ThrSer: 2.634 ± 0.052	2.773ThrThr: 2.773 ± 0.074	3.985ThrVal: 3.985 ± 0.069	0.756ThrTrp: 0.756 ± 0.026	1.224ThrTyr: 1.224 ± 0.045	0.0ThrXaa: 0.0 ± 0.0
Val	9.166ValAla: 9.166 ± 0.105	0.601ValCys: 0.601 ± 0.025	4.603ValAsp: 4.603 ± 0.066	4.13ValGlu: 4.13 ± 0.067	2.56ValPhe: 2.56 ± 0.051	5.589ValGly: 5.589 ± 0.078	1.518ValHis: 1.518 ± 0.034	3.506ValIle: 3.506 ± 0.051	1.937ValLys: 1.937 ± 0.053	8.124ValLeu: 8.124 ± 0.104	1.609ValMet: 1.609 ± 0.036	2.088ValAsn: 2.088 ± 0.054	3.692ValPro: 3.692 ± 0.059	2.694ValGln: 2.694 ± 0.049	5.166ValArg: 5.166 ± 0.067	4.384ValSer: 4.384 ± 0.065	3.798ValThr: 3.798 ± 0.072	5.874ValVal: 5.874 ± 0.082	0.934ValTrp: 0.934 ± 0.029	1.622ValTyr: 1.622 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	1.363TrpAla: 1.363 ± 0.038	0.146TrpCys: 0.146 ± 0.011	0.76TrpAsp: 0.76 ± 0.024	0.624TrpGlu: 0.624 ± 0.022	0.614TrpPhe: 0.614 ± 0.023	1.044TrpGly: 1.044 ± 0.033	0.393TrpHis: 0.393 ± 0.019	0.648TrpIle: 0.648 ± 0.023	0.561TrpLys: 0.561 ± 0.021	2.403TrpLeu: 2.403 ± 0.056	0.455TrpMet: 0.455 ± 0.018	0.566TrpAsn: 0.566 ± 0.021	0.786TrpPro: 0.786 ± 0.027	0.914TrpGln: 0.914 ± 0.033	1.498TrpArg: 1.498 ± 0.041	0.955TrpSer: 0.955 ± 0.031	0.809TrpThr: 0.809 ± 0.029	1.042TrpVal: 1.042 ± 0.031	0.366TrpTrp: 0.366 ± 0.02	0.407TrpTyr: 0.407 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.946TyrAla: 2.946 ± 0.051	0.226TyrCys: 0.226 ± 0.015	1.472TyrAsp: 1.472 ± 0.043	1.231TyrGlu: 1.231 ± 0.033	0.937TyrPhe: 0.937 ± 0.028	2.298TyrGly: 2.298 ± 0.048	0.509TyrHis: 0.509 ± 0.023	0.786TyrIle: 0.786 ± 0.029	0.601TyrLys: 0.601 ± 0.025	2.59TyrLeu: 2.59 ± 0.048	0.374TyrMet: 0.374 ± 0.02	0.707TyrAsn: 0.707 ± 0.03	1.21TyrPro: 1.21 ± 0.037	0.975TyrGln: 0.975 ± 0.027	1.99TyrArg: 1.99 ± 0.045	1.406TyrSer: 1.406 ± 0.038	1.311TyrThr: 1.311 ± 0.044	1.772TyrVal: 1.772 ± 0.039	0.422TyrTrp: 0.422 ± 0.021	0.688TyrTyr: 0.688 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3555 proteins (1197874 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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