Amino acid dipepetide frequency for Gray Lodge virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.216AlaAla: 1.216 ± 1.26
0.243AlaCys: 0.243 ± 0.376
2.675AlaAsp: 2.675 ± 0.67
2.918AlaGlu: 2.918 ± 1.368
1.702AlaPhe: 1.702 ± 1.263
2.189AlaGly: 2.189 ± 0.707
1.459AlaHis: 1.459 ± 0.477
3.648AlaIle: 3.648 ± 0.917
1.946AlaLys: 1.946 ± 0.809
5.837AlaLeu: 5.837 ± 0.816
0.73AlaMet: 0.73 ± 0.269
3.161AlaAsn: 3.161 ± 1.051
1.702AlaPro: 1.702 ± 0.777
1.216AlaGln: 1.216 ± 0.692
2.432AlaArg: 2.432 ± 0.505
3.405AlaSer: 3.405 ± 0.665
1.459AlaThr: 1.459 ± 0.598
1.946AlaVal: 1.946 ± 0.61
1.702AlaTrp: 1.702 ± 0.709
2.189AlaTyr: 2.189 ± 0.631
0.0AlaXaa: 0.0 ± 0.0
Cys
0.73CysAla: 0.73 ± 0.292
0.243CysCys: 0.243 ± 0.138
0.73CysAsp: 0.73 ± 0.641
1.216CysGlu: 1.216 ± 0.706
0.486CysPhe: 0.486 ± 0.277
1.216CysGly: 1.216 ± 0.328
0.243CysHis: 0.243 ± 0.272
0.973CysIle: 0.973 ± 0.38
1.702CysLys: 1.702 ± 0.639
0.243CysLeu: 0.243 ± 0.138
0.486CysMet: 0.486 ± 0.298
0.73CysAsn: 0.73 ± 0.269
0.973CysPro: 0.973 ± 0.744
0.486CysGln: 0.486 ± 0.592
1.459CysArg: 1.459 ± 0.538
1.946CysSer: 1.946 ± 0.412
0.486CysThr: 0.486 ± 0.232
0.73CysVal: 0.73 ± 0.426
0.243CysTrp: 0.243 ± 0.138
1.459CysTyr: 1.459 ± 0.442
0.0CysXaa: 0.0 ± 0.0
Asp
2.432AspAla: 2.432 ± 1.284
0.73AspCys: 0.73 ± 0.378
3.405AspAsp: 3.405 ± 1.279
4.621AspGlu: 4.621 ± 0.668
1.702AspPhe: 1.702 ± 0.424
2.432AspGly: 2.432 ± 0.48
1.702AspHis: 1.702 ± 0.525
3.161AspIle: 3.161 ± 1.1
3.648AspLys: 3.648 ± 1.429
8.512AspLeu: 8.512 ± 1.909
0.973AspMet: 0.973 ± 0.257
2.675AspAsn: 2.675 ± 1.209
3.891AspPro: 3.891 ± 0.56
1.946AspGln: 1.946 ± 0.75
0.73AspArg: 0.73 ± 0.415
4.377AspSer: 4.377 ± 1.698
1.702AspThr: 1.702 ± 0.742
2.918AspVal: 2.918 ± 1.588
0.73AspTrp: 0.73 ± 0.428
2.189AspTyr: 2.189 ± 0.582
0.0AspXaa: 0.0 ± 0.0
Glu
2.675GluAla: 2.675 ± 0.395
1.459GluCys: 1.459 ± 0.389
2.189GluAsp: 2.189 ± 0.631
5.593GluGlu: 5.593 ± 1.732
4.377GluPhe: 4.377 ± 1.009
2.675GluGly: 2.675 ± 0.475
1.216GluHis: 1.216 ± 0.692
5.107GluIle: 5.107 ± 1.004
5.593GluLys: 5.593 ± 1.598
7.053GluLeu: 7.053 ± 1.415
1.946GluMet: 1.946 ± 0.677
3.648GluAsn: 3.648 ± 0.664
2.432GluPro: 2.432 ± 0.754
0.73GluGln: 0.73 ± 0.416
1.459GluArg: 1.459 ± 0.538
5.593GluSer: 5.593 ± 1.529
3.405GluThr: 3.405 ± 0.53
3.161GluVal: 3.161 ± 0.465
1.459GluTrp: 1.459 ± 0.389
1.459GluTyr: 1.459 ± 0.423
0.0GluXaa: 0.0 ± 0.0
Phe
1.946PheAla: 1.946 ± 0.9
0.973PheCys: 0.973 ± 0.576
1.946PheAsp: 1.946 ± 0.317
2.675PheGlu: 2.675 ± 0.84
2.675PhePhe: 2.675 ± 0.639
2.189PheGly: 2.189 ± 0.703
1.216PheHis: 1.216 ± 0.55
2.675PheIle: 2.675 ± 0.595
2.675PheLys: 2.675 ± 0.718
5.107PheLeu: 5.107 ± 0.862
1.216PheMet: 1.216 ± 0.339
1.216PheAsn: 1.216 ± 0.328
2.918PhePro: 2.918 ± 0.411
2.189PheGln: 2.189 ± 1.245
2.675PheArg: 2.675 ± 0.682
4.377PheSer: 4.377 ± 1.444
0.973PheThr: 0.973 ± 0.415
4.134PheVal: 4.134 ± 0.901
0.243PheTrp: 0.243 ± 0.138
0.973PheTyr: 0.973 ± 0.412
0.0PheXaa: 0.0 ± 0.0
Gly
1.702GlyAla: 1.702 ± 0.636
0.486GlyCys: 0.486 ± 0.277
3.648GlyAsp: 3.648 ± 0.521
2.432GlyGlu: 2.432 ± 1.426
1.459GlyPhe: 1.459 ± 0.439
3.405GlyGly: 3.405 ± 0.856
1.216GlyHis: 1.216 ± 0.473
5.593GlyIle: 5.593 ± 0.965
2.432GlyLys: 2.432 ± 0.654
9.484GlyLeu: 9.484 ± 0.61
1.216GlyMet: 1.216 ± 1.095
1.216GlyAsn: 1.216 ± 0.904
1.459GlyPro: 1.459 ± 0.457
1.946GlyGln: 1.946 ± 0.543
2.918GlyArg: 2.918 ± 0.692
5.593GlySer: 5.593 ± 0.688
3.161GlyThr: 3.161 ± 1.297
3.161GlyVal: 3.161 ± 0.498
0.486GlyTrp: 0.486 ± 0.277
0.973GlyTyr: 0.973 ± 0.554
0.0GlyXaa: 0.0 ± 0.0
His
0.973HisAla: 0.973 ± 0.409
0.243HisCys: 0.243 ± 0.304
1.459HisAsp: 1.459 ± 0.438
1.459HisGlu: 1.459 ± 0.631
0.73HisPhe: 0.73 ± 0.415
0.486HisGly: 0.486 ± 0.232
0.973HisHis: 0.973 ± 0.429
1.702HisIle: 1.702 ± 0.602
0.73HisLys: 0.73 ± 0.269
2.675HisLeu: 2.675 ± 0.674
0.73HisMet: 0.73 ± 0.467
1.216HisAsn: 1.216 ± 0.473
2.189HisPro: 2.189 ± 0.621
1.216HisGln: 1.216 ± 0.565
1.216HisArg: 1.216 ± 0.384
1.216HisSer: 1.216 ± 0.384
0.73HisThr: 0.73 ± 0.428
2.189HisVal: 2.189 ± 0.555
1.216HisTrp: 1.216 ± 0.473
1.216HisTyr: 1.216 ± 0.716
0.0HisXaa: 0.0 ± 0.0
Ile
2.675IleAla: 2.675 ± 1.311
2.675IleCys: 2.675 ± 0.765
3.648IleAsp: 3.648 ± 0.652
4.377IleGlu: 4.377 ± 1.284
3.161IlePhe: 3.161 ± 0.812
6.08IleGly: 6.08 ± 1.409
2.432IleHis: 2.432 ± 1.086
7.053IleIle: 7.053 ± 1.927
4.621IleLys: 4.621 ± 0.877
7.782IleLeu: 7.782 ± 1.633
2.918IleMet: 2.918 ± 0.436
3.161IleAsn: 3.161 ± 0.858
3.405IlePro: 3.405 ± 0.855
3.405IleGln: 3.405 ± 1.136
5.837IleArg: 5.837 ± 1.001
7.296IleSer: 7.296 ± 1.509
2.918IleThr: 2.918 ± 1.167
4.377IleVal: 4.377 ± 1.313
0.73IleTrp: 0.73 ± 0.324
1.702IleTyr: 1.702 ± 0.488
0.0IleXaa: 0.0 ± 0.0
Lys
0.973LysAla: 0.973 ± 0.554
1.459LysCys: 1.459 ± 0.641
4.864LysAsp: 4.864 ± 1.487
5.107LysGlu: 5.107 ± 1.222
2.432LysPhe: 2.432 ± 1.111
3.405LysGly: 3.405 ± 0.552
0.0LysHis: 0.0 ± 0.0
6.566LysIle: 6.566 ± 1.372
5.593LysLys: 5.593 ± 1.275
6.809LysLeu: 6.809 ± 1.338
1.702LysMet: 1.702 ± 0.608
5.107LysAsn: 5.107 ± 0.827
1.702LysPro: 1.702 ± 0.505
1.946LysGln: 1.946 ± 0.571
4.134LysArg: 4.134 ± 0.972
3.405LysSer: 3.405 ± 0.886
3.648LysThr: 3.648 ± 0.939
3.161LysVal: 3.161 ± 0.895
1.946LysTrp: 1.946 ± 0.668
1.459LysTyr: 1.459 ± 0.595
0.0LysXaa: 0.0 ± 0.0
Leu
4.864LeuAla: 4.864 ± 0.541
2.432LeuCys: 2.432 ± 1.001
7.782LeuAsp: 7.782 ± 1.607
7.296LeuGlu: 7.296 ± 1.288
4.621LeuPhe: 4.621 ± 1.392
4.864LeuGly: 4.864 ± 0.962
2.675LeuHis: 2.675 ± 1.032
9.971LeuIle: 9.971 ± 2.123
7.296LeuLys: 7.296 ± 1.256
9.241LeuLeu: 9.241 ± 1.125
2.918LeuMet: 2.918 ± 0.496
4.864LeuAsn: 4.864 ± 1.457
1.459LeuPro: 1.459 ± 0.531
2.675LeuGln: 2.675 ± 0.771
7.053LeuArg: 7.053 ± 1.366
9.728LeuSer: 9.728 ± 2.65
4.134LeuThr: 4.134 ± 1.193
4.864LeuVal: 4.864 ± 1.532
1.946LeuTrp: 1.946 ± 0.955
5.35LeuTyr: 5.35 ± 0.975
0.0LeuXaa: 0.0 ± 0.0
Met
0.73MetAla: 0.73 ± 0.33
0.0MetCys: 0.0 ± 0.0
0.973MetAsp: 0.973 ± 0.63
1.946MetGlu: 1.946 ± 0.86
0.973MetPhe: 0.973 ± 0.64
1.459MetGly: 1.459 ± 0.51
0.243MetHis: 0.243 ± 0.284
4.134MetIle: 4.134 ± 0.9
1.702MetLys: 1.702 ± 1.038
2.432MetLeu: 2.432 ± 0.645
0.973MetMet: 0.973 ± 0.805
0.973MetAsn: 0.973 ± 0.257
0.486MetPro: 0.486 ± 0.395
0.73MetGln: 0.73 ± 0.378
1.216MetArg: 1.216 ± 0.292
1.459MetSer: 1.459 ± 0.821
1.216MetThr: 1.216 ± 0.899
1.216MetVal: 1.216 ± 0.486
0.73MetTrp: 0.73 ± 0.616
1.702MetTyr: 1.702 ± 0.8
0.0MetXaa: 0.0 ± 0.0
Asn
2.675AsnAla: 2.675 ± 0.815
0.486AsnCys: 0.486 ± 0.232
2.675AsnAsp: 2.675 ± 0.816
1.946AsnGlu: 1.946 ± 0.86
1.459AsnPhe: 1.459 ± 0.432
2.918AsnGly: 2.918 ± 1.186
2.189AsnHis: 2.189 ± 0.527
3.405AsnIle: 3.405 ± 0.865
1.702AsnLys: 1.702 ± 0.801
7.296AsnLeu: 7.296 ± 2.197
0.973AsnMet: 0.973 ± 0.623
3.161AsnAsn: 3.161 ± 1.054
2.918AsnPro: 2.918 ± 0.502
3.648AsnGln: 3.648 ± 0.9
0.973AsnArg: 0.973 ± 0.538
3.405AsnSer: 3.405 ± 0.599
4.864AsnThr: 4.864 ± 0.598
1.702AsnVal: 1.702 ± 1.007
1.216AsnTrp: 1.216 ± 0.825
1.216AsnTyr: 1.216 ± 0.572
0.0AsnXaa: 0.0 ± 0.0
Pro
2.189ProAla: 2.189 ± 0.884
0.486ProCys: 0.486 ± 0.321
2.675ProAsp: 2.675 ± 0.996
2.918ProGlu: 2.918 ± 0.576
1.216ProPhe: 1.216 ± 0.773
2.675ProGly: 2.675 ± 1.525
1.216ProHis: 1.216 ± 0.51
2.918ProIle: 2.918 ± 0.708
2.675ProLys: 2.675 ± 0.7
4.134ProLeu: 4.134 ± 0.71
0.973ProMet: 0.973 ± 0.526
2.675ProAsn: 2.675 ± 0.899
3.891ProPro: 3.891 ± 2.226
1.459ProGln: 1.459 ± 0.752
1.946ProArg: 1.946 ± 0.97
3.648ProSer: 3.648 ± 0.832
2.432ProThr: 2.432 ± 0.56
1.946ProVal: 1.946 ± 0.926
0.973ProTrp: 0.973 ± 0.478
1.459ProTyr: 1.459 ± 0.73
0.0ProXaa: 0.0 ± 0.0
Gln
1.459GlnAla: 1.459 ± 0.477
0.486GlnCys: 0.486 ± 0.468
1.216GlnAsp: 1.216 ± 0.774
2.675GlnGlu: 2.675 ± 0.581
2.675GlnPhe: 2.675 ± 0.378
2.189GlnGly: 2.189 ± 0.646
0.243GlnHis: 0.243 ± 0.138
1.216GlnIle: 1.216 ± 0.448
3.161GlnLys: 3.161 ± 0.632
2.675GlnLeu: 2.675 ± 0.543
0.486GlnMet: 0.486 ± 0.485
0.73GlnAsn: 0.73 ± 0.33
1.702GlnPro: 1.702 ± 0.71
0.73GlnGln: 0.73 ± 0.654
1.216GlnArg: 1.216 ± 0.465
2.675GlnSer: 2.675 ± 1.071
2.432GlnThr: 2.432 ± 0.797
2.918GlnVal: 2.918 ± 0.763
0.73GlnTrp: 0.73 ± 0.42
1.459GlnTyr: 1.459 ± 0.752
0.0GlnXaa: 0.0 ± 0.0
Arg
3.405ArgAla: 3.405 ± 0.694
0.486ArgCys: 0.486 ± 0.232
2.675ArgAsp: 2.675 ± 0.501
2.432ArgGlu: 2.432 ± 0.504
2.918ArgPhe: 2.918 ± 0.968
3.161ArgGly: 3.161 ± 0.953
1.216ArgHis: 1.216 ± 0.473
4.377ArgIle: 4.377 ± 1.132
3.648ArgLys: 3.648 ± 1.571
3.648ArgLeu: 3.648 ± 1.083
1.459ArgMet: 1.459 ± 1.188
3.405ArgAsn: 3.405 ± 0.755
2.918ArgPro: 2.918 ± 0.47
1.459ArgGln: 1.459 ± 0.494
2.675ArgArg: 2.675 ± 0.682
2.432ArgSer: 2.432 ± 0.417
4.134ArgThr: 4.134 ± 1.045
2.189ArgVal: 2.189 ± 0.593
0.73ArgTrp: 0.73 ± 0.415
1.459ArgTyr: 1.459 ± 0.534
0.0ArgXaa: 0.0 ± 0.0
Ser
6.323SerAla: 6.323 ± 0.955
1.459SerCys: 1.459 ± 0.587
4.864SerAsp: 4.864 ± 1.683
3.161SerGlu: 3.161 ± 0.719
4.134SerPhe: 4.134 ± 0.851
3.405SerGly: 3.405 ± 0.787
2.675SerHis: 2.675 ± 0.492
7.053SerIle: 7.053 ± 1.001
5.837SerLys: 5.837 ± 1.662
8.025SerLeu: 8.025 ± 2.759
1.459SerMet: 1.459 ± 1.1
4.377SerAsn: 4.377 ± 0.891
2.675SerPro: 2.675 ± 0.627
1.702SerGln: 1.702 ± 0.687
3.648SerArg: 3.648 ± 1.176
6.566SerSer: 6.566 ± 1.649
4.621SerThr: 4.621 ± 0.967
4.377SerVal: 4.377 ± 2.205
2.432SerTrp: 2.432 ± 0.577
1.702SerTyr: 1.702 ± 0.589
0.0SerXaa: 0.0 ± 0.0
Thr
2.189ThrAla: 2.189 ± 0.685
1.216ThrCys: 1.216 ± 0.576
0.973ThrAsp: 0.973 ± 0.375
2.918ThrGlu: 2.918 ± 1.586
2.189ThrPhe: 2.189 ± 0.674
2.918ThrGly: 2.918 ± 0.858
1.216ThrHis: 1.216 ± 0.525
3.161ThrIle: 3.161 ± 0.734
3.161ThrLys: 3.161 ± 0.771
5.35ThrLeu: 5.35 ± 1.188
0.973ThrMet: 0.973 ± 0.554
2.432ThrAsn: 2.432 ± 0.338
2.189ThrPro: 2.189 ± 1.032
2.675ThrGln: 2.675 ± 0.611
3.648ThrArg: 3.648 ± 1.302
3.648ThrSer: 3.648 ± 0.685
3.161ThrThr: 3.161 ± 1.04
3.161ThrVal: 3.161 ± 0.809
1.946ThrTrp: 1.946 ± 0.496
1.946ThrTyr: 1.946 ± 0.61
0.0ThrXaa: 0.0 ± 0.0
Val
1.946ValAla: 1.946 ± 1.229
1.216ValCys: 1.216 ± 0.292
3.648ValAsp: 3.648 ± 0.805
3.405ValGlu: 3.405 ± 1.004
2.918ValPhe: 2.918 ± 0.469
3.161ValGly: 3.161 ± 0.849
0.73ValHis: 0.73 ± 0.292
4.377ValIle: 4.377 ± 0.885
3.648ValLys: 3.648 ± 0.587
3.648ValLeu: 3.648 ± 0.751
1.459ValMet: 1.459 ± 0.543
1.216ValAsn: 1.216 ± 0.35
3.648ValPro: 3.648 ± 1.076
1.216ValGln: 1.216 ± 0.761
2.675ValArg: 2.675 ± 0.796
6.08ValSer: 6.08 ± 1.755
2.432ValThr: 2.432 ± 1.032
3.648ValVal: 3.648 ± 0.892
0.73ValTrp: 0.73 ± 0.35
3.161ValTyr: 3.161 ± 1.166
0.0ValXaa: 0.0 ± 0.0
Trp
0.973TrpAla: 0.973 ± 0.379
0.0TrpCys: 0.0 ± 0.0
0.73TrpAsp: 0.73 ± 0.324
2.675TrpGlu: 2.675 ± 0.777
0.973TrpPhe: 0.973 ± 0.429
1.702TrpGly: 1.702 ± 0.525
0.243TrpHis: 0.243 ± 0.138
1.946TrpIle: 1.946 ± 1.296
1.216TrpLys: 1.216 ± 0.525
1.216TrpLeu: 1.216 ± 0.429
0.973TrpMet: 0.973 ± 0.805
1.459TrpAsn: 1.459 ± 0.425
0.243TrpPro: 0.243 ± 0.138
0.486TrpGln: 0.486 ± 0.347
0.973TrpArg: 0.973 ± 0.412
1.459TrpSer: 1.459 ± 0.389
1.216TrpThr: 1.216 ± 0.72
1.216TrpVal: 1.216 ± 0.35
0.73TrpTrp: 0.73 ± 0.637
0.73TrpTyr: 0.73 ± 0.486
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.702TyrAla: 1.702 ± 0.488
0.0TyrCys: 0.0 ± 0.0
1.702TyrAsp: 1.702 ± 0.488
1.459TyrGlu: 1.459 ± 0.442
2.189TyrPhe: 2.189 ± 0.806
1.459TyrGly: 1.459 ± 0.496
1.459TyrHis: 1.459 ± 0.461
1.216TyrIle: 1.216 ± 0.565
2.432TyrLys: 2.432 ± 0.712
4.864TyrLeu: 4.864 ± 1.211
0.486TyrMet: 0.486 ± 0.38
3.405TyrAsn: 3.405 ± 0.715
1.702TyrPro: 1.702 ± 0.558
1.459TyrGln: 1.459 ± 0.86
1.946TyrArg: 1.946 ± 0.913
2.189TyrSer: 2.189 ± 0.607
1.946TyrThr: 1.946 ± 0.802
1.946TyrVal: 1.946 ± 0.609
0.243TyrTrp: 0.243 ± 0.272
0.486TyrTyr: 0.486 ± 0.277
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 9 proteins (4113 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski