Amino acid dipepetide frequency for Panacagrimonas perspica

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.797AlaAla: 15.797 ± 0.127	1.248AlaCys: 1.248 ± 0.031	6.691AlaAsp: 6.691 ± 0.071	6.727AlaGlu: 6.727 ± 0.073	3.97AlaPhe: 3.97 ± 0.051	10.074AlaGly: 10.074 ± 0.092	2.421AlaHis: 2.421 ± 0.042	5.199AlaIle: 5.199 ± 0.057	3.965AlaLys: 3.965 ± 0.062	12.856AlaLeu: 12.856 ± 0.116	3.175AlaMet: 3.175 ± 0.045	2.798AlaAsn: 2.798 ± 0.047	5.963AlaPro: 5.963 ± 0.072	4.602AlaGln: 4.602 ± 0.054	9.116AlaArg: 9.116 ± 0.103	6.719AlaSer: 6.719 ± 0.059	6.013AlaThr: 6.013 ± 0.089	8.399AlaVal: 8.399 ± 0.071	1.752AlaTrp: 1.752 ± 0.033	2.47AlaTyr: 2.47 ± 0.044	0.0AlaXaa: 0.0 ± 0.0
Cys	1.221CysAla: 1.221 ± 0.028	0.141CysCys: 0.141 ± 0.01	0.575CysAsp: 0.575 ± 0.021	0.575CysGlu: 0.575 ± 0.019	0.338CysPhe: 0.338 ± 0.014	1.011CysGly: 1.011 ± 0.027	0.277CysHis: 0.277 ± 0.016	0.388CysIle: 0.388 ± 0.014	0.255CysLys: 0.255 ± 0.014	0.879CysLeu: 0.879 ± 0.026	0.188CysMet: 0.188 ± 0.01	0.251CysAsn: 0.251 ± 0.012	0.492CysPro: 0.492 ± 0.022	0.237CysGln: 0.237 ± 0.013	0.666CysArg: 0.666 ± 0.02	0.561CysSer: 0.561 ± 0.02	0.492CysThr: 0.492 ± 0.018	0.788CysVal: 0.788 ± 0.024	0.16CysTrp: 0.16 ± 0.01	0.208CysTyr: 0.208 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	7.36AspAla: 7.36 ± 0.081	0.478AspCys: 0.478 ± 0.019	3.123AspAsp: 3.123 ± 0.052	3.448AspGlu: 3.448 ± 0.049	2.157AspPhe: 2.157 ± 0.033	5.143AspGly: 5.143 ± 0.066	1.175AspHis: 1.175 ± 0.032	2.412AspIle: 2.412 ± 0.039	1.618AspLys: 1.618 ± 0.041	5.933AspLeu: 5.933 ± 0.07	1.053AspMet: 1.053 ± 0.028	1.202AspAsn: 1.202 ± 0.029	3.462AspPro: 3.462 ± 0.056	1.689AspGln: 1.689 ± 0.035	4.27AspArg: 4.27 ± 0.059	2.548AspSer: 2.548 ± 0.04	2.518AspThr: 2.518 ± 0.038	4.43AspVal: 4.43 ± 0.047	0.975AspTrp: 0.975 ± 0.029	1.548AspTyr: 1.548 ± 0.033	0.0AspXaa: 0.0 ± 0.0
Glu	6.864GluAla: 6.864 ± 0.085	0.464GluCys: 0.464 ± 0.019	2.583GluAsp: 2.583 ± 0.043	2.827GluGlu: 2.827 ± 0.054	2.041GluPhe: 2.041 ± 0.036	4.008GluGly: 4.008 ± 0.047	1.423GluHis: 1.423 ± 0.031	2.913GluIle: 2.913 ± 0.046	2.2GluLys: 2.2 ± 0.046	6.125GluLeu: 6.125 ± 0.071	1.334GluMet: 1.334 ± 0.032	1.382GluAsn: 1.382 ± 0.029	2.756GluPro: 2.756 ± 0.042	2.439GluGln: 2.439 ± 0.044	5.017GluArg: 5.017 ± 0.068	3.18GluSer: 3.18 ± 0.04	2.885GluThr: 2.885 ± 0.041	3.838GluVal: 3.838 ± 0.055	0.862GluTrp: 0.862 ± 0.023	1.269GluTyr: 1.269 ± 0.031	0.0GluXaa: 0.0 ± 0.0
Phe	4.238PheAla: 4.238 ± 0.051	0.424PheCys: 0.424 ± 0.016	2.673PheAsp: 2.673 ± 0.047	2.411PheGlu: 2.411 ± 0.038	1.425PhePhe: 1.425 ± 0.03	3.568PheGly: 3.568 ± 0.049	0.792PheHis: 0.792 ± 0.023	1.401PheIle: 1.401 ± 0.035	1.101PheLys: 1.101 ± 0.029	3.237PheLeu: 3.237 ± 0.053	0.764PheMet: 0.764 ± 0.021	1.109PheAsn: 1.109 ± 0.029	1.636PhePro: 1.636 ± 0.034	1.02PheGln: 1.02 ± 0.025	2.31PheArg: 2.31 ± 0.042	2.207PheSer: 2.207 ± 0.044	1.921PheThr: 1.921 ± 0.039	2.877PheVal: 2.877 ± 0.04	0.529PheTrp: 0.529 ± 0.017	0.896PheTyr: 0.896 ± 0.025	0.0PheXaa: 0.0 ± 0.0
Gly	8.963GlyAla: 8.963 ± 0.096	0.917GlyCys: 0.917 ± 0.026	4.361GlyAsp: 4.361 ± 0.054	4.524GlyGlu: 4.524 ± 0.058	3.42GlyPhe: 3.42 ± 0.044	7.133GlyGly: 7.133 ± 0.088	1.906GlyHis: 1.906 ± 0.041	4.134GlyIle: 4.134 ± 0.062	3.264GlyLys: 3.264 ± 0.056	8.697GlyLeu: 8.697 ± 0.095	2.179GlyMet: 2.179 ± 0.037	2.225GlyAsn: 2.225 ± 0.045	3.471GlyPro: 3.471 ± 0.06	2.893GlyGln: 2.893 ± 0.045	5.891GlyArg: 5.891 ± 0.07	4.905GlySer: 4.905 ± 0.057	4.56GlyThr: 4.56 ± 0.054	6.455GlyVal: 6.455 ± 0.069	1.475GlyTrp: 1.475 ± 0.028	2.358GlyTyr: 2.358 ± 0.041	0.0GlyXaa: 0.0 ± 0.0
His	2.561HisAla: 2.561 ± 0.049	0.261HisCys: 0.261 ± 0.013	1.245HisAsp: 1.245 ± 0.03	1.24HisGlu: 1.24 ± 0.031	0.957HisPhe: 0.957 ± 0.026	1.976HisGly: 1.976 ± 0.034	0.658HisHis: 0.658 ± 0.024	0.785HisIle: 0.785 ± 0.026	0.539HisLys: 0.539 ± 0.019	2.349HisLeu: 2.349 ± 0.038	0.423HisMet: 0.423 ± 0.015	0.456HisAsn: 0.456 ± 0.015	1.452HisPro: 1.452 ± 0.03	0.672HisGln: 0.672 ± 0.018	1.701HisArg: 1.701 ± 0.041	0.997HisSer: 0.997 ± 0.025	0.964HisThr: 0.964 ± 0.026	1.621HisVal: 1.621 ± 0.032	0.373HisTrp: 0.373 ± 0.016	0.674HisTyr: 0.674 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	6.091IleAla: 6.091 ± 0.061	0.48IleCys: 0.48 ± 0.019	3.153IleAsp: 3.153 ± 0.045	3.418IleGlu: 3.418 ± 0.047	1.36IlePhe: 1.36 ± 0.034	4.431IleGly: 4.431 ± 0.058	0.926IleHis: 0.926 ± 0.024	1.388IleIle: 1.388 ± 0.032	1.382IleLys: 1.382 ± 0.029	3.505IleLeu: 3.505 ± 0.052	0.631IleMet: 0.631 ± 0.021	1.318IleAsn: 1.318 ± 0.028	2.371IlePro: 2.371 ± 0.036	1.326IleGln: 1.326 ± 0.031	3.072IleArg: 3.072 ± 0.043	2.398IleSer: 2.398 ± 0.043	2.396IleThr: 2.396 ± 0.046	3.718IleVal: 3.718 ± 0.049	0.54IleTrp: 0.54 ± 0.018	0.996IleTyr: 0.996 ± 0.027	0.0IleXaa: 0.0 ± 0.0
Lys	3.947LysAla: 3.947 ± 0.058	0.214LysCys: 0.214 ± 0.013	1.82LysAsp: 1.82 ± 0.039	1.532LysGlu: 1.532 ± 0.038	0.993LysPhe: 0.993 ± 0.026	2.567LysGly: 2.567 ± 0.046	0.671LysHis: 0.671 ± 0.019	1.596LysIle: 1.596 ± 0.037	1.504LysLys: 1.504 ± 0.043	3.785LysLeu: 3.785 ± 0.061	0.783LysMet: 0.783 ± 0.025	0.958LysAsn: 0.958 ± 0.024	2.204LysPro: 2.204 ± 0.043	1.14LysGln: 1.14 ± 0.03	2.385LysArg: 2.385 ± 0.039	1.831LysSer: 1.831 ± 0.036	1.906LysThr: 1.906 ± 0.042	2.525LysVal: 2.525 ± 0.047	0.345LysTrp: 0.345 ± 0.015	0.722LysTyr: 0.722 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	12.896LeuAla: 12.896 ± 0.108	1.091LeuCys: 1.091 ± 0.028	6.405LeuAsp: 6.405 ± 0.071	5.666LeuGlu: 5.666 ± 0.074	3.644LeuPhe: 3.644 ± 0.061	8.451LeuGly: 8.451 ± 0.085	2.248LeuHis: 2.248 ± 0.041	4.642LeuIle: 4.642 ± 0.06	3.578LeuLys: 3.578 ± 0.056	10.616LeuLeu: 10.616 ± 0.106	2.44LeuMet: 2.44 ± 0.042	2.502LeuAsn: 2.502 ± 0.041	5.79LeuPro: 5.79 ± 0.063	3.356LeuGln: 3.356 ± 0.05	8.444LeuArg: 8.444 ± 0.093	6.509LeuSer: 6.509 ± 0.07	5.053LeuThr: 5.053 ± 0.072	7.539LeuVal: 7.539 ± 0.076	1.263LeuTrp: 1.263 ± 0.035	2.103LeuTyr: 2.103 ± 0.043	0.0LeuXaa: 0.0 ± 0.0
Met	2.569MetAla: 2.569 ± 0.037	0.189MetCys: 0.189 ± 0.011	1.116MetAsp: 1.116 ± 0.028	1.107MetGlu: 1.107 ± 0.027	0.772MetPhe: 0.772 ± 0.023	1.689MetGly: 1.689 ± 0.035	0.491MetHis: 0.491 ± 0.017	1.098MetIle: 1.098 ± 0.031	1.025MetLys: 1.025 ± 0.029	2.452MetLeu: 2.452 ± 0.042	0.525MetMet: 0.525 ± 0.019	0.855MetAsn: 0.855 ± 0.022	1.452MetPro: 1.452 ± 0.032	0.893MetGln: 0.893 ± 0.024	1.808MetArg: 1.808 ± 0.034	1.775MetSer: 1.775 ± 0.029	1.488MetThr: 1.488 ± 0.029	1.45MetVal: 1.45 ± 0.03	0.231MetTrp: 0.231 ± 0.012	0.377MetTyr: 0.377 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.123AsnAla: 3.123 ± 0.047	0.287AsnCys: 0.287 ± 0.014	1.308AsnAsp: 1.308 ± 0.03	1.307AsnGlu: 1.307 ± 0.029	0.992AsnPhe: 0.992 ± 0.024	2.358AsnGly: 2.358 ± 0.049	0.504AsnHis: 0.504 ± 0.018	1.137AsnIle: 1.137 ± 0.028	0.689AsnLys: 0.689 ± 0.024	2.814AsnLeu: 2.814 ± 0.045	0.489AsnMet: 0.489 ± 0.015	0.679AsnAsn: 0.679 ± 0.026	1.785AsnPro: 1.785 ± 0.037	0.832AsnGln: 0.832 ± 0.02	1.789AsnArg: 1.789 ± 0.038	1.228AsnSer: 1.228 ± 0.033	1.272AsnThr: 1.272 ± 0.033	1.977AsnVal: 1.977 ± 0.041	0.434AsnTrp: 0.434 ± 0.015	0.652AsnTyr: 0.652 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	6.628ProAla: 6.628 ± 0.076	0.358ProCys: 0.358 ± 0.016	3.528ProAsp: 3.528 ± 0.052	3.583ProGlu: 3.583 ± 0.051	1.811ProPhe: 1.811 ± 0.035	4.637ProGly: 4.637 ± 0.062	1.051ProHis: 1.051 ± 0.028	2.22ProIle: 2.22 ± 0.042	1.775ProLys: 1.775 ± 0.041	5.184ProLeu: 5.184 ± 0.058	1.405ProMet: 1.405 ± 0.028	1.373ProAsn: 1.373 ± 0.031	2.912ProPro: 2.912 ± 0.069	1.833ProGln: 1.833 ± 0.03	3.398ProArg: 3.398 ± 0.047	2.913ProSer: 2.913 ± 0.041	2.698ProThr: 2.698 ± 0.051	4.185ProVal: 4.185 ± 0.056	0.754ProTrp: 0.754 ± 0.027	1.158ProTyr: 1.158 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	4.293GlnAla: 4.293 ± 0.056	0.252GlnCys: 0.252 ± 0.013	1.553GlnAsp: 1.553 ± 0.035	1.496GlnGlu: 1.496 ± 0.033	1.265GlnPhe: 1.265 ± 0.029	2.566GlnGly: 2.566 ± 0.039	0.801GlnHis: 0.801 ± 0.021	1.799GlnIle: 1.799 ± 0.034	1.201GlnLys: 1.201 ± 0.032	3.601GlnLeu: 3.601 ± 0.049	0.891GlnMet: 0.891 ± 0.023	0.838GlnAsn: 0.838 ± 0.024	1.82GlnPro: 1.82 ± 0.037	1.506GlnGln: 1.506 ± 0.03	2.996GlnArg: 2.996 ± 0.047	1.807GlnSer: 1.807 ± 0.034	1.81GlnThr: 1.81 ± 0.036	2.62GlnVal: 2.62 ± 0.049	0.52GlnTrp: 0.52 ± 0.018	0.783GlnTyr: 0.783 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	8.238ArgAla: 8.238 ± 0.095	0.689ArgCys: 0.689 ± 0.023	4.336ArgAsp: 4.336 ± 0.057	4.691ArgGlu: 4.691 ± 0.066	3.082ArgPhe: 3.082 ± 0.046	5.307ArgGly: 5.307 ± 0.057	1.818ArgHis: 1.818 ± 0.036	3.871ArgIle: 3.871 ± 0.049	2.433ArgLys: 2.433 ± 0.039	8.483ArgLeu: 8.483 ± 0.104	1.947ArgMet: 1.947 ± 0.035	1.961ArgAsn: 1.961 ± 0.033	3.432ArgPro: 3.432 ± 0.046	2.475ArgGln: 2.475 ± 0.044	5.903ArgArg: 5.903 ± 0.077	3.902ArgSer: 3.902 ± 0.052	3.553ArgThr: 3.553 ± 0.046	5.739ArgVal: 5.739 ± 0.067	1.284ArgTrp: 1.284 ± 0.029	2.167ArgTyr: 2.167 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	6.61SerAla: 6.61 ± 0.071	0.499SerCys: 0.499 ± 0.019	2.92SerAsp: 2.92 ± 0.045	2.837SerGlu: 2.837 ± 0.042	2.24SerPhe: 2.24 ± 0.043	5.383SerGly: 5.383 ± 0.067	1.124SerHis: 1.124 ± 0.025	2.642SerIle: 2.642 ± 0.038	1.783SerLys: 1.783 ± 0.035	5.901SerLeu: 5.901 ± 0.065	1.343SerMet: 1.343 ± 0.032	1.408SerAsn: 1.408 ± 0.032	3.026SerPro: 3.026 ± 0.046	1.786SerGln: 1.786 ± 0.032	4.19SerArg: 4.19 ± 0.062	3.43SerSer: 3.43 ± 0.065	2.895SerThr: 2.895 ± 0.045	4.12SerVal: 4.12 ± 0.053	0.816SerTrp: 0.816 ± 0.024	1.272SerTyr: 1.272 ± 0.031	0.0SerXaa: 0.0 ± 0.0
Thr	5.875ThrAla: 5.875 ± 0.077	0.483ThrCys: 0.483 ± 0.019	2.672ThrAsp: 2.672 ± 0.042	2.536ThrGlu: 2.536 ± 0.038	1.752ThrPhe: 1.752 ± 0.033	4.648ThrGly: 4.648 ± 0.071	1.145ThrHis: 1.145 ± 0.029	2.171ThrIle: 2.171 ± 0.047	1.345ThrLys: 1.345 ± 0.033	5.735ThrLeu: 5.735 ± 0.061	1.144ThrMet: 1.144 ± 0.028	1.134ThrAsn: 1.134 ± 0.03	3.501ThrPro: 3.501 ± 0.05	1.867ThrGln: 1.867 ± 0.034	3.81ThrArg: 3.81 ± 0.051	2.792ThrSer: 2.792 ± 0.045	2.733ThrThr: 2.733 ± 0.058	3.976ThrVal: 3.976 ± 0.056	0.839ThrTrp: 0.839 ± 0.025	1.149ThrTyr: 1.149 ± 0.026	0.0ThrXaa: 0.0 ± 0.0
Val	8.78ValAla: 8.78 ± 0.08	0.786ValCys: 0.786 ± 0.027	4.389ValAsp: 4.389 ± 0.049	4.503ValGlu: 4.503 ± 0.061	2.693ValPhe: 2.693 ± 0.051	5.779ValGly: 5.779 ± 0.074	1.602ValHis: 1.602 ± 0.036	3.52ValIle: 3.52 ± 0.048	2.48ValLys: 2.48 ± 0.048	7.776ValLeu: 7.776 ± 0.075	1.781ValMet: 1.781 ± 0.032	2.05ValAsn: 2.05 ± 0.043	4.066ValPro: 4.066 ± 0.051	2.493ValGln: 2.493 ± 0.041	5.426ValArg: 5.426 ± 0.063	4.275ValSer: 4.275 ± 0.056	4.161ValThr: 4.161 ± 0.06	6.007ValVal: 6.007 ± 0.068	0.92ValTrp: 0.92 ± 0.024	1.473ValTyr: 1.473 ± 0.03	0.0ValXaa: 0.0 ± 0.0
Trp	1.266TrpAla: 1.266 ± 0.027	0.182TrpCys: 0.182 ± 0.01	0.706TrpAsp: 0.706 ± 0.021	0.635TrpGlu: 0.635 ± 0.02	0.621TrpPhe: 0.621 ± 0.021	0.961TrpGly: 0.961 ± 0.023	0.358TrpHis: 0.358 ± 0.014	0.805TrpIle: 0.805 ± 0.022	0.627TrpLys: 0.627 ± 0.021	1.828TrpLeu: 1.828 ± 0.038	0.459TrpMet: 0.459 ± 0.018	0.54TrpAsn: 0.54 ± 0.02	0.681TrpPro: 0.681 ± 0.021	0.563TrpGln: 0.563 ± 0.021	1.136TrpArg: 1.136 ± 0.031	0.939TrpSer: 0.939 ± 0.025	0.86TrpThr: 0.86 ± 0.023	0.956TrpVal: 0.956 ± 0.027	0.251TrpTrp: 0.251 ± 0.014	0.371TrpTyr: 0.371 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.634TyrAla: 2.634 ± 0.045	0.259TyrCys: 0.259 ± 0.012	1.388TyrAsp: 1.388 ± 0.034	1.345TyrGlu: 1.345 ± 0.029	1.006TyrPhe: 1.006 ± 0.026	2.043TyrGly: 2.043 ± 0.039	0.513TyrHis: 0.513 ± 0.019	0.78TyrIle: 0.78 ± 0.022	0.666TyrLys: 0.666 ± 0.02	2.48TyrLeu: 2.48 ± 0.036	0.409TyrMet: 0.409 ± 0.017	0.616TyrAsn: 0.616 ± 0.02	1.135TyrPro: 1.135 ± 0.025	0.793TyrGln: 0.793 ± 0.024	1.983TyrArg: 1.983 ± 0.042	1.309TyrSer: 1.309 ± 0.031	1.127TyrThr: 1.127 ± 0.028	1.739TyrVal: 1.739 ± 0.033	0.421TyrTrp: 0.421 ± 0.017	0.618TyrTyr: 0.618 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4772 proteins (1604628 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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