Amino acid dipepetide frequency for Streptomyces netropsis (Streptoverticillium netropsis)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	22.487AlaAla: 22.487 ± 0.187	1.148AlaCys: 1.148 ± 0.024	8.606AlaAsp: 8.606 ± 0.087	9.08AlaGlu: 9.08 ± 0.109	3.563AlaPhe: 3.563 ± 0.047	13.534AlaGly: 13.534 ± 0.097	3.016AlaHis: 3.016 ± 0.038	3.296AlaIle: 3.296 ± 0.048	3.158AlaLys: 3.158 ± 0.066	14.966AlaLeu: 14.966 ± 0.112	2.543AlaMet: 2.543 ± 0.04	1.866AlaAsn: 1.866 ± 0.033	7.777AlaPro: 7.777 ± 0.103	3.532AlaGln: 3.532 ± 0.048	10.846AlaArg: 10.846 ± 0.096	5.657AlaSer: 5.657 ± 0.056	7.156AlaThr: 7.156 ± 0.065	12.518AlaVal: 12.518 ± 0.106	1.854AlaTrp: 1.854 ± 0.033	2.716AlaTyr: 2.716 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	1.214CysAla: 1.214 ± 0.03	0.096CysCys: 0.096 ± 0.007	0.504CysAsp: 0.504 ± 0.016	0.415CysGlu: 0.415 ± 0.013	0.22CysPhe: 0.22 ± 0.012	0.999CysGly: 0.999 ± 0.022	0.186CysHis: 0.186 ± 0.01	0.149CysIle: 0.149 ± 0.009	0.125CysLys: 0.125 ± 0.009	0.768CysLeu: 0.768 ± 0.021	0.121CysMet: 0.121 ± 0.007	0.124CysAsn: 0.124 ± 0.008	0.509CysPro: 0.509 ± 0.017	0.173CysGln: 0.173 ± 0.009	0.662CysArg: 0.662 ± 0.018	0.44CysSer: 0.44 ± 0.017	0.492CysThr: 0.492 ± 0.02	0.706CysVal: 0.706 ± 0.019	0.127CysTrp: 0.127 ± 0.008	0.157CysTyr: 0.157 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	7.981AspAla: 7.981 ± 0.077	0.462AspCys: 0.462 ± 0.016	3.578AspAsp: 3.578 ± 0.047	3.781AspGlu: 3.781 ± 0.043	1.655AspPhe: 1.655 ± 0.028	6.464AspGly: 6.464 ± 0.069	1.436AspHis: 1.436 ± 0.03	1.897AspIle: 1.897 ± 0.034	1.264AspLys: 1.264 ± 0.032	5.952AspLeu: 5.952 ± 0.054	0.783AspMet: 0.783 ± 0.022	0.898AspAsn: 0.898 ± 0.024	4.573AspPro: 4.573 ± 0.056	1.402AspGln: 1.402 ± 0.027	5.194AspArg: 5.194 ± 0.058	2.404AspSer: 2.404 ± 0.034	3.148AspThr: 3.148 ± 0.043	4.579AspVal: 4.579 ± 0.052	0.986AspTrp: 0.986 ± 0.024	1.113AspTyr: 1.113 ± 0.024	0.0AspXaa: 0.0 ± 0.0
Glu	7.525GluAla: 7.525 ± 0.087	0.39GluCys: 0.39 ± 0.016	2.798GluAsp: 2.798 ± 0.041	3.615GluGlu: 3.615 ± 0.063	1.424GluPhe: 1.424 ± 0.029	4.407GluGly: 4.407 ± 0.045	1.458GluHis: 1.458 ± 0.028	2.19GluIle: 2.19 ± 0.041	1.487GluLys: 1.487 ± 0.035	6.952GluLeu: 6.952 ± 0.068	0.829GluMet: 0.829 ± 0.023	0.959GluAsn: 0.959 ± 0.025	3.475GluPro: 3.475 ± 0.051	2.124GluGln: 2.124 ± 0.038	5.69GluArg: 5.69 ± 0.064	2.52GluSer: 2.52 ± 0.035	2.854GluThr: 2.854 ± 0.042	4.318GluVal: 4.318 ± 0.051	0.734GluTrp: 0.734 ± 0.019	1.027GluTyr: 1.027 ± 0.023	0.0GluXaa: 0.0 ± 0.0
Phe	3.816PheAla: 3.816 ± 0.047	0.273PheCys: 0.273 ± 0.011	1.987PheAsp: 1.987 ± 0.035	1.428PheGlu: 1.428 ± 0.027	0.91PhePhe: 0.91 ± 0.025	2.986PheGly: 2.986 ± 0.038	0.656PheHis: 0.656 ± 0.022	0.743PheIle: 0.743 ± 0.02	0.488PheLys: 0.488 ± 0.017	2.56PheLeu: 2.56 ± 0.047	0.407PheMet: 0.407 ± 0.013	0.523PheAsn: 0.523 ± 0.016	1.439PhePro: 1.439 ± 0.025	0.648PheGln: 0.648 ± 0.019	1.83PheArg: 1.83 ± 0.032	1.435PheSer: 1.435 ± 0.027	2.021PheThr: 2.021 ± 0.036	2.161PheVal: 2.161 ± 0.039	0.425PheTrp: 0.425 ± 0.015	0.538PheTyr: 0.538 ± 0.017	0.0PheXaa: 0.0 ± 0.0
Gly	11.383GlyAla: 11.383 ± 0.085	0.871GlyCys: 0.871 ± 0.023	5.272GlyAsp: 5.272 ± 0.053	5.137GlyGlu: 5.137 ± 0.056	2.931GlyPhe: 2.931 ± 0.045	9.222GlyGly: 9.222 ± 0.104	2.517GlyHis: 2.517 ± 0.045	3.388GlyIle: 3.388 ± 0.043	2.665GlyLys: 2.665 ± 0.053	9.483GlyLeu: 9.483 ± 0.082	2.062GlyMet: 2.062 ± 0.034	1.668GlyAsn: 1.668 ± 0.036	5.71GlyPro: 5.71 ± 0.069	2.642GlyGln: 2.642 ± 0.038	8.132GlyArg: 8.132 ± 0.077	5.338GlySer: 5.338 ± 0.068	6.43GlyThr: 6.43 ± 0.068	7.471GlyVal: 7.471 ± 0.074	1.626GlyTrp: 1.626 ± 0.031	2.216GlyTyr: 2.216 ± 0.037	0.0GlyXaa: 0.0 ± 0.0
His	2.744HisAla: 2.744 ± 0.039	0.221HisCys: 0.221 ± 0.012	1.386HisAsp: 1.386 ± 0.028	1.21HisGlu: 1.21 ± 0.025	0.659HisPhe: 0.659 ± 0.019	2.47HisGly: 2.47 ± 0.035	0.724HisHis: 0.724 ± 0.021	0.693HisIle: 0.693 ± 0.019	0.363HisLys: 0.363 ± 0.016	2.44HisLeu: 2.44 ± 0.039	0.35HisMet: 0.35 ± 0.015	0.363HisAsn: 0.363 ± 0.024	1.888HisPro: 1.888 ± 0.037	0.638HisGln: 0.638 ± 0.017	2.162HisArg: 2.162 ± 0.038	1.07HisSer: 1.07 ± 0.025	1.406HisThr: 1.406 ± 0.031	1.668HisVal: 1.668 ± 0.029	0.374HisTrp: 0.374 ± 0.015	0.474HisTyr: 0.474 ± 0.016	0.0HisXaa: 0.0 ± 0.0
Ile	4.717IleAla: 4.717 ± 0.059	0.288IleCys: 0.288 ± 0.012	2.133IleAsp: 2.133 ± 0.033	1.977IleGlu: 1.977 ± 0.03	0.672IlePhe: 0.672 ± 0.02	3.557IleGly: 3.557 ± 0.043	0.594IleHis: 0.594 ± 0.017	0.855IleIle: 0.855 ± 0.024	0.766IleLys: 0.766 ± 0.021	2.194IleLeu: 2.194 ± 0.036	0.446IleMet: 0.446 ± 0.018	0.656IleAsn: 0.656 ± 0.021	1.754IlePro: 1.754 ± 0.032	0.676IleGln: 0.676 ± 0.018	2.13IleArg: 2.13 ± 0.034	1.629IleSer: 1.629 ± 0.031	2.137IleThr: 2.137 ± 0.036	2.66IleVal: 2.66 ± 0.043	0.362IleTrp: 0.362 ± 0.012	0.48IleTyr: 0.48 ± 0.016	0.0IleXaa: 0.0 ± 0.0
Lys	3.174LysAla: 3.174 ± 0.058	0.13LysCys: 0.13 ± 0.008	1.448LysAsp: 1.448 ± 0.038	1.207LysGlu: 1.207 ± 0.033	0.463LysPhe: 0.463 ± 0.018	1.957LysGly: 1.957 ± 0.04	0.425LysHis: 0.425 ± 0.016	0.877LysIle: 0.877 ± 0.024	0.998LysLys: 0.998 ± 0.034	2.031LysLeu: 2.031 ± 0.036	0.413LysMet: 0.413 ± 0.015	0.546LysAsn: 0.546 ± 0.019	1.489LysPro: 1.489 ± 0.041	0.729LysGln: 0.729 ± 0.021	1.498LysArg: 1.498 ± 0.031	1.19LysSer: 1.19 ± 0.029	1.299LysThr: 1.299 ± 0.028	1.927LysVal: 1.927 ± 0.04	0.272LysTrp: 0.272 ± 0.011	0.416LysTyr: 0.416 ± 0.014	0.0LysXaa: 0.0 ± 0.0
Leu	15.337LeuAla: 15.337 ± 0.123	0.893LeuCys: 0.893 ± 0.023	6.632LeuAsp: 6.632 ± 0.068	4.684LeuGlu: 4.684 ± 0.054	2.662LeuPhe: 2.662 ± 0.038	9.264LeuGly: 9.264 ± 0.068	2.26LeuHis: 2.26 ± 0.037	3.172LeuIle: 3.172 ± 0.049	1.985LeuLys: 1.985 ± 0.039	11.31LeuLeu: 11.31 ± 0.107	1.676LeuMet: 1.676 ± 0.033	1.575LeuAsn: 1.575 ± 0.029	6.768LeuPro: 6.768 ± 0.061	2.013LeuGln: 2.013 ± 0.036	9.024LeuArg: 9.024 ± 0.076	5.242LeuSer: 5.242 ± 0.057	6.751LeuThr: 6.751 ± 0.064	8.623LeuVal: 8.623 ± 0.083	1.283LeuTrp: 1.283 ± 0.029	1.792LeuTyr: 1.792 ± 0.03	0.0LeuXaa: 0.0 ± 0.0
Met	2.317MetAla: 2.317 ± 0.036	0.141MetCys: 0.141 ± 0.009	0.911MetAsp: 0.911 ± 0.022	0.744MetGlu: 0.744 ± 0.02	0.441MetPhe: 0.441 ± 0.017	1.352MetGly: 1.352 ± 0.031	0.339MetHis: 0.339 ± 0.013	0.651MetIle: 0.651 ± 0.019	0.422MetLys: 0.422 ± 0.014	1.668MetLeu: 1.668 ± 0.031	0.303MetMet: 0.303 ± 0.014	0.419MetAsn: 0.419 ± 0.014	1.139MetPro: 1.139 ± 0.023	0.405MetGln: 0.405 ± 0.014	1.452MetArg: 1.452 ± 0.027	1.298MetSer: 1.298 ± 0.026	1.502MetThr: 1.502 ± 0.035	1.303MetVal: 1.303 ± 0.024	0.215MetTrp: 0.215 ± 0.011	0.322MetTyr: 0.322 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	2.133AsnAla: 2.133 ± 0.037	0.146AsnCys: 0.146 ± 0.009	0.916AsnAsp: 0.916 ± 0.022	0.748AsnGlu: 0.748 ± 0.022	0.426AsnPhe: 0.426 ± 0.015	1.805AsnGly: 1.805 ± 0.042	0.37AsnHis: 0.37 ± 0.014	0.614AsnIle: 0.614 ± 0.019	0.436AsnLys: 0.436 ± 0.017	1.573AsnLeu: 1.573 ± 0.029	0.297AsnMet: 0.297 ± 0.013	0.374AsnAsn: 0.374 ± 0.013	1.294AsnPro: 1.294 ± 0.025	0.446AsnGln: 0.446 ± 0.017	1.211AsnArg: 1.211 ± 0.026	0.843AsnSer: 0.843 ± 0.023	1.016AsnThr: 1.016 ± 0.024	1.293AsnVal: 1.293 ± 0.029	0.264AsnTrp: 0.264 ± 0.012	0.395AsnTyr: 0.395 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	9.482ProAla: 9.482 ± 0.123	0.385ProCys: 0.385 ± 0.017	4.559ProAsp: 4.559 ± 0.051	4.35ProGlu: 4.35 ± 0.053	1.568ProPhe: 1.568 ± 0.027	7.187ProGly: 7.187 ± 0.083	1.465ProHis: 1.465 ± 0.027	1.214ProIle: 1.214 ± 0.024	1.3ProLys: 1.3 ± 0.03	5.563ProLeu: 5.563 ± 0.059	1.013ProMet: 1.013 ± 0.026	0.867ProAsn: 0.867 ± 0.024	3.819ProPro: 3.819 ± 0.087	1.788ProGln: 1.788 ± 0.039	4.286ProArg: 4.286 ± 0.047	3.179ProSer: 3.179 ± 0.053	3.222ProThr: 3.222 ± 0.05	5.755ProVal: 5.755 ± 0.072	0.922ProTrp: 0.922 ± 0.022	1.405ProTyr: 1.405 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	3.588GlnAla: 3.588 ± 0.052	0.16GlnCys: 0.16 ± 0.008	1.348GlnAsp: 1.348 ± 0.025	1.356GlnGlu: 1.356 ± 0.029	0.641GlnPhe: 0.641 ± 0.02	2.255GlnGly: 2.255 ± 0.036	0.634GlnHis: 0.634 ± 0.019	1.011GlnIle: 1.011 ± 0.02	0.576GlnLys: 0.576 ± 0.021	2.835GlnLeu: 2.835 ± 0.041	0.45GlnMet: 0.45 ± 0.018	0.454GlnAsn: 0.454 ± 0.017	1.685GlnPro: 1.685 ± 0.036	1.183GlnGln: 1.183 ± 0.036	2.393GlnArg: 2.393 ± 0.04	1.235GlnSer: 1.235 ± 0.025	1.173GlnThr: 1.173 ± 0.024	2.151GlnVal: 2.151 ± 0.037	0.446GlnTrp: 0.446 ± 0.017	0.538GlnTyr: 0.538 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	10.434ArgAla: 10.434 ± 0.078	0.63ArgCys: 0.63 ± 0.021	4.381ArgAsp: 4.381 ± 0.05	4.94ArgGlu: 4.94 ± 0.051	2.382ArgPhe: 2.382 ± 0.039	6.013ArgGly: 6.013 ± 0.057	2.207ArgHis: 2.207 ± 0.038	3.165ArgIle: 3.165 ± 0.04	1.736ArgLys: 1.736 ± 0.031	9.054ArgLeu: 9.054 ± 0.085	1.764ArgMet: 1.764 ± 0.03	1.326ArgAsn: 1.326 ± 0.027	5.347ArgPro: 5.347 ± 0.061	2.266ArgGln: 2.266 ± 0.033	7.652ArgArg: 7.652 ± 0.086	4.046ArgSer: 4.046 ± 0.052	5.606ArgThr: 5.606 ± 0.057	5.985ArgVal: 5.985 ± 0.062	1.405ArgTrp: 1.405 ± 0.031	1.78ArgTyr: 1.78 ± 0.031	0.0ArgXaa: 0.0 ± 0.0
Ser	6.815SerAla: 6.815 ± 0.064	0.401SerCys: 0.401 ± 0.015	2.54SerAsp: 2.54 ± 0.047	2.314SerGlu: 2.314 ± 0.039	1.557SerPhe: 1.557 ± 0.026	5.923SerGly: 5.923 ± 0.064	1.033SerHis: 1.033 ± 0.026	1.341SerIle: 1.341 ± 0.029	1.019SerLys: 1.019 ± 0.023	4.753SerLeu: 4.753 ± 0.055	1.016SerMet: 1.016 ± 0.026	0.779SerAsn: 0.779 ± 0.022	3.267SerPro: 3.267 ± 0.044	1.127SerGln: 1.127 ± 0.027	3.627SerArg: 3.627 ± 0.043	2.639SerSer: 2.639 ± 0.044	2.798SerThr: 2.798 ± 0.038	4.203SerVal: 4.203 ± 0.053	0.833SerTrp: 0.833 ± 0.023	1.155SerTyr: 1.155 ± 0.028	0.0SerXaa: 0.0 ± 0.0
Thr	9.075ThrAla: 9.075 ± 0.074	0.426ThrCys: 0.426 ± 0.015	3.633ThrAsp: 3.633 ± 0.052	3.173ThrGlu: 3.173 ± 0.047	1.555ThrPhe: 1.555 ± 0.028	6.953ThrGly: 6.953 ± 0.064	1.251ThrHis: 1.251 ± 0.026	1.591ThrIle: 1.591 ± 0.029	1.199ThrLys: 1.199 ± 0.028	5.607ThrLeu: 5.607 ± 0.062	0.892ThrMet: 0.892 ± 0.023	0.912ThrAsn: 0.912 ± 0.02	4.168ThrPro: 4.168 ± 0.051	1.215ThrGln: 1.215 ± 0.029	3.903ThrArg: 3.903 ± 0.045	2.968ThrSer: 2.968 ± 0.046	3.78ThrThr: 3.78 ± 0.064	5.965ThrVal: 5.965 ± 0.067	0.826ThrTrp: 0.826 ± 0.021	1.249ThrTyr: 1.249 ± 0.024	0.0ThrXaa: 0.0 ± 0.0
Val	10.709ValAla: 10.709 ± 0.081	0.781ValCys: 0.781 ± 0.021	4.8ValAsp: 4.8 ± 0.052	4.673ValGlu: 4.673 ± 0.053	2.423ValPhe: 2.423 ± 0.04	6.517ValGly: 6.517 ± 0.064	1.98ValHis: 1.98 ± 0.032	2.891ValIle: 2.891 ± 0.043	1.756ValLys: 1.756 ± 0.036	9.456ValLeu: 9.456 ± 0.093	1.455ValMet: 1.455 ± 0.027	1.574ValAsn: 1.574 ± 0.03	5.367ValPro: 5.367 ± 0.059	1.931ValGln: 1.931 ± 0.036	7.295ValArg: 7.295 ± 0.073	4.197ValSer: 4.197 ± 0.058	5.495ValThr: 5.495 ± 0.059	7.803ValVal: 7.803 ± 0.078	1.058ValTrp: 1.058 ± 0.023	1.489ValTyr: 1.489 ± 0.03	0.0ValXaa: 0.0 ± 0.0
Trp	1.669TrpAla: 1.669 ± 0.034	0.166TrpCys: 0.166 ± 0.01	0.802TrpAsp: 0.802 ± 0.018	0.706TrpGlu: 0.706 ± 0.019	0.517TrpPhe: 0.517 ± 0.017	1.069TrpGly: 1.069 ± 0.026	0.368TrpHis: 0.368 ± 0.012	0.483TrpIle: 0.483 ± 0.017	0.361TrpLys: 0.361 ± 0.015	1.726TrpLeu: 1.726 ± 0.034	0.274TrpMet: 0.274 ± 0.012	0.343TrpAsn: 0.343 ± 0.014	0.779TrpPro: 0.779 ± 0.023	0.622TrpGln: 0.622 ± 0.019	1.301TrpArg: 1.301 ± 0.03	0.926TrpSer: 0.926 ± 0.023	0.964TrpThr: 0.964 ± 0.025	0.959TrpVal: 0.959 ± 0.022	0.317TrpTrp: 0.317 ± 0.013	0.328TrpTyr: 0.328 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.721TyrAla: 2.721 ± 0.039	0.182TyrCys: 0.182 ± 0.01	1.313TyrAsp: 1.313 ± 0.033	1.239TyrGlu: 1.239 ± 0.026	0.604TyrPhe: 0.604 ± 0.017	2.227TyrGly: 2.227 ± 0.04	0.385TyrHis: 0.385 ± 0.015	0.462TyrIle: 0.462 ± 0.014	0.385TyrLys: 0.385 ± 0.017	2.057TyrLeu: 2.057 ± 0.034	0.25TyrMet: 0.25 ± 0.012	0.374TyrAsn: 0.374 ± 0.015	1.081TyrPro: 1.081 ± 0.026	0.55TyrGln: 0.55 ± 0.019	1.833TyrArg: 1.833 ± 0.036	0.884TyrSer: 0.884 ± 0.023	1.091TyrThr: 1.091 ± 0.024	1.604TyrVal: 1.604 ± 0.033	0.348TyrTrp: 0.348 ± 0.014	0.407TyrTyr: 0.407 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5796 proteins (2018260 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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