Amino acid dipepetide frequency for Salinibacter sp. 10B

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.767AlaAla: 9.767 ± 0.127	0.699AlaCys: 0.699 ± 0.024	6.56AlaAsp: 6.56 ± 0.073	6.916AlaGlu: 6.916 ± 0.082	3.595AlaPhe: 3.595 ± 0.057	7.232AlaGly: 7.232 ± 0.086	2.083AlaHis: 2.083 ± 0.045	3.89AlaIle: 3.89 ± 0.064	2.119AlaLys: 2.119 ± 0.048	10.768AlaLeu: 10.768 ± 0.112	1.967AlaMet: 1.967 ± 0.041	2.357AlaAsn: 2.357 ± 0.05	5.045AlaPro: 5.045 ± 0.076	3.886AlaGln: 3.886 ± 0.065	6.316AlaArg: 6.316 ± 0.09	5.966AlaSer: 5.966 ± 0.074	5.449AlaThr: 5.449 ± 0.072	7.313AlaVal: 7.313 ± 0.09	1.166AlaTrp: 1.166 ± 0.035	2.63AlaTyr: 2.63 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	0.539CysAla: 0.539 ± 0.022	0.078CysCys: 0.078 ± 0.008	0.42CysAsp: 0.42 ± 0.017	0.378CysGlu: 0.378 ± 0.019	0.236CysPhe: 0.236 ± 0.015	0.583CysGly: 0.583 ± 0.023	0.163CysHis: 0.163 ± 0.014	0.274CysIle: 0.274 ± 0.013	0.118CysLys: 0.118 ± 0.009	0.574CysLeu: 0.574 ± 0.022	0.102CysMet: 0.102 ± 0.009	0.173CysAsn: 0.173 ± 0.012	0.401CysPro: 0.401 ± 0.017	0.168CysGln: 0.168 ± 0.012	0.404CysArg: 0.404 ± 0.021	0.42CysSer: 0.42 ± 0.017	0.468CysThr: 0.468 ± 0.019	0.441CysVal: 0.441 ± 0.021	0.075CysTrp: 0.075 ± 0.008	0.18CysTyr: 0.18 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	7.022AspAla: 7.022 ± 0.092	0.346AspCys: 0.346 ± 0.016	4.605AspAsp: 4.605 ± 0.078	5.366AspGlu: 5.366 ± 0.096	2.201AspPhe: 2.201 ± 0.042	5.835AspGly: 5.835 ± 0.088	1.473AspHis: 1.473 ± 0.037	2.475AspIle: 2.475 ± 0.047	1.178AspLys: 1.178 ± 0.033	6.785AspLeu: 6.785 ± 0.074	0.971AspMet: 0.971 ± 0.03	1.54AspAsn: 1.54 ± 0.038	3.921AspPro: 3.921 ± 0.063	2.204AspGln: 2.204 ± 0.041	5.251AspArg: 5.251 ± 0.073	3.652AspSer: 3.652 ± 0.069	4.174AspThr: 4.174 ± 0.064	5.688AspVal: 5.688 ± 0.075	1.055AspTrp: 1.055 ± 0.033	1.851AspTyr: 1.851 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	8.156GluAla: 8.156 ± 0.094	0.308GluCys: 0.308 ± 0.015	4.481GluAsp: 4.481 ± 0.072	6.933GluGlu: 6.933 ± 0.133	1.687GluPhe: 1.687 ± 0.036	5.679GluGly: 5.679 ± 0.07	1.836GluHis: 1.836 ± 0.042	3.203GluIle: 3.203 ± 0.052	2.488GluLys: 2.488 ± 0.055	5.563GluLeu: 5.563 ± 0.075	1.807GluMet: 1.807 ± 0.046	2.352GluAsn: 2.352 ± 0.047	3.016GluPro: 3.016 ± 0.051	3.326GluGln: 3.326 ± 0.053	5.846GluArg: 5.846 ± 0.073	3.636GluSer: 3.636 ± 0.053	4.773GluThr: 4.773 ± 0.061	5.184GluVal: 5.184 ± 0.068	1.011GluTrp: 1.011 ± 0.03	1.861GluTyr: 1.861 ± 0.036	0.0GluXaa: 0.0 ± 0.0
Phe	3.207PheAla: 3.207 ± 0.061	0.253PheCys: 0.253 ± 0.013	2.719PheAsp: 2.719 ± 0.05	2.6PheGlu: 2.6 ± 0.048	1.435PhePhe: 1.435 ± 0.044	3.273PheGly: 3.273 ± 0.055	0.713PheHis: 0.713 ± 0.025	1.236PheIle: 1.236 ± 0.036	0.682PheLys: 0.682 ± 0.022	3.221PheLeu: 3.221 ± 0.054	0.582PheMet: 0.582 ± 0.022	1.054PheAsn: 1.054 ± 0.032	1.533PhePro: 1.533 ± 0.033	1.297PheGln: 1.297 ± 0.035	2.38PheArg: 2.38 ± 0.042	2.499PheSer: 2.499 ± 0.049	2.05PheThr: 2.05 ± 0.049	2.862PheVal: 2.862 ± 0.05	0.552PheTrp: 0.552 ± 0.024	1.155PheTyr: 1.155 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	7.397GlyAla: 7.397 ± 0.098	0.646GlyCys: 0.646 ± 0.023	4.676GlyAsp: 4.676 ± 0.071	5.188GlyGlu: 5.188 ± 0.075	2.868GlyPhe: 2.868 ± 0.055	7.034GlyGly: 7.034 ± 0.112	1.766GlyHis: 1.766 ± 0.048	3.81GlyIle: 3.81 ± 0.056	2.011GlyLys: 2.011 ± 0.037	7.922GlyLeu: 7.922 ± 0.096	1.759GlyMet: 1.759 ± 0.041	2.162GlyAsn: 2.162 ± 0.05	3.56GlyPro: 3.56 ± 0.059	2.843GlyGln: 2.843 ± 0.049	5.491GlyArg: 5.491 ± 0.069	4.805GlySer: 4.805 ± 0.086	6.261GlyThr: 6.261 ± 0.103	5.805GlyVal: 5.805 ± 0.077	1.254GlyTrp: 1.254 ± 0.032	2.501GlyTyr: 2.501 ± 0.044	0.0GlyXaa: 0.0 ± 0.0
His	1.983HisAla: 1.983 ± 0.041	0.183HisCys: 0.183 ± 0.013	1.472HisAsp: 1.472 ± 0.036	1.555HisGlu: 1.555 ± 0.041	0.954HisPhe: 0.954 ± 0.024	1.664HisGly: 1.664 ± 0.034	0.63HisHis: 0.63 ± 0.024	0.872HisIle: 0.872 ± 0.029	0.443HisLys: 0.443 ± 0.022	2.436HisLeu: 2.436 ± 0.041	0.367HisMet: 0.367 ± 0.018	0.564HisAsn: 0.564 ± 0.021	1.554HisPro: 1.554 ± 0.041	0.719HisGln: 0.719 ± 0.024	1.697HisArg: 1.697 ± 0.04	1.149HisSer: 1.149 ± 0.027	1.233HisThr: 1.233 ± 0.034	1.917HisVal: 1.917 ± 0.038	0.363HisTrp: 0.363 ± 0.016	0.732HisTyr: 0.732 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	3.957IleAla: 3.957 ± 0.055	0.3IleCys: 0.3 ± 0.015	3.401IleAsp: 3.401 ± 0.061	3.573IleGlu: 3.573 ± 0.057	1.362IlePhe: 1.362 ± 0.035	3.955IleGly: 3.955 ± 0.07	0.898IleHis: 0.898 ± 0.025	1.498IleIle: 1.498 ± 0.038	0.893IleLys: 0.893 ± 0.028	3.73IleLeu: 3.73 ± 0.054	0.595IleMet: 0.595 ± 0.022	1.184IleAsn: 1.184 ± 0.031	2.191IlePro: 2.191 ± 0.048	1.654IleGln: 1.654 ± 0.041	2.942IleArg: 2.942 ± 0.054	2.338IleSer: 2.338 ± 0.046	2.436IleThr: 2.436 ± 0.053	3.283IleVal: 3.283 ± 0.06	0.407IleTrp: 0.407 ± 0.017	1.061IleTyr: 1.061 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	2.389LysAla: 2.389 ± 0.045	0.114LysCys: 0.114 ± 0.01	1.448LysAsp: 1.448 ± 0.036	2.108LysGlu: 2.108 ± 0.047	0.538LysPhe: 0.538 ± 0.02	1.986LysGly: 1.986 ± 0.038	0.596LysHis: 0.596 ± 0.022	1.165LysIle: 1.165 ± 0.03	1.048LysLys: 1.048 ± 0.038	1.973LysLeu: 1.973 ± 0.047	0.624LysMet: 0.624 ± 0.022	0.813LysAsn: 0.813 ± 0.028	1.084LysPro: 1.084 ± 0.026	1.156LysGln: 1.156 ± 0.033	1.919LysArg: 1.919 ± 0.049	1.426LysSer: 1.426 ± 0.036	1.721LysThr: 1.721 ± 0.04	1.594LysVal: 1.594 ± 0.034	0.3LysTrp: 0.3 ± 0.015	0.684LysTyr: 0.684 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	8.769LeuAla: 8.769 ± 0.103	0.654LeuCys: 0.654 ± 0.023	7.012LeuAsp: 7.012 ± 0.088	6.17LeuGlu: 6.17 ± 0.071	3.709LeuPhe: 3.709 ± 0.059	7.263LeuGly: 7.263 ± 0.099	2.256LeuHis: 2.256 ± 0.048	3.683LeuIle: 3.683 ± 0.063	2.543LeuLys: 2.543 ± 0.046	10.175LeuLeu: 10.175 ± 0.118	1.723LeuMet: 1.723 ± 0.038	2.806LeuAsn: 2.806 ± 0.051	5.084LeuPro: 5.084 ± 0.066	4.041LeuGln: 4.041 ± 0.072	7.751LeuArg: 7.751 ± 0.087	6.799LeuSer: 6.799 ± 0.082	5.982LeuThr: 5.982 ± 0.075	7.13LeuVal: 7.13 ± 0.096	1.204LeuTrp: 1.204 ± 0.035	2.839LeuTyr: 2.839 ± 0.05	0.0LeuXaa: 0.0 ± 0.0
Met	2.026MetAla: 2.026 ± 0.045	0.102MetCys: 0.102 ± 0.009	1.273MetAsp: 1.273 ± 0.031	1.457MetGlu: 1.457 ± 0.037	0.458MetPhe: 0.458 ± 0.021	1.586MetGly: 1.586 ± 0.041	0.425MetHis: 0.425 ± 0.019	0.853MetIle: 0.853 ± 0.025	0.633MetLys: 0.633 ± 0.026	1.686MetLeu: 1.686 ± 0.041	0.508MetMet: 0.508 ± 0.023	0.666MetAsn: 0.666 ± 0.023	1.231MetPro: 1.231 ± 0.032	0.823MetGln: 0.823 ± 0.029	1.321MetArg: 1.321 ± 0.032	1.484MetSer: 1.484 ± 0.035	1.376MetThr: 1.376 ± 0.033	1.345MetVal: 1.345 ± 0.036	0.19MetTrp: 0.19 ± 0.012	0.38MetTyr: 0.38 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	2.782AsnAla: 2.782 ± 0.047	0.182AsnCys: 0.182 ± 0.012	1.885AsnAsp: 1.885 ± 0.048	1.893AsnGlu: 1.893 ± 0.042	0.931AsnPhe: 0.931 ± 0.033	2.703AsnGly: 2.703 ± 0.057	0.577AsnHis: 0.577 ± 0.018	1.144AsnIle: 1.144 ± 0.032	0.58AsnLys: 0.58 ± 0.023	2.589AsnLeu: 2.589 ± 0.045	0.511AsnMet: 0.511 ± 0.02	0.842AsnAsn: 0.842 ± 0.032	1.877AsnPro: 1.877 ± 0.048	1.074AsnGln: 1.074 ± 0.031	2.015AsnArg: 2.015 ± 0.043	1.305AsnSer: 1.305 ± 0.042	1.694AsnThr: 1.694 ± 0.04	2.489AsnVal: 2.489 ± 0.043	0.396AsnTrp: 0.396 ± 0.015	0.838AsnTyr: 0.838 ± 0.025	0.0AsnXaa: 0.0 ± 0.0
Pro	4.45ProAla: 4.45 ± 0.06	0.216ProCys: 0.216 ± 0.015	4.78ProAsp: 4.78 ± 0.066	4.377ProGlu: 4.377 ± 0.062	1.962ProPhe: 1.962 ± 0.042	3.618ProGly: 3.618 ± 0.056	1.162ProHis: 1.162 ± 0.029	2.124ProIle: 2.124 ± 0.041	1.203ProLys: 1.203 ± 0.031	4.525ProLeu: 4.525 ± 0.062	0.968ProMet: 0.968 ± 0.029	1.763ProAsn: 1.763 ± 0.042	2.912ProPro: 2.912 ± 0.05	1.637ProGln: 1.637 ± 0.035	2.628ProArg: 2.628 ± 0.047	4.351ProSer: 4.351 ± 0.073	3.37ProThr: 3.37 ± 0.06	4.091ProVal: 4.091 ± 0.056	0.645ProTrp: 0.645 ± 0.025	1.476ProTyr: 1.476 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	3.946GlnAla: 3.946 ± 0.065	0.184GlnCys: 0.184 ± 0.012	2.129GlnAsp: 2.129 ± 0.048	2.761GlnGlu: 2.761 ± 0.056	1.414GlnPhe: 1.414 ± 0.037	2.641GlnGly: 2.641 ± 0.044	0.902GlnHis: 0.902 ± 0.028	1.726GlnIle: 1.726 ± 0.036	1.275GlnLys: 1.275 ± 0.031	3.279GlnLeu: 3.279 ± 0.064	0.891GlnMet: 0.891 ± 0.033	1.269GlnAsn: 1.269 ± 0.034	1.827GlnPro: 1.827 ± 0.04	1.95GlnGln: 1.95 ± 0.059	2.884GlnArg: 2.884 ± 0.048	2.457GlnSer: 2.457 ± 0.046	2.409GlnThr: 2.409 ± 0.046	2.657GlnVal: 2.657 ± 0.045	0.611GlnTrp: 0.611 ± 0.024	1.164GlnTyr: 1.164 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	6.469ArgAla: 6.469 ± 0.086	0.384ArgCys: 0.384 ± 0.018	4.096ArgAsp: 4.096 ± 0.057	4.916ArgGlu: 4.916 ± 0.074	2.881ArgPhe: 2.881 ± 0.048	4.274ArgGly: 4.274 ± 0.059	1.675ArgHis: 1.675 ± 0.04	3.382ArgIle: 3.382 ± 0.058	1.888ArgLys: 1.888 ± 0.045	7.707ArgLeu: 7.707 ± 0.084	1.658ArgMet: 1.658 ± 0.036	1.873ArgAsn: 1.873 ± 0.04	3.527ArgPro: 3.527 ± 0.061	2.853ArgGln: 2.853 ± 0.051	5.867ArgArg: 5.867 ± 0.099	4.553ArgSer: 4.553 ± 0.075	4.537ArgThr: 4.537 ± 0.057	5.07ArgVal: 5.07 ± 0.069	1.125ArgTrp: 1.125 ± 0.034	2.331ArgTyr: 2.331 ± 0.05	0.0ArgXaa: 0.0 ± 0.0
Ser	5.728SerAla: 5.728 ± 0.071	0.336SerCys: 0.336 ± 0.017	4.155SerAsp: 4.155 ± 0.064	3.918SerGlu: 3.918 ± 0.059	2.55SerPhe: 2.55 ± 0.045	5.359SerGly: 5.359 ± 0.071	1.132SerHis: 1.132 ± 0.03	2.921SerIle: 2.921 ± 0.052	1.41SerLys: 1.41 ± 0.037	6.121SerLeu: 6.121 ± 0.082	1.393SerMet: 1.393 ± 0.036	1.773SerAsn: 1.773 ± 0.046	3.651SerPro: 3.651 ± 0.06	1.922SerGln: 1.922 ± 0.042	3.594SerArg: 3.594 ± 0.055	4.935SerSer: 4.935 ± 0.098	4.213SerThr: 4.213 ± 0.059	5.036SerVal: 5.036 ± 0.059	0.793SerTrp: 0.793 ± 0.025	1.757SerTyr: 1.757 ± 0.04	0.0SerXaa: 0.0 ± 0.0
Thr	6.226ThrAla: 6.226 ± 0.076	0.366ThrCys: 0.366 ± 0.018	4.318ThrAsp: 4.318 ± 0.06	4.1ThrGlu: 4.1 ± 0.059	2.444ThrPhe: 2.444 ± 0.048	5.348ThrGly: 5.348 ± 0.067	1.362ThrHis: 1.362 ± 0.03	3.03ThrIle: 3.03 ± 0.055	1.358ThrLys: 1.358 ± 0.031	6.784ThrLeu: 6.784 ± 0.084	1.142ThrMet: 1.142 ± 0.032	1.665ThrAsn: 1.665 ± 0.043	3.772ThrPro: 3.772 ± 0.054	1.997ThrGln: 1.997 ± 0.042	3.531ThrArg: 3.531 ± 0.063	3.845ThrSer: 3.845 ± 0.057	4.162ThrThr: 4.162 ± 0.078	5.653ThrVal: 5.653 ± 0.076	0.891ThrTrp: 0.891 ± 0.027	1.955ThrTyr: 1.955 ± 0.043	0.0ThrXaa: 0.0 ± 0.0
Val	7.04ValAla: 7.04 ± 0.093	0.523ValCys: 0.523 ± 0.022	5.236ValAsp: 5.236 ± 0.065	6.018ValGlu: 6.018 ± 0.069	2.521ValPhe: 2.521 ± 0.043	6.123ValGly: 6.123 ± 0.086	1.739ValHis: 1.739 ± 0.037	2.859ValIle: 2.859 ± 0.053	1.742ValLys: 1.742 ± 0.038	7.825ValLeu: 7.825 ± 0.101	1.432ValMet: 1.432 ± 0.036	2.115ValAsn: 2.115 ± 0.039	4.17ValPro: 4.17 ± 0.055	3.26ValGln: 3.26 ± 0.054	5.724ValArg: 5.724 ± 0.072	4.717ValSer: 4.717 ± 0.061	4.787ValThr: 4.787 ± 0.073	6.166ValVal: 6.166 ± 0.089	0.927ValTrp: 0.927 ± 0.03	2.023ValTyr: 2.023 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.268TrpAla: 1.268 ± 0.036	0.103TrpCys: 0.103 ± 0.01	0.688TrpAsp: 0.688 ± 0.022	0.725TrpGlu: 0.725 ± 0.028	0.464TrpPhe: 0.464 ± 0.022	1.132TrpGly: 1.132 ± 0.027	0.357TrpHis: 0.357 ± 0.018	0.693TrpIle: 0.693 ± 0.023	0.435TrpLys: 0.435 ± 0.018	1.268TrpLeu: 1.268 ± 0.037	0.402TrpMet: 0.402 ± 0.019	0.461TrpAsn: 0.461 ± 0.019	0.585TrpPro: 0.585 ± 0.022	0.502TrpGln: 0.502 ± 0.021	1.005TrpArg: 1.005 ± 0.028	0.881TrpSer: 0.881 ± 0.026	1.188TrpThr: 1.188 ± 0.032	0.83TrpVal: 0.83 ± 0.023	0.26TrpTrp: 0.26 ± 0.016	0.4TrpTyr: 0.4 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.601TyrAla: 2.601 ± 0.043	0.22TyrCys: 0.22 ± 0.014	2.238TyrAsp: 2.238 ± 0.043	2.194TyrGlu: 2.194 ± 0.043	1.094TyrPhe: 1.094 ± 0.03	2.472TyrGly: 2.472 ± 0.051	0.742TyrHis: 0.742 ± 0.024	0.82TyrIle: 0.82 ± 0.027	0.64TyrLys: 0.64 ± 0.026	2.659TyrLeu: 2.659 ± 0.044	0.422TyrMet: 0.422 ± 0.02	0.877TyrAsn: 0.877 ± 0.03	1.316TyrPro: 1.316 ± 0.035	1.063TyrGln: 1.063 ± 0.029	2.501TyrArg: 2.501 ± 0.052	1.477TyrSer: 1.477 ± 0.038	1.664TyrThr: 1.664 ± 0.04	2.393TyrVal: 2.393 ± 0.057	0.424TyrTrp: 0.424 ± 0.021	0.971TyrTyr: 0.971 ± 0.03	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3709 proteins (1286740 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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