Amino acid dipepetide frequency for Paracoccus lutimaris

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.896AlaAla: 18.896 ± 0.188	1.049AlaCys: 1.049 ± 0.031	7.258AlaAsp: 7.258 ± 0.089	8.729AlaGlu: 8.729 ± 0.1	3.937AlaPhe: 3.937 ± 0.061	12.039AlaGly: 12.039 ± 0.106	2.434AlaHis: 2.434 ± 0.049	6.211AlaIle: 6.211 ± 0.085	3.379AlaLys: 3.379 ± 0.058	14.841AlaLeu: 14.841 ± 0.137	3.998AlaMet: 3.998 ± 0.058	2.678AlaAsn: 2.678 ± 0.049	6.834AlaPro: 6.834 ± 0.091	4.795AlaGln: 4.795 ± 0.072	10.427AlaArg: 10.427 ± 0.099	5.758AlaSer: 5.758 ± 0.068	6.154AlaThr: 6.154 ± 0.079	8.32AlaVal: 8.32 ± 0.086	1.556AlaTrp: 1.556 ± 0.035	2.311AlaTyr: 2.311 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	0.989CysAla: 0.989 ± 0.031	0.103CysCys: 0.103 ± 0.009	0.545CysAsp: 0.545 ± 0.021	0.392CysGlu: 0.392 ± 0.018	0.299CysPhe: 0.299 ± 0.015	0.917CysGly: 0.917 ± 0.037	0.263CysHis: 0.263 ± 0.016	0.349CysIle: 0.349 ± 0.017	0.18CysLys: 0.18 ± 0.012	0.77CysLeu: 0.77 ± 0.023	0.156CysMet: 0.156 ± 0.012	0.201CysAsn: 0.201 ± 0.012	0.509CysPro: 0.509 ± 0.022	0.242CysGln: 0.242 ± 0.015	0.583CysArg: 0.583 ± 0.023	0.41CysSer: 0.41 ± 0.016	0.369CysThr: 0.369 ± 0.018	0.532CysVal: 0.532 ± 0.021	0.128CysTrp: 0.128 ± 0.01	0.184CysTyr: 0.184 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	7.568AspAla: 7.568 ± 0.09	0.496AspCys: 0.496 ± 0.02	3.232AspAsp: 3.232 ± 0.074	3.441AspGlu: 3.441 ± 0.063	2.273AspPhe: 2.273 ± 0.041	5.42AspGly: 5.42 ± 0.078	1.35AspHis: 1.35 ± 0.034	2.86AspIle: 2.86 ± 0.05	1.553AspLys: 1.553 ± 0.042	6.723AspLeu: 6.723 ± 0.096	1.602AspMet: 1.602 ± 0.035	1.194AspAsn: 1.194 ± 0.037	4.11AspPro: 4.11 ± 0.061	2.026AspGln: 2.026 ± 0.039	4.73AspArg: 4.73 ± 0.07	2.407AspSer: 2.407 ± 0.05	2.509AspThr: 2.509 ± 0.059	3.381AspVal: 3.381 ± 0.05	1.302AspTrp: 1.302 ± 0.036	1.559AspTyr: 1.559 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	7.935GluAla: 7.935 ± 0.102	0.343GluCys: 0.343 ± 0.018	2.963GluAsp: 2.963 ± 0.051	2.725GluGlu: 2.725 ± 0.057	1.842GluPhe: 1.842 ± 0.039	4.556GluGly: 4.556 ± 0.065	1.092GluHis: 1.092 ± 0.031	3.563GluIle: 3.563 ± 0.055	1.82GluLys: 1.82 ± 0.048	5.203GluLeu: 5.203 ± 0.074	1.658GluMet: 1.658 ± 0.044	1.602GluAsn: 1.602 ± 0.033	2.562GluPro: 2.562 ± 0.05	1.823GluGln: 1.823 ± 0.042	4.207GluArg: 4.207 ± 0.069	2.291GluSer: 2.291 ± 0.042	3.461GluThr: 3.461 ± 0.057	3.936GluVal: 3.936 ± 0.056	0.758GluTrp: 0.758 ± 0.024	1.048GluTyr: 1.048 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	4.399PheAla: 4.399 ± 0.071	0.377PheCys: 0.377 ± 0.015	2.679PheAsp: 2.679 ± 0.046	1.768PheGlu: 1.768 ± 0.039	1.26PhePhe: 1.26 ± 0.035	3.524PheGly: 3.524 ± 0.058	0.75PheHis: 0.75 ± 0.025	1.511PheIle: 1.511 ± 0.037	0.738PheLys: 0.738 ± 0.026	3.416PheLeu: 3.416 ± 0.061	0.807PheMet: 0.807 ± 0.027	0.895PheAsn: 0.895 ± 0.029	1.59PhePro: 1.59 ± 0.038	1.042PheGln: 1.042 ± 0.029	2.337PheArg: 2.337 ± 0.04	1.988PheSer: 1.988 ± 0.035	1.846PheThr: 1.846 ± 0.04	2.399PheVal: 2.399 ± 0.048	0.599PheTrp: 0.599 ± 0.023	0.786PheTyr: 0.786 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	10.561GlyAla: 10.561 ± 0.1	0.783GlyCys: 0.783 ± 0.028	4.859GlyAsp: 4.859 ± 0.076	4.556GlyGlu: 4.556 ± 0.064	3.66GlyPhe: 3.66 ± 0.053	7.771GlyGly: 7.771 ± 0.125	2.023GlyHis: 2.023 ± 0.043	4.715GlyIle: 4.715 ± 0.068	3.062GlyLys: 3.062 ± 0.05	9.614GlyLeu: 9.614 ± 0.091	2.672GlyMet: 2.672 ± 0.053	2.429GlyAsn: 2.429 ± 0.094	3.997GlyPro: 3.997 ± 0.058	3.438GlyGln: 3.438 ± 0.057	6.611GlyArg: 6.611 ± 0.074	4.2GlySer: 4.2 ± 0.069	4.712GlyThr: 4.712 ± 0.091	5.985GlyVal: 5.985 ± 0.076	1.747GlyTrp: 1.747 ± 0.041	2.213GlyTyr: 2.213 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	2.47HisAla: 2.47 ± 0.053	0.212HisCys: 0.212 ± 0.015	1.429HisAsp: 1.429 ± 0.033	1.145HisGlu: 1.145 ± 0.03	0.795HisPhe: 0.795 ± 0.029	1.989HisGly: 1.989 ± 0.042	0.577HisHis: 0.577 ± 0.025	0.929HisIle: 0.929 ± 0.031	0.463HisLys: 0.463 ± 0.019	2.189HisLeu: 2.189 ± 0.046	0.512HisMet: 0.512 ± 0.02	0.414HisAsn: 0.414 ± 0.019	1.475HisPro: 1.475 ± 0.033	0.6HisGln: 0.6 ± 0.021	1.445HisArg: 1.445 ± 0.042	0.907HisSer: 0.907 ± 0.023	0.63HisThr: 0.63 ± 0.02	1.494HisVal: 1.494 ± 0.034	0.34HisTrp: 0.34 ± 0.016	0.504HisTyr: 0.504 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	7.568IleAla: 7.568 ± 0.085	0.585IleCys: 0.585 ± 0.022	3.439IleAsp: 3.439 ± 0.053	3.344IleGlu: 3.344 ± 0.055	1.684IlePhe: 1.684 ± 0.038	4.953IleGly: 4.953 ± 0.075	0.991IleHis: 0.991 ± 0.027	2.108IleIle: 2.108 ± 0.05	1.198IleLys: 1.198 ± 0.039	4.801IleLeu: 4.801 ± 0.063	1.079IleMet: 1.079 ± 0.032	1.231IleAsn: 1.231 ± 0.031	2.433IlePro: 2.433 ± 0.047	1.177IleGln: 1.177 ± 0.028	3.78IleArg: 3.78 ± 0.057	2.933IleSer: 2.933 ± 0.052	2.781IleThr: 2.781 ± 0.052	3.51IleVal: 3.51 ± 0.055	0.82IleTrp: 0.82 ± 0.029	1.052IleTyr: 1.052 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	3.57LysAla: 3.57 ± 0.064	0.148LysCys: 0.148 ± 0.011	1.571LysAsp: 1.571 ± 0.041	1.22LysGlu: 1.22 ± 0.035	0.793LysPhe: 0.793 ± 0.025	2.589LysGly: 2.589 ± 0.054	0.53LysHis: 0.53 ± 0.02	1.366LysIle: 1.366 ± 0.036	0.967LysLys: 0.967 ± 0.034	2.752LysLeu: 2.752 ± 0.048	0.733LysMet: 0.733 ± 0.026	0.684LysAsn: 0.684 ± 0.024	1.8LysPro: 1.8 ± 0.044	0.816LysGln: 0.816 ± 0.028	1.907LysArg: 1.907 ± 0.044	1.569LysSer: 1.569 ± 0.04	1.647LysThr: 1.647 ± 0.042	1.941LysVal: 1.941 ± 0.042	0.352LysTrp: 0.352 ± 0.016	0.564LysTyr: 0.564 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	14.691LeuAla: 14.691 ± 0.129	0.882LeuCys: 0.882 ± 0.027	6.085LeuAsp: 6.085 ± 0.074	4.836LeuGlu: 4.836 ± 0.071	3.325LeuPhe: 3.325 ± 0.06	8.714LeuGly: 8.714 ± 0.096	1.936LeuHis: 1.936 ± 0.044	5.675LeuIle: 5.675 ± 0.08	2.797LeuLys: 2.797 ± 0.061	8.968LeuLeu: 8.968 ± 0.123	2.73LeuMet: 2.73 ± 0.053	2.647LeuAsn: 2.647 ± 0.047	6.319LeuPro: 6.319 ± 0.087	2.657LeuGln: 2.657 ± 0.049	8.071LeuArg: 8.071 ± 0.096	6.25LeuSer: 6.25 ± 0.076	6.276LeuThr: 6.276 ± 0.08	6.89LeuVal: 6.89 ± 0.087	1.396LeuTrp: 1.396 ± 0.037	1.885LeuTyr: 1.885 ± 0.04	0.0LeuXaa: 0.0 ± 0.0
Met	3.765MetAla: 3.765 ± 0.055	0.147MetCys: 0.147 ± 0.011	1.357MetAsp: 1.357 ± 0.035	1.093MetGlu: 1.093 ± 0.033	0.712MetPhe: 0.712 ± 0.026	2.248MetGly: 2.248 ± 0.042	0.447MetHis: 0.447 ± 0.021	1.522MetIle: 1.522 ± 0.035	0.906MetLys: 0.906 ± 0.028	2.708MetLeu: 2.708 ± 0.049	0.706MetMet: 0.706 ± 0.027	0.82MetAsn: 0.82 ± 0.024	1.623MetPro: 1.623 ± 0.036	1.015MetGln: 1.015 ± 0.026	2.093MetArg: 2.093 ± 0.046	1.601MetSer: 1.601 ± 0.035	2.079MetThr: 2.079 ± 0.04	1.829MetVal: 1.829 ± 0.039	0.226MetTrp: 0.226 ± 0.014	0.272MetTyr: 0.272 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	3.02AsnAla: 3.02 ± 0.047	0.233AsnCys: 0.233 ± 0.015	1.621AsnAsp: 1.621 ± 0.074	1.097AsnGlu: 1.097 ± 0.03	0.9AsnPhe: 0.9 ± 0.026	2.264AsnGly: 2.264 ± 0.059	0.468AsnHis: 0.468 ± 0.018	1.228AsnIle: 1.228 ± 0.037	0.56AsnLys: 0.56 ± 0.022	2.431AsnLeu: 2.431 ± 0.05	0.622AsnMet: 0.622 ± 0.022	0.594AsnAsn: 0.594 ± 0.03	1.914AsnPro: 1.914 ± 0.039	0.671AsnGln: 0.671 ± 0.025	1.827AsnArg: 1.827 ± 0.041	1.16AsnSer: 1.16 ± 0.034	1.128AsnThr: 1.128 ± 0.034	1.608AsnVal: 1.608 ± 0.039	0.475AsnTrp: 0.475 ± 0.02	0.617AsnTyr: 0.617 ± 0.025	0.0AsnXaa: 0.0 ± 0.0
Pro	7.466ProAla: 7.466 ± 0.104	0.373ProCys: 0.373 ± 0.018	4.238ProAsp: 4.238 ± 0.065	4.396ProGlu: 4.396 ± 0.06	1.87ProPhe: 1.87 ± 0.041	5.395ProGly: 5.395 ± 0.075	1.075ProHis: 1.075 ± 0.033	2.23ProIle: 2.23 ± 0.043	1.482ProLys: 1.482 ± 0.038	4.883ProLeu: 4.883 ± 0.074	1.325ProMet: 1.325 ± 0.034	1.187ProAsn: 1.187 ± 0.03	2.675ProPro: 2.675 ± 0.058	2.006ProGln: 2.006 ± 0.042	3.417ProArg: 3.417 ± 0.064	2.395ProSer: 2.395 ± 0.046	2.289ProThr: 2.289 ± 0.045	4.606ProVal: 4.606 ± 0.062	0.76ProTrp: 0.76 ± 0.027	1.089ProTyr: 1.089 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	4.311GlnAla: 4.311 ± 0.067	0.171GlnCys: 0.171 ± 0.011	1.723GlnAsp: 1.723 ± 0.036	1.433GlnGlu: 1.433 ± 0.034	1.02GlnPhe: 1.02 ± 0.027	3.056GlnGly: 3.056 ± 0.049	0.628GlnHis: 0.628 ± 0.023	2.127GlnIle: 2.127 ± 0.045	1.018GlnLys: 1.018 ± 0.031	2.873GlnLeu: 2.873 ± 0.054	1.04GlnMet: 1.04 ± 0.025	0.942GlnAsn: 0.942 ± 0.028	2.005GlnPro: 2.005 ± 0.043	1.059GlnGln: 1.059 ± 0.031	2.434GlnArg: 2.434 ± 0.045	1.649GlnSer: 1.649 ± 0.037	1.772GlnThr: 1.772 ± 0.043	2.402GlnVal: 2.402 ± 0.047	0.398GlnTrp: 0.398 ± 0.016	0.572GlnTyr: 0.572 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	9.378ArgAla: 9.378 ± 0.102	0.484ArgCys: 0.484 ± 0.017	4.78ArgAsp: 4.78 ± 0.071	4.138ArgGlu: 4.138 ± 0.074	2.728ArgPhe: 2.728 ± 0.049	5.321ArgGly: 5.321 ± 0.076	1.831ArgHis: 1.831 ± 0.039	4.52ArgIle: 4.52 ± 0.065	2.224ArgLys: 2.224 ± 0.047	8.548ArgLeu: 8.548 ± 0.104	2.206ArgMet: 2.206 ± 0.044	1.825ArgAsn: 1.825 ± 0.035	3.928ArgPro: 3.928 ± 0.057	2.631ArgGln: 2.631 ± 0.052	6.01ArgArg: 6.01 ± 0.092	3.227ArgSer: 3.227 ± 0.055	2.834ArgThr: 2.834 ± 0.047	4.908ArgVal: 4.908 ± 0.058	1.108ArgTrp: 1.108 ± 0.033	1.581ArgTyr: 1.581 ± 0.032	0.0ArgXaa: 0.0 ± 0.0
Ser	5.925SerAla: 5.925 ± 0.071	0.396SerCys: 0.396 ± 0.02	3.165SerAsp: 3.165 ± 0.055	2.519SerGlu: 2.519 ± 0.044	2.078SerPhe: 2.078 ± 0.044	5.593SerGly: 5.593 ± 0.075	1.07SerHis: 1.07 ± 0.029	2.24SerIle: 2.24 ± 0.045	1.211SerLys: 1.211 ± 0.032	4.84SerLeu: 4.84 ± 0.066	1.234SerMet: 1.234 ± 0.028	1.103SerAsn: 1.103 ± 0.034	2.608SerPro: 2.608 ± 0.044	1.558SerGln: 1.558 ± 0.037	3.5SerArg: 3.5 ± 0.048	2.275SerSer: 2.275 ± 0.05	2.266SerThr: 2.266 ± 0.05	3.491SerVal: 3.491 ± 0.062	0.778SerTrp: 0.778 ± 0.025	1.197SerTyr: 1.197 ± 0.031	0.0SerXaa: 0.0 ± 0.0
Thr	6.178ThrAla: 6.178 ± 0.082	0.467ThrCys: 0.467 ± 0.021	2.97ThrAsp: 2.97 ± 0.045	2.871ThrGlu: 2.871 ± 0.047	1.662ThrPhe: 1.662 ± 0.039	5.386ThrGly: 5.386 ± 0.077	1.029ThrHis: 1.029 ± 0.027	2.531ThrIle: 2.531 ± 0.047	1.164ThrLys: 1.164 ± 0.035	5.585ThrLeu: 5.585 ± 0.076	1.197ThrMet: 1.197 ± 0.03	1.135ThrAsn: 1.135 ± 0.036	3.427ThrPro: 3.427 ± 0.057	1.524ThrGln: 1.524 ± 0.033	3.773ThrArg: 3.773 ± 0.061	2.369ThrSer: 2.369 ± 0.049	2.532ThrThr: 2.532 ± 0.058	3.973ThrVal: 3.973 ± 0.061	0.597ThrTrp: 0.597 ± 0.021	1.081ThrTyr: 1.081 ± 0.034	0.0ThrXaa: 0.0 ± 0.0
Val	8.942ValAla: 8.942 ± 0.082	0.536ValCys: 0.536 ± 0.022	3.559ValAsp: 3.559 ± 0.058	3.999ValGlu: 3.999 ± 0.065	2.494ValPhe: 2.494 ± 0.049	4.818ValGly: 4.818 ± 0.078	1.2ValHis: 1.2 ± 0.034	4.19ValIle: 4.19 ± 0.071	1.865ValLys: 1.865 ± 0.04	7.638ValLeu: 7.638 ± 0.088	2.079ValMet: 2.079 ± 0.04	1.89ValAsn: 1.89 ± 0.035	3.533ValPro: 3.533 ± 0.051	2.097ValGln: 2.097 ± 0.045	4.05ValArg: 4.05 ± 0.068	3.791ValSer: 3.791 ± 0.063	4.479ValThr: 4.479 ± 0.061	5.135ValVal: 5.135 ± 0.072	0.999ValTrp: 0.999 ± 0.025	1.317ValTyr: 1.317 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	1.534TrpAla: 1.534 ± 0.039	0.125TrpCys: 0.125 ± 0.01	0.783TrpAsp: 0.783 ± 0.025	0.554TrpGlu: 0.554 ± 0.022	0.573TrpPhe: 0.573 ± 0.018	1.068TrpGly: 1.068 ± 0.031	0.36TrpHis: 0.36 ± 0.017	0.777TrpIle: 0.777 ± 0.029	0.441TrpLys: 0.441 ± 0.02	2.009TrpLeu: 2.009 ± 0.044	0.388TrpMet: 0.388 ± 0.018	0.429TrpAsn: 0.429 ± 0.02	0.786TrpPro: 0.786 ± 0.025	0.758TrpGln: 0.758 ± 0.023	1.36TrpArg: 1.36 ± 0.033	0.845TrpSer: 0.845 ± 0.026	0.757TrpThr: 0.757 ± 0.029	0.855TrpVal: 0.855 ± 0.028	0.258TrpTrp: 0.258 ± 0.014	0.283TrpTyr: 0.283 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.438TyrAla: 2.438 ± 0.043	0.212TyrCys: 0.212 ± 0.014	1.48TyrAsp: 1.48 ± 0.039	1.129TyrGlu: 1.129 ± 0.031	0.807TyrPhe: 0.807 ± 0.024	1.986TyrGly: 1.986 ± 0.046	0.467TyrHis: 0.467 ± 0.018	0.818TyrIle: 0.818 ± 0.026	0.493TyrLys: 0.493 ± 0.021	2.238TyrLeu: 2.238 ± 0.043	0.423TyrMet: 0.423 ± 0.021	0.538TyrAsn: 0.538 ± 0.02	1.033TyrPro: 1.033 ± 0.029	0.699TyrGln: 0.699 ± 0.026	1.647TyrArg: 1.647 ± 0.032	1.021TyrSer: 1.021 ± 0.033	0.928TyrThr: 0.928 ± 0.027	1.415TyrVal: 1.415 ± 0.034	0.346TyrTrp: 0.346 ± 0.016	0.532TyrTyr: 0.532 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3955 proteins (1266796 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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