Amino acid dipepetide frequency for Streptococcus satellite phage Javan307

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.373AlaAla: 0.373 ± 0.324
0.0AlaCys: 0.0 ± 0.0
4.1AlaAsp: 4.1 ± 1.392
5.591AlaGlu: 5.591 ± 1.357
5.963AlaPhe: 5.963 ± 1.463
1.491AlaGly: 1.491 ± 0.62
0.745AlaHis: 0.745 ± 0.415
4.473AlaIle: 4.473 ± 0.955
4.473AlaLys: 4.473 ± 1.025
4.473AlaLeu: 4.473 ± 2.075
1.864AlaMet: 1.864 ± 0.853
2.236AlaAsn: 2.236 ± 1.048
1.118AlaPro: 1.118 ± 0.624
1.864AlaGln: 1.864 ± 0.844
2.236AlaArg: 2.236 ± 0.634
3.727AlaSer: 3.727 ± 0.958
3.727AlaThr: 3.727 ± 0.991
2.236AlaVal: 2.236 ± 0.728
0.745AlaTrp: 0.745 ± 0.522
0.373AlaTyr: 0.373 ± 0.286
0.0AlaXaa: 0.0 ± 0.0
Cys
0.373CysAla: 0.373 ± 0.344
0.0CysCys: 0.0 ± 0.0
0.373CysAsp: 0.373 ± 0.336
0.0CysGlu: 0.0 ± 0.0
0.0CysPhe: 0.0 ± 0.0
0.0CysGly: 0.0 ± 0.0
0.0CysHis: 0.0 ± 0.0
0.0CysIle: 0.0 ± 0.0
0.373CysLys: 0.373 ± 0.286
0.373CysLeu: 0.373 ± 0.353
0.0CysMet: 0.0 ± 0.0
0.373CysAsn: 0.373 ± 0.401
0.0CysPro: 0.0 ± 0.0
0.0CysGln: 0.0 ± 0.0
0.373CysArg: 0.373 ± 0.368
0.373CysSer: 0.373 ± 0.357
0.0CysThr: 0.0 ± 0.0
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
1.118AspAla: 1.118 ± 0.488
0.0AspCys: 0.0 ± 0.0
2.982AspAsp: 2.982 ± 0.917
2.609AspGlu: 2.609 ± 0.92
2.609AspPhe: 2.609 ± 0.779
2.236AspGly: 2.236 ± 0.692
0.373AspHis: 0.373 ± 0.324
6.709AspIle: 6.709 ± 1.326
6.709AspLys: 6.709 ± 1.453
9.691AspLeu: 9.691 ± 3.263
1.491AspMet: 1.491 ± 0.667
3.727AspAsn: 3.727 ± 1.17
0.745AspPro: 0.745 ± 0.399
1.491AspGln: 1.491 ± 0.718
4.1AspArg: 4.1 ± 0.909
2.982AspSer: 2.982 ± 1.02
3.354AspThr: 3.354 ± 1.187
2.236AspVal: 2.236 ± 0.797
0.0AspTrp: 0.0 ± 0.0
5.963AspTyr: 5.963 ± 1.881
0.0AspXaa: 0.0 ± 0.0
Glu
4.845GluAla: 4.845 ± 1.086
0.373GluCys: 0.373 ± 0.344
6.336GluAsp: 6.336 ± 1.444
6.709GluGlu: 6.709 ± 1.612
1.864GluPhe: 1.864 ± 0.618
3.354GluGly: 3.354 ± 1.514
0.745GluHis: 0.745 ± 0.63
7.082GluIle: 7.082 ± 1.704
4.845GluLys: 4.845 ± 1.115
10.809GluLeu: 10.809 ± 1.058
2.236GluMet: 2.236 ± 0.729
6.709GluAsn: 6.709 ± 1.623
1.864GluPro: 1.864 ± 1.022
4.1GluGln: 4.1 ± 0.989
5.963GluArg: 5.963 ± 1.899
4.473GluSer: 4.473 ± 1.154
5.218GluThr: 5.218 ± 0.981
4.845GluVal: 4.845 ± 1.281
0.373GluTrp: 0.373 ± 0.353
5.218GluTyr: 5.218 ± 1.309
0.0GluXaa: 0.0 ± 0.0
Phe
0.745PheAla: 0.745 ± 0.647
0.0PheCys: 0.0 ± 0.0
2.982PheAsp: 2.982 ± 0.947
4.473PheGlu: 4.473 ± 1.1
1.491PhePhe: 1.491 ± 0.655
1.864PheGly: 1.864 ± 0.651
1.118PheHis: 1.118 ± 0.403
1.864PheIle: 1.864 ± 0.675
4.473PheLys: 4.473 ± 1.096
4.845PheLeu: 4.845 ± 0.885
1.118PheMet: 1.118 ± 0.607
2.236PheAsn: 2.236 ± 0.967
0.373PhePro: 0.373 ± 0.357
1.118PheGln: 1.118 ± 0.403
2.609PheArg: 2.609 ± 0.912
2.609PheSer: 2.609 ± 0.805
2.236PheThr: 2.236 ± 0.99
1.864PheVal: 1.864 ± 1.074
0.745PheTrp: 0.745 ± 0.401
2.982PheTyr: 2.982 ± 0.605
0.0PheXaa: 0.0 ± 0.0
Gly
2.236GlyAla: 2.236 ± 1.061
0.373GlyCys: 0.373 ± 0.368
1.491GlyAsp: 1.491 ± 0.85
4.1GlyGlu: 4.1 ± 0.896
2.982GlyPhe: 2.982 ± 0.735
1.491GlyGly: 1.491 ± 0.603
1.118GlyHis: 1.118 ± 0.528
2.609GlyIle: 2.609 ± 0.512
4.473GlyLys: 4.473 ± 1.297
5.591GlyLeu: 5.591 ± 1.893
1.864GlyMet: 1.864 ± 0.685
2.236GlyAsn: 2.236 ± 0.765
0.0GlyPro: 0.0 ± 0.0
2.236GlyGln: 2.236 ± 0.537
2.982GlyArg: 2.982 ± 0.885
1.491GlySer: 1.491 ± 0.863
3.354GlyThr: 3.354 ± 1.192
3.727GlyVal: 3.727 ± 0.828
1.118GlyTrp: 1.118 ± 0.806
3.354GlyTyr: 3.354 ± 0.724
0.0GlyXaa: 0.0 ± 0.0
His
1.118HisAla: 1.118 ± 0.785
0.0HisCys: 0.0 ± 0.0
0.373HisAsp: 0.373 ± 0.344
1.864HisGlu: 1.864 ± 0.62
0.745HisPhe: 0.745 ± 0.736
1.864HisGly: 1.864 ± 0.573
0.0HisHis: 0.0 ± 0.0
0.745HisIle: 0.745 ± 0.736
0.745HisLys: 0.745 ± 0.376
1.864HisLeu: 1.864 ± 0.551
0.0HisMet: 0.0 ± 0.0
0.373HisAsn: 0.373 ± 0.286
0.745HisPro: 0.745 ± 0.571
0.0HisGln: 0.0 ± 0.0
1.118HisArg: 1.118 ± 0.707
1.864HisSer: 1.864 ± 0.537
0.745HisThr: 0.745 ± 0.426
0.0HisVal: 0.0 ± 0.0
0.0HisTrp: 0.0 ± 0.0
1.118HisTyr: 1.118 ± 0.484
0.0HisXaa: 0.0 ± 0.0
Ile
3.354IleAla: 3.354 ± 0.707
0.745IleCys: 0.745 ± 0.471
7.082IleAsp: 7.082 ± 2.282
4.845IleGlu: 4.845 ± 1.204
2.236IlePhe: 2.236 ± 0.809
3.354IleGly: 3.354 ± 0.918
1.118IleHis: 1.118 ± 0.691
4.1IleIle: 4.1 ± 1.124
6.336IleLys: 6.336 ± 1.098
5.218IleLeu: 5.218 ± 0.76
0.745IleMet: 0.745 ± 0.411
2.982IleAsn: 2.982 ± 0.913
2.236IlePro: 2.236 ± 0.74
2.982IleGln: 2.982 ± 1.008
2.609IleArg: 2.609 ± 1.041
7.082IleSer: 7.082 ± 2.07
6.336IleThr: 6.336 ± 1.327
1.864IleVal: 1.864 ± 0.787
1.491IleTrp: 1.491 ± 0.671
3.354IleTyr: 3.354 ± 0.935
0.0IleXaa: 0.0 ± 0.0
Lys
8.945LysAla: 8.945 ± 2.044
0.373LysCys: 0.373 ± 0.353
5.591LysAsp: 5.591 ± 1.24
8.572LysGlu: 8.572 ± 1.404
3.354LysPhe: 3.354 ± 1.037
6.336LysGly: 6.336 ± 1.313
1.491LysHis: 1.491 ± 0.723
5.963LysIle: 5.963 ± 1.307
6.709LysLys: 6.709 ± 1.505
6.709LysLeu: 6.709 ± 1.732
1.118LysMet: 1.118 ± 0.473
4.845LysAsn: 4.845 ± 1.301
3.354LysPro: 3.354 ± 0.789
4.845LysGln: 4.845 ± 0.837
5.218LysArg: 5.218 ± 1.587
4.1LysSer: 4.1 ± 1.545
5.218LysThr: 5.218 ± 1.367
4.845LysVal: 4.845 ± 1.114
1.118LysTrp: 1.118 ± 0.526
1.118LysTyr: 1.118 ± 0.579
0.0LysXaa: 0.0 ± 0.0
Leu
6.709LeuAla: 6.709 ± 1.249
0.0LeuCys: 0.0 ± 0.0
8.2LeuAsp: 8.2 ± 2.495
12.672LeuGlu: 12.672 ± 2.9
3.727LeuPhe: 3.727 ± 1.662
4.845LeuGly: 4.845 ± 1.369
1.864LeuHis: 1.864 ± 0.805
6.336LeuIle: 6.336 ± 1.276
9.691LeuLys: 9.691 ± 1.096
11.554LeuLeu: 11.554 ± 2.035
1.491LeuMet: 1.491 ± 0.528
6.709LeuAsn: 6.709 ± 1.617
3.354LeuPro: 3.354 ± 1.067
4.845LeuGln: 4.845 ± 1.231
3.727LeuArg: 3.727 ± 0.672
5.963LeuSer: 5.963 ± 0.95
7.082LeuThr: 7.082 ± 1.45
3.354LeuVal: 3.354 ± 0.947
0.745LeuTrp: 0.745 ± 0.493
3.727LeuTyr: 3.727 ± 1.178
0.0LeuXaa: 0.0 ± 0.0
Met
0.373MetAla: 0.373 ± 0.324
0.0MetCys: 0.0 ± 0.0
3.727MetAsp: 3.727 ± 1.105
3.354MetGlu: 3.354 ± 1.161
1.118MetPhe: 1.118 ± 0.579
1.118MetGly: 1.118 ± 0.567
0.0MetHis: 0.0 ± 0.0
2.609MetIle: 2.609 ± 0.967
1.491MetLys: 1.491 ± 0.596
1.118MetLeu: 1.118 ± 0.561
0.373MetMet: 0.373 ± 0.353
1.864MetAsn: 1.864 ± 0.689
0.373MetPro: 0.373 ± 0.357
1.118MetGln: 1.118 ± 0.483
0.745MetArg: 0.745 ± 0.565
0.745MetSer: 0.745 ± 0.464
3.727MetThr: 3.727 ± 1.153
1.118MetVal: 1.118 ± 0.548
0.0MetTrp: 0.0 ± 0.0
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
2.236AsnAla: 2.236 ± 0.871
0.0AsnCys: 0.0 ± 0.0
2.609AsnAsp: 2.609 ± 0.857
3.354AsnGlu: 3.354 ± 0.531
1.491AsnPhe: 1.491 ± 0.966
4.1AsnGly: 4.1 ± 1.376
0.745AsnHis: 0.745 ± 0.423
2.236AsnIle: 2.236 ± 0.695
5.963AsnLys: 5.963 ± 0.885
7.082AsnLeu: 7.082 ± 1.565
3.354AsnMet: 3.354 ± 0.901
2.609AsnAsn: 2.609 ± 1.286
1.864AsnPro: 1.864 ± 0.649
2.982AsnGln: 2.982 ± 0.786
2.236AsnArg: 2.236 ± 0.832
2.982AsnSer: 2.982 ± 0.997
2.609AsnThr: 2.609 ± 1.261
1.864AsnVal: 1.864 ± 0.751
1.118AsnTrp: 1.118 ± 0.722
1.864AsnTyr: 1.864 ± 0.717
0.0AsnXaa: 0.0 ± 0.0
Pro
1.118ProAla: 1.118 ± 0.482
0.0ProCys: 0.0 ± 0.0
1.864ProAsp: 1.864 ± 0.835
1.864ProGlu: 1.864 ± 1.134
0.373ProPhe: 0.373 ± 0.286
0.0ProGly: 0.0 ± 0.0
0.373ProHis: 0.373 ± 0.286
1.864ProIle: 1.864 ± 0.607
1.491ProLys: 1.491 ± 0.8
2.609ProLeu: 2.609 ± 0.862
1.118ProMet: 1.118 ± 0.622
2.236ProAsn: 2.236 ± 0.677
0.373ProPro: 0.373 ± 0.349
0.373ProGln: 0.373 ± 0.324
1.118ProArg: 1.118 ± 0.466
3.727ProSer: 3.727 ± 1.232
1.864ProThr: 1.864 ± 0.684
1.491ProVal: 1.491 ± 0.511
0.0ProTrp: 0.0 ± 0.0
1.864ProTyr: 1.864 ± 0.805
0.0ProXaa: 0.0 ± 0.0
Gln
4.1GlnAla: 4.1 ± 1.018
0.0GlnCys: 0.0 ± 0.0
1.118GlnAsp: 1.118 ± 0.581
5.218GlnGlu: 5.218 ± 0.871
1.491GlnPhe: 1.491 ± 0.726
2.236GlnGly: 2.236 ± 0.488
0.0GlnHis: 0.0 ± 0.0
1.491GlnIle: 1.491 ± 0.972
5.963GlnLys: 5.963 ± 1.801
4.473GlnLeu: 4.473 ± 1.034
0.745GlnMet: 0.745 ± 0.366
1.118GlnAsn: 1.118 ± 0.471
1.118GlnPro: 1.118 ± 0.566
2.236GlnGln: 2.236 ± 0.687
3.354GlnArg: 3.354 ± 0.752
1.864GlnSer: 1.864 ± 0.607
2.609GlnThr: 2.609 ± 0.863
2.236GlnVal: 2.236 ± 1.037
0.373GlnTrp: 0.373 ± 0.324
1.491GlnTyr: 1.491 ± 1.107
0.0GlnXaa: 0.0 ± 0.0
Arg
2.236ArgAla: 2.236 ± 1.158
0.373ArgCys: 0.373 ± 0.357
2.609ArgAsp: 2.609 ± 1.056
5.963ArgGlu: 5.963 ± 0.952
1.864ArgPhe: 1.864 ± 0.996
2.236ArgGly: 2.236 ± 0.516
1.491ArgHis: 1.491 ± 0.735
3.727ArgIle: 3.727 ± 0.9
3.354ArgLys: 3.354 ± 1.24
7.082ArgLeu: 7.082 ± 1.424
1.491ArgMet: 1.491 ± 0.56
2.982ArgAsn: 2.982 ± 1.218
1.118ArgPro: 1.118 ± 0.857
2.982ArgGln: 2.982 ± 0.95
2.609ArgArg: 2.609 ± 0.825
2.609ArgSer: 2.609 ± 0.741
1.864ArgThr: 1.864 ± 0.604
3.354ArgVal: 3.354 ± 1.176
0.0ArgTrp: 0.0 ± 0.0
4.473ArgTyr: 4.473 ± 1.385
0.0ArgXaa: 0.0 ± 0.0
Ser
2.236SerAla: 2.236 ± 0.943
0.0SerCys: 0.0 ± 0.0
3.727SerAsp: 3.727 ± 0.993
4.1SerGlu: 4.1 ± 1.204
2.609SerPhe: 2.609 ± 0.649
1.864SerGly: 1.864 ± 0.567
0.745SerHis: 0.745 ± 0.522
6.336SerIle: 6.336 ± 1.142
5.963SerLys: 5.963 ± 1.175
5.218SerLeu: 5.218 ± 1.265
1.118SerMet: 1.118 ± 0.785
2.236SerAsn: 2.236 ± 0.767
2.236SerPro: 2.236 ± 0.524
1.864SerGln: 1.864 ± 0.893
2.982SerArg: 2.982 ± 1.161
3.727SerSer: 3.727 ± 0.756
3.727SerThr: 3.727 ± 0.997
3.354SerVal: 3.354 ± 1.337
0.745SerTrp: 0.745 ± 0.379
2.982SerTyr: 2.982 ± 0.647
0.0SerXaa: 0.0 ± 0.0
Thr
3.727ThrAla: 3.727 ± 1.288
0.0ThrCys: 0.0 ± 0.0
2.609ThrAsp: 2.609 ± 1.016
5.591ThrGlu: 5.591 ± 1.104
3.727ThrPhe: 3.727 ± 1.342
4.845ThrGly: 4.845 ± 1.087
1.118ThrHis: 1.118 ± 0.785
3.727ThrIle: 3.727 ± 1.31
4.845ThrLys: 4.845 ± 0.838
7.082ThrLeu: 7.082 ± 1.654
1.864ThrMet: 1.864 ± 0.747
1.491ThrAsn: 1.491 ± 0.573
2.236ThrPro: 2.236 ± 0.825
2.982ThrGln: 2.982 ± 1.037
4.473ThrArg: 4.473 ± 0.827
3.727ThrSer: 3.727 ± 1.016
2.982ThrThr: 2.982 ± 0.878
2.609ThrVal: 2.609 ± 0.896
0.745ThrTrp: 0.745 ± 0.441
2.236ThrTyr: 2.236 ± 0.942
0.0ThrXaa: 0.0 ± 0.0
Val
3.727ValAla: 3.727 ± 1.321
0.373ValCys: 0.373 ± 0.286
1.491ValAsp: 1.491 ± 0.593
1.864ValGlu: 1.864 ± 0.906
1.118ValPhe: 1.118 ± 0.561
2.982ValGly: 2.982 ± 1.175
0.745ValHis: 0.745 ± 0.441
4.473ValIle: 4.473 ± 1.497
4.845ValLys: 4.845 ± 1.882
4.473ValLeu: 4.473 ± 1.175
0.745ValMet: 0.745 ± 0.487
2.609ValAsn: 2.609 ± 1.066
1.491ValPro: 1.491 ± 0.578
2.609ValGln: 2.609 ± 0.863
2.609ValArg: 2.609 ± 0.577
1.491ValSer: 1.491 ± 0.722
2.236ValThr: 2.236 ± 1.027
2.236ValVal: 2.236 ± 1.067
0.745ValTrp: 0.745 ± 0.512
1.864ValTyr: 1.864 ± 0.795
0.0ValXaa: 0.0 ± 0.0
Trp
0.745TrpAla: 0.745 ± 0.441
0.0TrpCys: 0.0 ± 0.0
0.373TrpAsp: 0.373 ± 0.364
1.864TrpGlu: 1.864 ± 0.618
0.0TrpPhe: 0.0 ± 0.0
0.373TrpGly: 0.373 ± 0.353
0.0TrpHis: 0.0 ± 0.0
1.118TrpIle: 1.118 ± 0.63
1.864TrpLys: 1.864 ± 0.535
1.491TrpLeu: 1.491 ± 0.871
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.373TrpGln: 0.373 ± 0.397
0.373TrpArg: 0.373 ± 0.353
0.373TrpSer: 0.373 ± 0.368
1.118TrpThr: 1.118 ± 0.532
0.0TrpVal: 0.0 ± 0.0
0.373TrpTrp: 0.373 ± 0.368
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.491TyrAla: 1.491 ± 0.718
0.0TyrCys: 0.0 ± 0.0
1.491TyrAsp: 1.491 ± 0.625
3.354TyrGlu: 3.354 ± 1.067
2.982TyrPhe: 2.982 ± 1.146
2.236TyrGly: 2.236 ± 0.854
1.491TyrHis: 1.491 ± 0.69
2.609TyrIle: 2.609 ± 1.22
5.218TyrLys: 5.218 ± 1.781
4.845TyrLeu: 4.845 ± 0.847
1.864TyrMet: 1.864 ± 0.712
4.1TyrAsn: 4.1 ± 1.171
1.118TyrPro: 1.118 ± 0.454
2.236TyrGln: 2.236 ± 0.752
2.982TyrArg: 2.982 ± 1.365
1.864TyrSer: 1.864 ± 0.528
2.609TyrThr: 2.609 ± 0.697
1.491TyrVal: 1.491 ± 0.694
0.0TyrTrp: 0.0 ± 0.0
2.982TyrTyr: 2.982 ± 0.751
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 14 proteins (2684 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski