Amino acid dipepetide frequency for Cytobacillus horneckiae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.053AlaAla: 6.053 ± 0.082	0.593AlaCys: 0.593 ± 0.017	3.5AlaAsp: 3.5 ± 0.052	5.053AlaGlu: 5.053 ± 0.068	3.394AlaPhe: 3.394 ± 0.048	5.33AlaGly: 5.33 ± 0.074	1.283AlaHis: 1.283 ± 0.028	6.092AlaIle: 6.092 ± 0.081	4.777AlaLys: 4.777 ± 0.062	6.979AlaLeu: 6.979 ± 0.084	2.003AlaMet: 2.003 ± 0.036	2.957AlaAsn: 2.957 ± 0.054	1.949AlaPro: 1.949 ± 0.046	2.086AlaGln: 2.086 ± 0.036	2.427AlaArg: 2.427 ± 0.046	4.144AlaSer: 4.144 ± 0.052	3.185AlaThr: 3.185 ± 0.053	5.344AlaVal: 5.344 ± 0.064	0.576AlaTrp: 0.576 ± 0.019	2.229AlaTyr: 2.229 ± 0.041	0.0AlaXaa: 0.0 ± 0.0
Cys	0.471CysAla: 0.471 ± 0.02	0.087CysCys: 0.087 ± 0.008	0.402CysAsp: 0.402 ± 0.017	0.512CysGlu: 0.512 ± 0.021	0.338CysPhe: 0.338 ± 0.015	0.672CysGly: 0.672 ± 0.022	0.191CysHis: 0.191 ± 0.011	0.592CysIle: 0.592 ± 0.022	0.409CysLys: 0.409 ± 0.019	0.715CysLeu: 0.715 ± 0.021	0.193CysMet: 0.193 ± 0.009	0.309CysAsn: 0.309 ± 0.016	0.336CysPro: 0.336 ± 0.016	0.238CysGln: 0.238 ± 0.013	0.277CysArg: 0.277 ± 0.014	0.511CysSer: 0.511 ± 0.022	0.366CysThr: 0.366 ± 0.014	0.402CysVal: 0.402 ± 0.017	0.064CysTrp: 0.064 ± 0.006	0.252CysTyr: 0.252 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	3.165AspAla: 3.165 ± 0.053	0.396AspCys: 0.396 ± 0.018	2.517AspAsp: 2.517 ± 0.044	4.616AspGlu: 4.616 ± 0.058	2.435AspPhe: 2.435 ± 0.046	3.298AspGly: 3.298 ± 0.057	1.163AspHis: 1.163 ± 0.029	4.398AspIle: 4.398 ± 0.057	3.299AspLys: 3.299 ± 0.049	4.919AspLeu: 4.919 ± 0.063	1.334AspMet: 1.334 ± 0.032	1.89AspAsn: 1.89 ± 0.034	1.757AspPro: 1.757 ± 0.044	1.824AspGln: 1.824 ± 0.035	2.107AspArg: 2.107 ± 0.034	2.79AspSer: 2.79 ± 0.053	2.252AspThr: 2.252 ± 0.041	3.42AspVal: 3.42 ± 0.051	0.633AspTrp: 0.633 ± 0.02	2.207AspTyr: 2.207 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	5.448GluAla: 5.448 ± 0.071	0.431GluCys: 0.431 ± 0.017	3.833GluAsp: 3.833 ± 0.058	7.21GluGlu: 7.21 ± 0.092	2.564GluPhe: 2.564 ± 0.043	4.302GluGly: 4.302 ± 0.056	1.438GluHis: 1.438 ± 0.032	6.073GluIle: 6.073 ± 0.075	6.956GluLys: 6.956 ± 0.075	7.116GluLeu: 7.116 ± 0.076	2.428GluMet: 2.428 ± 0.039	3.952GluAsn: 3.952 ± 0.049	1.927GluPro: 1.927 ± 0.034	3.318GluGln: 3.318 ± 0.054	3.395GluArg: 3.395 ± 0.049	3.851GluSer: 3.851 ± 0.053	3.646GluThr: 3.646 ± 0.048	5.118GluVal: 5.118 ± 0.064	0.833GluTrp: 0.833 ± 0.025	2.373GluTyr: 2.373 ± 0.041	0.0GluXaa: 0.0 ± 0.0
Phe	3.132PheAla: 3.132 ± 0.049	0.352PheCys: 0.352 ± 0.016	2.302PheAsp: 2.302 ± 0.048	2.867PheGlu: 2.867 ± 0.046	2.392PhePhe: 2.392 ± 0.057	3.179PheGly: 3.179 ± 0.05	0.965PheHis: 0.965 ± 0.026	4.328PheIle: 4.328 ± 0.067	2.58PheLys: 2.58 ± 0.046	4.641PheLeu: 4.641 ± 0.066	1.173PheMet: 1.173 ± 0.032	2.196PheAsn: 2.196 ± 0.043	1.638PhePro: 1.638 ± 0.031	1.556PheGln: 1.556 ± 0.032	1.43PheArg: 1.43 ± 0.033	3.373PheSer: 3.373 ± 0.056	2.59PheThr: 2.59 ± 0.042	2.857PheVal: 2.857 ± 0.05	0.469PheTrp: 0.469 ± 0.017	1.715PheTyr: 1.715 ± 0.035	0.0PheXaa: 0.0 ± 0.0
Gly	4.814GlyAla: 4.814 ± 0.065	0.606GlyCys: 0.606 ± 0.02	3.051GlyAsp: 3.051 ± 0.048	4.633GlyGlu: 4.633 ± 0.061	3.325GlyPhe: 3.325 ± 0.054	4.745GlyGly: 4.745 ± 0.071	1.342GlyHis: 1.342 ± 0.029	5.917GlyIle: 5.917 ± 0.07	5.086GlyLys: 5.086 ± 0.061	6.545GlyLeu: 6.545 ± 0.068	2.031GlyMet: 2.031 ± 0.038	2.79GlyAsn: 2.79 ± 0.043	1.695GlyPro: 1.695 ± 0.04	2.195GlyGln: 2.195 ± 0.04	2.547GlyArg: 2.547 ± 0.045	3.917GlySer: 3.917 ± 0.055	3.791GlyThr: 3.791 ± 0.058	4.775GlyVal: 4.775 ± 0.061	0.802GlyTrp: 0.802 ± 0.027	2.79GlyTyr: 2.79 ± 0.052	0.0GlyXaa: 0.0 ± 0.0
His	1.295HisAla: 1.295 ± 0.034	0.219HisCys: 0.219 ± 0.013	1.035HisAsp: 1.035 ± 0.027	1.422HisGlu: 1.422 ± 0.033	1.084HisPhe: 1.084 ± 0.026	1.344HisGly: 1.344 ± 0.027	0.692HisHis: 0.692 ± 0.025	1.621HisIle: 1.621 ± 0.033	1.058HisLys: 1.058 ± 0.027	2.18HisLeu: 2.18 ± 0.043	0.529HisMet: 0.529 ± 0.017	0.781HisAsn: 0.781 ± 0.021	1.115HisPro: 1.115 ± 0.032	0.845HisGln: 0.845 ± 0.023	0.813HisArg: 0.813 ± 0.021	1.314HisSer: 1.314 ± 0.033	1.035HisThr: 1.035 ± 0.026	1.296HisVal: 1.296 ± 0.033	0.193HisTrp: 0.193 ± 0.011	0.859HisTyr: 0.859 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	6.355IleAla: 6.355 ± 0.076	0.678IleCys: 0.678 ± 0.023	4.614IleAsp: 4.614 ± 0.061	6.181IleGlu: 6.181 ± 0.066	3.62IlePhe: 3.62 ± 0.069	6.176IleGly: 6.176 ± 0.079	1.791IleHis: 1.791 ± 0.036	6.937IleIle: 6.937 ± 0.101	5.328IleLys: 5.328 ± 0.06	7.568IleLeu: 7.568 ± 0.088	1.948IleMet: 1.948 ± 0.041	3.942IleAsn: 3.942 ± 0.059	3.483IlePro: 3.483 ± 0.049	2.93IleGln: 2.93 ± 0.044	3.034IleArg: 3.034 ± 0.047	5.525IleSer: 5.525 ± 0.06	4.38IleThr: 4.38 ± 0.062	5.516IleVal: 5.516 ± 0.06	0.662IleTrp: 0.662 ± 0.023	2.669IleTyr: 2.669 ± 0.043	0.0IleXaa: 0.0 ± 0.0
Lys	4.728LysAla: 4.728 ± 0.067	0.374LysCys: 0.374 ± 0.018	3.897LysAsp: 3.897 ± 0.06	7.03LysGlu: 7.03 ± 0.067	2.101LysPhe: 2.101 ± 0.04	4.619LysGly: 4.619 ± 0.065	1.343LysHis: 1.343 ± 0.03	5.087LysIle: 5.087 ± 0.064	6.057LysLys: 6.057 ± 0.078	6.248LysLeu: 6.248 ± 0.072	2.4LysMet: 2.4 ± 0.046	3.699LysAsn: 3.699 ± 0.056	2.207LysPro: 2.207 ± 0.041	3.158LysGln: 3.158 ± 0.05	3.19LysArg: 3.19 ± 0.049	3.862LysSer: 3.862 ± 0.058	3.602LysThr: 3.602 ± 0.052	4.745LysVal: 4.745 ± 0.057	0.835LysTrp: 0.835 ± 0.023	2.442LysTyr: 2.442 ± 0.044	0.0LysXaa: 0.0 ± 0.0
Leu	7.077LeuAla: 7.077 ± 0.076	0.729LeuCys: 0.729 ± 0.026	4.647LeuAsp: 4.647 ± 0.065	6.537LeuGlu: 6.537 ± 0.077	4.886LeuPhe: 4.886 ± 0.069	6.193LeuGly: 6.193 ± 0.076	1.913LeuHis: 1.913 ± 0.038	7.762LeuIle: 7.762 ± 0.084	6.83LeuLys: 6.83 ± 0.077	9.889LeuLeu: 9.889 ± 0.111	2.574LeuMet: 2.574 ± 0.043	4.753LeuAsn: 4.753 ± 0.052	3.88LeuPro: 3.88 ± 0.052	3.627LeuGln: 3.627 ± 0.06	3.379LeuArg: 3.379 ± 0.053	7.122LeuSer: 7.122 ± 0.073	5.54LeuThr: 5.54 ± 0.061	5.827LeuVal: 5.827 ± 0.069	0.791LeuTrp: 0.791 ± 0.027	3.153LeuTyr: 3.153 ± 0.052	0.0LeuXaa: 0.0 ± 0.0
Met	2.05MetAla: 2.05 ± 0.04	0.134MetCys: 0.134 ± 0.008	1.499MetAsp: 1.499 ± 0.03	2.06MetGlu: 2.06 ± 0.032	1.059MetPhe: 1.059 ± 0.031	1.716MetGly: 1.716 ± 0.035	0.41MetHis: 0.41 ± 0.017	2.374MetIle: 2.374 ± 0.044	2.649MetLys: 2.649 ± 0.04	2.629MetLeu: 2.629 ± 0.045	0.931MetMet: 0.931 ± 0.023	1.744MetAsn: 1.744 ± 0.034	0.988MetPro: 0.988 ± 0.024	0.922MetGln: 0.922 ± 0.023	1.075MetArg: 1.075 ± 0.026	1.73MetSer: 1.73 ± 0.028	1.611MetThr: 1.611 ± 0.034	1.72MetVal: 1.72 ± 0.034	0.179MetTrp: 0.179 ± 0.012	0.762MetTyr: 0.762 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	2.758AsnAla: 2.758 ± 0.046	0.329AsnCys: 0.329 ± 0.014	2.487AsnAsp: 2.487 ± 0.043	4.102AsnGlu: 4.102 ± 0.058	1.722AsnPhe: 1.722 ± 0.037	3.468AsnGly: 3.468 ± 0.054	1.248AsnHis: 1.248 ± 0.03	3.87AsnIle: 3.87 ± 0.053	3.51AsnLys: 3.51 ± 0.058	4.0AsnLeu: 4.0 ± 0.052	1.296AsnMet: 1.296 ± 0.028	2.392AsnAsn: 2.392 ± 0.052	2.17AsnPro: 2.17 ± 0.045	2.145AsnGln: 2.145 ± 0.037	2.078AsnArg: 2.078 ± 0.04	2.496AsnSer: 2.496 ± 0.04	2.194AsnThr: 2.194 ± 0.046	2.87AsnVal: 2.87 ± 0.049	0.508AsnTrp: 0.508 ± 0.017	1.651AsnTyr: 1.651 ± 0.03	0.0AsnXaa: 0.0 ± 0.0
Pro	2.3ProAla: 2.3 ± 0.044	0.211ProCys: 0.211 ± 0.013	1.872ProAsp: 1.872 ± 0.037	2.827ProGlu: 2.827 ± 0.047	1.984ProPhe: 1.984 ± 0.036	2.2ProGly: 2.2 ± 0.046	0.808ProHis: 0.808 ± 0.025	2.994ProIle: 2.994 ± 0.043	2.123ProLys: 2.123 ± 0.04	3.462ProLeu: 3.462 ± 0.052	0.845ProMet: 0.845 ± 0.024	1.673ProAsn: 1.673 ± 0.033	0.987ProPro: 0.987 ± 0.025	1.146ProGln: 1.146 ± 0.029	1.06ProArg: 1.06 ± 0.027	2.256ProSer: 2.256 ± 0.032	1.737ProThr: 1.737 ± 0.031	2.568ProVal: 2.568 ± 0.041	0.314ProTrp: 0.314 ± 0.015	1.399ProTyr: 1.399 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	2.679GlnAla: 2.679 ± 0.044	0.22GlnCys: 0.22 ± 0.014	1.512GlnAsp: 1.512 ± 0.032	2.689GlnGlu: 2.689 ± 0.045	1.706GlnPhe: 1.706 ± 0.034	2.033GlnGly: 2.033 ± 0.034	0.728GlnHis: 0.728 ± 0.023	2.686GlnIle: 2.686 ± 0.042	2.626GlnLys: 2.626 ± 0.05	4.059GlnLeu: 4.059 ± 0.052	1.143GlnMet: 1.143 ± 0.028	1.667GlnAsn: 1.667 ± 0.035	1.203GlnPro: 1.203 ± 0.026	1.72GlnGln: 1.72 ± 0.04	1.455GlnArg: 1.455 ± 0.033	2.485GlnSer: 2.485 ± 0.043	2.009GlnThr: 2.009 ± 0.037	2.117GlnVal: 2.117 ± 0.036	0.396GlnTrp: 0.396 ± 0.019	1.471GlnTyr: 1.471 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	2.351ArgAla: 2.351 ± 0.042	0.251ArgCys: 0.251 ± 0.013	1.866ArgAsp: 1.866 ± 0.043	3.035ArgGlu: 3.035 ± 0.048	1.804ArgPhe: 1.804 ± 0.032	2.235ArgGly: 2.235 ± 0.038	0.752ArgHis: 0.752 ± 0.021	3.104ArgIle: 3.104 ± 0.042	3.263ArgLys: 3.263 ± 0.048	3.76ArgLeu: 3.76 ± 0.048	1.242ArgMet: 1.242 ± 0.03	1.929ArgAsn: 1.929 ± 0.031	1.169ArgPro: 1.169 ± 0.029	1.449ArgGln: 1.449 ± 0.035	1.709ArgArg: 1.709 ± 0.038	2.123ArgSer: 2.123 ± 0.04	1.997ArgThr: 1.997 ± 0.04	2.374ArgVal: 2.374 ± 0.04	0.371ArgTrp: 0.371 ± 0.015	1.428ArgTyr: 1.428 ± 0.028	0.0ArgXaa: 0.0 ± 0.0
Ser	4.025SerAla: 4.025 ± 0.053	0.423SerCys: 0.423 ± 0.021	2.89SerAsp: 2.89 ± 0.042	4.06SerGlu: 4.06 ± 0.052	3.366SerPhe: 3.366 ± 0.049	4.485SerGly: 4.485 ± 0.059	1.282SerHis: 1.282 ± 0.028	5.609SerIle: 5.609 ± 0.061	4.037SerLys: 4.037 ± 0.056	6.386SerLeu: 6.386 ± 0.073	1.873SerMet: 1.873 ± 0.037	2.855SerAsn: 2.855 ± 0.043	2.16SerPro: 2.16 ± 0.04	2.015SerGln: 2.015 ± 0.041	2.259SerArg: 2.259 ± 0.042	4.151SerSer: 4.151 ± 0.059	3.13SerThr: 3.13 ± 0.041	3.979SerVal: 3.979 ± 0.052	0.672SerTrp: 0.672 ± 0.022	2.317SerTyr: 2.317 ± 0.047	0.0SerXaa: 0.0 ± 0.0
Thr	3.948ThrAla: 3.948 ± 0.053	0.343ThrCys: 0.343 ± 0.017	2.635ThrAsp: 2.635 ± 0.048	3.525ThrGlu: 3.525 ± 0.05	2.476ThrPhe: 2.476 ± 0.047	4.092ThrGly: 4.092 ± 0.051	0.99ThrHis: 0.99 ± 0.024	4.613ThrIle: 4.613 ± 0.057	3.31ThrLys: 3.31 ± 0.047	4.915ThrLeu: 4.915 ± 0.062	1.32ThrMet: 1.32 ± 0.033	2.412ThrAsn: 2.412 ± 0.049	2.046ThrPro: 2.046 ± 0.038	1.318ThrGln: 1.318 ± 0.032	1.717ThrArg: 1.717 ± 0.034	3.177ThrSer: 3.177 ± 0.05	2.675ThrThr: 2.675 ± 0.053	3.932ThrVal: 3.932 ± 0.053	0.5ThrTrp: 0.5 ± 0.019	1.773ThrTyr: 1.773 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	4.641ValAla: 4.641 ± 0.066	0.541ValCys: 0.541 ± 0.022	3.379ValAsp: 3.379 ± 0.051	4.52ValGlu: 4.52 ± 0.067	3.1ValPhe: 3.1 ± 0.054	4.286ValGly: 4.286 ± 0.056	1.279ValHis: 1.279 ± 0.028	5.772ValIle: 5.772 ± 0.066	4.75ValLys: 4.75 ± 0.063	6.416ValLeu: 6.416 ± 0.068	1.757ValMet: 1.757 ± 0.038	3.252ValAsn: 3.252 ± 0.042	2.433ValPro: 2.433 ± 0.044	2.279ValGln: 2.279 ± 0.04	2.287ValArg: 2.287 ± 0.037	4.335ValSer: 4.335 ± 0.055	3.673ValThr: 3.673 ± 0.05	4.357ValVal: 4.357 ± 0.057	0.611ValTrp: 0.611 ± 0.022	2.157ValTyr: 2.157 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	0.565TrpAla: 0.565 ± 0.02	0.084TrpCys: 0.084 ± 0.008	0.503TrpAsp: 0.503 ± 0.019	0.695TrpGlu: 0.695 ± 0.024	0.48TrpPhe: 0.48 ± 0.018	0.642TrpGly: 0.642 ± 0.024	0.215TrpHis: 0.215 ± 0.013	0.847TrpIle: 0.847 ± 0.024	0.72TrpLys: 0.72 ± 0.022	1.161TrpLeu: 1.161 ± 0.03	0.346TrpMet: 0.346 ± 0.017	0.522TrpAsn: 0.522 ± 0.022	0.251TrpPro: 0.251 ± 0.013	0.356TrpGln: 0.356 ± 0.016	0.38TrpArg: 0.38 ± 0.016	0.58TrpSer: 0.58 ± 0.019	0.495TrpThr: 0.495 ± 0.018	0.625TrpVal: 0.625 ± 0.025	0.137TrpTrp: 0.137 ± 0.011	0.335TrpTyr: 0.335 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.098TyrAla: 2.098 ± 0.039	0.337TyrCys: 0.337 ± 0.015	1.977TyrAsp: 1.977 ± 0.041	2.64TyrGlu: 2.64 ± 0.045	1.901TyrPhe: 1.901 ± 0.036	2.383TyrGly: 2.383 ± 0.047	0.9TyrHis: 0.9 ± 0.028	2.665TyrIle: 2.665 ± 0.051	2.252TyrLys: 2.252 ± 0.046	3.523TyrLeu: 3.523 ± 0.053	0.876TyrMet: 0.876 ± 0.022	1.578TyrAsn: 1.578 ± 0.034	1.371TyrPro: 1.371 ± 0.032	1.475TyrGln: 1.475 ± 0.032	1.592TyrArg: 1.592 ± 0.033	2.23TyrSer: 2.23 ± 0.046	1.813TyrThr: 1.813 ± 0.037	1.981TyrVal: 1.981 ± 0.039	0.393TyrTrp: 0.393 ± 0.018	1.579TyrTyr: 1.579 ± 0.037	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5301 proteins (1490556 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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