Amino acid dipepetide frequency for Moraxella phage Mcat28

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.511AlaAla: 3.511 ± 0.525
1.392AlaCys: 1.392 ± 0.395
5.025AlaAsp: 5.025 ± 0.464
4.661AlaGlu: 4.661 ± 0.579
3.753AlaPhe: 3.753 ± 0.465
5.448AlaGly: 5.448 ± 0.641
1.877AlaHis: 1.877 ± 0.349
5.63AlaIle: 5.63 ± 0.53
7.567AlaLys: 7.567 ± 1.008
7.022AlaLeu: 7.022 ± 0.669
2.058AlaMet: 2.058 ± 0.387
4.298AlaAsn: 4.298 ± 0.606
1.816AlaPro: 1.816 ± 0.46
3.935AlaGln: 3.935 ± 0.5
3.39AlaArg: 3.39 ± 0.456
6.598AlaSer: 6.598 ± 0.654
4.843AlaThr: 4.843 ± 0.717
4.722AlaVal: 4.722 ± 0.503
1.392AlaTrp: 1.392 ± 0.275
3.511AlaTyr: 3.511 ± 0.498
0.0AlaXaa: 0.0 ± 0.0
Cys
0.605CysAla: 0.605 ± 0.191
0.121CysCys: 0.121 ± 0.085
0.545CysAsp: 0.545 ± 0.181
0.605CysGlu: 0.605 ± 0.241
0.242CysPhe: 0.242 ± 0.108
0.969CysGly: 0.969 ± 0.316
0.484CysHis: 0.484 ± 0.177
0.424CysIle: 0.424 ± 0.18
0.908CysLys: 0.908 ± 0.32
1.09CysLeu: 1.09 ± 0.229
0.182CysMet: 0.182 ± 0.107
0.242CysAsn: 0.242 ± 0.141
0.424CysPro: 0.424 ± 0.175
0.484CysGln: 0.484 ± 0.169
1.029CysArg: 1.029 ± 0.258
0.726CysSer: 0.726 ± 0.223
0.363CysThr: 0.363 ± 0.19
1.09CysVal: 1.09 ± 0.258
0.061CysTrp: 0.061 ± 0.064
0.484CysTyr: 0.484 ± 0.21
0.0CysXaa: 0.0 ± 0.0
Asp
4.661AspAla: 4.661 ± 0.547
0.605AspCys: 0.605 ± 0.229
5.811AspAsp: 5.811 ± 0.638
5.085AspGlu: 5.085 ± 0.45
3.632AspPhe: 3.632 ± 0.543
6.114AspGly: 6.114 ± 0.571
0.545AspHis: 0.545 ± 0.167
4.116AspIle: 4.116 ± 0.498
4.964AspLys: 4.964 ± 0.518
4.903AspLeu: 4.903 ± 0.435
1.574AspMet: 1.574 ± 0.291
3.511AspAsn: 3.511 ± 0.489
1.513AspPro: 1.513 ± 0.327
1.029AspGln: 1.029 ± 0.26
2.119AspArg: 2.119 ± 0.381
3.148AspSer: 3.148 ± 0.418
3.087AspThr: 3.087 ± 0.387
3.814AspVal: 3.814 ± 0.549
0.605AspTrp: 0.605 ± 0.201
1.937AspTyr: 1.937 ± 0.455
0.0AspXaa: 0.0 ± 0.0
Glu
3.693GluAla: 3.693 ± 0.592
0.848GluCys: 0.848 ± 0.234
2.361GluAsp: 2.361 ± 0.447
1.816GluGlu: 1.816 ± 0.416
2.906GluPhe: 2.906 ± 0.398
2.3GluGly: 2.3 ± 0.353
1.816GluHis: 1.816 ± 0.393
5.085GluIle: 5.085 ± 0.562
4.177GluLys: 4.177 ± 0.581
7.567GluLeu: 7.567 ± 0.635
2.543GluMet: 2.543 ± 0.41
2.664GluAsn: 2.664 ± 0.464
2.179GluPro: 2.179 ± 0.401
3.632GluGln: 3.632 ± 0.493
2.966GluArg: 2.966 ± 0.408
2.482GluSer: 2.482 ± 0.403
3.087GluThr: 3.087 ± 0.422
3.027GluVal: 3.027 ± 0.504
0.969GluTrp: 0.969 ± 0.216
2.119GluTyr: 2.119 ± 0.334
0.0GluXaa: 0.0 ± 0.0
Phe
2.543PheAla: 2.543 ± 0.415
0.605PheCys: 0.605 ± 0.209
3.329PheAsp: 3.329 ± 0.427
3.208PheGlu: 3.208 ± 0.523
0.848PhePhe: 0.848 ± 0.246
3.511PheGly: 3.511 ± 0.466
0.908PheHis: 0.908 ± 0.257
2.664PheIle: 2.664 ± 0.444
1.574PheLys: 1.574 ± 0.352
2.421PheLeu: 2.421 ± 0.422
1.15PheMet: 1.15 ± 0.254
2.24PheAsn: 2.24 ± 0.346
0.848PhePro: 0.848 ± 0.185
0.666PheGln: 0.666 ± 0.203
1.392PheArg: 1.392 ± 0.26
2.3PheSer: 2.3 ± 0.373
2.482PheThr: 2.482 ± 0.366
2.3PheVal: 2.3 ± 0.493
0.605PheTrp: 0.605 ± 0.159
1.15PheTyr: 1.15 ± 0.259
0.0PheXaa: 0.0 ± 0.0
Gly
4.238GlyAla: 4.238 ± 0.719
0.666GlyCys: 0.666 ± 0.207
3.632GlyAsp: 3.632 ± 0.537
4.419GlyGlu: 4.419 ± 0.605
2.724GlyPhe: 2.724 ± 0.423
4.54GlyGly: 4.54 ± 0.679
1.09GlyHis: 1.09 ± 0.241
3.693GlyIle: 3.693 ± 0.361
6.054GlyLys: 6.054 ± 0.703
6.175GlyLeu: 6.175 ± 0.464
2.058GlyMet: 2.058 ± 0.345
3.148GlyAsn: 3.148 ± 0.459
0.242GlyPro: 0.242 ± 0.13
2.24GlyGln: 2.24 ± 0.437
3.814GlyArg: 3.814 ± 0.547
3.693GlySer: 3.693 ± 0.538
2.906GlyThr: 2.906 ± 0.502
5.388GlyVal: 5.388 ± 0.638
1.029GlyTrp: 1.029 ± 0.285
2.058GlyTyr: 2.058 ± 0.475
0.0GlyXaa: 0.0 ± 0.0
His
2.179HisAla: 2.179 ± 0.386
0.242HisCys: 0.242 ± 0.102
1.695HisAsp: 1.695 ± 0.294
1.513HisGlu: 1.513 ± 0.301
0.969HisPhe: 0.969 ± 0.206
2.179HisGly: 2.179 ± 0.437
1.211HisHis: 1.211 ± 0.376
1.392HisIle: 1.392 ± 0.301
0.969HisLys: 0.969 ± 0.198
2.724HisLeu: 2.724 ± 0.362
0.484HisMet: 0.484 ± 0.222
1.029HisAsn: 1.029 ± 0.278
0.787HisPro: 0.787 ± 0.227
0.848HisGln: 0.848 ± 0.214
1.029HisArg: 1.029 ± 0.276
1.271HisSer: 1.271 ± 0.285
1.695HisThr: 1.695 ± 0.427
0.787HisVal: 0.787 ± 0.219
0.363HisTrp: 0.363 ± 0.143
0.848HisTyr: 0.848 ± 0.278
0.0HisXaa: 0.0 ± 0.0
Ile
5.751IleAla: 5.751 ± 0.615
0.787IleCys: 0.787 ± 0.228
4.298IleAsp: 4.298 ± 0.567
3.995IleGlu: 3.995 ± 0.459
1.877IlePhe: 1.877 ± 0.478
4.238IleGly: 4.238 ± 0.473
1.332IleHis: 1.332 ± 0.251
4.359IleIle: 4.359 ± 0.552
6.296IleLys: 6.296 ± 0.636
5.025IleLeu: 5.025 ± 0.576
1.392IleMet: 1.392 ± 0.293
4.056IleAsn: 4.056 ± 0.446
2.058IlePro: 2.058 ± 0.346
2.543IleGln: 2.543 ± 0.379
1.877IleArg: 1.877 ± 0.308
4.238IleSer: 4.238 ± 0.623
5.388IleThr: 5.388 ± 0.772
2.845IleVal: 2.845 ± 0.513
0.545IleTrp: 0.545 ± 0.184
2.058IleTyr: 2.058 ± 0.344
0.0IleXaa: 0.0 ± 0.0
Lys
7.264LysAla: 7.264 ± 0.64
0.545LysCys: 0.545 ± 0.183
3.753LysAsp: 3.753 ± 0.558
2.724LysGlu: 2.724 ± 0.443
2.421LysPhe: 2.421 ± 0.435
3.451LysGly: 3.451 ± 0.49
1.453LysHis: 1.453 ± 0.355
4.964LysIle: 4.964 ± 0.596
5.025LysLys: 5.025 ± 0.735
5.993LysLeu: 5.993 ± 0.539
1.634LysMet: 1.634 ± 0.327
4.54LysAsn: 4.54 ± 0.587
3.39LysPro: 3.39 ± 0.573
4.238LysGln: 4.238 ± 0.59
3.935LysArg: 3.935 ± 0.557
5.267LysSer: 5.267 ± 0.8
4.964LysThr: 4.964 ± 0.679
3.451LysVal: 3.451 ± 0.503
1.15LysTrp: 1.15 ± 0.245
2.058LysTyr: 2.058 ± 0.337
0.0LysXaa: 0.0 ± 0.0
Leu
9.444LeuAla: 9.444 ± 0.948
1.029LeuCys: 1.029 ± 0.297
6.235LeuAsp: 6.235 ± 0.544
5.146LeuGlu: 5.146 ± 0.572
2.482LeuPhe: 2.482 ± 0.425
6.114LeuGly: 6.114 ± 0.68
2.119LeuHis: 2.119 ± 0.34
5.206LeuIle: 5.206 ± 0.597
5.872LeuLys: 5.872 ± 0.591
7.143LeuLeu: 7.143 ± 0.886
1.937LeuMet: 1.937 ± 0.416
3.814LeuAsn: 3.814 ± 0.5
3.814LeuPro: 3.814 ± 0.488
4.419LeuGln: 4.419 ± 0.388
3.935LeuArg: 3.935 ± 0.481
6.78LeuSer: 6.78 ± 0.637
5.327LeuThr: 5.327 ± 0.607
4.298LeuVal: 4.298 ± 0.546
0.908LeuTrp: 0.908 ± 0.184
3.148LeuTyr: 3.148 ± 0.365
0.0LeuXaa: 0.0 ± 0.0
Met
2.3MetAla: 2.3 ± 0.483
0.242MetCys: 0.242 ± 0.118
1.271MetAsp: 1.271 ± 0.238
1.09MetGlu: 1.09 ± 0.246
0.908MetPhe: 0.908 ± 0.242
1.574MetGly: 1.574 ± 0.254
0.605MetHis: 0.605 ± 0.191
1.937MetIle: 1.937 ± 0.427
1.695MetLys: 1.695 ± 0.305
2.179MetLeu: 2.179 ± 0.404
0.848MetMet: 0.848 ± 0.229
1.695MetAsn: 1.695 ± 0.283
1.15MetPro: 1.15 ± 0.253
1.453MetGln: 1.453 ± 0.31
1.211MetArg: 1.211 ± 0.264
2.24MetSer: 2.24 ± 0.36
2.24MetThr: 2.24 ± 0.4
1.756MetVal: 1.756 ± 0.462
0.061MetTrp: 0.061 ± 0.057
0.484MetTyr: 0.484 ± 0.176
0.0MetXaa: 0.0 ± 0.0
Asn
5.146AsnAla: 5.146 ± 0.553
0.363AsnCys: 0.363 ± 0.177
2.785AsnAsp: 2.785 ± 0.511
2.724AsnGlu: 2.724 ± 0.354
1.998AsnPhe: 1.998 ± 0.38
3.329AsnGly: 3.329 ± 0.498
1.634AsnHis: 1.634 ± 0.418
2.664AsnIle: 2.664 ± 0.415
3.451AsnLys: 3.451 ± 0.628
4.48AsnLeu: 4.48 ± 0.53
1.756AsnMet: 1.756 ± 0.377
3.329AsnAsn: 3.329 ± 0.452
2.421AsnPro: 2.421 ± 0.47
3.148AsnGln: 3.148 ± 0.509
2.421AsnArg: 2.421 ± 0.4
3.572AsnSer: 3.572 ± 0.67
2.845AsnThr: 2.845 ± 0.335
2.482AsnVal: 2.482 ± 0.378
0.605AsnTrp: 0.605 ± 0.194
1.756AsnTyr: 1.756 ± 0.303
0.0AsnXaa: 0.0 ± 0.0
Pro
2.179ProAla: 2.179 ± 0.404
0.605ProCys: 0.605 ± 0.152
2.119ProAsp: 2.119 ± 0.367
1.574ProGlu: 1.574 ± 0.452
1.513ProPhe: 1.513 ± 0.317
0.424ProGly: 0.424 ± 0.151
0.605ProHis: 0.605 ± 0.218
3.451ProIle: 3.451 ± 0.432
2.966ProLys: 2.966 ± 0.491
2.3ProLeu: 2.3 ± 0.415
0.787ProMet: 0.787 ± 0.212
2.24ProAsn: 2.24 ± 0.447
1.15ProPro: 1.15 ± 0.261
1.332ProGln: 1.332 ± 0.315
1.271ProArg: 1.271 ± 0.289
2.785ProSer: 2.785 ± 0.464
2.361ProThr: 2.361 ± 0.403
1.998ProVal: 1.998 ± 0.377
0.303ProTrp: 0.303 ± 0.136
0.848ProTyr: 0.848 ± 0.209
0.0ProXaa: 0.0 ± 0.0
Gln
4.661GlnAla: 4.661 ± 0.568
0.303GlnCys: 0.303 ± 0.13
2.603GlnAsp: 2.603 ± 0.397
2.966GlnGlu: 2.966 ± 0.487
1.271GlnPhe: 1.271 ± 0.235
2.361GlnGly: 2.361 ± 0.348
0.787GlnHis: 0.787 ± 0.19
3.208GlnIle: 3.208 ± 0.389
3.572GlnLys: 3.572 ± 0.416
3.693GlnLeu: 3.693 ± 0.511
1.332GlnMet: 1.332 ± 0.281
2.24GlnAsn: 2.24 ± 0.483
1.09GlnPro: 1.09 ± 0.242
1.877GlnGln: 1.877 ± 0.418
2.058GlnArg: 2.058 ± 0.417
2.724GlnSer: 2.724 ± 0.411
3.329GlnThr: 3.329 ± 0.532
2.966GlnVal: 2.966 ± 0.46
0.484GlnTrp: 0.484 ± 0.187
1.816GlnTyr: 1.816 ± 0.326
0.0GlnXaa: 0.0 ± 0.0
Arg
4.359ArgAla: 4.359 ± 0.465
0.363ArgCys: 0.363 ± 0.159
2.543ArgAsp: 2.543 ± 0.342
2.966ArgGlu: 2.966 ± 0.543
2.24ArgPhe: 2.24 ± 0.42
2.3ArgGly: 2.3 ± 0.469
1.513ArgHis: 1.513 ± 0.287
2.603ArgIle: 2.603 ± 0.418
2.119ArgLys: 2.119 ± 0.378
5.146ArgLeu: 5.146 ± 0.73
1.09ArgMet: 1.09 ± 0.281
1.756ArgAsn: 1.756 ± 0.292
1.271ArgPro: 1.271 ± 0.248
2.179ArgGln: 2.179 ± 0.327
2.24ArgArg: 2.24 ± 0.451
3.027ArgSer: 3.027 ± 0.432
2.785ArgThr: 2.785 ± 0.429
2.058ArgVal: 2.058 ± 0.303
0.666ArgTrp: 0.666 ± 0.183
2.724ArgTyr: 2.724 ± 0.416
0.0ArgXaa: 0.0 ± 0.0
Ser
4.601SerAla: 4.601 ± 0.61
0.363SerCys: 0.363 ± 0.128
3.632SerAsp: 3.632 ± 0.548
4.601SerGlu: 4.601 ± 0.496
2.785SerPhe: 2.785 ± 0.491
3.511SerGly: 3.511 ± 0.592
2.24SerHis: 2.24 ± 0.485
3.39SerIle: 3.39 ± 0.544
4.238SerLys: 4.238 ± 0.561
6.598SerLeu: 6.598 ± 0.698
1.15SerMet: 1.15 ± 0.248
4.298SerAsn: 4.298 ± 0.63
1.937SerPro: 1.937 ± 0.453
2.724SerGln: 2.724 ± 0.527
3.39SerArg: 3.39 ± 0.377
4.177SerSer: 4.177 ± 0.852
3.632SerThr: 3.632 ± 0.448
4.843SerVal: 4.843 ± 0.64
0.605SerTrp: 0.605 ± 0.235
1.877SerTyr: 1.877 ± 0.353
0.0SerXaa: 0.0 ± 0.0
Thr
7.567ThrAla: 7.567 ± 0.913
0.242ThrCys: 0.242 ± 0.128
3.995ThrAsp: 3.995 ± 0.517
3.632ThrGlu: 3.632 ± 0.545
1.271ThrPhe: 1.271 ± 0.312
4.116ThrGly: 4.116 ± 0.486
1.574ThrHis: 1.574 ± 0.285
3.39ThrIle: 3.39 ± 0.425
3.874ThrLys: 3.874 ± 0.477
5.933ThrLeu: 5.933 ± 0.683
1.634ThrMet: 1.634 ± 0.29
3.451ThrAsn: 3.451 ± 0.62
3.632ThrPro: 3.632 ± 0.418
2.664ThrGln: 2.664 ± 0.437
1.513ThrArg: 1.513 ± 0.295
2.906ThrSer: 2.906 ± 0.556
3.451ThrThr: 3.451 ± 0.505
3.451ThrVal: 3.451 ± 0.403
0.787ThrTrp: 0.787 ± 0.22
1.877ThrTyr: 1.877 ± 0.285
0.0ThrXaa: 0.0 ± 0.0
Val
4.177ValAla: 4.177 ± 0.508
1.029ValCys: 1.029 ± 0.276
3.874ValAsp: 3.874 ± 0.558
2.724ValGlu: 2.724 ± 0.359
1.513ValPhe: 1.513 ± 0.323
3.572ValGly: 3.572 ± 0.523
1.15ValHis: 1.15 ± 0.26
3.935ValIle: 3.935 ± 0.506
4.116ValLys: 4.116 ± 0.568
4.54ValLeu: 4.54 ± 0.629
1.877ValMet: 1.877 ± 0.353
2.543ValAsn: 2.543 ± 0.369
1.634ValPro: 1.634 ± 0.255
2.966ValGln: 2.966 ± 0.364
3.39ValArg: 3.39 ± 0.449
3.753ValSer: 3.753 ± 0.453
4.056ValThr: 4.056 ± 0.448
3.632ValVal: 3.632 ± 0.54
0.908ValTrp: 0.908 ± 0.206
2.119ValTyr: 2.119 ± 0.442
0.0ValXaa: 0.0 ± 0.0
Trp
0.969TrpAla: 0.969 ± 0.243
0.182TrpCys: 0.182 ± 0.108
1.15TrpAsp: 1.15 ± 0.254
0.726TrpGlu: 0.726 ± 0.213
0.303TrpPhe: 0.303 ± 0.14
0.605TrpGly: 0.605 ± 0.193
0.121TrpHis: 0.121 ± 0.088
0.484TrpIle: 0.484 ± 0.155
0.787TrpLys: 0.787 ± 0.191
1.392TrpLeu: 1.392 ± 0.294
0.303TrpMet: 0.303 ± 0.13
0.363TrpAsn: 0.363 ± 0.184
0.242TrpPro: 0.242 ± 0.106
1.029TrpGln: 1.029 ± 0.267
0.787TrpArg: 0.787 ± 0.252
0.969TrpSer: 0.969 ± 0.295
0.484TrpThr: 0.484 ± 0.156
0.726TrpVal: 0.726 ± 0.173
0.242TrpTrp: 0.242 ± 0.105
0.545TrpTyr: 0.545 ± 0.171
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.603TyrAla: 2.603 ± 0.452
0.545TyrCys: 0.545 ± 0.228
2.119TyrAsp: 2.119 ± 0.407
2.058TyrGlu: 2.058 ± 0.395
1.09TyrPhe: 1.09 ± 0.266
3.208TyrGly: 3.208 ± 0.504
1.15TyrHis: 1.15 ± 0.288
2.361TyrIle: 2.361 ± 0.443
1.998TyrLys: 1.998 ± 0.385
2.845TyrLeu: 2.845 ± 0.405
1.09TyrMet: 1.09 ± 0.316
1.453TyrAsn: 1.453 ± 0.292
1.211TyrPro: 1.211 ± 0.265
1.937TyrGln: 1.937 ± 0.363
2.179TyrArg: 2.179 ± 0.35
1.937TyrSer: 1.937 ± 0.385
1.634TyrThr: 1.634 ± 0.287
1.877TyrVal: 1.877 ± 0.361
0.121TyrTrp: 0.121 ± 0.088
1.513TyrTyr: 1.513 ± 0.366
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 86 proteins (16520 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski