Amino acid dipepetide frequency for Idiomarinaceae phage Phi1M2-2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.952AlaAla: 8.952 ± 0.907
1.377AlaCys: 1.377 ± 0.339
5.595AlaAsp: 5.595 ± 0.72
6.37AlaGlu: 6.37 ± 0.596
4.046AlaPhe: 4.046 ± 0.658
6.628AlaGly: 6.628 ± 0.984
1.291AlaHis: 1.291 ± 0.379
6.456AlaIle: 6.456 ± 0.853
4.821AlaLys: 4.821 ± 0.836
7.747AlaLeu: 7.747 ± 0.916
2.41AlaMet: 2.41 ± 0.464
3.529AlaAsn: 3.529 ± 0.498
3.013AlaPro: 3.013 ± 0.591
5.165AlaGln: 5.165 ± 0.924
6.284AlaArg: 6.284 ± 0.874
6.026AlaSer: 6.026 ± 0.584
6.198AlaThr: 6.198 ± 0.75
5.509AlaVal: 5.509 ± 0.663
1.291AlaTrp: 1.291 ± 0.286
2.238AlaTyr: 2.238 ± 0.387
0.0AlaXaa: 0.0 ± 0.0
Cys
0.775CysAla: 0.775 ± 0.264
0.344CysCys: 0.344 ± 0.217
1.291CysAsp: 1.291 ± 0.283
0.861CysGlu: 0.861 ± 0.327
0.344CysPhe: 0.344 ± 0.158
0.775CysGly: 0.775 ± 0.313
0.344CysHis: 0.344 ± 0.176
0.516CysIle: 0.516 ± 0.234
1.205CysLys: 1.205 ± 0.434
1.377CysLeu: 1.377 ± 0.403
0.258CysMet: 0.258 ± 0.154
0.258CysAsn: 0.258 ± 0.15
0.689CysPro: 0.689 ± 0.211
0.344CysGln: 0.344 ± 0.175
1.205CysArg: 1.205 ± 0.355
0.344CysSer: 0.344 ± 0.192
0.172CysThr: 0.172 ± 0.117
0.603CysVal: 0.603 ± 0.239
0.258CysTrp: 0.258 ± 0.18
0.344CysTyr: 0.344 ± 0.177
0.0CysXaa: 0.0 ± 0.0
Asp
6.628AspAla: 6.628 ± 0.774
0.43AspCys: 0.43 ± 0.168
4.476AspAsp: 4.476 ± 0.793
6.628AspGlu: 6.628 ± 0.843
2.582AspPhe: 2.582 ± 0.412
5.681AspGly: 5.681 ± 0.675
0.861AspHis: 0.861 ± 0.286
3.615AspIle: 3.615 ± 0.582
3.357AspLys: 3.357 ± 0.582
5.337AspLeu: 5.337 ± 0.885
1.808AspMet: 1.808 ± 0.389
1.98AspAsn: 1.98 ± 0.452
2.41AspPro: 2.41 ± 0.444
1.549AspGln: 1.549 ± 0.321
2.152AspArg: 2.152 ± 0.398
3.529AspSer: 3.529 ± 0.567
3.529AspThr: 3.529 ± 0.536
4.907AspVal: 4.907 ± 0.566
1.033AspTrp: 1.033 ± 0.269
3.185AspTyr: 3.185 ± 0.381
0.0AspXaa: 0.0 ± 0.0
Glu
7.059GluAla: 7.059 ± 0.827
1.463GluCys: 1.463 ± 0.418
3.615GluAsp: 3.615 ± 0.515
4.218GluGlu: 4.218 ± 0.709
2.841GluPhe: 2.841 ± 0.479
5.681GluGly: 5.681 ± 0.859
1.291GluHis: 1.291 ± 0.27
4.218GluIle: 4.218 ± 0.693
2.927GluLys: 2.927 ± 0.464
6.8GluLeu: 6.8 ± 0.77
1.291GluMet: 1.291 ± 0.289
2.496GluAsn: 2.496 ± 0.517
3.013GluPro: 3.013 ± 0.577
5.251GluGln: 5.251 ± 0.666
5.509GluArg: 5.509 ± 0.77
5.337GluSer: 5.337 ± 0.691
3.96GluThr: 3.96 ± 0.54
5.165GluVal: 5.165 ± 0.63
1.205GluTrp: 1.205 ± 0.277
2.927GluTyr: 2.927 ± 0.625
0.0GluXaa: 0.0 ± 0.0
Phe
2.669PheAla: 2.669 ± 0.421
0.516PheCys: 0.516 ± 0.224
3.615PheAsp: 3.615 ± 0.529
2.41PheGlu: 2.41 ± 0.42
1.119PhePhe: 1.119 ± 0.333
3.529PheGly: 3.529 ± 0.592
0.775PheHis: 0.775 ± 0.298
2.582PheIle: 2.582 ± 0.506
1.98PheLys: 1.98 ± 0.432
2.324PheLeu: 2.324 ± 0.407
0.344PheMet: 0.344 ± 0.15
1.894PheAsn: 1.894 ± 0.384
1.463PhePro: 1.463 ± 0.307
1.119PheGln: 1.119 ± 0.313
1.98PheArg: 1.98 ± 0.48
1.894PheSer: 1.894 ± 0.437
2.841PheThr: 2.841 ± 0.376
2.41PheVal: 2.41 ± 0.356
0.603PheTrp: 0.603 ± 0.257
0.947PheTyr: 0.947 ± 0.35
0.0PheXaa: 0.0 ± 0.0
Gly
6.456GlyAla: 6.456 ± 0.994
0.947GlyCys: 0.947 ± 0.268
5.94GlyAsp: 5.94 ± 0.806
6.112GlyGlu: 6.112 ± 0.755
4.304GlyPhe: 4.304 ± 0.737
6.886GlyGly: 6.886 ± 0.915
0.43GlyHis: 0.43 ± 0.204
3.443GlyIle: 3.443 ± 0.464
4.046GlyLys: 4.046 ± 0.702
4.821GlyLeu: 4.821 ± 0.589
2.582GlyMet: 2.582 ± 0.593
3.013GlyAsn: 3.013 ± 0.523
0.689GlyPro: 0.689 ± 0.246
2.496GlyGln: 2.496 ± 0.411
3.96GlyArg: 3.96 ± 0.562
3.874GlySer: 3.874 ± 0.653
3.615GlyThr: 3.615 ± 0.653
4.39GlyVal: 4.39 ± 0.535
1.291GlyTrp: 1.291 ± 0.321
2.755GlyTyr: 2.755 ± 0.565
0.0GlyXaa: 0.0 ± 0.0
His
1.463HisAla: 1.463 ± 0.418
0.344HisCys: 0.344 ± 0.239
1.98HisAsp: 1.98 ± 0.415
1.291HisGlu: 1.291 ± 0.401
0.516HisPhe: 0.516 ± 0.204
1.033HisGly: 1.033 ± 0.388
0.516HisHis: 0.516 ± 0.224
0.172HisIle: 0.172 ± 0.122
0.861HisLys: 0.861 ± 0.298
0.775HisLeu: 0.775 ± 0.235
0.344HisMet: 0.344 ± 0.226
0.603HisAsn: 0.603 ± 0.225
0.947HisPro: 0.947 ± 0.241
0.861HisGln: 0.861 ± 0.286
1.119HisArg: 1.119 ± 0.301
1.291HisSer: 1.291 ± 0.338
0.603HisThr: 0.603 ± 0.219
1.377HisVal: 1.377 ± 0.402
0.086HisTrp: 0.086 ± 0.085
0.689HisTyr: 0.689 ± 0.265
0.0HisXaa: 0.0 ± 0.0
Ile
6.198IleAla: 6.198 ± 0.71
0.775IleCys: 0.775 ± 0.291
4.218IleAsp: 4.218 ± 0.563
5.251IleGlu: 5.251 ± 0.669
1.894IlePhe: 1.894 ± 0.445
3.357IleGly: 3.357 ± 0.439
1.033IleHis: 1.033 ± 0.36
2.755IleIle: 2.755 ± 0.52
3.013IleLys: 3.013 ± 0.626
2.324IleLeu: 2.324 ± 0.451
1.291IleMet: 1.291 ± 0.369
2.496IleAsn: 2.496 ± 0.464
2.152IlePro: 2.152 ± 0.425
2.152IleGln: 2.152 ± 0.541
3.701IleArg: 3.701 ± 0.608
3.443IleSer: 3.443 ± 0.473
4.046IleThr: 4.046 ± 0.581
3.099IleVal: 3.099 ± 0.469
0.344IleTrp: 0.344 ± 0.156
0.775IleTyr: 0.775 ± 0.255
0.0IleXaa: 0.0 ± 0.0
Lys
5.423LysAla: 5.423 ± 0.952
0.344LysCys: 0.344 ± 0.178
2.324LysAsp: 2.324 ± 0.527
3.443LysGlu: 3.443 ± 0.622
1.205LysPhe: 1.205 ± 0.325
3.185LysGly: 3.185 ± 0.556
1.119LysHis: 1.119 ± 0.347
2.669LysIle: 2.669 ± 0.437
3.185LysLys: 3.185 ± 0.816
3.788LysLeu: 3.788 ± 0.605
1.722LysMet: 1.722 ± 0.424
2.066LysAsn: 2.066 ± 0.411
3.185LysPro: 3.185 ± 0.691
2.496LysGln: 2.496 ± 0.445
3.529LysArg: 3.529 ± 0.489
4.046LysSer: 4.046 ± 0.652
2.755LysThr: 2.755 ± 0.4
2.496LysVal: 2.496 ± 0.516
0.861LysTrp: 0.861 ± 0.28
1.463LysTyr: 1.463 ± 0.352
0.0LysXaa: 0.0 ± 0.0
Leu
5.94LeuAla: 5.94 ± 0.688
1.291LeuCys: 1.291 ± 0.302
4.218LeuAsp: 4.218 ± 0.594
6.714LeuGlu: 6.714 ± 0.928
1.894LeuPhe: 1.894 ± 0.436
3.788LeuGly: 3.788 ± 0.615
1.463LeuHis: 1.463 ± 0.343
4.218LeuIle: 4.218 ± 0.529
3.443LeuLys: 3.443 ± 0.657
6.026LeuLeu: 6.026 ± 0.701
1.291LeuMet: 1.291 ± 0.317
4.218LeuAsn: 4.218 ± 0.54
2.927LeuPro: 2.927 ± 0.58
2.755LeuGln: 2.755 ± 0.509
4.218LeuArg: 4.218 ± 0.667
4.218LeuSer: 4.218 ± 0.662
5.165LeuThr: 5.165 ± 0.586
4.907LeuVal: 4.907 ± 0.68
1.205LeuTrp: 1.205 ± 0.298
2.238LeuTyr: 2.238 ± 0.481
0.0LeuXaa: 0.0 ± 0.0
Met
1.98MetAla: 1.98 ± 0.461
0.258MetCys: 0.258 ± 0.136
1.377MetAsp: 1.377 ± 0.328
2.41MetGlu: 2.41 ± 0.463
0.947MetPhe: 0.947 ± 0.284
1.033MetGly: 1.033 ± 0.245
0.603MetHis: 0.603 ± 0.235
0.861MetIle: 0.861 ± 0.255
1.722MetLys: 1.722 ± 0.486
1.033MetLeu: 1.033 ± 0.33
0.516MetMet: 0.516 ± 0.215
1.549MetAsn: 1.549 ± 0.334
0.861MetPro: 0.861 ± 0.285
1.033MetGln: 1.033 ± 0.286
1.636MetArg: 1.636 ± 0.353
1.722MetSer: 1.722 ± 0.422
2.324MetThr: 2.324 ± 0.421
1.205MetVal: 1.205 ± 0.311
0.258MetTrp: 0.258 ± 0.141
0.516MetTyr: 0.516 ± 0.214
0.0MetXaa: 0.0 ± 0.0
Asn
5.165AsnAla: 5.165 ± 0.714
0.172AsnCys: 0.172 ± 0.101
2.927AsnAsp: 2.927 ± 0.51
3.443AsnGlu: 3.443 ± 0.423
0.775AsnPhe: 0.775 ± 0.26
4.734AsnGly: 4.734 ± 0.904
0.516AsnHis: 0.516 ± 0.23
1.636AsnIle: 1.636 ± 0.329
1.549AsnLys: 1.549 ± 0.39
2.841AsnLeu: 2.841 ± 0.492
0.861AsnMet: 0.861 ± 0.344
1.205AsnAsn: 1.205 ± 0.35
2.324AsnPro: 2.324 ± 0.434
2.152AsnGln: 2.152 ± 0.471
2.238AsnArg: 2.238 ± 0.37
3.185AsnSer: 3.185 ± 0.457
2.324AsnThr: 2.324 ± 0.431
2.669AsnVal: 2.669 ± 0.479
0.516AsnTrp: 0.516 ± 0.204
1.119AsnTyr: 1.119 ± 0.365
0.0AsnXaa: 0.0 ± 0.0
Pro
3.529ProAla: 3.529 ± 0.596
0.516ProCys: 0.516 ± 0.24
3.701ProAsp: 3.701 ± 0.741
3.357ProGlu: 3.357 ± 0.505
1.894ProPhe: 1.894 ± 0.395
0.775ProGly: 0.775 ± 0.215
0.947ProHis: 0.947 ± 0.251
1.808ProIle: 1.808 ± 0.295
2.669ProLys: 2.669 ± 0.667
2.582ProLeu: 2.582 ± 0.505
0.775ProMet: 0.775 ± 0.231
1.98ProAsn: 1.98 ± 0.525
1.463ProPro: 1.463 ± 0.299
1.205ProGln: 1.205 ± 0.325
2.41ProArg: 2.41 ± 0.362
3.013ProSer: 3.013 ± 0.548
1.98ProThr: 1.98 ± 0.485
3.357ProVal: 3.357 ± 0.503
0.516ProTrp: 0.516 ± 0.224
1.119ProTyr: 1.119 ± 0.326
0.0ProXaa: 0.0 ± 0.0
Gln
4.821GlnAla: 4.821 ± 0.726
0.344GlnCys: 0.344 ± 0.17
1.808GlnAsp: 1.808 ± 0.344
2.324GlnGlu: 2.324 ± 0.474
1.894GlnPhe: 1.894 ± 0.36
2.496GlnGly: 2.496 ± 0.418
0.775GlnHis: 0.775 ± 0.283
2.152GlnIle: 2.152 ± 0.464
2.152GlnLys: 2.152 ± 0.436
4.907GlnLeu: 4.907 ± 0.857
1.291GlnMet: 1.291 ± 0.429
1.722GlnAsn: 1.722 ± 0.294
1.636GlnPro: 1.636 ± 0.378
2.927GlnGln: 2.927 ± 0.762
2.41GlnArg: 2.41 ± 0.718
2.496GlnSer: 2.496 ± 0.407
2.238GlnThr: 2.238 ± 0.459
4.562GlnVal: 4.562 ± 0.818
0.516GlnTrp: 0.516 ± 0.202
1.636GlnTyr: 1.636 ± 0.366
0.0GlnXaa: 0.0 ± 0.0
Arg
6.198ArgAla: 6.198 ± 0.724
0.775ArgCys: 0.775 ± 0.29
3.96ArgAsp: 3.96 ± 0.549
4.046ArgGlu: 4.046 ± 0.609
1.808ArgPhe: 1.808 ± 0.409
3.701ArgGly: 3.701 ± 0.57
1.463ArgHis: 1.463 ± 0.405
3.701ArgIle: 3.701 ± 0.536
3.788ArgLys: 3.788 ± 0.547
3.788ArgLeu: 3.788 ± 0.624
1.98ArgMet: 1.98 ± 0.386
3.013ArgAsn: 3.013 ± 0.511
1.894ArgPro: 1.894 ± 0.316
2.841ArgGln: 2.841 ± 0.661
4.046ArgArg: 4.046 ± 0.785
3.185ArgSer: 3.185 ± 0.621
4.132ArgThr: 4.132 ± 0.796
5.079ArgVal: 5.079 ± 0.868
0.603ArgTrp: 0.603 ± 0.198
1.894ArgTyr: 1.894 ± 0.391
0.0ArgXaa: 0.0 ± 0.0
Ser
5.423SerAla: 5.423 ± 0.688
0.43SerCys: 0.43 ± 0.168
3.701SerAsp: 3.701 ± 0.659
5.165SerGlu: 5.165 ± 0.801
2.755SerPhe: 2.755 ± 0.424
4.821SerGly: 4.821 ± 0.695
0.603SerHis: 0.603 ± 0.236
4.218SerIle: 4.218 ± 0.538
2.669SerLys: 2.669 ± 0.479
4.476SerLeu: 4.476 ± 0.557
1.636SerMet: 1.636 ± 0.338
3.013SerAsn: 3.013 ± 0.563
3.185SerPro: 3.185 ± 0.543
2.152SerGln: 2.152 ± 0.432
4.132SerArg: 4.132 ± 0.556
3.529SerSer: 3.529 ± 0.691
3.788SerThr: 3.788 ± 0.531
4.132SerVal: 4.132 ± 0.546
0.861SerTrp: 0.861 ± 0.26
1.722SerTyr: 1.722 ± 0.351
0.0SerXaa: 0.0 ± 0.0
Thr
6.8ThrAla: 6.8 ± 0.702
0.344ThrCys: 0.344 ± 0.221
3.099ThrAsp: 3.099 ± 0.446
3.099ThrGlu: 3.099 ± 0.599
2.927ThrPhe: 2.927 ± 0.447
5.681ThrGly: 5.681 ± 0.79
0.516ThrHis: 0.516 ± 0.193
3.271ThrIle: 3.271 ± 0.475
2.755ThrLys: 2.755 ± 0.585
4.304ThrLeu: 4.304 ± 0.637
1.119ThrMet: 1.119 ± 0.272
2.152ThrAsn: 2.152 ± 0.419
3.615ThrPro: 3.615 ± 0.646
2.324ThrGln: 2.324 ± 0.431
3.357ThrArg: 3.357 ± 0.532
3.874ThrSer: 3.874 ± 0.628
3.788ThrThr: 3.788 ± 0.547
4.218ThrVal: 4.218 ± 0.569
0.689ThrTrp: 0.689 ± 0.23
1.808ThrTyr: 1.808 ± 0.516
0.0ThrXaa: 0.0 ± 0.0
Val
6.456ValAla: 6.456 ± 0.648
0.947ValCys: 0.947 ± 0.291
5.337ValAsp: 5.337 ± 0.51
4.907ValGlu: 4.907 ± 0.817
1.463ValPhe: 1.463 ± 0.325
4.993ValGly: 4.993 ± 0.7
1.119ValHis: 1.119 ± 0.351
3.615ValIle: 3.615 ± 0.488
3.701ValLys: 3.701 ± 0.725
3.96ValLeu: 3.96 ± 0.685
1.377ValMet: 1.377 ± 0.293
3.788ValAsn: 3.788 ± 0.608
2.238ValPro: 2.238 ± 0.409
3.874ValGln: 3.874 ± 0.452
4.907ValArg: 4.907 ± 0.67
4.562ValSer: 4.562 ± 0.735
4.046ValThr: 4.046 ± 0.591
4.39ValVal: 4.39 ± 0.601
0.775ValTrp: 0.775 ± 0.242
1.722ValTyr: 1.722 ± 0.434
0.0ValXaa: 0.0 ± 0.0
Trp
0.603TrpAla: 0.603 ± 0.189
0.43TrpCys: 0.43 ± 0.178
0.689TrpAsp: 0.689 ± 0.222
1.033TrpGlu: 1.033 ± 0.323
0.947TrpPhe: 0.947 ± 0.286
0.775TrpGly: 0.775 ± 0.293
0.344TrpHis: 0.344 ± 0.213
0.775TrpIle: 0.775 ± 0.23
0.43TrpLys: 0.43 ± 0.203
0.775TrpLeu: 0.775 ± 0.251
0.258TrpMet: 0.258 ± 0.152
0.603TrpAsn: 0.603 ± 0.222
0.43TrpPro: 0.43 ± 0.193
0.603TrpGln: 0.603 ± 0.285
1.033TrpArg: 1.033 ± 0.327
1.033TrpSer: 1.033 ± 0.254
0.516TrpThr: 0.516 ± 0.177
1.636TrpVal: 1.636 ± 0.329
0.172TrpTrp: 0.172 ± 0.109
0.258TrpTyr: 0.258 ± 0.158
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.41TyrAla: 2.41 ± 0.434
0.258TyrCys: 0.258 ± 0.132
1.808TyrAsp: 1.808 ± 0.439
3.185TyrGlu: 3.185 ± 0.516
0.861TyrPhe: 0.861 ± 0.303
2.496TyrGly: 2.496 ± 0.453
0.861TyrHis: 0.861 ± 0.28
1.636TyrIle: 1.636 ± 0.354
1.119TyrLys: 1.119 ± 0.276
2.152TyrLeu: 2.152 ± 0.485
0.603TyrMet: 0.603 ± 0.241
0.775TyrAsn: 0.775 ± 0.232
1.463TyrPro: 1.463 ± 0.598
1.808TyrGln: 1.808 ± 0.435
2.066TyrArg: 2.066 ± 0.432
1.808TyrSer: 1.808 ± 0.43
1.722TyrThr: 1.722 ± 0.405
2.066TyrVal: 2.066 ± 0.469
0.258TyrTrp: 0.258 ± 0.149
1.291TyrTyr: 1.291 ± 0.303
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 65 proteins (11618 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski