Amino acid dipepetide frequency for Chryseobacterium sp. legu1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.058AlaAla: 5.058 ± 0.12
0.516AlaCys: 0.516 ± 0.024
3.821AlaAsp: 3.821 ± 0.068
4.999AlaGlu: 4.999 ± 0.086
3.344AlaPhe: 3.344 ± 0.076
4.826AlaGly: 4.826 ± 0.086
1.052AlaHis: 1.052 ± 0.04
4.331AlaIle: 4.331 ± 0.089
4.863AlaLys: 4.863 ± 0.086
6.182AlaLeu: 6.182 ± 0.102
1.729AlaMet: 1.729 ± 0.042
3.33AlaAsn: 3.33 ± 0.084
1.942AlaPro: 1.942 ± 0.062
2.538AlaGln: 2.538 ± 0.061
2.055AlaArg: 2.055 ± 0.049
3.924AlaSer: 3.924 ± 0.081
3.681AlaThr: 3.681 ± 0.107
4.878AlaVal: 4.878 ± 0.084
0.56AlaTrp: 0.56 ± 0.028
2.297AlaTyr: 2.297 ± 0.053
0.0AlaXaa: 0.0 ± 0.0
Cys
0.497CysAla: 0.497 ± 0.026
0.093CysCys: 0.093 ± 0.012
0.413CysAsp: 0.413 ± 0.022
0.45CysGlu: 0.45 ± 0.02
0.396CysPhe: 0.396 ± 0.024
0.719CysGly: 0.719 ± 0.039
0.174CysHis: 0.174 ± 0.014
0.579CysIle: 0.579 ± 0.024
0.436CysLys: 0.436 ± 0.022
0.616CysLeu: 0.616 ± 0.028
0.147CysMet: 0.147 ± 0.015
0.33CysAsn: 0.33 ± 0.021
0.346CysPro: 0.346 ± 0.027
0.172CysGln: 0.172 ± 0.017
0.243CysArg: 0.243 ± 0.021
0.543CysSer: 0.543 ± 0.03
0.43CysThr: 0.43 ± 0.029
0.407CysVal: 0.407 ± 0.024
0.056CysTrp: 0.056 ± 0.009
0.262CysTyr: 0.262 ± 0.018
0.0CysXaa: 0.0 ± 0.0
Asp
3.552AspAla: 3.552 ± 0.07
0.38AspCys: 0.38 ± 0.022
2.718AspAsp: 2.718 ± 0.058
4.092AspGlu: 4.092 ± 0.085
4.041AspPhe: 4.041 ± 0.083
3.364AspGly: 3.364 ± 0.064
1.065AspHis: 1.065 ± 0.043
3.791AspIle: 3.791 ± 0.079
3.743AspLys: 3.743 ± 0.074
5.548AspLeu: 5.548 ± 0.084
1.105AspMet: 1.105 ± 0.037
2.307AspAsn: 2.307 ± 0.057
1.781AspPro: 1.781 ± 0.056
1.736AspGln: 1.736 ± 0.05
2.162AspArg: 2.162 ± 0.05
3.052AspSer: 3.052 ± 0.062
2.293AspThr: 2.293 ± 0.053
3.162AspVal: 3.162 ± 0.066
0.699AspTrp: 0.699 ± 0.032
2.59AspTyr: 2.59 ± 0.06
0.0AspXaa: 0.0 ± 0.0
Glu
4.045GluAla: 4.045 ± 0.09
0.332GluCys: 0.332 ± 0.02
3.419GluAsp: 3.419 ± 0.07
5.262GluGlu: 5.262 ± 0.115
3.355GluPhe: 3.355 ± 0.065
3.504GluGly: 3.504 ± 0.073
1.136GluHis: 1.136 ± 0.03
6.333GluIle: 6.333 ± 0.09
7.164GluLys: 7.164 ± 0.128
5.738GluLeu: 5.738 ± 0.094
2.021GluMet: 2.021 ± 0.058
5.512GluAsn: 5.512 ± 0.094
1.548GluPro: 1.548 ± 0.048
2.15GluGln: 2.15 ± 0.053
2.531GluArg: 2.531 ± 0.067
3.259GluSer: 3.259 ± 0.066
3.7GluThr: 3.7 ± 0.061
4.253GluVal: 4.253 ± 0.078
0.663GluTrp: 0.663 ± 0.03
2.346GluTyr: 2.346 ± 0.055
0.0GluXaa: 0.0 ± 0.0
Phe
3.608PheAla: 3.608 ± 0.069
0.492PheCys: 0.492 ± 0.023
3.128PheAsp: 3.128 ± 0.06
3.467PheGlu: 3.467 ± 0.076
3.181PhePhe: 3.181 ± 0.076
3.903PheGly: 3.903 ± 0.085
0.968PheHis: 0.968 ± 0.039
3.98PheIle: 3.98 ± 0.088
3.57PheLys: 3.57 ± 0.066
5.357PheLeu: 5.357 ± 0.096
1.287PheMet: 1.287 ± 0.04
2.917PheAsn: 2.917 ± 0.061
2.005PhePro: 2.005 ± 0.04
1.724PheGln: 1.724 ± 0.044
2.136PheArg: 2.136 ± 0.055
4.504PheSer: 4.504 ± 0.088
3.21PheThr: 3.21 ± 0.063
3.242PheVal: 3.242 ± 0.073
0.679PheTrp: 0.679 ± 0.031
2.268PheTyr: 2.268 ± 0.065
0.0PheXaa: 0.0 ± 0.0
Gly
4.192GlyAla: 4.192 ± 0.099
0.544GlyCys: 0.544 ± 0.028
3.071GlyAsp: 3.071 ± 0.067
3.738GlyGlu: 3.738 ± 0.066
3.861GlyPhe: 3.861 ± 0.09
4.451GlyGly: 4.451 ± 0.103
1.035GlyHis: 1.035 ± 0.038
5.569GlyIle: 5.569 ± 0.095
5.615GlyLys: 5.615 ± 0.093
5.607GlyLeu: 5.607 ± 0.09
1.705GlyMet: 1.705 ± 0.05
3.954GlyAsn: 3.954 ± 0.083
1.268GlyPro: 1.268 ± 0.047
1.837GlyGln: 1.837 ± 0.045
2.204GlyArg: 2.204 ± 0.056
4.038GlySer: 4.038 ± 0.092
4.144GlyThr: 4.144 ± 0.087
3.98GlyVal: 3.98 ± 0.076
0.724GlyTrp: 0.724 ± 0.031
2.62GlyTyr: 2.62 ± 0.06
0.0GlyXaa: 0.0 ± 0.0
His
0.97HisAla: 0.97 ± 0.033
0.179HisCys: 0.179 ± 0.015
0.814HisAsp: 0.814 ± 0.03
1.048HisGlu: 1.048 ± 0.04
1.265HisPhe: 1.265 ± 0.044
0.991HisGly: 0.991 ± 0.042
0.561HisHis: 0.561 ± 0.032
1.248HisIle: 1.248 ± 0.041
1.063HisLys: 1.063 ± 0.038
1.883HisLeu: 1.883 ± 0.052
0.338HisMet: 0.338 ± 0.021
0.848HisAsn: 0.848 ± 0.034
0.903HisPro: 0.903 ± 0.036
0.756HisGln: 0.756 ± 0.034
0.728HisArg: 0.728 ± 0.028
1.166HisSer: 1.166 ± 0.036
0.908HisThr: 0.908 ± 0.034
0.736HisVal: 0.736 ± 0.031
0.203HisTrp: 0.203 ± 0.016
0.792HisTyr: 0.792 ± 0.026
0.0HisXaa: 0.0 ± 0.0
Ile
5.122IleAla: 5.122 ± 0.086
0.699IleCys: 0.699 ± 0.028
4.215IleAsp: 4.215 ± 0.066
4.763IleGlu: 4.763 ± 0.076
4.064IlePhe: 4.064 ± 0.091
4.834IleGly: 4.834 ± 0.087
1.327IleHis: 1.327 ± 0.046
5.811IleIle: 5.811 ± 0.116
5.246IleLys: 5.246 ± 0.1
7.563IleLeu: 7.563 ± 0.111
1.445IleMet: 1.445 ± 0.043
4.038IleAsn: 4.038 ± 0.081
3.436IlePro: 3.436 ± 0.062
2.56IleGln: 2.56 ± 0.057
2.779IleArg: 2.779 ± 0.06
6.073IleSer: 6.073 ± 0.103
4.492IleThr: 4.492 ± 0.075
4.26IleVal: 4.26 ± 0.075
0.697IleTrp: 0.697 ± 0.027
2.733IleTyr: 2.733 ± 0.063
0.0IleXaa: 0.0 ± 0.0
Lys
4.658LysAla: 4.658 ± 0.087
0.335LysCys: 0.335 ± 0.023
4.5LysAsp: 4.5 ± 0.075
5.94LysGlu: 5.94 ± 0.099
3.64LysPhe: 3.64 ± 0.07
4.192LysGly: 4.192 ± 0.082
1.162LysHis: 1.162 ± 0.037
7.39LysIle: 7.39 ± 0.098
7.272LysLys: 7.272 ± 0.119
6.371LysLeu: 6.371 ± 0.101
2.528LysMet: 2.528 ± 0.057
5.978LysAsn: 5.978 ± 0.102
2.704LysPro: 2.704 ± 0.059
2.332LysGln: 2.332 ± 0.051
2.604LysArg: 2.604 ± 0.057
4.641LysSer: 4.641 ± 0.089
4.836LysThr: 4.836 ± 0.081
4.542LysVal: 4.542 ± 0.083
0.78LysTrp: 0.78 ± 0.032
3.021LysTyr: 3.021 ± 0.071
0.0LysXaa: 0.0 ± 0.0
Leu
5.969LeuAla: 5.969 ± 0.097
0.657LeuCys: 0.657 ± 0.03
4.624LeuAsp: 4.624 ± 0.077
6.122LeuGlu: 6.122 ± 0.105
4.873LeuPhe: 4.873 ± 0.095
5.815LeuGly: 5.815 ± 0.101
1.584LeuHis: 1.584 ± 0.056
6.723LeuIle: 6.723 ± 0.115
8.15LeuLys: 8.15 ± 0.101
8.81LeuLeu: 8.81 ± 0.156
2.413LeuMet: 2.413 ± 0.06
5.569LeuAsn: 5.569 ± 0.095
3.634LeuPro: 3.634 ± 0.064
3.402LeuGln: 3.402 ± 0.079
3.299LeuArg: 3.299 ± 0.065
6.425LeuSer: 6.425 ± 0.094
5.132LeuThr: 5.132 ± 0.092
5.278LeuVal: 5.278 ± 0.084
0.777LeuTrp: 0.777 ± 0.033
3.088LeuTyr: 3.088 ± 0.062
0.0LeuXaa: 0.0 ± 0.0
Met
1.708MetAla: 1.708 ± 0.047
0.136MetCys: 0.136 ± 0.011
1.246MetAsp: 1.246 ± 0.037
1.713MetGlu: 1.713 ± 0.047
1.009MetPhe: 1.009 ± 0.04
1.587MetGly: 1.587 ± 0.043
0.391MetHis: 0.391 ± 0.023
1.766MetIle: 1.766 ± 0.048
2.758MetLys: 2.758 ± 0.052
2.108MetLeu: 2.108 ± 0.054
0.857MetMet: 0.857 ± 0.033
1.652MetAsn: 1.652 ± 0.039
0.919MetPro: 0.919 ± 0.034
0.942MetGln: 0.942 ± 0.036
0.926MetArg: 0.926 ± 0.031
1.458MetSer: 1.458 ± 0.042
1.333MetThr: 1.333 ± 0.038
1.53MetVal: 1.53 ± 0.049
0.181MetTrp: 0.181 ± 0.015
0.652MetTyr: 0.652 ± 0.029
0.0MetXaa: 0.0 ± 0.0
Asn
3.991AsnAla: 3.991 ± 0.077
0.427AsnCys: 0.427 ± 0.026
2.993AsnAsp: 2.993 ± 0.067
3.45AsnGlu: 3.45 ± 0.069
3.64AsnPhe: 3.64 ± 0.071
4.041AsnGly: 4.041 ± 0.08
1.054AsnHis: 1.054 ± 0.038
4.763AsnIle: 4.763 ± 0.089
3.702AsnLys: 3.702 ± 0.084
5.672AsnLeu: 5.672 ± 0.106
1.274AsnMet: 1.274 ± 0.039
3.181AsnAsn: 3.181 ± 0.082
2.859AsnPro: 2.859 ± 0.06
2.043AsnGln: 2.043 ± 0.062
2.193AsnArg: 2.193 ± 0.06
3.844AsnSer: 3.844 ± 0.078
3.248AsnThr: 3.248 ± 0.063
3.407AsnVal: 3.407 ± 0.069
0.734AsnTrp: 0.734 ± 0.032
2.756AsnTyr: 2.756 ± 0.07
0.0AsnXaa: 0.0 ± 0.0
Pro
2.521ProAla: 2.521 ± 0.078
0.217ProCys: 0.217 ± 0.021
2.102ProAsp: 2.102 ± 0.051
3.293ProGlu: 3.293 ± 0.075
1.923ProPhe: 1.923 ± 0.052
2.077ProGly: 2.077 ± 0.052
0.659ProHis: 0.659 ± 0.028
2.189ProIle: 2.189 ± 0.054
2.626ProLys: 2.626 ± 0.058
2.932ProLeu: 2.932 ± 0.065
0.839ProMet: 0.839 ± 0.031
1.972ProAsn: 1.972 ± 0.048
0.893ProPro: 0.893 ± 0.044
1.295ProGln: 1.295 ± 0.046
0.964ProArg: 0.964 ± 0.035
2.12ProSer: 2.12 ± 0.06
1.994ProThr: 1.994 ± 0.066
2.809ProVal: 2.809 ± 0.071
0.303ProTrp: 0.303 ± 0.021
1.341ProTyr: 1.341 ± 0.038
0.0ProXaa: 0.0 ± 0.0
Gln
1.867GlnAla: 1.867 ± 0.051
0.152GlnCys: 0.152 ± 0.013
1.575GlnAsp: 1.575 ± 0.046
2.267GlnGlu: 2.267 ± 0.05
1.66GlnPhe: 1.66 ± 0.045
1.658GlnGly: 1.658 ± 0.046
0.663GlnHis: 0.663 ± 0.028
2.813GlnIle: 2.813 ± 0.058
3.463GlnLys: 3.463 ± 0.073
3.216GlnLeu: 3.216 ± 0.066
0.956GlnMet: 0.956 ± 0.029
2.734GlnAsn: 2.734 ± 0.068
1.031GlnPro: 1.031 ± 0.041
1.512GlnGln: 1.512 ± 0.05
1.33GlnArg: 1.33 ± 0.036
1.905GlnSer: 1.905 ± 0.048
2.029GlnThr: 2.029 ± 0.051
1.759GlnVal: 1.759 ± 0.048
0.327GlnTrp: 0.327 ± 0.018
1.441GlnTyr: 1.441 ± 0.049
0.0GlnXaa: 0.0 ± 0.0
Arg
1.989ArgAla: 1.989 ± 0.048
0.212ArgCys: 0.212 ± 0.016
1.811ArgAsp: 1.811 ± 0.055
2.533ArgGlu: 2.533 ± 0.049
1.972ArgPhe: 1.972 ± 0.055
1.84ArgGly: 1.84 ± 0.05
0.632ArgHis: 0.632 ± 0.03
3.104ArgIle: 3.104 ± 0.063
3.334ArgLys: 3.334 ± 0.076
3.151ArgLeu: 3.151 ± 0.065
1.05ArgMet: 1.05 ± 0.04
2.503ArgAsn: 2.503 ± 0.064
1.121ArgPro: 1.121 ± 0.037
1.249ArgGln: 1.249 ± 0.034
1.417ArgArg: 1.417 ± 0.048
2.028ArgSer: 2.028 ± 0.058
1.978ArgThr: 1.978 ± 0.051
1.956ArgVal: 1.956 ± 0.043
0.346ArgTrp: 0.346 ± 0.023
1.472ArgTyr: 1.472 ± 0.042
0.0ArgXaa: 0.0 ± 0.0
Ser
4.718SerAla: 4.718 ± 0.072
0.618SerCys: 0.618 ± 0.029
3.445SerAsp: 3.445 ± 0.063
4.469SerGlu: 4.469 ± 0.069
3.711SerPhe: 3.711 ± 0.067
5.137SerGly: 5.137 ± 0.091
1.033SerHis: 1.033 ± 0.038
4.253SerIle: 4.253 ± 0.084
4.522SerLys: 4.522 ± 0.073
5.772SerLeu: 5.772 ± 0.102
1.43SerMet: 1.43 ± 0.039
3.19SerAsn: 3.19 ± 0.069
2.275SerPro: 2.275 ± 0.054
2.152SerGln: 2.152 ± 0.057
2.282SerArg: 2.282 ± 0.051
4.203SerSer: 4.203 ± 0.09
3.584SerThr: 3.584 ± 0.095
4.346SerVal: 4.346 ± 0.076
0.665SerTrp: 0.665 ± 0.031
2.48SerTyr: 2.48 ± 0.063
0.0SerXaa: 0.0 ± 0.0
Thr
4.426ThrAla: 4.426 ± 0.107
0.38ThrCys: 0.38 ± 0.025
3.355ThrAsp: 3.355 ± 0.073
3.794ThrGlu: 3.794 ± 0.063
2.914ThrPhe: 2.914 ± 0.059
4.266ThrGly: 4.266 ± 0.08
0.951ThrHis: 0.951 ± 0.035
3.586ThrIle: 3.586 ± 0.078
3.735ThrLys: 3.735 ± 0.071
5.195ThrLeu: 5.195 ± 0.08
1.085ThrMet: 1.085 ± 0.045
2.88ThrAsn: 2.88 ± 0.082
2.464ThrPro: 2.464 ± 0.075
1.923ThrGln: 1.923 ± 0.052
1.627ThrArg: 1.627 ± 0.042
3.435ThrSer: 3.435 ± 0.081
3.254ThrThr: 3.254 ± 0.12
4.327ThrVal: 4.327 ± 0.088
0.53ThrTrp: 0.53 ± 0.033
2.139ThrTyr: 2.139 ± 0.066
0.0ThrXaa: 0.0 ± 0.0
Val
4.051ValAla: 4.051 ± 0.078
0.511ValCys: 0.511 ± 0.026
3.121ValAsp: 3.121 ± 0.068
3.881ValGlu: 3.881 ± 0.083
3.588ValPhe: 3.588 ± 0.071
3.788ValGly: 3.788 ± 0.078
0.932ValHis: 0.932 ± 0.036
4.598ValIle: 4.598 ± 0.078
4.73ValLys: 4.73 ± 0.088
5.882ValLeu: 5.882 ± 0.086
1.597ValMet: 1.597 ± 0.048
3.541ValAsn: 3.541 ± 0.076
2.256ValPro: 2.256 ± 0.049
2.044ValGln: 2.044 ± 0.055
2.068ValArg: 2.068 ± 0.054
4.456ValSer: 4.456 ± 0.067
3.377ValThr: 3.377 ± 0.084
3.842ValVal: 3.842 ± 0.073
0.582ValTrp: 0.582 ± 0.028
2.415ValTyr: 2.415 ± 0.056
0.0ValXaa: 0.0 ± 0.0
Trp
0.611TrpAla: 0.611 ± 0.029
0.089TrpCys: 0.089 ± 0.01
0.583TrpAsp: 0.583 ± 0.027
0.68TrpGlu: 0.68 ± 0.033
0.585TrpPhe: 0.585 ± 0.028
0.605TrpGly: 0.605 ± 0.03
0.173TrpHis: 0.173 ± 0.016
0.761TrpIle: 0.761 ± 0.041
0.895TrpLys: 0.895 ± 0.038
0.934TrpLeu: 0.934 ± 0.029
0.31TrpMet: 0.31 ± 0.019
0.745TrpAsn: 0.745 ± 0.034
0.196TrpPro: 0.196 ± 0.017
0.39TrpGln: 0.39 ± 0.022
0.335TrpArg: 0.335 ± 0.019
0.548TrpSer: 0.548 ± 0.025
0.532TrpThr: 0.532 ± 0.03
0.573TrpVal: 0.573 ± 0.025
0.123TrpTrp: 0.123 ± 0.014
0.425TrpTyr: 0.425 ± 0.024
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.371TyrAla: 2.371 ± 0.058
0.338TyrCys: 0.338 ± 0.02
2.225TyrAsp: 2.225 ± 0.052
2.31TyrGlu: 2.31 ± 0.06
2.601TyrPhe: 2.601 ± 0.062
2.557TyrGly: 2.557 ± 0.06
0.851TyrHis: 0.851 ± 0.034
2.57TyrIle: 2.57 ± 0.052
2.542TyrLys: 2.542 ± 0.061
3.803TyrLeu: 3.803 ± 0.077
0.757TyrMet: 0.757 ± 0.032
2.095TyrAsn: 2.095 ± 0.061
1.489TyrPro: 1.489 ± 0.041
1.604TyrGln: 1.604 ± 0.049
1.814TyrArg: 1.814 ± 0.057
2.663TyrSer: 2.663 ± 0.062
2.112TyrThr: 2.112 ± 0.055
1.972TyrVal: 1.972 ± 0.053
0.463TyrTrp: 0.463 ± 0.022
1.89TyrTyr: 1.89 ± 0.065
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2570 proteins (821522 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski