Amino acid dipepetide frequency for Fischerella thermalis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.818AlaAla: 7.818 ± 0.105
0.874AlaCys: 0.874 ± 0.023
3.993AlaAsp: 3.993 ± 0.058
5.166AlaGlu: 5.166 ± 0.06
3.021AlaPhe: 3.021 ± 0.052
5.487AlaGly: 5.487 ± 0.077
1.347AlaHis: 1.347 ± 0.032
6.944AlaIle: 6.944 ± 0.079
4.369AlaLys: 4.369 ± 0.074
8.562AlaLeu: 8.562 ± 0.09
1.746AlaMet: 1.746 ± 0.035
3.413AlaAsn: 3.413 ± 0.059
2.808AlaPro: 2.808 ± 0.045
4.106AlaGln: 4.106 ± 0.071
3.683AlaArg: 3.683 ± 0.058
4.685AlaSer: 4.685 ± 0.061
4.803AlaThr: 4.803 ± 0.063
5.961AlaVal: 5.961 ± 0.071
1.049AlaTrp: 1.049 ± 0.031
2.39AlaTyr: 2.39 ± 0.05
0.0AlaXaa: 0.0 ± 0.0
Cys
0.696CysAla: 0.696 ± 0.023
0.184CysCys: 0.184 ± 0.01
0.615CysAsp: 0.615 ± 0.021
0.549CysGlu: 0.549 ± 0.019
0.419CysPhe: 0.419 ± 0.015
0.78CysGly: 0.78 ± 0.027
0.266CysHis: 0.266 ± 0.013
0.625CysIle: 0.625 ± 0.022
0.363CysLys: 0.363 ± 0.016
1.125CysLeu: 1.125 ± 0.03
0.198CysMet: 0.198 ± 0.012
0.407CysAsn: 0.407 ± 0.017
0.538CysPro: 0.538 ± 0.022
0.615CysGln: 0.615 ± 0.021
0.566CysArg: 0.566 ± 0.022
0.612CysSer: 0.612 ± 0.022
0.49CysThr: 0.49 ± 0.017
0.65CysVal: 0.65 ± 0.021
0.143CysTrp: 0.143 ± 0.01
0.362CysTyr: 0.362 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
3.543AspAla: 3.543 ± 0.054
0.495AspCys: 0.495 ± 0.017
1.976AspAsp: 1.976 ± 0.046
2.867AspGlu: 2.867 ± 0.052
2.203AspPhe: 2.203 ± 0.04
3.163AspGly: 3.163 ± 0.055
0.77AspHis: 0.77 ± 0.023
3.279AspIle: 3.279 ± 0.05
2.203AspLys: 2.203 ± 0.04
5.391AspLeu: 5.391 ± 0.071
0.772AspMet: 0.772 ± 0.023
1.919AspAsn: 1.919 ± 0.036
2.34AspPro: 2.34 ± 0.051
1.817AspGln: 1.817 ± 0.041
3.114AspArg: 3.114 ± 0.048
2.624AspSer: 2.624 ± 0.043
2.504AspThr: 2.504 ± 0.044
3.17AspVal: 3.17 ± 0.048
0.857AspTrp: 0.857 ± 0.026
1.74AspTyr: 1.74 ± 0.035
0.0AspXaa: 0.0 ± 0.0
Glu
5.208GluAla: 5.208 ± 0.062
0.505GluCys: 0.505 ± 0.019
2.606GluAsp: 2.606 ± 0.046
4.067GluGlu: 4.067 ± 0.06
2.433GluPhe: 2.433 ± 0.042
3.058GluGly: 3.058 ± 0.045
1.004GluHis: 1.004 ± 0.031
4.953GluIle: 4.953 ± 0.065
3.605GluLys: 3.605 ± 0.054
6.934GluLeu: 6.934 ± 0.075
1.35GluMet: 1.35 ± 0.036
2.811GluAsn: 2.811 ± 0.047
2.38GluPro: 2.38 ± 0.049
3.53GluGln: 3.53 ± 0.058
3.32GluArg: 3.32 ± 0.056
3.139GluSer: 3.139 ± 0.051
3.386GluThr: 3.386 ± 0.057
4.413GluVal: 4.413 ± 0.065
0.761GluTrp: 0.761 ± 0.023
1.841GluTyr: 1.841 ± 0.04
0.0GluXaa: 0.0 ± 0.0
Phe
3.273PheAla: 3.273 ± 0.05
0.576PheCys: 0.576 ± 0.022
2.102PheAsp: 2.102 ± 0.039
2.004PheGlu: 2.004 ± 0.036
1.711PhePhe: 1.711 ± 0.042
3.004PheGly: 3.004 ± 0.059
0.814PheHis: 0.814 ± 0.025
2.411PheIle: 2.411 ± 0.048
1.473PheLys: 1.473 ± 0.038
4.255PheLeu: 4.255 ± 0.061
0.7PheMet: 0.7 ± 0.019
1.729PheAsn: 1.729 ± 0.034
1.831PhePro: 1.831 ± 0.038
1.824PheGln: 1.824 ± 0.039
1.802PheArg: 1.802 ± 0.037
2.812PheSer: 2.812 ± 0.049
2.33PheThr: 2.33 ± 0.041
2.598PheVal: 2.598 ± 0.043
0.751PheTrp: 0.751 ± 0.024
1.339PheTyr: 1.339 ± 0.033
0.0PheXaa: 0.0 ± 0.0
Gly
4.708GlyAla: 4.708 ± 0.084
0.812GlyCys: 0.812 ± 0.024
3.306GlyAsp: 3.306 ± 0.052
4.029GlyGlu: 4.029 ± 0.067
2.899GlyPhe: 2.899 ± 0.047
4.61GlyGly: 4.61 ± 0.08
1.245GlyHis: 1.245 ± 0.033
5.255GlyIle: 5.255 ± 0.069
4.073GlyLys: 4.073 ± 0.059
6.846GlyLeu: 6.846 ± 0.089
1.602GlyMet: 1.602 ± 0.039
2.814GlyAsn: 2.814 ± 0.059
1.432GlyPro: 1.432 ± 0.031
2.8GlyGln: 2.8 ± 0.046
3.413GlyArg: 3.413 ± 0.061
4.036GlySer: 4.036 ± 0.055
3.724GlyThr: 3.724 ± 0.064
4.938GlyVal: 4.938 ± 0.063
1.112GlyTrp: 1.112 ± 0.03
2.408GlyTyr: 2.408 ± 0.048
0.0GlyXaa: 0.0 ± 0.0
His
1.17HisAla: 1.17 ± 0.038
0.24HisCys: 0.24 ± 0.013
0.719HisAsp: 0.719 ± 0.027
0.931HisGlu: 0.931 ± 0.025
0.831HisPhe: 0.831 ± 0.027
1.161HisGly: 1.161 ± 0.035
0.635HisHis: 0.635 ± 0.027
1.164HisIle: 1.164 ± 0.035
0.851HisLys: 0.851 ± 0.026
2.229HisLeu: 2.229 ± 0.043
0.31HisMet: 0.31 ± 0.017
0.806HisAsn: 0.806 ± 0.024
1.405HisPro: 1.405 ± 0.032
1.155HisGln: 1.155 ± 0.034
1.091HisArg: 1.091 ± 0.028
1.181HisSer: 1.181 ± 0.029
1.073HisThr: 1.073 ± 0.032
0.941HisVal: 0.941 ± 0.029
0.343HisTrp: 0.343 ± 0.015
0.714HisTyr: 0.714 ± 0.022
0.0HisXaa: 0.0 ± 0.0
Ile
7.365IleAla: 7.365 ± 0.073
0.814IleCys: 0.814 ± 0.024
3.532IleAsp: 3.532 ± 0.053
4.013IleGlu: 4.013 ± 0.06
2.687IlePhe: 2.687 ± 0.054
4.531IleGly: 4.531 ± 0.075
1.279IleHis: 1.279 ± 0.029
3.921IleIle: 3.921 ± 0.062
3.045IleLys: 3.045 ± 0.043
7.059IleLeu: 7.059 ± 0.08
0.933IleMet: 0.933 ± 0.03
3.038IleAsn: 3.038 ± 0.048
3.69IlePro: 3.69 ± 0.05
3.043IleGln: 3.043 ± 0.048
3.17IleArg: 3.17 ± 0.054
4.369IleSer: 4.369 ± 0.058
3.867IleThr: 3.867 ± 0.058
4.532IleVal: 4.532 ± 0.057
0.931IleTrp: 0.931 ± 0.027
2.058IleTyr: 2.058 ± 0.036
0.0IleXaa: 0.0 ± 0.0
Lys
4.065LysAla: 4.065 ± 0.061
0.325LysCys: 0.325 ± 0.016
2.095LysAsp: 2.095 ± 0.044
2.9LysGlu: 2.9 ± 0.057
1.887LysPhe: 1.887 ± 0.043
2.672LysGly: 2.672 ± 0.047
0.795LysHis: 0.795 ± 0.026
3.586LysIle: 3.586 ± 0.06
2.401LysLys: 2.401 ± 0.051
5.598LysLeu: 5.598 ± 0.073
0.971LysMet: 0.971 ± 0.028
2.263LysAsn: 2.263 ± 0.043
2.486LysPro: 2.486 ± 0.044
2.901LysGln: 2.901 ± 0.061
2.445LysArg: 2.445 ± 0.047
2.945LysSer: 2.945 ± 0.054
2.943LysThr: 2.943 ± 0.052
3.236LysVal: 3.236 ± 0.049
0.517LysTrp: 0.517 ± 0.02
1.507LysTyr: 1.507 ± 0.034
0.0LysXaa: 0.0 ± 0.0
Leu
9.654LeuAla: 9.654 ± 0.097
1.071LeuCys: 1.071 ± 0.026
5.065LeuAsp: 5.065 ± 0.067
7.188LeuGlu: 7.188 ± 0.074
3.869LeuPhe: 3.869 ± 0.059
7.687LeuGly: 7.687 ± 0.083
1.977LeuHis: 1.977 ± 0.041
6.754LeuIle: 6.754 ± 0.083
5.384LeuLys: 5.384 ± 0.068
11.709LeuLeu: 11.709 ± 0.119
2.129LeuMet: 2.129 ± 0.042
4.34LeuAsn: 4.34 ± 0.063
5.904LeuPro: 5.904 ± 0.078
6.129LeuGln: 6.129 ± 0.084
5.761LeuArg: 5.761 ± 0.071
7.236LeuSer: 7.236 ± 0.09
6.292LeuThr: 6.292 ± 0.077
7.459LeuVal: 7.459 ± 0.069
1.465LeuTrp: 1.465 ± 0.041
2.685LeuTyr: 2.685 ± 0.047
0.0LeuXaa: 0.0 ± 0.0
Met
1.752MetAla: 1.752 ± 0.038
0.134MetCys: 0.134 ± 0.009
0.719MetAsp: 0.719 ± 0.026
0.989MetGlu: 0.989 ± 0.029
0.595MetPhe: 0.595 ± 0.021
1.402MetGly: 1.402 ± 0.032
0.354MetHis: 0.354 ± 0.017
1.198MetIle: 1.198 ± 0.03
0.953MetLys: 0.953 ± 0.028
2.082MetLeu: 2.082 ± 0.046
0.447MetMet: 0.447 ± 0.021
0.859MetAsn: 0.859 ± 0.026
0.931MetPro: 0.931 ± 0.028
1.074MetGln: 1.074 ± 0.025
1.043MetArg: 1.043 ± 0.027
1.293MetSer: 1.293 ± 0.03
1.289MetThr: 1.289 ± 0.032
1.389MetVal: 1.389 ± 0.03
0.168MetTrp: 0.168 ± 0.011
0.387MetTyr: 0.387 ± 0.016
0.0MetXaa: 0.0 ± 0.0
Asn
2.886AsnAla: 2.886 ± 0.056
0.476AsnCys: 0.476 ± 0.018
1.563AsnAsp: 1.563 ± 0.034
1.751AsnGlu: 1.751 ± 0.036
2.016AsnPhe: 2.016 ± 0.042
2.601AsnGly: 2.601 ± 0.05
0.953AsnHis: 0.953 ± 0.026
2.895AsnIle: 2.895 ± 0.051
1.773AsnLys: 1.773 ± 0.042
5.434AsnLeu: 5.434 ± 0.077
0.651AsnMet: 0.651 ± 0.021
2.035AsnAsn: 2.035 ± 0.046
2.868AsnPro: 2.868 ± 0.054
2.788AsnGln: 2.788 ± 0.052
2.279AsnArg: 2.279 ± 0.043
3.035AsnSer: 3.035 ± 0.049
2.459AsnThr: 2.459 ± 0.049
2.196AsnVal: 2.196 ± 0.039
0.741AsnTrp: 0.741 ± 0.024
1.563AsnTyr: 1.563 ± 0.041
0.0AsnXaa: 0.0 ± 0.0
Pro
3.303ProAla: 3.303 ± 0.049
0.379ProCys: 0.379 ± 0.018
2.802ProAsp: 2.802 ± 0.047
3.936ProGlu: 3.936 ± 0.052
1.723ProPhe: 1.723 ± 0.034
3.133ProGly: 3.133 ± 0.049
1.034ProHis: 1.034 ± 0.029
3.073ProIle: 3.073 ± 0.051
2.303ProLys: 2.303 ± 0.04
4.715ProLeu: 4.715 ± 0.069
0.782ProMet: 0.782 ± 0.026
2.288ProAsn: 2.288 ± 0.051
2.521ProPro: 2.521 ± 0.059
2.756ProGln: 2.756 ± 0.052
1.82ProArg: 1.82 ± 0.038
2.887ProSer: 2.887 ± 0.05
3.101ProThr: 3.101 ± 0.067
3.521ProVal: 3.521 ± 0.053
0.61ProTrp: 0.61 ± 0.023
1.417ProTyr: 1.417 ± 0.031
0.0ProXaa: 0.0 ± 0.0
Gln
5.044GlnAla: 5.044 ± 0.084
0.337GlnCys: 0.337 ± 0.016
2.131GlnAsp: 2.131 ± 0.041
3.743GlnGlu: 3.743 ± 0.068
1.673GlnPhe: 1.673 ± 0.034
3.243GlnGly: 3.243 ± 0.047
0.894GlnHis: 0.894 ± 0.027
3.811GlnIle: 3.811 ± 0.055
3.052GlnLys: 3.052 ± 0.052
6.073GlnLeu: 6.073 ± 0.083
1.147GlnMet: 1.147 ± 0.03
2.225GlnAsn: 2.225 ± 0.043
2.721GlnPro: 2.721 ± 0.052
4.241GlnGln: 4.241 ± 0.096
3.021GlnArg: 3.021 ± 0.051
2.766GlnSer: 2.766 ± 0.05
3.111GlnThr: 3.111 ± 0.054
3.902GlnVal: 3.902 ± 0.062
0.651GlnTrp: 0.651 ± 0.022
1.266GlnTyr: 1.266 ± 0.028
0.0GlnXaa: 0.0 ± 0.0
Arg
3.274ArgAla: 3.274 ± 0.052
0.529ArgCys: 0.529 ± 0.019
2.501ArgAsp: 2.501 ± 0.049
3.274ArgGlu: 3.274 ± 0.048
2.165ArgPhe: 2.165 ± 0.038
3.043ArgGly: 3.043 ± 0.055
1.045ArgHis: 1.045 ± 0.028
3.337ArgIle: 3.337 ± 0.054
2.268ArgLys: 2.268 ± 0.044
6.127ArgLeu: 6.127 ± 0.066
1.097ArgMet: 1.097 ± 0.032
2.147ArgAsn: 2.147 ± 0.039
2.165ArgPro: 2.165 ± 0.041
3.341ArgGln: 3.341 ± 0.051
3.324ArgArg: 3.324 ± 0.06
3.101ArgSer: 3.101 ± 0.05
2.586ArgThr: 2.586 ± 0.044
3.515ArgVal: 3.515 ± 0.058
0.808ArgTrp: 0.808 ± 0.027
1.967ArgTyr: 1.967 ± 0.041
0.0ArgXaa: 0.0 ± 0.0
Ser
4.302SerAla: 4.302 ± 0.053
0.642SerCys: 0.642 ± 0.023
2.871SerAsp: 2.871 ± 0.049
3.501SerGlu: 3.501 ± 0.057
2.481SerPhe: 2.481 ± 0.049
4.408SerGly: 4.408 ± 0.064
1.359SerHis: 1.359 ± 0.03
3.671SerIle: 3.671 ± 0.056
2.651SerLys: 2.651 ± 0.05
7.106SerLeu: 7.106 ± 0.08
1.152SerMet: 1.152 ± 0.029
2.627SerAsn: 2.627 ± 0.045
3.399SerPro: 3.399 ± 0.061
3.589SerGln: 3.589 ± 0.054
3.171SerArg: 3.171 ± 0.043
4.204SerSer: 4.204 ± 0.073
3.492SerThr: 3.492 ± 0.063
4.089SerVal: 4.089 ± 0.058
0.958SerTrp: 0.958 ± 0.024
1.752SerTyr: 1.752 ± 0.038
0.0SerXaa: 0.0 ± 0.0
Thr
4.902ThrAla: 4.902 ± 0.064
0.5ThrCys: 0.5 ± 0.017
2.706ThrAsp: 2.706 ± 0.043
3.357ThrGlu: 3.357 ± 0.053
2.067ThrPhe: 2.067 ± 0.036
4.284ThrGly: 4.284 ± 0.068
1.033ThrHis: 1.033 ± 0.028
3.679ThrIle: 3.679 ± 0.06
2.434ThrLys: 2.434 ± 0.045
6.046ThrLeu: 6.046 ± 0.067
0.811ThrMet: 0.811 ± 0.027
2.444ThrAsn: 2.444 ± 0.054
3.769ThrPro: 3.769 ± 0.066
3.019ThrGln: 3.019 ± 0.056
2.463ThrArg: 2.463 ± 0.048
3.591ThrSer: 3.591 ± 0.06
3.66ThrThr: 3.66 ± 0.061
4.239ThrVal: 4.239 ± 0.066
0.7ThrTrp: 0.7 ± 0.021
1.654ThrTyr: 1.654 ± 0.033
0.0ThrXaa: 0.0 ± 0.0
Val
6.214ValAla: 6.214 ± 0.075
0.758ValCys: 0.758 ± 0.021
3.419ValAsp: 3.419 ± 0.052
4.438ValGlu: 4.438 ± 0.059
2.678ValPhe: 2.678 ± 0.048
4.788ValGly: 4.788 ± 0.072
1.112ValHis: 1.112 ± 0.027
4.69ValIle: 4.69 ± 0.063
3.404ValLys: 3.404 ± 0.054
6.901ValLeu: 6.901 ± 0.079
1.466ValMet: 1.466 ± 0.031
2.986ValAsn: 2.986 ± 0.051
2.997ValPro: 2.997 ± 0.05
3.058ValGln: 3.058 ± 0.051
3.389ValArg: 3.389 ± 0.06
4.264ValSer: 4.264 ± 0.056
4.018ValThr: 4.018 ± 0.058
5.245ValVal: 5.245 ± 0.075
0.873ValTrp: 0.873 ± 0.029
1.965ValTyr: 1.965 ± 0.037
0.0ValXaa: 0.0 ± 0.0
Trp
0.871TrpAla: 0.871 ± 0.024
0.152TrpCys: 0.152 ± 0.011
0.605TrpAsp: 0.605 ± 0.023
0.891TrpGlu: 0.891 ± 0.029
0.638TrpPhe: 0.638 ± 0.025
0.967TrpGly: 0.967 ± 0.03
0.361TrpHis: 0.361 ± 0.016
0.852TrpIle: 0.852 ± 0.027
0.597TrpLys: 0.597 ± 0.021
1.944TrpLeu: 1.944 ± 0.042
0.329TrpMet: 0.329 ± 0.014
0.565TrpAsn: 0.565 ± 0.022
0.275TrpPro: 0.275 ± 0.015
1.274TrpGln: 1.274 ± 0.033
0.883TrpArg: 0.883 ± 0.028
0.8TrpSer: 0.8 ± 0.024
0.599TrpThr: 0.599 ± 0.021
0.944TrpVal: 0.944 ± 0.027
0.249TrpTrp: 0.249 ± 0.014
0.426TrpTyr: 0.426 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.177TyrAla: 2.177 ± 0.039
0.4TyrCys: 0.4 ± 0.017
1.416TyrAsp: 1.416 ± 0.04
1.71TyrGlu: 1.71 ± 0.038
1.342TyrPhe: 1.342 ± 0.032
2.039TyrGly: 2.039 ± 0.037
0.675TyrHis: 0.675 ± 0.021
1.78TyrIle: 1.78 ± 0.039
1.338TyrLys: 1.338 ± 0.029
3.623TyrLeu: 3.623 ± 0.054
0.468TyrMet: 0.468 ± 0.019
1.245TyrAsn: 1.245 ± 0.037
1.643TyrPro: 1.643 ± 0.034
1.989TyrGln: 1.989 ± 0.044
1.859TyrArg: 1.859 ± 0.034
1.845TyrSer: 1.845 ± 0.041
1.632TyrThr: 1.632 ± 0.032
1.724TyrVal: 1.724 ± 0.029
0.535TyrTrp: 0.535 ± 0.02
1.094TyrTyr: 1.094 ± 0.027
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4557 proteins (1410942 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski