Amino acid dipepetide frequency for Streptomyces gilvigriseus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
26.392AlaAla: 26.392 ± 0.265
1.08AlaCys: 1.08 ± 0.029
8.814AlaAsp: 8.814 ± 0.093
9.469AlaGlu: 9.469 ± 0.124
3.616AlaPhe: 3.616 ± 0.046
14.168AlaGly: 14.168 ± 0.125
2.88AlaHis: 2.88 ± 0.047
3.545AlaIle: 3.545 ± 0.053
3.135AlaLys: 3.135 ± 0.067
15.122AlaLeu: 15.122 ± 0.137
2.607AlaMet: 2.607 ± 0.043
2.075AlaAsn: 2.075 ± 0.045
7.987AlaPro: 7.987 ± 0.116
3.699AlaGln: 3.699 ± 0.055
10.86AlaArg: 10.86 ± 0.121
6.532AlaSer: 6.532 ± 0.084
6.868AlaThr: 6.868 ± 0.088
13.161AlaVal: 13.161 ± 0.128
2.032AlaTrp: 2.032 ± 0.045
2.525AlaTyr: 2.525 ± 0.039
0.0AlaXaa: 0.0 ± 0.0
Cys
1.063CysAla: 1.063 ± 0.025
0.081CysCys: 0.081 ± 0.008
0.384CysAsp: 0.384 ± 0.017
0.33CysGlu: 0.33 ± 0.016
0.185CysPhe: 0.185 ± 0.01
1.017CysGly: 1.017 ± 0.031
0.187CysHis: 0.187 ± 0.012
0.169CysIle: 0.169 ± 0.01
0.096CysLys: 0.096 ± 0.008
0.673CysLeu: 0.673 ± 0.022
0.125CysMet: 0.125 ± 0.01
0.123CysAsn: 0.123 ± 0.009
0.492CysPro: 0.492 ± 0.02
0.142CysGln: 0.142 ± 0.009
0.631CysArg: 0.631 ± 0.022
0.428CysSer: 0.428 ± 0.018
0.517CysThr: 0.517 ± 0.021
0.541CysVal: 0.541 ± 0.022
0.132CysTrp: 0.132 ± 0.009
0.155CysTyr: 0.155 ± 0.011
0.0CysXaa: 0.0 ± 0.0
Asp
8.585AspAla: 8.585 ± 0.098
0.367AspCys: 0.367 ± 0.017
3.348AspAsp: 3.348 ± 0.059
3.572AspGlu: 3.572 ± 0.058
1.457AspPhe: 1.457 ± 0.033
6.98AspGly: 6.98 ± 0.086
1.302AspHis: 1.302 ± 0.031
1.658AspIle: 1.658 ± 0.038
1.021AspLys: 1.021 ± 0.031
5.839AspLeu: 5.839 ± 0.067
0.697AspMet: 0.697 ± 0.025
0.914AspAsn: 0.914 ± 0.03
4.702AspPro: 4.702 ± 0.065
1.458AspGln: 1.458 ± 0.038
4.728AspArg: 4.728 ± 0.073
2.217AspSer: 2.217 ± 0.041
2.825AspThr: 2.825 ± 0.054
4.193AspVal: 4.193 ± 0.062
0.901AspTrp: 0.901 ± 0.028
1.09AspTyr: 1.09 ± 0.035
0.0AspXaa: 0.0 ± 0.0
Glu
7.665GluAla: 7.665 ± 0.105
0.338GluCys: 0.338 ± 0.018
2.76GluAsp: 2.76 ± 0.046
3.567GluGlu: 3.567 ± 0.07
1.396GluPhe: 1.396 ± 0.031
4.069GluGly: 4.069 ± 0.061
1.459GluHis: 1.459 ± 0.03
1.954GluIle: 1.954 ± 0.041
1.294GluLys: 1.294 ± 0.04
6.554GluLeu: 6.554 ± 0.093
0.875GluMet: 0.875 ± 0.026
0.927GluAsn: 0.927 ± 0.026
3.256GluPro: 3.256 ± 0.053
2.2GluGln: 2.2 ± 0.045
5.46GluArg: 5.46 ± 0.081
2.294GluSer: 2.294 ± 0.04
2.52GluThr: 2.52 ± 0.046
4.422GluVal: 4.422 ± 0.064
0.775GluTrp: 0.775 ± 0.027
1.01GluTyr: 1.01 ± 0.028
0.0GluXaa: 0.0 ± 0.0
Phe
3.703PheAla: 3.703 ± 0.057
0.243PheCys: 0.243 ± 0.013
1.843PheAsp: 1.843 ± 0.041
1.277PheGlu: 1.277 ± 0.036
0.797PhePhe: 0.797 ± 0.029
2.98PheGly: 2.98 ± 0.053
0.569PheHis: 0.569 ± 0.018
0.654PheIle: 0.654 ± 0.023
0.486PheLys: 0.486 ± 0.021
2.531PheLeu: 2.531 ± 0.049
0.383PheMet: 0.383 ± 0.017
0.563PheAsn: 0.563 ± 0.021
1.309PhePro: 1.309 ± 0.035
0.634PheGln: 0.634 ± 0.024
1.834PheArg: 1.834 ± 0.037
1.361PheSer: 1.361 ± 0.034
1.888PheThr: 1.888 ± 0.044
2.089PheVal: 2.089 ± 0.041
0.418PheTrp: 0.418 ± 0.02
0.549PheTyr: 0.549 ± 0.025
0.0PheXaa: 0.0 ± 0.0
Gly
12.417GlyAla: 12.417 ± 0.124
0.865GlyCys: 0.865 ± 0.023
5.149GlyAsp: 5.149 ± 0.06
4.921GlyGlu: 4.921 ± 0.069
2.819GlyPhe: 2.819 ± 0.046
9.967GlyGly: 9.967 ± 0.127
2.205GlyHis: 2.205 ± 0.039
3.422GlyIle: 3.422 ± 0.049
2.361GlyLys: 2.361 ± 0.049
9.657GlyLeu: 9.657 ± 0.103
2.114GlyMet: 2.114 ± 0.038
1.845GlyAsn: 1.845 ± 0.049
5.389GlyPro: 5.389 ± 0.073
2.637GlyGln: 2.637 ± 0.05
8.351GlyArg: 8.351 ± 0.083
5.698GlySer: 5.698 ± 0.074
6.183GlyThr: 6.183 ± 0.081
7.325GlyVal: 7.325 ± 0.082
1.777GlyTrp: 1.777 ± 0.04
2.309GlyTyr: 2.309 ± 0.045
0.0GlyXaa: 0.0 ± 0.0
His
2.868HisAla: 2.868 ± 0.049
0.199HisCys: 0.199 ± 0.011
1.225HisAsp: 1.225 ± 0.03
1.031HisGlu: 1.031 ± 0.03
0.573HisPhe: 0.573 ± 0.019
2.393HisGly: 2.393 ± 0.043
0.701HisHis: 0.701 ± 0.027
0.627HisIle: 0.627 ± 0.021
0.32HisLys: 0.32 ± 0.014
2.517HisLeu: 2.517 ± 0.045
0.304HisMet: 0.304 ± 0.015
0.405HisAsn: 0.405 ± 0.017
1.877HisPro: 1.877 ± 0.034
0.701HisGln: 0.701 ± 0.02
2.239HisArg: 2.239 ± 0.041
0.906HisSer: 0.906 ± 0.025
1.24HisThr: 1.24 ± 0.033
1.426HisVal: 1.426 ± 0.033
0.368HisTrp: 0.368 ± 0.018
0.498HisTyr: 0.498 ± 0.017
0.0HisXaa: 0.0 ± 0.0
Ile
4.796IleAla: 4.796 ± 0.061
0.26IleCys: 0.26 ± 0.014
2.142IleAsp: 2.142 ± 0.04
1.764IleGlu: 1.764 ± 0.042
0.703IlePhe: 0.703 ± 0.027
3.57IleGly: 3.57 ± 0.063
0.599IleHis: 0.599 ± 0.02
0.919IleIle: 0.919 ± 0.031
0.726IleLys: 0.726 ± 0.022
2.352IleLeu: 2.352 ± 0.047
0.413IleMet: 0.413 ± 0.018
0.71IleAsn: 0.71 ± 0.026
1.822IlePro: 1.822 ± 0.035
0.696IleGln: 0.696 ± 0.022
2.168IleArg: 2.168 ± 0.043
1.536IleSer: 1.536 ± 0.033
2.123IleThr: 2.123 ± 0.046
2.675IleVal: 2.675 ± 0.046
0.341IleTrp: 0.341 ± 0.017
0.54IleTyr: 0.54 ± 0.024
0.0IleXaa: 0.0 ± 0.0
Lys
2.922LysAla: 2.922 ± 0.063
0.105LysCys: 0.105 ± 0.009
1.241LysAsp: 1.241 ± 0.035
1.087LysGlu: 1.087 ± 0.034
0.418LysPhe: 0.418 ± 0.019
1.757LysGly: 1.757 ± 0.042
0.46LysHis: 0.46 ± 0.02
0.805LysIle: 0.805 ± 0.025
0.867LysLys: 0.867 ± 0.042
1.983LysLeu: 1.983 ± 0.042
0.406LysMet: 0.406 ± 0.021
0.537LysAsn: 0.537 ± 0.024
1.366LysPro: 1.366 ± 0.035
0.8LysGln: 0.8 ± 0.026
1.475LysArg: 1.475 ± 0.035
1.168LysSer: 1.168 ± 0.036
1.219LysThr: 1.219 ± 0.037
1.778LysVal: 1.778 ± 0.043
0.238LysTrp: 0.238 ± 0.014
0.455LysTyr: 0.455 ± 0.02
0.0LysXaa: 0.0 ± 0.0
Leu
16.344LeuAla: 16.344 ± 0.137
0.77LeuCys: 0.77 ± 0.024
6.584LeuAsp: 6.584 ± 0.079
4.832LeuGlu: 4.832 ± 0.059
2.465LeuPhe: 2.465 ± 0.046
9.604LeuGly: 9.604 ± 0.097
2.327LeuHis: 2.327 ± 0.037
3.204LeuIle: 3.204 ± 0.056
2.035LeuLys: 2.035 ± 0.05
11.373LeuLeu: 11.373 ± 0.13
1.655LeuMet: 1.655 ± 0.032
1.756LeuAsn: 1.756 ± 0.039
6.565LeuPro: 6.565 ± 0.073
2.344LeuGln: 2.344 ± 0.047
8.637LeuArg: 8.637 ± 0.105
4.807LeuSer: 4.807 ± 0.07
6.425LeuThr: 6.425 ± 0.077
8.683LeuVal: 8.683 ± 0.095
1.302LeuTrp: 1.302 ± 0.031
1.783LeuTyr: 1.783 ± 0.033
0.0LeuXaa: 0.0 ± 0.0
Met
2.316MetAla: 2.316 ± 0.038
0.123MetCys: 0.123 ± 0.01
0.908MetAsp: 0.908 ± 0.028
0.715MetGlu: 0.715 ± 0.026
0.464MetPhe: 0.464 ± 0.019
1.348MetGly: 1.348 ± 0.037
0.363MetHis: 0.363 ± 0.017
0.652MetIle: 0.652 ± 0.021
0.376MetLys: 0.376 ± 0.017
1.804MetLeu: 1.804 ± 0.043
0.3MetMet: 0.3 ± 0.015
0.387MetAsn: 0.387 ± 0.017
1.224MetPro: 1.224 ± 0.03
0.459MetGln: 0.459 ± 0.018
1.553MetArg: 1.553 ± 0.032
1.228MetSer: 1.228 ± 0.031
1.372MetThr: 1.372 ± 0.03
1.408MetVal: 1.408 ± 0.038
0.204MetTrp: 0.204 ± 0.013
0.308MetTyr: 0.308 ± 0.013
0.0MetXaa: 0.0 ± 0.0
Asn
2.347AsnAla: 2.347 ± 0.043
0.158AsnCys: 0.158 ± 0.013
0.906AsnAsp: 0.906 ± 0.029
0.739AsnGlu: 0.739 ± 0.026
0.445AsnPhe: 0.445 ± 0.02
2.018AsnGly: 2.018 ± 0.043
0.395AsnHis: 0.395 ± 0.016
0.632AsnIle: 0.632 ± 0.024
0.411AsnLys: 0.411 ± 0.018
1.848AsnLeu: 1.848 ± 0.041
0.293AsnMet: 0.293 ± 0.015
0.409AsnAsn: 0.409 ± 0.018
1.516AsnPro: 1.516 ± 0.037
0.55AsnGln: 0.55 ± 0.024
1.3AsnArg: 1.3 ± 0.03
0.941AsnSer: 0.941 ± 0.026
1.092AsnThr: 1.092 ± 0.031
1.254AsnVal: 1.254 ± 0.032
0.302AsnTrp: 0.302 ± 0.015
0.45AsnTyr: 0.45 ± 0.021
0.0AsnXaa: 0.0 ± 0.0
Pro
9.475ProAla: 9.475 ± 0.124
0.325ProCys: 0.325 ± 0.014
4.426ProAsp: 4.426 ± 0.062
4.477ProGlu: 4.477 ± 0.07
1.532ProPhe: 1.532 ± 0.03
6.782ProGly: 6.782 ± 0.09
1.414ProHis: 1.414 ± 0.039
1.436ProIle: 1.436 ± 0.028
1.217ProLys: 1.217 ± 0.038
5.32ProLeu: 5.32 ± 0.072
1.081ProMet: 1.081 ± 0.029
1.035ProAsn: 1.035 ± 0.026
3.595ProPro: 3.595 ± 0.074
1.846ProGln: 1.846 ± 0.054
4.24ProArg: 4.24 ± 0.068
3.582ProSer: 3.582 ± 0.062
3.193ProThr: 3.193 ± 0.057
5.208ProVal: 5.208 ± 0.064
0.919ProTrp: 0.919 ± 0.026
1.233ProTyr: 1.233 ± 0.031
0.0ProXaa: 0.0 ± 0.0
Gln
3.809GlnAla: 3.809 ± 0.059
0.164GlnCys: 0.164 ± 0.011
1.332GlnAsp: 1.332 ± 0.037
1.37GlnGlu: 1.37 ± 0.037
0.662GlnPhe: 0.662 ± 0.024
2.219GlnGly: 2.219 ± 0.047
0.663GlnHis: 0.663 ± 0.022
1.092GlnIle: 1.092 ± 0.031
0.64GlnLys: 0.64 ± 0.025
3.235GlnLeu: 3.235 ± 0.054
0.528GlnMet: 0.528 ± 0.021
0.545GlnAsn: 0.545 ± 0.022
1.722GlnPro: 1.722 ± 0.046
1.521GlnGln: 1.521 ± 0.049
2.391GlnArg: 2.391 ± 0.045
1.229GlnSer: 1.229 ± 0.032
1.296GlnThr: 1.296 ± 0.031
2.384GlnVal: 2.384 ± 0.041
0.45GlnTrp: 0.45 ± 0.017
0.664GlnTyr: 0.664 ± 0.026
0.0GlnXaa: 0.0 ± 0.0
Arg
10.621ArgAla: 10.621 ± 0.124
0.597ArgCys: 0.597 ± 0.023
4.036ArgAsp: 4.036 ± 0.063
4.629ArgGlu: 4.629 ± 0.069
2.299ArgPhe: 2.299 ± 0.044
6.285ArgGly: 6.285 ± 0.08
2.05ArgHis: 2.05 ± 0.041
3.447ArgIle: 3.447 ± 0.053
1.587ArgLys: 1.587 ± 0.041
9.153ArgLeu: 9.153 ± 0.101
1.898ArgMet: 1.898 ± 0.036
1.405ArgAsn: 1.405 ± 0.029
5.239ArgPro: 5.239 ± 0.071
2.315ArgGln: 2.315 ± 0.044
8.469ArgArg: 8.469 ± 0.104
3.908ArgSer: 3.908 ± 0.05
5.077ArgThr: 5.077 ± 0.062
5.799ArgVal: 5.799 ± 0.065
1.374ArgTrp: 1.374 ± 0.032
1.738ArgTyr: 1.738 ± 0.041
0.0ArgXaa: 0.0 ± 0.0
Ser
7.182SerAla: 7.182 ± 0.078
0.366SerCys: 0.366 ± 0.015
2.619SerAsp: 2.619 ± 0.05
2.212SerGlu: 2.212 ± 0.044
1.405SerPhe: 1.405 ± 0.034
6.263SerGly: 6.263 ± 0.082
0.975SerHis: 0.975 ± 0.024
1.418SerIle: 1.418 ± 0.039
1.043SerLys: 1.043 ± 0.03
4.35SerLeu: 4.35 ± 0.061
1.018SerMet: 1.018 ± 0.027
0.948SerAsn: 0.948 ± 0.029
3.117SerPro: 3.117 ± 0.053
1.21SerGln: 1.21 ± 0.03
3.494SerArg: 3.494 ± 0.049
3.072SerSer: 3.072 ± 0.069
3.151SerThr: 3.151 ± 0.061
3.862SerVal: 3.862 ± 0.058
0.864SerTrp: 0.864 ± 0.023
1.112SerTyr: 1.112 ± 0.035
0.0SerXaa: 0.0 ± 0.0
Thr
9.129ThrAla: 9.129 ± 0.097
0.386ThrCys: 0.386 ± 0.017
3.251ThrAsp: 3.251 ± 0.055
2.707ThrGlu: 2.707 ± 0.047
1.456ThrPhe: 1.456 ± 0.038
6.339ThrGly: 6.339 ± 0.085
1.129ThrHis: 1.129 ± 0.028
1.615ThrIle: 1.615 ± 0.041
1.087ThrLys: 1.087 ± 0.033
5.485ThrLeu: 5.485 ± 0.075
0.896ThrMet: 0.896 ± 0.029
0.968ThrAsn: 0.968 ± 0.029
3.904ThrPro: 3.904 ± 0.062
1.29ThrGln: 1.29 ± 0.035
3.777ThrArg: 3.777 ± 0.053
2.969ThrSer: 2.969 ± 0.057
3.556ThrThr: 3.556 ± 0.083
5.824ThrVal: 5.824 ± 0.075
0.805ThrTrp: 0.805 ± 0.029
1.149ThrTyr: 1.149 ± 0.038
0.0ThrXaa: 0.0 ± 0.0
Val
10.757ValAla: 10.757 ± 0.099
0.694ValCys: 0.694 ± 0.022
4.854ValAsp: 4.854 ± 0.073
4.462ValGlu: 4.462 ± 0.068
2.276ValPhe: 2.276 ± 0.044
6.62ValGly: 6.62 ± 0.073
1.923ValHis: 1.923 ± 0.037
2.565ValIle: 2.565 ± 0.045
1.661ValLys: 1.661 ± 0.037
9.752ValLeu: 9.752 ± 0.096
1.361ValMet: 1.361 ± 0.03
1.621ValAsn: 1.621 ± 0.034
5.312ValPro: 5.312 ± 0.069
2.059ValGln: 2.059 ± 0.044
7.046ValArg: 7.046 ± 0.082
3.901ValSer: 3.901 ± 0.051
4.855ValThr: 4.855 ± 0.068
7.544ValVal: 7.544 ± 0.09
1.129ValTrp: 1.129 ± 0.028
1.497ValTyr: 1.497 ± 0.034
0.0ValXaa: 0.0 ± 0.0
Trp
1.686TrpAla: 1.686 ± 0.036
0.163TrpCys: 0.163 ± 0.011
0.768TrpAsp: 0.768 ± 0.024
0.655TrpGlu: 0.655 ± 0.022
0.516TrpPhe: 0.516 ± 0.022
1.037TrpGly: 1.037 ± 0.033
0.417TrpHis: 0.417 ± 0.017
0.551TrpIle: 0.551 ± 0.021
0.362TrpLys: 0.362 ± 0.016
1.695TrpLeu: 1.695 ± 0.037
0.315TrpMet: 0.315 ± 0.014
0.376TrpAsn: 0.376 ± 0.018
0.814TrpPro: 0.814 ± 0.023
0.625TrpGln: 0.625 ± 0.021
1.364TrpArg: 1.364 ± 0.035
0.919TrpSer: 0.919 ± 0.024
1.092TrpThr: 1.092 ± 0.026
0.987TrpVal: 0.987 ± 0.032
0.376TrpTrp: 0.376 ± 0.018
0.344TrpTyr: 0.344 ± 0.016
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.493TyrAla: 2.493 ± 0.048
0.185TyrCys: 0.185 ± 0.013
1.264TyrAsp: 1.264 ± 0.045
0.977TyrGlu: 0.977 ± 0.028
0.627TyrPhe: 0.627 ± 0.021
1.996TyrGly: 1.996 ± 0.038
0.402TyrHis: 0.402 ± 0.017
0.492TyrIle: 0.492 ± 0.019
0.359TyrLys: 0.359 ± 0.016
2.251TyrLeu: 2.251 ± 0.045
0.243TyrMet: 0.243 ± 0.013
0.459TyrAsn: 0.459 ± 0.023
1.129TyrPro: 1.129 ± 0.033
0.729TyrGln: 0.729 ± 0.024
1.912TyrArg: 1.912 ± 0.038
0.982TyrSer: 0.982 ± 0.027
1.228TyrThr: 1.228 ± 0.039
1.325TyrVal: 1.325 ± 0.031
0.353TyrTrp: 0.353 ± 0.019
0.479TyrTyr: 0.479 ± 0.019
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4337 proteins (1434332 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski