Amino acid dipepetide frequency for Columbid alphaherpesvirus 1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
13.251AlaAla: 13.251 ± 1.04
1.818AlaCys: 1.818 ± 0.225
5.539AlaAsp: 5.539 ± 0.409
5.539AlaGlu: 5.539 ± 0.467
3.7AlaPhe: 3.7 ± 0.319
7.566AlaGly: 7.566 ± 0.6
1.296AlaHis: 1.296 ± 0.17
3.867AlaIle: 3.867 ± 0.28
3.261AlaLys: 3.261 ± 0.283
8.904AlaLeu: 8.904 ± 0.547
2.132AlaMet: 2.132 ± 0.206
2.696AlaAsn: 2.696 ± 0.271
5.413AlaPro: 5.413 ± 0.391
2.132AlaGln: 2.132 ± 0.186
8.298AlaArg: 8.298 ± 0.492
7.942AlaSer: 7.942 ± 0.53
5.727AlaThr: 5.727 ± 0.322
7.754AlaVal: 7.754 ± 0.342
1.024AlaTrp: 1.024 ± 0.175
2.801AlaTyr: 2.801 ± 0.254
0.0AlaXaa: 0.0 ± 0.0
Cys
1.777CysAla: 1.777 ± 0.276
0.669CysCys: 0.669 ± 0.136
1.505CysAsp: 1.505 ± 0.198
1.024CysGlu: 1.024 ± 0.147
0.648CysPhe: 0.648 ± 0.118
1.4CysGly: 1.4 ± 0.238
0.376CysHis: 0.376 ± 0.085
0.982CysIle: 0.982 ± 0.174
0.606CysLys: 0.606 ± 0.109
2.153CysLeu: 2.153 ± 0.244
0.585CysMet: 0.585 ± 0.115
0.711CysAsn: 0.711 ± 0.14
0.982CysPro: 0.982 ± 0.148
0.334CysGln: 0.334 ± 0.081
1.651CysArg: 1.651 ± 0.228
1.568CysSer: 1.568 ± 0.206
1.212CysThr: 1.212 ± 0.187
1.672CysVal: 1.672 ± 0.203
0.23CysTrp: 0.23 ± 0.075
0.585CysTyr: 0.585 ± 0.096
0.0CysXaa: 0.0 ± 0.0
Asp
7.796AspAla: 7.796 ± 0.455
0.794AspCys: 0.794 ± 0.143
5.748AspAsp: 5.748 ± 0.539
4.201AspGlu: 4.201 ± 0.37
1.693AspPhe: 1.693 ± 0.182
5.455AspGly: 5.455 ± 0.38
0.92AspHis: 0.92 ± 0.137
2.027AspIle: 2.027 ± 0.182
1.526AspLys: 1.526 ± 0.164
4.703AspLeu: 4.703 ± 0.333
1.547AspMet: 1.547 ± 0.157
1.526AspAsn: 1.526 ± 0.217
3.428AspPro: 3.428 ± 0.31
1.296AspGln: 1.296 ± 0.186
4.745AspArg: 4.745 ± 0.359
4.786AspSer: 4.786 ± 0.383
2.508AspThr: 2.508 ± 0.264
4.912AspVal: 4.912 ± 0.353
0.815AspTrp: 0.815 ± 0.142
1.965AspTyr: 1.965 ± 0.159
0.0AspXaa: 0.0 ± 0.0
Glu
4.912GluAla: 4.912 ± 0.358
1.212GluCys: 1.212 ± 0.217
4.013GluAsp: 4.013 ± 0.342
4.682GluGlu: 4.682 ± 0.406
1.379GluPhe: 1.379 ± 0.204
3.846GluGly: 3.846 ± 0.297
0.982GluHis: 0.982 ± 0.172
2.111GluIle: 2.111 ± 0.192
1.735GluLys: 1.735 ± 0.236
4.765GluLeu: 4.765 ± 0.423
1.379GluMet: 1.379 ± 0.148
1.798GluAsn: 1.798 ± 0.194
2.947GluPro: 2.947 ± 0.267
1.212GluGln: 1.212 ± 0.166
4.975GluArg: 4.975 ± 0.381
3.7GluSer: 3.7 ± 0.243
3.386GluThr: 3.386 ± 0.245
3.052GluVal: 3.052 ± 0.248
0.606GluTrp: 0.606 ± 0.106
1.798GluTyr: 1.798 ± 0.197
0.0GluXaa: 0.0 ± 0.0
Phe
3.052PheAla: 3.052 ± 0.28
0.773PheCys: 0.773 ± 0.134
2.341PheAsp: 2.341 ± 0.228
1.463PheGlu: 1.463 ± 0.203
1.609PhePhe: 1.609 ± 0.242
2.383PheGly: 2.383 ± 0.224
0.669PheHis: 0.669 ± 0.124
1.798PheIle: 1.798 ± 0.195
1.129PheLys: 1.129 ± 0.169
3.052PheLeu: 3.052 ± 0.347
0.836PheMet: 0.836 ± 0.162
1.066PheAsn: 1.066 ± 0.146
2.069PhePro: 2.069 ± 0.25
0.69PheGln: 0.69 ± 0.11
1.965PheArg: 1.965 ± 0.182
3.114PheSer: 3.114 ± 0.302
1.735PheThr: 1.735 ± 0.168
2.508PheVal: 2.508 ± 0.262
0.606PheTrp: 0.606 ± 0.118
1.379PheTyr: 1.379 ± 0.168
0.0PheXaa: 0.0 ± 0.0
Gly
7.211GlyAla: 7.211 ± 0.514
1.547GlyCys: 1.547 ± 0.203
4.661GlyAsp: 4.661 ± 0.441
5.037GlyGlu: 5.037 ± 0.356
2.216GlyPhe: 2.216 ± 0.296
9.865GlyGly: 9.865 ± 1.109
1.317GlyHis: 1.317 ± 0.154
1.923GlyIle: 1.923 ± 0.186
2.634GlyLys: 2.634 ± 0.251
5.978GlyLeu: 5.978 ± 0.306
1.756GlyMet: 1.756 ± 0.169
1.798GlyAsn: 1.798 ± 0.203
4.431GlyPro: 4.431 ± 0.453
2.048GlyGln: 2.048 ± 0.176
7.608GlyArg: 7.608 ± 0.572
6.249GlySer: 6.249 ± 0.406
3.971GlyThr: 3.971 ± 0.315
4.368GlyVal: 4.368 ± 0.372
0.982GlyTrp: 0.982 ± 0.184
1.588GlyTyr: 1.588 ± 0.182
0.0GlyXaa: 0.0 ± 0.0
His
1.693HisAla: 1.693 ± 0.184
0.481HisCys: 0.481 ± 0.14
0.773HisAsp: 0.773 ± 0.118
0.752HisGlu: 0.752 ± 0.124
0.773HisPhe: 0.773 ± 0.137
1.651HisGly: 1.651 ± 0.197
0.523HisHis: 0.523 ± 0.109
0.669HisIle: 0.669 ± 0.135
0.606HisLys: 0.606 ± 0.135
1.902HisLeu: 1.902 ± 0.211
0.314HisMet: 0.314 ± 0.087
0.732HisAsn: 0.732 ± 0.149
1.588HisPro: 1.588 ± 0.201
0.314HisGln: 0.314 ± 0.079
1.86HisArg: 1.86 ± 0.239
1.4HisSer: 1.4 ± 0.233
1.108HisThr: 1.108 ± 0.174
1.421HisVal: 1.421 ± 0.186
0.105HisTrp: 0.105 ± 0.045
0.439HisTyr: 0.439 ± 0.123
0.0HisXaa: 0.0 ± 0.0
Ile
3.595IleAla: 3.595 ± 0.346
0.899IleCys: 0.899 ± 0.135
2.32IleAsp: 2.32 ± 0.235
2.048IleGlu: 2.048 ± 0.247
1.735IlePhe: 1.735 ± 0.21
2.341IleGly: 2.341 ± 0.239
0.752IleHis: 0.752 ± 0.138
1.881IleIle: 1.881 ± 0.198
1.923IleLys: 1.923 ± 0.211
3.261IleLeu: 3.261 ± 0.298
1.15IleMet: 1.15 ± 0.162
1.484IleAsn: 1.484 ± 0.195
2.508IlePro: 2.508 ± 0.232
1.233IleGln: 1.233 ± 0.157
2.696IleArg: 2.696 ± 0.223
2.905IleSer: 2.905 ± 0.197
2.466IleThr: 2.466 ± 0.234
2.592IleVal: 2.592 ± 0.321
0.397IleTrp: 0.397 ± 0.087
1.233IleTyr: 1.233 ± 0.161
0.0IleXaa: 0.0 ± 0.0
Lys
2.822LysAla: 2.822 ± 0.296
0.669LysCys: 0.669 ± 0.123
1.756LysAsp: 1.756 ± 0.215
1.839LysGlu: 1.839 ± 0.244
0.794LysPhe: 0.794 ± 0.163
2.257LysGly: 2.257 ± 0.2
0.961LysHis: 0.961 ± 0.151
1.588LysIle: 1.588 ± 0.191
1.63LysLys: 1.63 ± 0.248
2.592LysLeu: 2.592 ± 0.288
0.773LysMet: 0.773 ± 0.125
1.108LysAsn: 1.108 ± 0.128
1.86LysPro: 1.86 ± 0.261
0.941LysGln: 0.941 ± 0.145
3.449LysArg: 3.449 ± 0.334
2.195LysSer: 2.195 ± 0.241
2.613LysThr: 2.613 ± 0.221
1.798LysVal: 1.798 ± 0.217
0.585LysTrp: 0.585 ± 0.116
1.108LysTyr: 1.108 ± 0.13
0.0LysXaa: 0.0 ± 0.0
Leu
7.963LeuAla: 7.963 ± 0.434
2.09LeuCys: 2.09 ± 0.263
4.765LeuAsp: 4.765 ± 0.349
4.577LeuGlu: 4.577 ± 0.357
3.658LeuPhe: 3.658 ± 0.313
5.748LeuGly: 5.748 ± 0.363
1.86LeuHis: 1.86 ± 0.208
3.532LeuIle: 3.532 ± 0.323
3.01LeuLys: 3.01 ± 0.326
8.298LeuLeu: 8.298 ± 0.443
1.839LeuMet: 1.839 ± 0.233
2.362LeuAsn: 2.362 ± 0.272
4.954LeuPro: 4.954 ± 0.29
2.257LeuGln: 2.257 ± 0.241
6.897LeuArg: 6.897 ± 0.378
6.939LeuSer: 6.939 ± 0.357
4.912LeuThr: 4.912 ± 0.343
5.602LeuVal: 5.602 ± 0.341
1.191LeuTrp: 1.191 ± 0.137
2.78LeuTyr: 2.78 ± 0.231
0.0LeuXaa: 0.0 ± 0.0
Met
2.801MetAla: 2.801 ± 0.312
0.376MetCys: 0.376 ± 0.083
1.547MetAsp: 1.547 ± 0.161
1.024MetGlu: 1.024 ± 0.158
1.003MetPhe: 1.003 ± 0.154
1.442MetGly: 1.442 ± 0.156
0.376MetHis: 0.376 ± 0.093
1.024MetIle: 1.024 ± 0.165
0.732MetLys: 0.732 ± 0.124
1.944MetLeu: 1.944 ± 0.231
0.46MetMet: 0.46 ± 0.119
0.711MetAsn: 0.711 ± 0.126
1.15MetPro: 1.15 ± 0.185
0.606MetGln: 0.606 ± 0.11
1.86MetArg: 1.86 ± 0.233
2.132MetSer: 2.132 ± 0.244
1.317MetThr: 1.317 ± 0.189
1.338MetVal: 1.338 ± 0.187
0.209MetTrp: 0.209 ± 0.075
0.732MetTyr: 0.732 ± 0.115
0.0MetXaa: 0.0 ± 0.0
Asn
2.738AsnAla: 2.738 ± 0.259
0.669AsnCys: 0.669 ± 0.152
1.839AsnAsp: 1.839 ± 0.206
1.254AsnGlu: 1.254 ± 0.158
1.066AsnPhe: 1.066 ± 0.118
2.027AsnGly: 2.027 ± 0.251
0.564AsnHis: 0.564 ± 0.111
1.484AsnIle: 1.484 ± 0.185
1.129AsnLys: 1.129 ± 0.144
2.299AsnLeu: 2.299 ± 0.262
0.836AsnMet: 0.836 ± 0.12
0.961AsnAsn: 0.961 ± 0.13
1.63AsnPro: 1.63 ± 0.174
0.543AsnGln: 0.543 ± 0.119
2.069AsnArg: 2.069 ± 0.236
2.236AsnSer: 2.236 ± 0.241
1.275AsnThr: 1.275 ± 0.18
2.174AsnVal: 2.174 ± 0.265
0.23AsnTrp: 0.23 ± 0.073
0.961AsnTyr: 0.961 ± 0.169
0.0AsnXaa: 0.0 ± 0.0
Pro
5.999ProAla: 5.999 ± 0.498
1.233ProCys: 1.233 ± 0.191
3.449ProAsp: 3.449 ± 0.247
3.428ProGlu: 3.428 ± 0.32
1.693ProPhe: 1.693 ± 0.188
4.285ProGly: 4.285 ± 0.415
1.254ProHis: 1.254 ± 0.172
2.048ProIle: 2.048 ± 0.199
1.986ProLys: 1.986 ± 0.215
4.598ProLeu: 4.598 ± 0.276
1.338ProMet: 1.338 ± 0.175
1.379ProAsn: 1.379 ± 0.165
6.605ProPro: 6.605 ± 0.608
2.257ProGln: 2.257 ± 0.312
5.33ProArg: 5.33 ± 0.393
6.082ProSer: 6.082 ± 0.492
3.428ProThr: 3.428 ± 0.285
3.449ProVal: 3.449 ± 0.211
0.585ProTrp: 0.585 ± 0.096
1.484ProTyr: 1.484 ± 0.176
0.0ProXaa: 0.0 ± 0.0
Gln
2.007GlnAla: 2.007 ± 0.181
0.543GlnCys: 0.543 ± 0.097
1.296GlnAsp: 1.296 ± 0.162
1.254GlnGlu: 1.254 ± 0.152
0.961GlnPhe: 0.961 ± 0.18
1.818GlnGly: 1.818 ± 0.193
0.523GlnHis: 0.523 ± 0.104
0.899GlnIle: 0.899 ± 0.127
1.003GlnLys: 1.003 ± 0.143
2.216GlnLeu: 2.216 ± 0.2
0.752GlnMet: 0.752 ± 0.174
0.773GlnAsn: 0.773 ± 0.119
1.568GlnPro: 1.568 ± 0.199
1.233GlnGln: 1.233 ± 0.269
2.425GlnArg: 2.425 ± 0.236
1.818GlnSer: 1.818 ± 0.227
2.216GlnThr: 2.216 ± 0.238
1.317GlnVal: 1.317 ± 0.14
0.251GlnTrp: 0.251 ± 0.084
0.711GlnTyr: 0.711 ± 0.123
0.0GlnXaa: 0.0 ± 0.0
Arg
7.608ArgAla: 7.608 ± 0.49
1.923ArgCys: 1.923 ± 0.289
5.058ArgAsp: 5.058 ± 0.332
4.201ArgGlu: 4.201 ± 0.307
2.822ArgPhe: 2.822 ± 0.225
6.96ArgGly: 6.96 ± 0.515
1.818ArgHis: 1.818 ± 0.229
3.219ArgIle: 3.219 ± 0.297
2.717ArgLys: 2.717 ± 0.289
6.939ArgLeu: 6.939 ± 0.458
1.693ArgMet: 1.693 ± 0.183
2.153ArgAsn: 2.153 ± 0.232
5.852ArgPro: 5.852 ± 0.374
2.466ArgGln: 2.466 ± 0.184
10.931ArgArg: 10.931 ± 0.87
7.002ArgSer: 7.002 ± 0.472
4.327ArgThr: 4.327 ± 0.306
5.518ArgVal: 5.518 ± 0.38
0.815ArgTrp: 0.815 ± 0.158
2.613ArgTyr: 2.613 ± 0.201
0.0ArgXaa: 0.0 ± 0.0
Ser
8.423SerAla: 8.423 ± 0.676
1.359SerCys: 1.359 ± 0.165
5.351SerAsp: 5.351 ± 0.408
3.95SerGlu: 3.95 ± 0.306
2.278SerPhe: 2.278 ± 0.243
6.751SerGly: 6.751 ± 0.432
1.651SerHis: 1.651 ± 0.237
2.968SerIle: 2.968 ± 0.269
2.153SerLys: 2.153 ± 0.226
6.856SerLeu: 6.856 ± 0.408
1.756SerMet: 1.756 ± 0.212
1.735SerAsn: 1.735 ± 0.204
4.849SerPro: 4.849 ± 0.377
1.965SerGln: 1.965 ± 0.247
7.127SerArg: 7.127 ± 0.396
9.573SerSer: 9.573 ± 1.087
5.142SerThr: 5.142 ± 0.336
5.497SerVal: 5.497 ± 0.346
0.773SerTrp: 0.773 ± 0.131
1.902SerTyr: 1.902 ± 0.178
0.0SerXaa: 0.0 ± 0.0
Thr
6.458ThrAla: 6.458 ± 0.474
0.899ThrCys: 0.899 ± 0.134
3.093ThrAsp: 3.093 ± 0.329
2.32ThrGlu: 2.32 ± 0.234
2.32ThrPhe: 2.32 ± 0.246
4.097ThrGly: 4.097 ± 0.297
1.421ThrHis: 1.421 ± 0.172
2.843ThrIle: 2.843 ± 0.32
1.693ThrLys: 1.693 ± 0.177
4.724ThrLeu: 4.724 ± 0.298
1.024ThrMet: 1.024 ± 0.125
1.588ThrAsn: 1.588 ± 0.217
4.138ThrPro: 4.138 ± 0.305
1.421ThrGln: 1.421 ± 0.192
4.201ThrArg: 4.201 ± 0.285
4.389ThrSer: 4.389 ± 0.341
4.494ThrThr: 4.494 ± 0.511
4.159ThrVal: 4.159 ± 0.316
0.752ThrTrp: 0.752 ± 0.108
1.881ThrTyr: 1.881 ± 0.222
0.0ThrXaa: 0.0 ± 0.0
Val
6.751ValAla: 6.751 ± 0.456
1.672ValCys: 1.672 ± 0.177
4.306ValAsp: 4.306 ± 0.294
3.637ValGlu: 3.637 ± 0.254
2.257ValPhe: 2.257 ± 0.236
4.536ValGly: 4.536 ± 0.361
1.066ValHis: 1.066 ± 0.149
2.884ValIle: 2.884 ± 0.238
2.132ValLys: 2.132 ± 0.216
6.647ValLeu: 6.647 ± 0.335
1.463ValMet: 1.463 ± 0.153
2.09ValAsn: 2.09 ± 0.221
4.201ValPro: 4.201 ± 0.286
1.756ValGln: 1.756 ± 0.193
5.163ValArg: 5.163 ± 0.358
5.142ValSer: 5.142 ± 0.329
3.595ValThr: 3.595 ± 0.299
5.288ValVal: 5.288 ± 0.371
0.732ValTrp: 0.732 ± 0.162
2.174ValTyr: 2.174 ± 0.25
0.0ValXaa: 0.0 ± 0.0
Trp
0.899TrpAla: 0.899 ± 0.166
0.251TrpCys: 0.251 ± 0.073
0.878TrpAsp: 0.878 ± 0.105
0.543TrpGlu: 0.543 ± 0.094
0.481TrpPhe: 0.481 ± 0.103
0.941TrpGly: 0.941 ± 0.176
0.209TrpHis: 0.209 ± 0.07
0.397TrpIle: 0.397 ± 0.084
0.606TrpLys: 0.606 ± 0.114
1.024TrpLeu: 1.024 ± 0.202
0.272TrpMet: 0.272 ± 0.073
0.293TrpAsn: 0.293 ± 0.08
0.606TrpPro: 0.606 ± 0.102
0.334TrpGln: 0.334 ± 0.086
1.296TrpArg: 1.296 ± 0.192
0.815TrpSer: 0.815 ± 0.151
0.711TrpThr: 0.711 ± 0.128
0.397TrpVal: 0.397 ± 0.074
0.293TrpTrp: 0.293 ± 0.104
0.334TrpTyr: 0.334 ± 0.093
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.905TyrAla: 2.905 ± 0.265
0.794TyrCys: 0.794 ± 0.109
2.153TyrAsp: 2.153 ± 0.203
1.714TyrGlu: 1.714 ± 0.173
1.15TyrPhe: 1.15 ± 0.187
1.818TyrGly: 1.818 ± 0.24
0.564TyrHis: 0.564 ± 0.11
1.296TyrIle: 1.296 ± 0.178
1.129TyrLys: 1.129 ± 0.157
2.383TyrLeu: 2.383 ± 0.222
0.857TyrMet: 0.857 ± 0.127
1.024TyrAsn: 1.024 ± 0.157
1.129TyrPro: 1.129 ± 0.147
0.543TyrGln: 0.543 ± 0.087
2.09TyrArg: 2.09 ± 0.241
2.069TyrSer: 2.069 ± 0.238
1.777TyrThr: 1.777 ± 0.184
2.675TyrVal: 2.675 ± 0.246
0.397TyrTrp: 0.397 ± 0.095
0.857TyrTyr: 0.857 ± 0.123
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 108 proteins (47845 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski