Amino acid dipepetide frequency for Bartonella apis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.303AlaAla: 9.303 ± 0.152	0.851AlaCys: 0.851 ± 0.038	5.197AlaAsp: 5.197 ± 0.089	5.783AlaGlu: 5.783 ± 0.112	4.043AlaPhe: 4.043 ± 0.097	7.34AlaGly: 7.34 ± 0.126	1.899AlaHis: 1.899 ± 0.054	6.554AlaIle: 6.554 ± 0.13	5.41AlaLys: 5.41 ± 0.111	10.1AlaLeu: 10.1 ± 0.172	2.676AlaMet: 2.676 ± 0.069	3.414AlaAsn: 3.414 ± 0.082	3.493AlaPro: 3.493 ± 0.076	2.857AlaGln: 2.857 ± 0.067	5.364AlaArg: 5.364 ± 0.104	5.274AlaSer: 5.274 ± 0.1	4.834AlaThr: 4.834 ± 0.098	6.378AlaVal: 6.378 ± 0.104	0.826AlaTrp: 0.826 ± 0.033	2.427AlaTyr: 2.427 ± 0.063	0.0AlaXaa: 0.0 ± 0.0
Cys	0.739CysAla: 0.739 ± 0.032	0.119CysCys: 0.119 ± 0.013	0.499CysAsp: 0.499 ± 0.031	0.453CysGlu: 0.453 ± 0.03	0.46CysPhe: 0.46 ± 0.026	0.888CysGly: 0.888 ± 0.039	0.249CysHis: 0.249 ± 0.018	0.422CysIle: 0.422 ± 0.027	0.32CysLys: 0.32 ± 0.021	0.869CysLeu: 0.869 ± 0.037	0.161CysMet: 0.161 ± 0.014	0.276CysAsn: 0.276 ± 0.021	0.441CysPro: 0.441 ± 0.028	0.242CysGln: 0.242 ± 0.017	0.49CysArg: 0.49 ± 0.032	0.532CysSer: 0.532 ± 0.03	0.347CysThr: 0.347 ± 0.023	0.568CysVal: 0.568 ± 0.028	0.08CysTrp: 0.08 ± 0.012	0.229CysTyr: 0.229 ± 0.021	0.0CysXaa: 0.0 ± 0.0
Asp	4.899AspAla: 4.899 ± 0.103	0.486AspCys: 0.486 ± 0.027	3.535AspAsp: 3.535 ± 0.138	4.238AspGlu: 4.238 ± 0.08	2.557AspPhe: 2.557 ± 0.064	4.465AspGly: 4.465 ± 0.155	1.366AspHis: 1.366 ± 0.048	4.298AspIle: 4.298 ± 0.086	3.694AspLys: 3.694 ± 0.091	5.08AspLeu: 5.08 ± 0.096	1.538AspMet: 1.538 ± 0.045	2.487AspAsn: 2.487 ± 0.103	2.557AspPro: 2.557 ± 0.064	1.74AspGln: 1.74 ± 0.053	3.272AspArg: 3.272 ± 0.078	2.579AspSer: 2.579 ± 0.078	2.547AspThr: 2.547 ± 0.091	4.007AspVal: 4.007 ± 0.087	0.775AspTrp: 0.775 ± 0.03	1.813AspTyr: 1.813 ± 0.051	0.0AspXaa: 0.0 ± 0.0
Glu	6.041GluAla: 6.041 ± 0.121	0.356GluCys: 0.356 ± 0.023	2.999GluAsp: 2.999 ± 0.066	4.017GluGlu: 4.017 ± 0.09	2.012GluPhe: 2.012 ± 0.061	3.948GluGly: 3.948 ± 0.081	1.287GluHis: 1.287 ± 0.046	4.212GluIle: 4.212 ± 0.082	5.317GluLys: 5.317 ± 0.095	5.459GluLeu: 5.459 ± 0.105	1.708GluMet: 1.708 ± 0.058	3.246GluAsn: 3.246 ± 0.073	2.32GluPro: 2.32 ± 0.059	2.332GluGln: 2.332 ± 0.063	3.809GluArg: 3.809 ± 0.105	2.456GluSer: 2.456 ± 0.057	3.736GluThr: 3.736 ± 0.085	3.586GluVal: 3.586 ± 0.078	0.657GluTrp: 0.657 ± 0.035	1.185GluTyr: 1.185 ± 0.042	0.0GluXaa: 0.0 ± 0.0
Phe	4.003PheAla: 4.003 ± 0.088	0.538PheCys: 0.538 ± 0.029	2.905PheAsp: 2.905 ± 0.073	2.242PheGlu: 2.242 ± 0.06	2.097PhePhe: 2.097 ± 0.073	3.634PheGly: 3.634 ± 0.081	0.91PheHis: 0.91 ± 0.032	2.96PheIle: 2.96 ± 0.087	1.817PheLys: 1.817 ± 0.056	4.007PheLeu: 4.007 ± 0.119	1.06PheMet: 1.06 ± 0.047	1.76PheAsn: 1.76 ± 0.061	1.666PhePro: 1.666 ± 0.057	1.137PheGln: 1.137 ± 0.04	1.879PheArg: 1.879 ± 0.056	3.443PheSer: 3.443 ± 0.076	2.092PheThr: 2.092 ± 0.06	3.072PheVal: 3.072 ± 0.075	0.567PheTrp: 0.567 ± 0.034	1.282PheTyr: 1.282 ± 0.05	0.0PheXaa: 0.0 ± 0.0
Gly	6.622GlyAla: 6.622 ± 0.111	0.712GlyCys: 0.712 ± 0.037	3.917GlyAsp: 3.917 ± 0.125	4.513GlyGlu: 4.513 ± 0.095	3.767GlyPhe: 3.767 ± 0.075	6.048GlyGly: 6.048 ± 0.219	1.831GlyHis: 1.831 ± 0.055	5.044GlyIle: 5.044 ± 0.103	5.252GlyLys: 5.252 ± 0.122	7.599GlyLeu: 7.599 ± 0.128	1.944GlyMet: 1.944 ± 0.054	2.958GlyAsn: 2.958 ± 0.123	2.408GlyPro: 2.408 ± 0.068	2.513GlyGln: 2.513 ± 0.072	4.16GlyArg: 4.16 ± 0.075	4.432GlySer: 4.432 ± 0.105	4.034GlyThr: 4.034 ± 0.126	5.316GlyVal: 5.316 ± 0.095	0.932GlyTrp: 0.932 ± 0.04	2.286GlyTyr: 2.286 ± 0.063	0.0GlyXaa: 0.0 ± 0.0
His	1.756HisAla: 1.756 ± 0.044	0.226HisCys: 0.226 ± 0.019	1.279HisAsp: 1.279 ± 0.042	1.234HisGlu: 1.234 ± 0.045	1.102HisPhe: 1.102 ± 0.039	1.724HisGly: 1.724 ± 0.059	0.736HisHis: 0.736 ± 0.041	1.528HisIle: 1.528 ± 0.046	1.017HisLys: 1.017 ± 0.038	1.979HisLeu: 1.979 ± 0.055	0.576HisMet: 0.576 ± 0.029	0.803HisAsn: 0.803 ± 0.035	1.199HisPro: 1.199 ± 0.043	0.661HisGln: 0.661 ± 0.032	1.043HisArg: 1.043 ± 0.035	1.211HisSer: 1.211 ± 0.047	0.853HisThr: 0.853 ± 0.038	1.407HisVal: 1.407 ± 0.041	0.328HisTrp: 0.328 ± 0.023	0.757HisTyr: 0.757 ± 0.031	0.0HisXaa: 0.0 ± 0.0
Ile	7.27IleAla: 7.27 ± 0.118	0.648IleCys: 0.648 ± 0.034	4.487IleAsp: 4.487 ± 0.092	4.321IleGlu: 4.321 ± 0.094	2.845IlePhe: 2.845 ± 0.077	5.857IleGly: 5.857 ± 0.103	1.248IleHis: 1.248 ± 0.049	4.529IleIle: 4.529 ± 0.101	3.258IleLys: 3.258 ± 0.069	5.84IleLeu: 5.84 ± 0.121	1.434IleMet: 1.434 ± 0.044	2.618IleAsn: 2.618 ± 0.068	2.763IlePro: 2.763 ± 0.071	1.394IleGln: 1.394 ± 0.049	3.392IleArg: 3.392 ± 0.085	4.322IleSer: 4.322 ± 0.095	3.276IleThr: 3.276 ± 0.072	5.236IleVal: 5.236 ± 0.094	0.645IleTrp: 0.645 ± 0.032	1.682IleTyr: 1.682 ± 0.061	0.0IleXaa: 0.0 ± 0.0
Lys	5.741LysAla: 5.741 ± 0.094	0.321LysCys: 0.321 ± 0.022	3.266LysAsp: 3.266 ± 0.067	3.275LysGlu: 3.275 ± 0.069	1.617LysPhe: 1.617 ± 0.047	3.829LysGly: 3.829 ± 0.087	1.107LysHis: 1.107 ± 0.041	3.992LysIle: 3.992 ± 0.07	4.289LysLys: 4.289 ± 0.089	5.67LysLeu: 5.67 ± 0.106	1.529LysMet: 1.529 ± 0.047	2.944LysAsn: 2.944 ± 0.067	3.026LysPro: 3.026 ± 0.071	2.093LysGln: 2.093 ± 0.059	3.491LysArg: 3.491 ± 0.077	3.391LysSer: 3.391 ± 0.074	3.991LysThr: 3.991 ± 0.1	3.534LysVal: 3.534 ± 0.091	0.597LysTrp: 0.597 ± 0.03	1.177LysTyr: 1.177 ± 0.049	0.0LysXaa: 0.0 ± 0.0
Leu	9.478LeuAla: 9.478 ± 0.163	0.921LeuCys: 0.921 ± 0.041	5.769LeuAsp: 5.769 ± 0.094	5.466LeuGlu: 5.466 ± 0.099	4.182LeuPhe: 4.182 ± 0.107	6.867LeuGly: 6.867 ± 0.129	1.839LeuHis: 1.839 ± 0.058	6.116LeuIle: 6.116 ± 0.114	5.973LeuLys: 5.973 ± 0.094	8.579LeuLeu: 8.579 ± 0.176	2.385LeuMet: 2.385 ± 0.064	3.412LeuAsn: 3.412 ± 0.064	4.82LeuPro: 4.82 ± 0.1	2.929LeuGln: 2.929 ± 0.067	4.752LeuArg: 4.752 ± 0.097	7.01LeuSer: 7.01 ± 0.13	5.331LeuThr: 5.331 ± 0.106	6.929LeuVal: 6.929 ± 0.116	1.036LeuTrp: 1.036 ± 0.044	2.505LeuTyr: 2.505 ± 0.065	0.0LeuXaa: 0.0 ± 0.0
Met	2.54MetAla: 2.54 ± 0.064	0.143MetCys: 0.143 ± 0.014	1.205MetAsp: 1.205 ± 0.034	1.39MetGlu: 1.39 ± 0.048	0.845MetPhe: 0.845 ± 0.035	1.736MetGly: 1.736 ± 0.055	0.435MetHis: 0.435 ± 0.023	1.674MetIle: 1.674 ± 0.054	1.568MetLys: 1.568 ± 0.048	2.335MetLeu: 2.335 ± 0.065	0.771MetMet: 0.771 ± 0.041	1.002MetAsn: 1.002 ± 0.039	1.345MetPro: 1.345 ± 0.045	0.916MetGln: 0.916 ± 0.038	1.585MetArg: 1.585 ± 0.048	1.697MetSer: 1.697 ± 0.051	1.784MetThr: 1.784 ± 0.055	1.775MetVal: 1.775 ± 0.056	0.198MetTrp: 0.198 ± 0.02	0.286MetTyr: 0.286 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	3.784AsnAla: 3.784 ± 0.087	0.312AsnCys: 0.312 ± 0.023	2.361AsnAsp: 2.361 ± 0.096	2.338AsnGlu: 2.338 ± 0.056	1.651AsnPhe: 1.651 ± 0.058	3.658AsnGly: 3.658 ± 0.133	0.875AsnHis: 0.875 ± 0.04	2.683AsnIle: 2.683 ± 0.074	2.034AsnLys: 2.034 ± 0.058	3.531AsnLeu: 3.531 ± 0.078	0.94AsnMet: 0.94 ± 0.036	1.837AsnAsn: 1.837 ± 0.104	2.207AsnPro: 2.207 ± 0.056	1.241AsnGln: 1.241 ± 0.044	2.339AsnArg: 2.339 ± 0.051	2.232AsnSer: 2.232 ± 0.076	1.844AsnThr: 1.844 ± 0.079	2.714AsnVal: 2.714 ± 0.074	0.551AsnTrp: 0.551 ± 0.033	1.264AsnTyr: 1.264 ± 0.046	0.0AsnXaa: 0.0 ± 0.0
Pro	3.839ProAla: 3.839 ± 0.084	0.282ProCys: 0.282 ± 0.021	3.297ProAsp: 3.297 ± 0.085	3.629ProGlu: 3.629 ± 0.089	2.142ProPhe: 2.142 ± 0.056	2.728ProGly: 2.728 ± 0.061	0.991ProHis: 0.991 ± 0.039	2.55ProIle: 2.55 ± 0.068	2.294ProLys: 2.294 ± 0.055	4.176ProLeu: 4.176 ± 0.079	0.906ProMet: 0.906 ± 0.035	1.429ProAsn: 1.429 ± 0.054	1.583ProPro: 1.583 ± 0.066	1.733ProGln: 1.733 ± 0.056	1.972ProArg: 1.972 ± 0.057	2.478ProSer: 2.478 ± 0.057	2.303ProThr: 2.303 ± 0.089	3.877ProVal: 3.877 ± 0.072	0.483ProTrp: 0.483 ± 0.029	1.212ProTyr: 1.212 ± 0.048	0.0ProXaa: 0.0 ± 0.0
Gln	3.067GlnAla: 3.067 ± 0.073	0.22GlnCys: 0.22 ± 0.018	1.383GlnAsp: 1.383 ± 0.044	1.742GlnGlu: 1.742 ± 0.05	1.191GlnPhe: 1.191 ± 0.037	2.076GlnGly: 2.076 ± 0.061	0.663GlnHis: 0.663 ± 0.03	2.058GlnIle: 2.058 ± 0.055	2.287GlnLys: 2.287 ± 0.057	2.882GlnLeu: 2.882 ± 0.063	0.907GlnMet: 0.907 ± 0.035	1.556GlnAsn: 1.556 ± 0.05	1.325GlnPro: 1.325 ± 0.048	1.325GlnGln: 1.325 ± 0.051	1.843GlnArg: 1.843 ± 0.054	2.382GlnSer: 2.382 ± 0.07	1.788GlnThr: 1.788 ± 0.048	1.875GlnVal: 1.875 ± 0.055	0.398GlnTrp: 0.398 ± 0.02	0.809GlnTyr: 0.809 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	4.691ArgAla: 4.691 ± 0.094	0.341ArgCys: 0.341 ± 0.023	2.945ArgAsp: 2.945 ± 0.066	3.356ArgGlu: 3.356 ± 0.068	2.618ArgPhe: 2.618 ± 0.074	3.242ArgGly: 3.242 ± 0.079	1.347ArgHis: 1.347 ± 0.038	3.739ArgIle: 3.739 ± 0.075	3.122ArgLys: 3.122 ± 0.075	6.036ArgLeu: 6.036 ± 0.113	1.502ArgMet: 1.502 ± 0.047	2.257ArgAsn: 2.257 ± 0.048	2.325ArgPro: 2.325 ± 0.072	2.259ArgGln: 2.259 ± 0.06	3.237ArgArg: 3.237 ± 0.086	3.1ArgSer: 3.1 ± 0.075	2.436ArgThr: 2.436 ± 0.061	3.382ArgVal: 3.382 ± 0.072	0.547ArgTrp: 0.547 ± 0.032	1.698ArgTyr: 1.698 ± 0.057	0.0ArgXaa: 0.0 ± 0.0
Ser	5.406SerAla: 5.406 ± 0.094	0.47SerCys: 0.47 ± 0.027	3.54SerAsp: 3.54 ± 0.095	3.53SerGlu: 3.53 ± 0.072	2.925SerPhe: 2.925 ± 0.071	5.613SerGly: 5.613 ± 0.111	1.36SerHis: 1.36 ± 0.041	3.734SerIle: 3.734 ± 0.07	2.873SerLys: 2.873 ± 0.064	6.193SerLeu: 6.193 ± 0.122	1.347SerMet: 1.347 ± 0.042	2.278SerAsn: 2.278 ± 0.068	2.675SerPro: 2.675 ± 0.066	1.759SerGln: 1.759 ± 0.047	3.055SerArg: 3.055 ± 0.082	3.773SerSer: 3.773 ± 0.104	2.989SerThr: 2.989 ± 0.071	4.131SerVal: 4.131 ± 0.072	0.739SerTrp: 0.739 ± 0.038	1.759SerTyr: 1.759 ± 0.05	0.0SerXaa: 0.0 ± 0.0
Thr	4.967ThrAla: 4.967 ± 0.095	0.417ThrCys: 0.417 ± 0.025	2.916ThrAsp: 2.916 ± 0.108	2.646ThrGlu: 2.646 ± 0.063	2.21ThrPhe: 2.21 ± 0.056	4.772ThrGly: 4.772 ± 0.105	1.0ThrHis: 1.0 ± 0.042	3.92ThrIle: 3.92 ± 0.09	2.595ThrLys: 2.595 ± 0.074	5.348ThrLeu: 5.348 ± 0.096	1.219ThrMet: 1.219 ± 0.041	1.979ThrAsn: 1.979 ± 0.072	3.015ThrPro: 3.015 ± 0.096	1.384ThrGln: 1.384 ± 0.052	2.659ThrArg: 2.659 ± 0.055	3.039ThrSer: 3.039 ± 0.072	3.013ThrThr: 3.013 ± 0.105	4.185ThrVal: 4.185 ± 0.1	0.544ThrTrp: 0.544 ± 0.034	1.299ThrTyr: 1.299 ± 0.044	0.0ThrXaa: 0.0 ± 0.0
Val	6.758ValAla: 6.758 ± 0.11	0.592ValCys: 0.592 ± 0.031	4.199ValAsp: 4.199 ± 0.128	4.584ValGlu: 4.584 ± 0.08	3.062ValPhe: 3.062 ± 0.077	4.897ValGly: 4.897 ± 0.093	1.311ValHis: 1.311 ± 0.042	4.85ValIle: 4.85 ± 0.094	3.917ValLys: 3.917 ± 0.086	6.648ValLeu: 6.648 ± 0.133	1.737ValMet: 1.737 ± 0.057	2.646ValAsn: 2.646 ± 0.085	3.022ValPro: 3.022 ± 0.075	1.747ValGln: 1.747 ± 0.049	3.381ValArg: 3.381 ± 0.074	4.464ValSer: 4.464 ± 0.085	4.16ValThr: 4.16 ± 0.094	5.245ValVal: 5.245 ± 0.1	0.615ValTrp: 0.615 ± 0.029	1.755ValTyr: 1.755 ± 0.053	0.0ValXaa: 0.0 ± 0.0
Trp	0.833TrpAla: 0.833 ± 0.04	0.127TrpCys: 0.127 ± 0.012	0.454TrpAsp: 0.454 ± 0.025	0.441TrpGlu: 0.441 ± 0.025	0.521TrpPhe: 0.521 ± 0.032	0.751TrpGly: 0.751 ± 0.034	0.276TrpHis: 0.276 ± 0.019	0.652TrpIle: 0.652 ± 0.034	0.642TrpLys: 0.642 ± 0.031	1.353TrpLeu: 1.353 ± 0.05	0.273TrpMet: 0.273 ± 0.023	0.472TrpAsn: 0.472 ± 0.027	0.508TrpPro: 0.508 ± 0.027	0.564TrpGln: 0.564 ± 0.026	0.757TrpArg: 0.757 ± 0.04	0.7TrpSer: 0.7 ± 0.051	0.548TrpThr: 0.548 ± 0.038	0.668TrpVal: 0.668 ± 0.029	0.191TrpTrp: 0.191 ± 0.02	0.317TrpTyr: 0.317 ± 0.024	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.286TyrAla: 2.286 ± 0.054	0.302TyrCys: 0.302 ± 0.022	1.782TyrAsp: 1.782 ± 0.072	1.486TyrGlu: 1.486 ± 0.049	1.222TyrPhe: 1.222 ± 0.05	2.218TyrGly: 2.218 ± 0.068	0.69TyrHis: 0.69 ± 0.03	1.551TyrIle: 1.551 ± 0.049	1.204TyrLys: 1.204 ± 0.044	2.615TyrLeu: 2.615 ± 0.07	0.616TyrMet: 0.616 ± 0.033	1.023TyrAsn: 1.023 ± 0.044	1.205TyrPro: 1.205 ± 0.046	0.947TyrGln: 0.947 ± 0.035	1.701TyrArg: 1.701 ± 0.051	1.63TyrSer: 1.63 ± 0.054	1.219TyrThr: 1.219 ± 0.055	1.704TyrVal: 1.704 ± 0.055	0.34TyrTrp: 0.34 ± 0.02	0.806TyrTyr: 0.806 ± 0.037	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2111 proteins (691305 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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