Amino acid dipepetide frequency for Oceanococcus atlanticus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.356AlaAla: 14.356 ± 0.169	1.355AlaCys: 1.355 ± 0.037	6.868AlaAsp: 6.868 ± 0.085	7.127AlaGlu: 7.127 ± 0.097	3.556AlaPhe: 3.556 ± 0.067	9.223AlaGly: 9.223 ± 0.105	2.586AlaHis: 2.586 ± 0.059	4.891AlaIle: 4.891 ± 0.072	2.878AlaLys: 2.878 ± 0.062	14.275AlaLeu: 14.275 ± 0.156	3.131AlaMet: 3.131 ± 0.056	2.827AlaAsn: 2.827 ± 0.061	5.031AlaPro: 5.031 ± 0.081	5.984AlaGln: 5.984 ± 0.079	8.157AlaArg: 8.157 ± 0.11	6.561AlaSer: 6.561 ± 0.091	5.104AlaThr: 5.104 ± 0.076	8.026AlaVal: 8.026 ± 0.1	1.822AlaTrp: 1.822 ± 0.047	2.689AlaTyr: 2.689 ± 0.055	0.0AlaXaa: 0.0 ± 0.0
Cys	1.235CysAla: 1.235 ± 0.036	0.115CysCys: 0.115 ± 0.01	0.633CysAsp: 0.633 ± 0.024	0.575CysGlu: 0.575 ± 0.024	0.323CysPhe: 0.323 ± 0.014	1.022CysGly: 1.022 ± 0.033	0.274CysHis: 0.274 ± 0.017	0.399CysIle: 0.399 ± 0.02	0.212CysLys: 0.212 ± 0.015	1.041CysLeu: 1.041 ± 0.032	0.201CysMet: 0.201 ± 0.013	0.293CysAsn: 0.293 ± 0.016	0.545CysPro: 0.545 ± 0.027	0.397CysGln: 0.397 ± 0.02	0.622CysArg: 0.622 ± 0.024	0.59CysSer: 0.59 ± 0.022	0.441CysThr: 0.441 ± 0.02	0.769CysVal: 0.769 ± 0.028	0.134CysTrp: 0.134 ± 0.011	0.212CysTyr: 0.212 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	7.404AspAla: 7.404 ± 0.086	0.578AspCys: 0.578 ± 0.023	4.031AspAsp: 4.031 ± 0.082	3.984AspGlu: 3.984 ± 0.066	2.344AspPhe: 2.344 ± 0.048	5.156AspGly: 5.156 ± 0.093	1.292AspHis: 1.292 ± 0.038	3.075AspIle: 3.075 ± 0.057	1.818AspLys: 1.818 ± 0.049	6.01AspLeu: 6.01 ± 0.078	1.421AspMet: 1.421 ± 0.032	1.905AspAsn: 1.905 ± 0.048	3.141AspPro: 3.141 ± 0.056	2.635AspGln: 2.635 ± 0.053	3.212AspArg: 3.212 ± 0.053	3.126AspSer: 3.126 ± 0.066	2.84AspThr: 2.84 ± 0.052	4.361AspVal: 4.361 ± 0.073	1.02AspTrp: 1.02 ± 0.033	1.847AspTyr: 1.847 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	6.557GluAla: 6.557 ± 0.095	0.434GluCys: 0.434 ± 0.021	2.897GluAsp: 2.897 ± 0.049	2.625GluGlu: 2.625 ± 0.06	1.979GluPhe: 1.979 ± 0.044	3.48GluGly: 3.48 ± 0.053	1.681GluHis: 1.681 ± 0.043	2.862GluIle: 2.862 ± 0.049	1.719GluLys: 1.719 ± 0.043	6.675GluLeu: 6.675 ± 0.091	1.255GluMet: 1.255 ± 0.035	1.651GluAsn: 1.651 ± 0.041	2.573GluPro: 2.573 ± 0.047	3.439GluGln: 3.439 ± 0.053	4.72GluArg: 4.72 ± 0.076	2.998GluSer: 2.998 ± 0.056	2.673GluThr: 2.673 ± 0.05	4.042GluVal: 4.042 ± 0.064	0.701GluTrp: 0.701 ± 0.026	1.341GluTyr: 1.341 ± 0.037	0.0GluXaa: 0.0 ± 0.0
Phe	4.005PheAla: 4.005 ± 0.075	0.405PheCys: 0.405 ± 0.02	2.604PheAsp: 2.604 ± 0.054	2.324PheGlu: 2.324 ± 0.048	1.316PhePhe: 1.316 ± 0.043	3.291PheGly: 3.291 ± 0.06	0.707PheHis: 0.707 ± 0.026	1.462PheIle: 1.462 ± 0.042	1.009PheLys: 1.009 ± 0.029	2.93PheLeu: 2.93 ± 0.049	0.809PheMet: 0.809 ± 0.029	1.229PheAsn: 1.229 ± 0.035	1.414PhePro: 1.414 ± 0.04	1.168PheGln: 1.168 ± 0.032	1.981PheArg: 1.981 ± 0.041	2.521PheSer: 2.521 ± 0.053	1.688PheThr: 1.688 ± 0.04	2.639PheVal: 2.639 ± 0.057	0.49PheTrp: 0.49 ± 0.024	0.96PheTyr: 0.96 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	7.674GlyAla: 7.674 ± 0.093	0.919GlyCys: 0.919 ± 0.031	4.586GlyAsp: 4.586 ± 0.089	4.773GlyGlu: 4.773 ± 0.064	3.256GlyPhe: 3.256 ± 0.054	6.52GlyGly: 6.52 ± 0.104	2.034GlyHis: 2.034 ± 0.045	3.757GlyIle: 3.757 ± 0.062	2.507GlyLys: 2.507 ± 0.051	9.075GlyLeu: 9.075 ± 0.097	2.11GlyMet: 2.11 ± 0.042	2.203GlyAsn: 2.203 ± 0.06	2.937GlyPro: 2.937 ± 0.057	3.943GlyGln: 3.943 ± 0.061	5.248GlyArg: 5.248 ± 0.079	4.339GlySer: 4.339 ± 0.081	3.552GlyThr: 3.552 ± 0.076	6.069GlyVal: 6.069 ± 0.085	1.263GlyTrp: 1.263 ± 0.037	2.31GlyTyr: 2.31 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	2.797HisAla: 2.797 ± 0.052	0.31HisCys: 0.31 ± 0.019	1.389HisAsp: 1.389 ± 0.037	1.192HisGlu: 1.192 ± 0.032	1.01HisPhe: 1.01 ± 0.034	2.087HisGly: 2.087 ± 0.048	0.655HisHis: 0.655 ± 0.025	1.109HisIle: 1.109 ± 0.034	0.684HisLys: 0.684 ± 0.028	2.423HisLeu: 2.423 ± 0.056	0.55HisMet: 0.55 ± 0.021	0.73HisAsn: 0.73 ± 0.027	1.438HisPro: 1.438 ± 0.036	0.999HisGln: 0.999 ± 0.036	1.513HisArg: 1.513 ± 0.041	1.285HisSer: 1.285 ± 0.039	0.985HisThr: 0.985 ± 0.027	1.468HisVal: 1.468 ± 0.037	0.49HisTrp: 0.49 ± 0.021	0.67HisTyr: 0.67 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	5.605IleAla: 5.605 ± 0.084	0.493IleCys: 0.493 ± 0.022	3.42IleAsp: 3.42 ± 0.063	3.455IleGlu: 3.455 ± 0.059	1.398IlePhe: 1.398 ± 0.038	4.019IleGly: 4.019 ± 0.063	1.017IleHis: 1.017 ± 0.034	1.863IleIle: 1.863 ± 0.047	1.481IleLys: 1.481 ± 0.04	3.825IleLeu: 3.825 ± 0.063	0.853IleMet: 0.853 ± 0.028	1.754IleAsn: 1.754 ± 0.04	2.172IlePro: 2.172 ± 0.043	1.705IleGln: 1.705 ± 0.039	3.054IleArg: 3.054 ± 0.056	3.0IleSer: 3.0 ± 0.05	2.472IleThr: 2.472 ± 0.052	3.393IleVal: 3.393 ± 0.058	0.604IleTrp: 0.604 ± 0.026	1.126IleTyr: 1.126 ± 0.035	0.0IleXaa: 0.0 ± 0.0
Lys	3.547LysAla: 3.547 ± 0.078	0.128LysCys: 0.128 ± 0.013	1.561LysAsp: 1.561 ± 0.039	1.1LysGlu: 1.1 ± 0.04	0.754LysPhe: 0.754 ± 0.029	1.792LysGly: 1.792 ± 0.045	0.659LysHis: 0.659 ± 0.025	1.408LysIle: 1.408 ± 0.039	1.008LysLys: 1.008 ± 0.037	3.309LysLeu: 3.309 ± 0.063	0.606LysMet: 0.606 ± 0.025	0.872LysAsn: 0.872 ± 0.03	1.854LysPro: 1.854 ± 0.045	1.316LysGln: 1.316 ± 0.039	2.133LysArg: 2.133 ± 0.046	1.584LysSer: 1.584 ± 0.041	1.658LysThr: 1.658 ± 0.039	2.031LysVal: 2.031 ± 0.049	0.263LysTrp: 0.263 ± 0.016	0.638LysTyr: 0.638 ± 0.028	0.0LysXaa: 0.0 ± 0.0
Leu	13.036LeuAla: 13.036 ± 0.13	1.207LeuCys: 1.207 ± 0.034	7.254LeuAsp: 7.254 ± 0.084	6.098LeuGlu: 6.098 ± 0.075	3.523LeuPhe: 3.523 ± 0.059	8.796LeuGly: 8.796 ± 0.089	2.387LeuHis: 2.387 ± 0.048	5.528LeuIle: 5.528 ± 0.082	3.564LeuLys: 3.564 ± 0.061	11.016LeuLeu: 11.016 ± 0.158	2.535LeuMet: 2.535 ± 0.047	3.63LeuAsn: 3.63 ± 0.062	5.759LeuPro: 5.759 ± 0.079	4.249LeuGln: 4.249 ± 0.065	7.762LeuArg: 7.762 ± 0.096	7.637LeuSer: 7.637 ± 0.101	5.011LeuThr: 5.011 ± 0.065	6.825LeuVal: 6.825 ± 0.093	1.426LeuTrp: 1.426 ± 0.046	2.353LeuTyr: 2.353 ± 0.049	0.0LeuXaa: 0.0 ± 0.0
Met	2.725MetAla: 2.725 ± 0.047	0.185MetCys: 0.185 ± 0.012	1.242MetAsp: 1.242 ± 0.037	0.936MetGlu: 0.936 ± 0.03	0.729MetPhe: 0.729 ± 0.022	1.67MetGly: 1.67 ± 0.039	0.583MetHis: 0.583 ± 0.021	1.075MetIle: 1.075 ± 0.035	0.795MetLys: 0.795 ± 0.028	2.752MetLeu: 2.752 ± 0.053	0.556MetMet: 0.556 ± 0.02	0.834MetAsn: 0.834 ± 0.025	1.313MetPro: 1.313 ± 0.036	1.194MetGln: 1.194 ± 0.031	1.701MetArg: 1.701 ± 0.042	1.877MetSer: 1.877 ± 0.037	1.378MetThr: 1.378 ± 0.032	1.462MetVal: 1.462 ± 0.036	0.233MetTrp: 0.233 ± 0.014	0.402MetTyr: 0.402 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.398AsnAla: 3.398 ± 0.051	0.308AsnCys: 0.308 ± 0.019	1.658AsnAsp: 1.658 ± 0.044	1.387AsnGlu: 1.387 ± 0.031	1.071AsnPhe: 1.071 ± 0.033	2.408AsnGly: 2.408 ± 0.054	0.638AsnHis: 0.638 ± 0.025	1.429AsnIle: 1.429 ± 0.041	0.8AsnLys: 0.8 ± 0.029	3.164AsnLeu: 3.164 ± 0.062	0.668AsnMet: 0.668 ± 0.028	0.974AsnAsn: 0.974 ± 0.037	2.063AsnPro: 2.063 ± 0.047	1.259AsnGln: 1.259 ± 0.036	1.901AsnArg: 1.901 ± 0.038	1.531AsnSer: 1.531 ± 0.038	1.594AsnThr: 1.594 ± 0.038	1.956AsnVal: 1.956 ± 0.043	0.552AsnTrp: 0.552 ± 0.025	0.824AsnTyr: 0.824 ± 0.033	0.0AsnXaa: 0.0 ± 0.0
Pro	5.77ProAla: 5.77 ± 0.091	0.361ProCys: 0.361 ± 0.019	3.598ProAsp: 3.598 ± 0.065	3.189ProGlu: 3.189 ± 0.055	1.574ProPhe: 1.574 ± 0.042	4.24ProGly: 4.24 ± 0.075	1.097ProHis: 1.097 ± 0.034	1.981ProIle: 1.981 ± 0.044	1.311ProLys: 1.311 ± 0.031	5.175ProLeu: 5.175 ± 0.073	1.105ProMet: 1.105 ± 0.032	1.344ProAsn: 1.344 ± 0.039	2.275ProPro: 2.275 ± 0.052	2.6ProGln: 2.6 ± 0.055	2.842ProArg: 2.842 ± 0.052	2.74ProSer: 2.74 ± 0.059	2.2ProThr: 2.2 ± 0.059	3.717ProVal: 3.717 ± 0.059	0.772ProTrp: 0.772 ± 0.028	1.186ProTyr: 1.186 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	6.51GlnAla: 6.51 ± 0.095	0.383GlnCys: 0.383 ± 0.017	2.372GlnAsp: 2.372 ± 0.04	1.764GlnGlu: 1.764 ± 0.043	1.447GlnPhe: 1.447 ± 0.034	3.374GlnGly: 3.374 ± 0.058	1.308GlnHis: 1.308 ± 0.033	2.259GlnIle: 2.259 ± 0.046	0.957GlnLys: 0.957 ± 0.033	5.069GlnLeu: 5.069 ± 0.087	0.971GlnMet: 0.971 ± 0.029	1.046GlnAsn: 1.046 ± 0.032	2.377GlnPro: 2.377 ± 0.046	2.461GlnGln: 2.461 ± 0.051	4.186GlnArg: 4.186 ± 0.068	2.3GlnSer: 2.3 ± 0.048	2.201GlnThr: 2.201 ± 0.045	3.176GlnVal: 3.176 ± 0.049	0.745GlnTrp: 0.745 ± 0.025	0.853GlnTyr: 0.853 ± 0.027	0.0GlnXaa: 0.0 ± 0.0
Arg	7.141ArgAla: 7.141 ± 0.1	0.651ArgCys: 0.651 ± 0.025	4.199ArgAsp: 4.199 ± 0.064	4.399ArgGlu: 4.399 ± 0.074	2.743ArgPhe: 2.743 ± 0.051	4.53ArgGly: 4.53 ± 0.063	1.891ArgHis: 1.891 ± 0.041	3.786ArgIle: 3.786 ± 0.06	2.095ArgLys: 2.095 ± 0.052	7.806ArgLeu: 7.806 ± 0.1	1.841ArgMet: 1.841 ± 0.042	1.971ArgAsn: 1.971 ± 0.045	2.859ArgPro: 2.859 ± 0.048	3.341ArgGln: 3.341 ± 0.057	4.952ArgArg: 4.952 ± 0.073	3.651ArgSer: 3.651 ± 0.066	2.681ArgThr: 2.681 ± 0.044	4.838ArgVal: 4.838 ± 0.076	1.269ArgTrp: 1.269 ± 0.037	2.325ArgTyr: 2.325 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	7.125SerAla: 7.125 ± 0.078	0.536SerCys: 0.536 ± 0.023	3.538SerAsp: 3.538 ± 0.073	3.138SerGlu: 3.138 ± 0.058	2.149SerPhe: 2.149 ± 0.048	5.528SerGly: 5.528 ± 0.09	1.275SerHis: 1.275 ± 0.035	2.529SerIle: 2.529 ± 0.05	1.582SerLys: 1.582 ± 0.037	6.209SerLeu: 6.209 ± 0.077	1.477SerMet: 1.477 ± 0.04	1.742SerAsn: 1.742 ± 0.047	2.808SerPro: 2.808 ± 0.06	2.382SerGln: 2.382 ± 0.048	3.768SerArg: 3.768 ± 0.058	3.562SerSer: 3.562 ± 0.083	2.836SerThr: 2.836 ± 0.065	4.203SerVal: 4.203 ± 0.073	0.917SerTrp: 0.917 ± 0.03	1.465SerTyr: 1.465 ± 0.042	0.0SerXaa: 0.0 ± 0.0
Thr	5.36ThrAla: 5.36 ± 0.08	0.426ThrCys: 0.426 ± 0.019	2.602ThrAsp: 2.602 ± 0.059	2.193ThrGlu: 2.193 ± 0.043	1.467ThrPhe: 1.467 ± 0.034	3.993ThrGly: 3.993 ± 0.062	1.177ThrHis: 1.177 ± 0.032	2.057ThrIle: 2.057 ± 0.049	0.949ThrLys: 0.949 ± 0.032	6.122ThrLeu: 6.122 ± 0.086	0.885ThrMet: 0.885 ± 0.029	1.158ThrAsn: 1.158 ± 0.036	3.175ThrPro: 3.175 ± 0.064	2.122ThrGln: 2.122 ± 0.046	3.275ThrArg: 3.275 ± 0.055	2.59ThrSer: 2.59 ± 0.05	2.529ThrThr: 2.529 ± 0.057	3.403ThrVal: 3.403 ± 0.063	0.646ThrTrp: 0.646 ± 0.028	1.162ThrTyr: 1.162 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	8.036ValAla: 8.036 ± 0.092	0.789ValCys: 0.789 ± 0.03	4.471ValAsp: 4.471 ± 0.069	4.24ValGlu: 4.24 ± 0.067	2.677ValPhe: 2.677 ± 0.052	5.041ValGly: 5.041 ± 0.071	1.539ValHis: 1.539 ± 0.04	3.649ValIle: 3.649 ± 0.057	1.826ValLys: 1.826 ± 0.044	7.836ValLeu: 7.836 ± 0.096	1.75ValMet: 1.75 ± 0.044	2.194ValAsn: 2.194 ± 0.044	3.302ValPro: 3.302 ± 0.056	2.463ValGln: 2.463 ± 0.053	4.627ValArg: 4.627 ± 0.07	4.488ValSer: 4.488 ± 0.069	3.5ValThr: 3.5 ± 0.062	5.606ValVal: 5.606 ± 0.086	0.913ValTrp: 0.913 ± 0.028	1.646ValTyr: 1.646 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	1.349TrpAla: 1.349 ± 0.043	0.166TrpCys: 0.166 ± 0.012	0.754TrpAsp: 0.754 ± 0.029	0.56TrpGlu: 0.56 ± 0.022	0.574TrpPhe: 0.574 ± 0.023	0.916TrpGly: 0.916 ± 0.028	0.416TrpHis: 0.416 ± 0.021	0.637TrpIle: 0.637 ± 0.022	0.361TrpLys: 0.361 ± 0.017	2.133TrpLeu: 2.133 ± 0.055	0.436TrpMet: 0.436 ± 0.019	0.424TrpAsn: 0.424 ± 0.02	0.805TrpPro: 0.805 ± 0.029	0.91TrpGln: 0.91 ± 0.03	1.237TrpArg: 1.237 ± 0.038	0.947TrpSer: 0.947 ± 0.029	0.702TrpThr: 0.702 ± 0.031	0.978TrpVal: 0.978 ± 0.032	0.257TrpTrp: 0.257 ± 0.016	0.359TrpTyr: 0.359 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.817TyrAla: 2.817 ± 0.057	0.287TyrCys: 0.287 ± 0.016	1.524TyrAsp: 1.524 ± 0.042	1.246TyrGlu: 1.246 ± 0.033	1.061TyrPhe: 1.061 ± 0.035	1.991TyrGly: 1.991 ± 0.046	0.567TyrHis: 0.567 ± 0.024	0.951TyrIle: 0.951 ± 0.032	0.663TyrLys: 0.663 ± 0.027	2.75TyrLeu: 2.75 ± 0.052	0.48TyrMet: 0.48 ± 0.021	0.804TyrAsn: 0.804 ± 0.031	1.236TyrPro: 1.236 ± 0.039	1.192TyrGln: 1.192 ± 0.036	2.081TyrArg: 2.081 ± 0.044	1.44TyrSer: 1.44 ± 0.038	1.245TyrThr: 1.245 ± 0.031	1.631TyrVal: 1.631 ± 0.037	0.403TyrTrp: 0.403 ± 0.019	0.706TyrTyr: 0.706 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3284 proteins (1129603 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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