Amino acid dipepetide frequency for Leptonychotes weddellii (Weddell seal) (Otaria weddellii)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.868AlaAla: 6.868 ± 0.035	1.409AlaCys: 1.409 ± 0.012	2.925AlaAsp: 2.925 ± 0.012	4.833AlaGlu: 4.833 ± 0.029	2.657AlaPhe: 2.657 ± 0.013	4.902AlaGly: 4.902 ± 0.026	1.603AlaHis: 1.603 ± 0.009	2.591AlaIle: 2.591 ± 0.013	3.366AlaLys: 3.366 ± 0.02	7.277AlaLeu: 7.277 ± 0.028	1.436AlaMet: 1.436 ± 0.009	1.939AlaAsn: 1.939 ± 0.012	4.497AlaPro: 4.497 ± 0.028	3.404AlaGln: 3.404 ± 0.019	3.858AlaArg: 3.858 ± 0.021	5.923AlaSer: 5.923 ± 0.025	3.49AlaThr: 3.49 ± 0.018	4.745AlaVal: 4.745 ± 0.02	0.81AlaTrp: 0.81 ± 0.008	1.48AlaTyr: 1.48 ± 0.011	0.007AlaXaa: 0.007 ± 0.001
Cys	1.235CysAla: 1.235 ± 0.011	0.601CysCys: 0.601 ± 0.008	0.96CysAsp: 0.96 ± 0.011	1.23CysGlu: 1.23 ± 0.011	0.825CysPhe: 0.825 ± 0.008	1.851CysGly: 1.851 ± 0.019	0.66CysHis: 0.66 ± 0.009	0.89CysIle: 0.89 ± 0.009	1.105CysLys: 1.105 ± 0.011	2.147CysLeu: 2.147 ± 0.012	0.393CysMet: 0.393 ± 0.005	0.772CysAsn: 0.772 ± 0.008	1.421CysPro: 1.421 ± 0.016	1.04CysGln: 1.04 ± 0.01	1.289CysArg: 1.289 ± 0.011	2.0CysSer: 2.0 ± 0.016	1.058CysThr: 1.058 ± 0.01	1.268CysVal: 1.268 ± 0.012	0.293CysTrp: 0.293 ± 0.004	0.548CysTyr: 0.548 ± 0.006	0.003CysXaa: 0.003 ± 0.0
Asp	2.841AspAla: 2.841 ± 0.013	1.008AspCys: 1.008 ± 0.009	2.576AspAsp: 2.576 ± 0.016	3.401AspGlu: 3.401 ± 0.019	2.086AspPhe: 2.086 ± 0.012	3.215AspGly: 3.215 ± 0.02	1.144AspHis: 1.144 ± 0.008	2.476AspIle: 2.476 ± 0.02	2.487AspLys: 2.487 ± 0.012	5.002AspLeu: 5.002 ± 0.02	1.082AspMet: 1.082 ± 0.008	1.607AspAsn: 1.607 ± 0.011	2.942AspPro: 2.942 ± 0.016	1.841AspGln: 1.841 ± 0.012	2.458AspArg: 2.458 ± 0.014	4.199AspSer: 4.199 ± 0.019	2.417AspThr: 2.417 ± 0.014	3.069AspVal: 3.069 ± 0.025	0.631AspTrp: 0.631 ± 0.007	1.418AspTyr: 1.418 ± 0.011	0.004AspXaa: 0.004 ± 0.0
Glu	5.367GluAla: 5.367 ± 0.03	1.524GluCys: 1.524 ± 0.022	4.407GluAsp: 4.407 ± 0.019	8.169GluGlu: 8.169 ± 0.046	1.994GluPhe: 1.994 ± 0.011	4.303GluGly: 4.303 ± 0.022	1.499GluHis: 1.499 ± 0.011	3.071GluIle: 3.071 ± 0.017	5.464GluLys: 5.464 ± 0.036	6.474GluLeu: 6.474 ± 0.029	1.657GluMet: 1.657 ± 0.011	3.068GluAsn: 3.068 ± 0.018	3.408GluPro: 3.408 ± 0.023	3.232GluGln: 3.232 ± 0.02	4.182GluArg: 4.182 ± 0.024	4.473GluSer: 4.473 ± 0.02	3.333GluThr: 3.333 ± 0.015	4.186GluVal: 4.186 ± 0.02	0.679GluTrp: 0.679 ± 0.007	1.53GluTyr: 1.53 ± 0.013	0.004GluXaa: 0.004 ± 0.0
Phe	1.947PheAla: 1.947 ± 0.012	0.93PheCys: 0.93 ± 0.008	1.6PheAsp: 1.6 ± 0.01	1.965PheGlu: 1.965 ± 0.012	1.569PhePhe: 1.569 ± 0.012	2.179PheGly: 2.179 ± 0.015	1.017PheHis: 1.017 ± 0.007	1.758PheIle: 1.758 ± 0.012	1.727PheLys: 1.727 ± 0.012	4.024PheLeu: 4.024 ± 0.022	0.757PheMet: 0.757 ± 0.008	1.257PheAsn: 1.257 ± 0.01	2.042PhePro: 2.042 ± 0.012	1.784PheGln: 1.784 ± 0.01	1.985PheArg: 1.985 ± 0.013	3.489PheSer: 3.489 ± 0.015	1.938PheThr: 1.938 ± 0.013	2.043PheVal: 2.043 ± 0.012	0.485PheTrp: 0.485 ± 0.006	1.114PheTyr: 1.114 ± 0.01	0.005PheXaa: 0.005 ± 0.001
Gly	4.699GlyAla: 4.699 ± 0.029	1.277GlyCys: 1.277 ± 0.01	3.136GlyAsp: 3.136 ± 0.017	4.273GlyGlu: 4.273 ± 0.025	2.383GlyPhe: 2.383 ± 0.016	5.21GlyGly: 5.21 ± 0.034	1.748GlyHis: 1.748 ± 0.011	2.622GlyIle: 2.622 ± 0.015	3.856GlyLys: 3.856 ± 0.02	5.983GlyLeu: 5.983 ± 0.028	1.288GlyMet: 1.288 ± 0.011	2.289GlyAsn: 2.289 ± 0.015	4.75GlyPro: 4.75 ± 0.051	2.87GlyGln: 2.87 ± 0.017	3.977GlyArg: 3.977 ± 0.02	5.978GlySer: 5.978 ± 0.025	3.565GlyThr: 3.565 ± 0.017	3.507GlyVal: 3.507 ± 0.019	0.801GlyTrp: 0.801 ± 0.008	1.672GlyTyr: 1.672 ± 0.014	0.007GlyXaa: 0.007 ± 0.001
His	1.357HisAla: 1.357 ± 0.009	0.721HisCys: 0.721 ± 0.008	0.867HisAsp: 0.867 ± 0.006	1.305HisGlu: 1.305 ± 0.009	1.087HisPhe: 1.087 ± 0.008	1.569HisGly: 1.569 ± 0.012	0.917HisHis: 0.917 ± 0.01	1.214HisIle: 1.214 ± 0.009	1.275HisLys: 1.275 ± 0.01	3.01HisLeu: 3.01 ± 0.015	0.59HisMet: 0.59 ± 0.006	0.831HisAsn: 0.831 ± 0.006	1.692HisPro: 1.692 ± 0.013	1.481HisGln: 1.481 ± 0.015	1.656HisArg: 1.656 ± 0.011	2.349HisSer: 2.349 ± 0.015	1.61HisThr: 1.61 ± 0.016	1.499HisVal: 1.499 ± 0.01	0.351HisTrp: 0.351 ± 0.005	0.79HisTyr: 0.79 ± 0.007	0.003HisXaa: 0.003 ± 0.0
Ile	2.399IleAla: 2.399 ± 0.013	1.024IleCys: 1.024 ± 0.009	1.901IleAsp: 1.901 ± 0.013	2.487IleGlu: 2.487 ± 0.014	1.796IlePhe: 1.796 ± 0.012	2.104IleGly: 2.104 ± 0.012	1.358IleHis: 1.358 ± 0.014	2.193IleIle: 2.193 ± 0.015	2.494IleLys: 2.494 ± 0.017	4.354IleLeu: 4.354 ± 0.023	0.955IleMet: 0.955 ± 0.008	1.691IleAsn: 1.691 ± 0.011	2.57IlePro: 2.57 ± 0.014	2.26IleGln: 2.26 ± 0.013	2.303IleArg: 2.303 ± 0.013	3.596IleSer: 3.596 ± 0.018	2.42IleThr: 2.42 ± 0.016	2.336IleVal: 2.336 ± 0.015	0.491IleTrp: 0.491 ± 0.006	1.298IleTyr: 1.298 ± 0.009	0.003IleXaa: 0.003 ± 0.0
Lys	4.017LysAla: 4.017 ± 0.024	1.105LysCys: 1.105 ± 0.01	3.114LysAsp: 3.114 ± 0.02	5.148LysGlu: 5.148 ± 0.032	1.65LysPhe: 1.65 ± 0.012	3.244LysGly: 3.244 ± 0.024	1.382LysHis: 1.382 ± 0.01	2.663LysIle: 2.663 ± 0.017	4.676LysLys: 4.676 ± 0.028	5.107LysLeu: 5.107 ± 0.024	1.454LysMet: 1.454 ± 0.013	2.337LysAsn: 2.337 ± 0.015	3.269LysPro: 3.269 ± 0.023	2.614LysGln: 2.614 ± 0.017	3.291LysArg: 3.291 ± 0.019	3.995LysSer: 3.995 ± 0.022	3.091LysThr: 3.091 ± 0.018	3.401LysVal: 3.401 ± 0.021	0.577LysTrp: 0.577 ± 0.007	1.487LysTyr: 1.487 ± 0.012	0.004LysXaa: 0.004 ± 0.001
Leu	6.866LeuAla: 6.866 ± 0.027	2.17LeuCys: 2.17 ± 0.013	4.671LeuAsp: 4.671 ± 0.018	7.319LeuGlu: 7.319 ± 0.034	3.307LeuPhe: 3.307 ± 0.018	6.007LeuGly: 6.007 ± 0.023	2.763LeuHis: 2.763 ± 0.013	3.737LeuIle: 3.737 ± 0.018	5.774LeuLys: 5.774 ± 0.029	10.765LeuLeu: 10.765 ± 0.044	1.99LeuMet: 1.99 ± 0.013	3.391LeuAsn: 3.391 ± 0.017	6.234LeuPro: 6.234 ± 0.026	5.89LeuGln: 5.89 ± 0.031	6.084LeuArg: 6.084 ± 0.029	8.111LeuSer: 8.111 ± 0.025	5.017LeuThr: 5.017 ± 0.017	5.458LeuVal: 5.458 ± 0.021	1.153LeuTrp: 1.153 ± 0.008	2.463LeuTyr: 2.463 ± 0.013	0.01LeuXaa: 0.01 ± 0.001
Met	1.88MetAla: 1.88 ± 0.011	0.382MetCys: 0.382 ± 0.005	1.231MetAsp: 1.231 ± 0.01	1.849MetGlu: 1.849 ± 0.012	0.707MetPhe: 0.707 ± 0.006	1.292MetGly: 1.292 ± 0.01	0.469MetHis: 0.469 ± 0.005	0.794MetIle: 0.794 ± 0.007	1.43MetLys: 1.43 ± 0.01	1.957MetLeu: 1.957 ± 0.012	0.549MetMet: 0.549 ± 0.006	0.859MetAsn: 0.859 ± 0.008	1.131MetPro: 1.131 ± 0.015	0.926MetGln: 0.926 ± 0.008	1.061MetArg: 1.061 ± 0.007	1.57MetSer: 1.57 ± 0.01	1.084MetThr: 1.084 ± 0.008	1.363MetVal: 1.363 ± 0.011	0.241MetTrp: 0.241 ± 0.004	0.56MetTyr: 0.56 ± 0.006	0.002MetXaa: 0.002 ± 0.0
Asn	1.974AsnAla: 1.974 ± 0.011	0.79AsnCys: 0.79 ± 0.008	1.415AsnAsp: 1.415 ± 0.009	2.148AsnGlu: 2.148 ± 0.014	1.396AsnPhe: 1.396 ± 0.009	2.317AsnGly: 2.317 ± 0.017	0.955AsnHis: 0.955 ± 0.008	2.01AsnIle: 2.01 ± 0.013	2.147AsnLys: 2.147 ± 0.013	3.63AsnLeu: 3.63 ± 0.017	0.857AsnMet: 0.857 ± 0.007	1.409AsnAsn: 1.409 ± 0.011	2.112AsnPro: 2.112 ± 0.012	1.646AsnGln: 1.646 ± 0.012	1.784AsnArg: 1.784 ± 0.011	3.056AsnSer: 3.056 ± 0.017	1.883AsnThr: 1.883 ± 0.013	2.09AsnVal: 2.09 ± 0.013	0.419AsnTrp: 0.419 ± 0.005	1.047AsnTyr: 1.047 ± 0.009	0.002AsnXaa: 0.002 ± 0.0
Pro	5.267ProAla: 5.267 ± 0.029	1.186ProCys: 1.186 ± 0.014	2.867ProAsp: 2.867 ± 0.019	4.665ProGlu: 4.665 ± 0.025	1.971ProPhe: 1.971 ± 0.011	5.687ProGly: 5.687 ± 0.053	1.529ProHis: 1.529 ± 0.01	1.818ProIle: 1.818 ± 0.013	2.887ProLys: 2.887 ± 0.029	5.479ProLeu: 5.479 ± 0.02	1.071ProMet: 1.071 ± 0.009	1.767ProAsn: 1.767 ± 0.011	6.429ProPro: 6.429 ± 0.055	3.04ProGln: 3.04 ± 0.02	3.595ProArg: 3.595 ± 0.021	6.022ProSer: 6.022 ± 0.032	3.153ProThr: 3.153 ± 0.019	3.91ProVal: 3.91 ± 0.021	0.729ProTrp: 0.729 ± 0.008	1.57ProTyr: 1.57 ± 0.014	0.007ProXaa: 0.007 ± 0.001
Gln	3.639GlnAla: 3.639 ± 0.021	0.9GlnCys: 0.9 ± 0.009	2.339GlnAsp: 2.339 ± 0.011	4.013GlnGlu: 4.013 ± 0.024	1.325GlnPhe: 1.325 ± 0.008	2.955GlnGly: 2.955 ± 0.018	1.356GlnHis: 1.356 ± 0.013	1.928GlnIle: 1.928 ± 0.011	3.013GlnLys: 3.013 ± 0.021	4.863GlnLeu: 4.863 ± 0.026	1.142GlnMet: 1.142 ± 0.009	1.835GlnAsn: 1.835 ± 0.012	2.929GlnPro: 2.929 ± 0.019	3.077GlnGln: 3.077 ± 0.029	3.193GlnArg: 3.193 ± 0.022	3.209GlnSer: 3.209 ± 0.019	2.324GlnThr: 2.324 ± 0.012	2.869GlnVal: 2.869 ± 0.015	0.531GlnTrp: 0.531 ± 0.006	1.112GlnTyr: 1.112 ± 0.009	0.004GlnXaa: 0.004 ± 0.001
Arg	4.078ArgAla: 4.078 ± 0.022	1.191ArgCys: 1.191 ± 0.013	2.828ArgAsp: 2.828 ± 0.016	4.199ArgGlu: 4.199 ± 0.022	1.823ArgPhe: 1.823 ± 0.012	3.822ArgGly: 3.822 ± 0.023	1.6ArgHis: 1.6 ± 0.012	2.401ArgIle: 2.401 ± 0.013	3.689ArgLys: 3.689 ± 0.018	5.557ArgLeu: 5.557 ± 0.029	1.21ArgMet: 1.21 ± 0.009	2.063ArgAsn: 2.063 ± 0.012	3.505ArgPro: 3.505 ± 0.021	2.687ArgGln: 2.687 ± 0.019	4.533ArgArg: 4.533 ± 0.026	4.552ArgSer: 4.552 ± 0.03	2.885ArgThr: 2.885 ± 0.016	3.217ArgVal: 3.217 ± 0.017	0.713ArgTrp: 0.713 ± 0.007	1.398ArgTyr: 1.398 ± 0.009	0.006ArgXaa: 0.006 ± 0.001
Ser	5.452SerAla: 5.452 ± 0.019	1.834SerCys: 1.834 ± 0.017	3.917SerAsp: 3.917 ± 0.019	5.313SerGlu: 5.313 ± 0.025	3.049SerPhe: 3.049 ± 0.016	5.793SerGly: 5.793 ± 0.027	2.18SerHis: 2.18 ± 0.014	3.098SerIle: 3.098 ± 0.016	4.124SerLys: 4.124 ± 0.02	8.382SerLeu: 8.382 ± 0.029	1.641SerMet: 1.641 ± 0.011	2.615SerAsn: 2.615 ± 0.015	6.428SerPro: 6.428 ± 0.038	3.999SerGln: 3.999 ± 0.021	4.8SerArg: 4.8 ± 0.028	9.653SerSer: 9.653 ± 0.053	4.398SerThr: 4.398 ± 0.019	4.904SerVal: 4.904 ± 0.02	1.088SerTrp: 1.088 ± 0.01	2.01SerTyr: 2.01 ± 0.013	0.007SerXaa: 0.007 ± 0.001
Thr	3.696ThrAla: 3.696 ± 0.016	1.232ThrCys: 1.232 ± 0.011	2.392ThrAsp: 2.392 ± 0.013	3.473ThrGlu: 3.473 ± 0.018	2.057ThrPhe: 2.057 ± 0.012	3.587ThrGly: 3.587 ± 0.02	1.344ThrHis: 1.344 ± 0.012	2.214ThrIle: 2.214 ± 0.014	2.584ThrLys: 2.584 ± 0.018	5.222ThrLeu: 5.222 ± 0.018	1.09ThrMet: 1.09 ± 0.008	1.639ThrAsn: 1.639 ± 0.012	3.636ThrPro: 3.636 ± 0.022	2.284ThrGln: 2.284 ± 0.012	2.497ThrArg: 2.497 ± 0.014	4.618ThrSer: 4.618 ± 0.021	2.81ThrThr: 2.81 ± 0.02	3.741ThrVal: 3.741 ± 0.019	0.669ThrTrp: 0.669 ± 0.007	1.361ThrTyr: 1.361 ± 0.009	0.006ThrXaa: 0.006 ± 0.001
Val	4.267ValAla: 4.267 ± 0.019	1.407ValCys: 1.407 ± 0.012	2.903ValAsp: 2.903 ± 0.021	3.757ValGlu: 3.757 ± 0.02	2.332ValPhe: 2.332 ± 0.013	3.435ValGly: 3.435 ± 0.017	1.601ValHis: 1.601 ± 0.011	2.756ValIle: 2.756 ± 0.018	3.314ValLys: 3.314 ± 0.018	6.214ValLeu: 6.214 ± 0.02	1.293ValMet: 1.293 ± 0.007	2.173ValAsn: 2.173 ± 0.014	3.786ValPro: 3.786 ± 0.021	2.711ValGln: 2.711 ± 0.012	3.087ValArg: 3.087 ± 0.016	4.857ValSer: 4.857 ± 0.02	3.636ValThr: 3.636 ± 0.024	3.861ValVal: 3.861 ± 0.019	0.701ValTrp: 0.701 ± 0.007	1.554ValTyr: 1.554 ± 0.012	0.004ValXaa: 0.004 ± 0.001
Trp	0.817TrpAla: 0.817 ± 0.007	0.244TrpCys: 0.244 ± 0.004	0.655TrpAsp: 0.655 ± 0.007	0.804TrpGlu: 0.804 ± 0.008	0.433TrpPhe: 0.433 ± 0.005	0.773TrpGly: 0.773 ± 0.009	0.304TrpHis: 0.304 ± 0.004	0.509TrpIle: 0.509 ± 0.006	0.782TrpLys: 0.782 ± 0.008	1.191TrpLeu: 1.191 ± 0.011	0.303TrpMet: 0.303 ± 0.005	0.507TrpAsn: 0.507 ± 0.006	0.562TrpPro: 0.562 ± 0.006	0.528TrpGln: 0.528 ± 0.006	0.75TrpArg: 0.75 ± 0.007	0.869TrpSer: 0.869 ± 0.009	0.658TrpThr: 0.658 ± 0.006	0.684TrpVal: 0.684 ± 0.007	0.187TrpTrp: 0.187 ± 0.003	0.319TrpTyr: 0.319 ± 0.005	0.001TrpXaa: 0.001 ± 0.0
Tyr	1.344TyrAla: 1.344 ± 0.01	0.65TyrCys: 0.65 ± 0.006	1.198TyrAsp: 1.198 ± 0.009	1.666TyrGlu: 1.666 ± 0.012	1.163TyrPhe: 1.163 ± 0.01	1.637TyrGly: 1.637 ± 0.012	0.74TyrHis: 0.74 ± 0.007	1.287TyrIle: 1.287 ± 0.01	1.427TyrLys: 1.427 ± 0.012	2.531TyrLeu: 2.531 ± 0.014	0.574TyrMet: 0.574 ± 0.007	1.037TyrAsn: 1.037 ± 0.008	1.302TyrPro: 1.302 ± 0.01	1.24TyrGln: 1.24 ± 0.009	1.571TyrArg: 1.571 ± 0.009	2.158TyrSer: 2.158 ± 0.013	1.379TyrThr: 1.379 ± 0.011	1.493TyrVal: 1.493 ± 0.011	0.333TyrTrp: 0.333 ± 0.005	0.899TyrTyr: 0.899 ± 0.008	0.002TyrXaa: 0.002 ± 0.0
Xaa	0.008XaaAla: 0.008 ± 0.001	0.002XaaCys: 0.002 ± 0.0	0.003XaaAsp: 0.003 ± 0.0	0.005XaaGlu: 0.005 ± 0.001	0.004XaaPhe: 0.004 ± 0.001	0.008XaaGly: 0.008 ± 0.001	0.003XaaHis: 0.003 ± 0.0	0.004XaaIle: 0.004 ± 0.001	0.005XaaLys: 0.005 ± 0.001	0.009XaaLeu: 0.009 ± 0.001	0.002XaaMet: 0.002 ± 0.0	0.003XaaAsn: 0.003 ± 0.0	0.007XaaPro: 0.007 ± 0.001	0.004XaaGln: 0.004 ± 0.001	0.004XaaArg: 0.004 ± 0.001	0.007XaaSer: 0.007 ± 0.001	0.004XaaThr: 0.004 ± 0.0	0.006XaaVal: 0.006 ± 0.001	0.001XaaTrp: 0.001 ± 0.0	0.002XaaTyr: 0.002 ± 0.0	0.258XaaXaa: 0.258 ± 0.022

Statistics based on 34224 proteins (18266267 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---