Amino acid dipepetide frequency for Calidithermus roseus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.883AlaAla: 11.883 ± 0.133
0.718AlaCys: 0.718 ± 0.028
4.064AlaAsp: 4.064 ± 0.061
7.442AlaGlu: 7.442 ± 0.101
4.102AlaPhe: 4.102 ± 0.058
8.911AlaGly: 8.911 ± 0.109
2.199AlaHis: 2.199 ± 0.047
4.515AlaIle: 4.515 ± 0.072
3.222AlaLys: 3.222 ± 0.064
15.925AlaLeu: 15.925 ± 0.18
2.328AlaMet: 2.328 ± 0.047
2.168AlaAsn: 2.168 ± 0.05
4.645AlaPro: 4.645 ± 0.081
5.331AlaGln: 5.331 ± 0.084
8.867AlaArg: 8.867 ± 0.108
5.232AlaSer: 5.232 ± 0.076
4.388AlaThr: 4.388 ± 0.07
7.942AlaVal: 7.942 ± 0.088
1.806AlaTrp: 1.806 ± 0.043
3.267AlaTyr: 3.267 ± 0.052
0.0AlaXaa: 0.0 ± 0.0
Cys
0.591CysAla: 0.591 ± 0.023
0.088CysCys: 0.088 ± 0.01
0.285CysAsp: 0.285 ± 0.015
0.344CysGlu: 0.344 ± 0.018
0.225CysPhe: 0.225 ± 0.015
0.657CysGly: 0.657 ± 0.024
0.175CysHis: 0.175 ± 0.014
0.204CysIle: 0.204 ± 0.014
0.183CysLys: 0.183 ± 0.014
0.58CysLeu: 0.58 ± 0.025
0.102CysMet: 0.102 ± 0.01
0.15CysAsn: 0.15 ± 0.011
0.462CysPro: 0.462 ± 0.02
0.198CysGln: 0.198 ± 0.014
0.425CysArg: 0.425 ± 0.023
0.328CysSer: 0.328 ± 0.02
0.347CysThr: 0.347 ± 0.017
0.423CysVal: 0.423 ± 0.018
0.083CysTrp: 0.083 ± 0.008
0.183CysTyr: 0.183 ± 0.012
0.0CysXaa: 0.0 ± 0.0
Asp
3.942AspAla: 3.942 ± 0.051
0.247AspCys: 0.247 ± 0.015
1.636AspAsp: 1.636 ± 0.045
2.717AspGlu: 2.717 ± 0.052
1.805AspPhe: 1.805 ± 0.043
3.512AspGly: 3.512 ± 0.072
0.794AspHis: 0.794 ± 0.024
1.623AspIle: 1.623 ± 0.041
1.193AspLys: 1.193 ± 0.038
5.789AspLeu: 5.789 ± 0.079
0.657AspMet: 0.657 ± 0.026
0.881AspAsn: 0.881 ± 0.03
3.795AspPro: 3.795 ± 0.073
1.254AspGln: 1.254 ± 0.037
2.654AspArg: 2.654 ± 0.056
1.73AspSer: 1.73 ± 0.039
1.791AspThr: 1.791 ± 0.039
2.85AspVal: 2.85 ± 0.063
0.839AspTrp: 0.839 ± 0.03
1.4AspTyr: 1.4 ± 0.038
0.0AspXaa: 0.0 ± 0.0
Glu
10.311GluAla: 10.311 ± 0.145
0.297GluCys: 0.297 ± 0.015
2.563GluAsp: 2.563 ± 0.049
4.816GluGlu: 4.816 ± 0.083
2.092GluPhe: 2.092 ± 0.048
6.71GluGly: 6.71 ± 0.092
1.466GluHis: 1.466 ± 0.036
2.804GluIle: 2.804 ± 0.05
2.248GluLys: 2.248 ± 0.054
8.03GluLeu: 8.03 ± 0.094
1.202GluMet: 1.202 ± 0.032
1.454GluAsn: 1.454 ± 0.036
3.504GluPro: 3.504 ± 0.054
2.768GluGln: 2.768 ± 0.058
6.505GluArg: 6.505 ± 0.094
2.535GluSer: 2.535 ± 0.043
2.411GluThr: 2.411 ± 0.051
6.295GluVal: 6.295 ± 0.087
1.081GluTrp: 1.081 ± 0.03
1.522GluTyr: 1.522 ± 0.034
0.0GluXaa: 0.0 ± 0.0
Phe
3.798PheAla: 3.798 ± 0.072
0.235PheCys: 0.235 ± 0.015
1.902PheAsp: 1.902 ± 0.047
2.278PheGlu: 2.278 ± 0.045
1.472PhePhe: 1.472 ± 0.046
3.206PheGly: 3.206 ± 0.06
0.7PheHis: 0.7 ± 0.026
1.479PheIle: 1.479 ± 0.044
1.19PheLys: 1.19 ± 0.037
3.98PheLeu: 3.98 ± 0.068
0.582PheMet: 0.582 ± 0.025
0.983PheAsn: 0.983 ± 0.04
1.883PhePro: 1.883 ± 0.039
1.066PheGln: 1.066 ± 0.032
2.458PheArg: 2.458 ± 0.047
2.182PheSer: 2.182 ± 0.049
2.025PheThr: 2.025 ± 0.046
2.753PheVal: 2.753 ± 0.061
0.671PheTrp: 0.671 ± 0.027
1.181PheTyr: 1.181 ± 0.035
0.0PheXaa: 0.0 ± 0.0
Gly
7.866GlyAla: 7.866 ± 0.1
0.632GlyCys: 0.632 ± 0.024
3.344GlyAsp: 3.344 ± 0.057
5.905GlyGlu: 5.905 ± 0.078
3.733GlyPhe: 3.733 ± 0.061
7.662GlyGly: 7.662 ± 0.102
1.806GlyHis: 1.806 ± 0.043
3.883GlyIle: 3.883 ± 0.061
3.428GlyLys: 3.428 ± 0.063
11.668GlyLeu: 11.668 ± 0.128
1.967GlyMet: 1.967 ± 0.044
2.133GlyAsn: 2.133 ± 0.044
3.654GlyPro: 3.654 ± 0.061
3.511GlyGln: 3.511 ± 0.07
6.305GlyArg: 6.305 ± 0.076
4.878GlySer: 4.878 ± 0.084
3.891GlyThr: 3.891 ± 0.076
7.48GlyVal: 7.48 ± 0.081
1.547GlyTrp: 1.547 ± 0.039
3.006GlyTyr: 3.006 ± 0.055
0.0GlyXaa: 0.0 ± 0.0
His
1.83HisAla: 1.83 ± 0.041
0.156HisCys: 0.156 ± 0.012
0.922HisAsp: 0.922 ± 0.031
1.01HisGlu: 1.01 ± 0.033
0.772HisPhe: 0.772 ± 0.028
1.611HisGly: 1.611 ± 0.042
0.555HisHis: 0.555 ± 0.026
0.745HisIle: 0.745 ± 0.028
0.613HisLys: 0.613 ± 0.024
2.631HisLeu: 2.631 ± 0.06
0.307HisMet: 0.307 ± 0.019
0.531HisAsn: 0.531 ± 0.026
1.695HisPro: 1.695 ± 0.038
0.717HisGln: 0.717 ± 0.026
1.466HisArg: 1.466 ± 0.039
0.998HisSer: 0.998 ± 0.031
1.005HisThr: 1.005 ± 0.03
1.149HisVal: 1.149 ± 0.035
0.337HisTrp: 0.337 ± 0.018
0.666HisTyr: 0.666 ± 0.025
0.0HisXaa: 0.0 ± 0.0
Ile
4.792IleAla: 4.792 ± 0.067
0.274IleCys: 0.274 ± 0.015
1.755IleAsp: 1.755 ± 0.045
2.557IleGlu: 2.557 ± 0.053
1.346IlePhe: 1.346 ± 0.04
3.653IleGly: 3.653 ± 0.068
0.839IleHis: 0.839 ± 0.032
1.383IleIle: 1.383 ± 0.042
1.176IleLys: 1.176 ± 0.037
4.404IleLeu: 4.404 ± 0.075
0.515IleMet: 0.515 ± 0.024
1.052IleAsn: 1.052 ± 0.032
2.777IlePro: 2.777 ± 0.054
1.303IleGln: 1.303 ± 0.033
2.871IleArg: 2.871 ± 0.053
2.03IleSer: 2.03 ± 0.05
2.148IleThr: 2.148 ± 0.052
2.986IleVal: 2.986 ± 0.058
0.56IleTrp: 0.56 ± 0.024
1.095IleTyr: 1.095 ± 0.03
0.0IleXaa: 0.0 ± 0.0
Lys
4.073LysAla: 4.073 ± 0.07
0.117LysCys: 0.117 ± 0.012
1.523LysAsp: 1.523 ± 0.043
2.096LysGlu: 2.096 ± 0.057
0.739LysPhe: 0.739 ± 0.028
2.881LysGly: 2.881 ± 0.064
0.649LysHis: 0.649 ± 0.023
1.241LysIle: 1.241 ± 0.039
1.207LysLys: 1.207 ± 0.04
3.504LysLeu: 3.504 ± 0.056
0.527LysMet: 0.527 ± 0.028
0.901LysAsn: 0.901 ± 0.028
2.15LysPro: 2.15 ± 0.044
1.004LysGln: 1.004 ± 0.033
2.183LysArg: 2.183 ± 0.05
1.486LysSer: 1.486 ± 0.04
1.634LysThr: 1.634 ± 0.038
2.667LysVal: 2.667 ± 0.054
0.359LysTrp: 0.359 ± 0.018
0.809LysTyr: 0.809 ± 0.027
0.0LysXaa: 0.0 ± 0.0
Leu
14.525LeuAla: 14.525 ± 0.158
0.732LeuCys: 0.732 ± 0.023
4.967LeuAsp: 4.967 ± 0.073
13.332LeuGlu: 13.332 ± 0.154
3.834LeuPhe: 3.834 ± 0.071
11.332LeuGly: 11.332 ± 0.134
2.122LeuHis: 2.122 ± 0.048
4.591LeuIle: 4.591 ± 0.079
4.226LeuLys: 4.226 ± 0.079
14.664LeuLeu: 14.664 ± 0.211
2.098LeuMet: 2.098 ± 0.044
2.587LeuAsn: 2.587 ± 0.049
7.121LeuPro: 7.121 ± 0.082
4.013LeuGln: 4.013 ± 0.067
9.358LeuArg: 9.358 ± 0.108
7.75LeuSer: 7.75 ± 0.105
5.551LeuThr: 5.551 ± 0.081
8.606LeuVal: 8.606 ± 0.094
1.914LeuTrp: 1.914 ± 0.046
3.108LeuTyr: 3.108 ± 0.055
0.0LeuXaa: 0.0 ± 0.0
Met
2.12MetAla: 2.12 ± 0.041
0.086MetCys: 0.086 ± 0.009
0.766MetAsp: 0.766 ± 0.023
1.028MetGlu: 1.028 ± 0.029
0.487MetPhe: 0.487 ± 0.023
1.787MetGly: 1.787 ± 0.04
0.31MetHis: 0.31 ± 0.016
0.759MetIle: 0.759 ± 0.026
0.821MetLys: 0.821 ± 0.025
2.124MetLeu: 2.124 ± 0.043
0.314MetMet: 0.314 ± 0.019
0.559MetAsn: 0.559 ± 0.024
1.054MetPro: 1.054 ± 0.033
0.64MetGln: 0.64 ± 0.025
1.538MetArg: 1.538 ± 0.038
1.122MetSer: 1.122 ± 0.033
0.857MetThr: 0.857 ± 0.029
1.423MetVal: 1.423 ± 0.033
0.208MetTrp: 0.208 ± 0.015
0.367MetTyr: 0.367 ± 0.02
0.0MetXaa: 0.0 ± 0.0
Asn
2.367AsnAla: 2.367 ± 0.057
0.173AsnCys: 0.173 ± 0.012
0.945AsnAsp: 0.945 ± 0.033
0.981AsnGlu: 0.981 ± 0.035
0.902AsnPhe: 0.902 ± 0.031
1.74AsnGly: 1.74 ± 0.042
0.46AsnHis: 0.46 ± 0.022
0.931AsnIle: 0.931 ± 0.03
0.625AsnLys: 0.625 ± 0.026
3.247AsnLeu: 3.247 ± 0.064
0.341AsnMet: 0.341 ± 0.019
0.638AsnAsn: 0.638 ± 0.03
2.541AsnPro: 2.541 ± 0.053
0.837AsnGln: 0.837 ± 0.028
1.654AsnArg: 1.654 ± 0.039
1.042AsnSer: 1.042 ± 0.033
1.173AsnThr: 1.173 ± 0.035
1.542AsnVal: 1.542 ± 0.045
0.392AsnTrp: 0.392 ± 0.021
0.71AsnTyr: 0.71 ± 0.029
0.0AsnXaa: 0.0 ± 0.0
Pro
5.566ProAla: 5.566 ± 0.088
0.309ProCys: 0.309 ± 0.017
3.052ProAsp: 3.052 ± 0.055
5.165ProGlu: 5.165 ± 0.079
2.12ProPhe: 2.12 ± 0.045
5.308ProGly: 5.308 ± 0.091
1.285ProHis: 1.285 ± 0.032
2.019ProIle: 2.019 ± 0.046
1.942ProLys: 1.942 ± 0.046
6.398ProLeu: 6.398 ± 0.086
1.001ProMet: 1.001 ± 0.028
1.459ProAsn: 1.459 ± 0.04
3.31ProPro: 3.31 ± 0.059
2.565ProGln: 2.565 ± 0.053
3.663ProArg: 3.663 ± 0.062
3.142ProSer: 3.142 ± 0.059
2.821ProThr: 2.821 ± 0.062
4.133ProVal: 4.133 ± 0.061
0.942ProTrp: 0.942 ± 0.032
1.732ProTyr: 1.732 ± 0.046
0.0ProXaa: 0.0 ± 0.0
Gln
5.515GlnAla: 5.515 ± 0.095
0.141GlnCys: 0.141 ± 0.015
1.563GlnAsp: 1.563 ± 0.038
2.403GlnGlu: 2.403 ± 0.049
0.991GlnPhe: 0.991 ± 0.029
3.925GlnGly: 3.925 ± 0.073
0.708GlnHis: 0.708 ± 0.028
1.607GlnIle: 1.607 ± 0.036
1.193GlnLys: 1.193 ± 0.032
3.463GlnLeu: 3.463 ± 0.06
0.748GlnMet: 0.748 ± 0.023
0.967GlnAsn: 0.967 ± 0.033
2.17GlnPro: 2.17 ± 0.047
1.731GlnGln: 1.731 ± 0.047
2.764GlnArg: 2.764 ± 0.068
1.951GlnSer: 1.951 ± 0.038
1.812GlnThr: 1.812 ± 0.048
3.148GlnVal: 3.148 ± 0.055
0.465GlnTrp: 0.465 ± 0.025
0.769GlnTyr: 0.769 ± 0.03
0.0GlnXaa: 0.0 ± 0.0
Arg
7.533ArgAla: 7.533 ± 0.098
0.418ArgCys: 0.418 ± 0.021
2.812ArgAsp: 2.812 ± 0.054
5.755ArgGlu: 5.755 ± 0.076
3.19ArgPhe: 3.19 ± 0.049
5.614ArgGly: 5.614 ± 0.086
1.463ArgHis: 1.463 ± 0.043
3.291ArgIle: 3.291 ± 0.054
2.377ArgLys: 2.377 ± 0.055
10.388ArgLeu: 10.388 ± 0.123
1.885ArgMet: 1.885 ± 0.043
1.552ArgAsn: 1.552 ± 0.039
3.865ArgPro: 3.865 ± 0.064
2.994ArgGln: 2.994 ± 0.059
5.897ArgArg: 5.897 ± 0.092
3.638ArgSer: 3.638 ± 0.066
3.003ArgThr: 3.003 ± 0.049
6.144ArgVal: 6.144 ± 0.083
1.368ArgTrp: 1.368 ± 0.045
2.622ArgTyr: 2.622 ± 0.051
0.0ArgXaa: 0.0 ± 0.0
Ser
4.945SerAla: 4.945 ± 0.091
0.328SerCys: 0.328 ± 0.018
2.129SerAsp: 2.129 ± 0.046
2.969SerGlu: 2.969 ± 0.058
2.117SerPhe: 2.117 ± 0.051
5.165SerGly: 5.165 ± 0.098
0.834SerHis: 0.834 ± 0.028
1.936SerIle: 1.936 ± 0.049
1.485SerLys: 1.485 ± 0.037
6.845SerLeu: 6.845 ± 0.091
0.918SerMet: 0.918 ± 0.029
1.208SerAsn: 1.208 ± 0.04
3.278SerPro: 3.278 ± 0.054
1.867SerGln: 1.867 ± 0.044
3.932SerArg: 3.932 ± 0.063
2.924SerSer: 2.924 ± 0.069
2.414SerThr: 2.414 ± 0.056
3.585SerVal: 3.585 ± 0.068
0.876SerTrp: 0.876 ± 0.029
1.551SerTyr: 1.551 ± 0.043
0.0SerXaa: 0.0 ± 0.0
Thr
4.424ThrAla: 4.424 ± 0.069
0.285ThrCys: 0.285 ± 0.015
1.927ThrAsp: 1.927 ± 0.043
2.03ThrGlu: 2.03 ± 0.043
1.719ThrPhe: 1.719 ± 0.047
3.957ThrGly: 3.957 ± 0.068
1.054ThrHis: 1.054 ± 0.035
1.714ThrIle: 1.714 ± 0.047
1.037ThrLys: 1.037 ± 0.033
6.668ThrLeu: 6.668 ± 0.089
0.598ThrMet: 0.598 ± 0.024
1.007ThrAsn: 1.007 ± 0.034
3.634ThrPro: 3.634 ± 0.069
1.703ThrGln: 1.703 ± 0.033
3.055ThrArg: 3.055 ± 0.053
2.198ThrSer: 2.198 ± 0.053
2.203ThrThr: 2.203 ± 0.055
3.644ThrVal: 3.644 ± 0.065
0.706ThrTrp: 0.706 ± 0.026
1.408ThrTyr: 1.408 ± 0.037
0.0ThrXaa: 0.0 ± 0.0
Val
8.127ValAla: 8.127 ± 0.107
0.505ValCys: 0.505 ± 0.023
2.965ValAsp: 2.965 ± 0.055
5.235ValGlu: 5.235 ± 0.079
2.75ValPhe: 2.75 ± 0.051
6.701ValGly: 6.701 ± 0.089
1.392ValHis: 1.392 ± 0.034
3.267ValIle: 3.267 ± 0.062
2.228ValLys: 2.228 ± 0.051
10.133ValLeu: 10.133 ± 0.105
1.563ValMet: 1.563 ± 0.037
1.803ValAsn: 1.803 ± 0.043
3.814ValPro: 3.814 ± 0.059
2.734ValGln: 2.734 ± 0.049
6.259ValArg: 6.259 ± 0.083
3.965ValSer: 3.965 ± 0.064
3.241ValThr: 3.241 ± 0.064
6.693ValVal: 6.693 ± 0.082
1.276ValTrp: 1.276 ± 0.035
2.149ValTyr: 2.149 ± 0.045
0.0ValXaa: 0.0 ± 0.0
Trp
1.608TrpAla: 1.608 ± 0.033
0.088TrpCys: 0.088 ± 0.008
0.625TrpAsp: 0.625 ± 0.026
1.015TrpGlu: 1.015 ± 0.031
0.538TrpPhe: 0.538 ± 0.025
1.408TrpGly: 1.408 ± 0.038
0.328TrpHis: 0.328 ± 0.016
0.625TrpIle: 0.625 ± 0.026
0.551TrpLys: 0.551 ± 0.024
2.199TrpLeu: 2.199 ± 0.044
0.361TrpMet: 0.361 ± 0.021
0.477TrpAsn: 0.477 ± 0.022
0.807TrpPro: 0.807 ± 0.026
0.709TrpGln: 0.709 ± 0.026
1.272TrpArg: 1.272 ± 0.034
0.812TrpSer: 0.812 ± 0.027
0.669TrpThr: 0.669 ± 0.025
1.431TrpVal: 1.431 ± 0.035
0.296TrpTrp: 0.296 ± 0.019
0.396TrpTyr: 0.396 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.138TyrAla: 3.138 ± 0.056
0.204TyrCys: 0.204 ± 0.013
1.363TyrAsp: 1.363 ± 0.036
1.536TyrGlu: 1.536 ± 0.039
1.09TyrPhe: 1.09 ± 0.033
2.558TyrGly: 2.558 ± 0.052
0.577TyrHis: 0.577 ± 0.022
0.899TyrIle: 0.899 ± 0.027
0.802TyrLys: 0.802 ± 0.027
3.793TyrLeu: 3.793 ± 0.07
0.355TyrMet: 0.355 ± 0.02
0.729TyrAsn: 0.729 ± 0.029
1.773TyrPro: 1.773 ± 0.042
1.09TyrGln: 1.09 ± 0.033
2.684TyrArg: 2.684 ± 0.052
1.364TyrSer: 1.364 ± 0.041
1.586TyrThr: 1.586 ± 0.036
1.906TyrVal: 1.906 ± 0.045
0.492TyrTrp: 0.492 ± 0.024
0.927TyrTyr: 0.927 ± 0.034
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3553 proteins (1074463 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski