Amino acid dipepetide frequency for Simian cytomegalovirus (strain Colburn)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.569AlaAla: 6.569 ± 0.464
1.55AlaCys: 1.55 ± 0.176
3.032AlaAsp: 3.032 ± 0.204
3.419AlaGlu: 3.419 ± 0.292
2.678AlaPhe: 2.678 ± 0.226
3.2AlaGly: 3.2 ± 0.285
1.668AlaHis: 1.668 ± 0.172
3.487AlaIle: 3.487 ± 0.273
2.51AlaLys: 2.51 ± 0.237
6.805AlaLeu: 6.805 ± 0.35
1.769AlaMet: 1.769 ± 0.198
2.341AlaAsn: 2.341 ± 0.198
3.605AlaPro: 3.605 ± 0.354
2.24AlaGln: 2.24 ± 0.255
3.554AlaArg: 3.554 ± 0.252
5.121AlaSer: 5.121 ± 0.33
4.481AlaThr: 4.481 ± 0.345
5.559AlaVal: 5.559 ± 0.359
1.196AlaTrp: 1.196 ± 0.151
1.971AlaTyr: 1.971 ± 0.162
0.0AlaXaa: 0.0 ± 0.0
Cys
1.684CysAla: 1.684 ± 0.167
1.044CysCys: 1.044 ± 0.165
1.213CysAsp: 1.213 ± 0.169
1.364CysGlu: 1.364 ± 0.144
1.078CysPhe: 1.078 ± 0.144
1.55CysGly: 1.55 ± 0.182
0.758CysHis: 0.758 ± 0.109
1.331CysIle: 1.331 ± 0.142
0.943CysLys: 0.943 ± 0.139
3.083CysLeu: 3.083 ± 0.25
0.573CysMet: 0.573 ± 0.114
1.213CysAsn: 1.213 ± 0.155
1.533CysPro: 1.533 ± 0.198
0.893CysGln: 0.893 ± 0.114
1.6CysArg: 1.6 ± 0.16
1.718CysSer: 1.718 ± 0.187
1.853CysThr: 1.853 ± 0.216
2.223CysVal: 2.223 ± 0.23
0.32CysTrp: 0.32 ± 0.065
1.23CysTyr: 1.23 ± 0.159
0.0CysXaa: 0.0 ± 0.0
Asp
2.998AspAla: 2.998 ± 0.239
0.977AspCys: 0.977 ± 0.145
3.571AspAsp: 3.571 ± 0.299
3.992AspGlu: 3.992 ± 0.282
2.308AspPhe: 2.308 ± 0.203
2.156AspGly: 2.156 ± 0.216
1.213AspHis: 1.213 ± 0.144
2.594AspIle: 2.594 ± 0.209
1.482AspLys: 1.482 ± 0.184
5.003AspLeu: 5.003 ± 0.358
1.314AspMet: 1.314 ± 0.144
1.617AspAsn: 1.617 ± 0.169
2.459AspPro: 2.459 ± 0.235
1.28AspGln: 1.28 ± 0.152
2.813AspArg: 2.813 ± 0.252
3.706AspSer: 3.706 ± 0.344
2.544AspThr: 2.544 ± 0.171
3.47AspVal: 3.47 ± 0.256
0.724AspTrp: 0.724 ± 0.126
1.735AspTyr: 1.735 ± 0.15
0.0AspXaa: 0.0 ± 0.0
Glu
3.942GluAla: 3.942 ± 0.303
1.028GluCys: 1.028 ± 0.134
3.386GluAsp: 3.386 ± 0.216
4.278GluGlu: 4.278 ± 0.379
1.634GluPhe: 1.634 ± 0.19
2.392GluGly: 2.392 ± 0.227
1.887GluHis: 1.887 ± 0.194
2.426GluIle: 2.426 ± 0.212
2.122GluLys: 2.122 ± 0.196
5.171GluLeu: 5.171 ± 0.307
1.314GluMet: 1.314 ± 0.148
2.661GluAsn: 2.661 ± 0.215
2.746GluPro: 2.746 ± 0.255
2.038GluGln: 2.038 ± 0.209
3.369GluArg: 3.369 ± 0.282
3.386GluSer: 3.386 ± 0.21
4.11GluThr: 4.11 ± 0.269
3.672GluVal: 3.672 ± 0.276
0.623GluTrp: 0.623 ± 0.084
1.533GluTyr: 1.533 ± 0.135
0.0GluXaa: 0.0 ± 0.0
Phe
2.223PheAla: 2.223 ± 0.223
1.213PheCys: 1.213 ± 0.163
1.752PheAsp: 1.752 ± 0.202
1.937PheGlu: 1.937 ± 0.212
2.004PhePhe: 2.004 ± 0.198
2.207PheGly: 2.207 ± 0.194
0.842PheHis: 0.842 ± 0.128
2.661PheIle: 2.661 ± 0.229
1.482PheLys: 1.482 ± 0.12
4.413PheLeu: 4.413 ± 0.244
0.926PheMet: 0.926 ± 0.145
1.903PheAsn: 1.903 ± 0.153
1.887PhePro: 1.887 ± 0.162
1.567PheGln: 1.567 ± 0.165
2.577PheArg: 2.577 ± 0.226
2.931PheSer: 2.931 ± 0.23
2.948PheThr: 2.948 ± 0.214
3.184PheVal: 3.184 ± 0.263
0.691PheTrp: 0.691 ± 0.115
1.819PheTyr: 1.819 ± 0.189
0.0PheXaa: 0.0 ± 0.0
Gly
3.032GlyAla: 3.032 ± 0.281
1.297GlyCys: 1.297 ± 0.146
2.24GlyAsp: 2.24 ± 0.197
2.813GlyGlu: 2.813 ± 0.237
1.482GlyPhe: 1.482 ± 0.159
2.965GlyGly: 2.965 ± 0.299
1.011GlyHis: 1.011 ± 0.112
2.409GlyIle: 2.409 ± 0.164
1.6GlyLys: 1.6 ± 0.172
4.885GlyLeu: 4.885 ± 0.274
0.809GlyMet: 0.809 ± 0.101
2.409GlyAsn: 2.409 ± 0.188
2.106GlyPro: 2.106 ± 0.213
1.937GlyGln: 1.937 ± 0.158
3.15GlyArg: 3.15 ± 0.289
3.453GlySer: 3.453 ± 0.277
3.099GlyThr: 3.099 ± 0.225
3.672GlyVal: 3.672 ± 0.291
0.556GlyTrp: 0.556 ± 0.094
1.819GlyTyr: 1.819 ± 0.186
0.0GlyXaa: 0.0 ± 0.0
His
2.156HisAla: 2.156 ± 0.192
0.792HisCys: 0.792 ± 0.104
1.583HisAsp: 1.583 ± 0.182
1.348HisGlu: 1.348 ± 0.154
1.213HisPhe: 1.213 ± 0.14
1.87HisGly: 1.87 ± 0.204
1.533HisHis: 1.533 ± 0.215
1.297HisIle: 1.297 ± 0.14
0.91HisLys: 0.91 ± 0.118
2.981HisLeu: 2.981 ± 0.222
0.623HisMet: 0.623 ± 0.1
1.162HisAsn: 1.162 ± 0.141
1.567HisPro: 1.567 ± 0.171
1.162HisGln: 1.162 ± 0.152
2.223HisArg: 2.223 ± 0.211
1.819HisSer: 1.819 ± 0.193
2.19HisThr: 2.19 ± 0.203
2.089HisVal: 2.089 ± 0.18
0.32HisTrp: 0.32 ± 0.083
0.91HisTyr: 0.91 ± 0.123
0.0HisXaa: 0.0 ± 0.0
Ile
2.762IleAla: 2.762 ± 0.24
1.583IleCys: 1.583 ± 0.151
1.92IleAsp: 1.92 ± 0.178
2.038IleGlu: 2.038 ± 0.192
2.476IlePhe: 2.476 ± 0.197
2.055IleGly: 2.055 ± 0.199
1.449IleHis: 1.449 ± 0.164
3.453IleIle: 3.453 ± 0.239
2.156IleLys: 2.156 ± 0.209
5.053IleLeu: 5.053 ± 0.302
1.449IleMet: 1.449 ± 0.164
2.24IleAsn: 2.24 ± 0.201
3.386IlePro: 3.386 ± 0.234
2.139IleGln: 2.139 ± 0.222
2.51IleArg: 2.51 ± 0.201
3.52IleSer: 3.52 ± 0.241
3.537IleThr: 3.537 ± 0.311
3.975IleVal: 3.975 ± 0.276
0.691IleTrp: 0.691 ± 0.109
2.055IleTyr: 2.055 ± 0.224
0.0IleXaa: 0.0 ± 0.0
Lys
2.476LysAla: 2.476 ± 0.221
0.96LysCys: 0.96 ± 0.135
1.684LysAsp: 1.684 ± 0.21
1.853LysGlu: 1.853 ± 0.214
1.331LysPhe: 1.331 ± 0.153
1.516LysGly: 1.516 ± 0.148
1.348LysHis: 1.348 ± 0.151
2.325LysIle: 2.325 ± 0.225
2.594LysLys: 2.594 ± 0.269
3.386LysLeu: 3.386 ± 0.258
1.213LysMet: 1.213 ± 0.126
2.156LysAsn: 2.156 ± 0.208
2.51LysPro: 2.51 ± 0.341
1.6LysGln: 1.6 ± 0.187
3.2LysArg: 3.2 ± 0.218
2.358LysSer: 2.358 ± 0.211
3.285LysThr: 3.285 ± 0.289
2.358LysVal: 2.358 ± 0.197
0.421LysTrp: 0.421 ± 0.085
1.297LysTyr: 1.297 ± 0.155
0.0LysXaa: 0.0 ± 0.0
Leu
6.687LeuAla: 6.687 ± 0.32
3.857LeuCys: 3.857 ± 0.258
4.026LeuAsp: 4.026 ± 0.29
4.295LeuGlu: 4.295 ± 0.278
4.615LeuPhe: 4.615 ± 0.272
4.363LeuGly: 4.363 ± 0.278
2.948LeuHis: 2.948 ± 0.22
5.121LeuIle: 5.121 ± 0.322
4.346LeuLys: 4.346 ± 0.286
11.117LeuLeu: 11.117 ± 0.489
2.931LeuMet: 2.931 ± 0.222
4.228LeuAsn: 4.228 ± 0.325
5.138LeuPro: 5.138 ± 0.358
4.026LeuGln: 4.026 ± 0.36
7.193LeuArg: 7.193 ± 0.435
7.563LeuSer: 7.563 ± 0.381
6.957LeuThr: 6.957 ± 0.385
5.693LeuVal: 5.693 ± 0.325
1.465LeuTrp: 1.465 ± 0.162
4.059LeuTyr: 4.059 ± 0.289
0.0LeuXaa: 0.0 ± 0.0
Met
1.819MetAla: 1.819 ± 0.192
0.691MetCys: 0.691 ± 0.104
1.044MetAsp: 1.044 ± 0.121
1.55MetGlu: 1.55 ± 0.137
1.297MetPhe: 1.297 ± 0.149
0.994MetGly: 0.994 ± 0.129
0.505MetHis: 0.505 ± 0.097
1.246MetIle: 1.246 ± 0.127
1.028MetLys: 1.028 ± 0.116
2.628MetLeu: 2.628 ± 0.271
0.707MetMet: 0.707 ± 0.099
1.095MetAsn: 1.095 ± 0.134
1.129MetPro: 1.129 ± 0.137
0.809MetGln: 0.809 ± 0.113
1.415MetArg: 1.415 ± 0.187
2.476MetSer: 2.476 ± 0.242
1.482MetThr: 1.482 ± 0.145
1.415MetVal: 1.415 ± 0.144
0.472MetTrp: 0.472 ± 0.084
1.129MetTyr: 1.129 ± 0.138
0.0MetXaa: 0.0 ± 0.0
Asn
2.897AsnAla: 2.897 ± 0.231
0.96AsnCys: 0.96 ± 0.122
2.055AsnAsp: 2.055 ± 0.214
1.887AsnGlu: 1.887 ± 0.157
1.567AsnPhe: 1.567 ± 0.177
1.988AsnGly: 1.988 ± 0.155
1.263AsnHis: 1.263 ± 0.143
2.661AsnIle: 2.661 ± 0.23
1.617AsnLys: 1.617 ± 0.176
3.891AsnLeu: 3.891 ± 0.253
0.926AsnMet: 0.926 ± 0.136
2.004AsnAsn: 2.004 ± 0.187
2.089AsnPro: 2.089 ± 0.196
1.499AsnGln: 1.499 ± 0.179
2.392AsnArg: 2.392 ± 0.208
3.015AsnSer: 3.015 ± 0.254
3.571AsnThr: 3.571 ± 0.344
3.857AsnVal: 3.857 ± 0.267
0.421AsnTrp: 0.421 ± 0.067
1.617AsnTyr: 1.617 ± 0.158
0.0AsnXaa: 0.0 ± 0.0
Pro
3.739ProAla: 3.739 ± 0.381
1.297ProCys: 1.297 ± 0.13
2.577ProAsp: 2.577 ± 0.229
3.133ProGlu: 3.133 ± 0.283
1.887ProPhe: 1.887 ± 0.174
2.426ProGly: 2.426 ± 0.255
1.634ProHis: 1.634 ± 0.199
2.257ProIle: 2.257 ± 0.237
2.308ProLys: 2.308 ± 0.254
4.75ProLeu: 4.75 ± 0.325
1.112ProMet: 1.112 ± 0.125
1.6ProAsn: 1.6 ± 0.189
5.946ProPro: 5.946 ± 0.567
2.106ProGln: 2.106 ± 0.204
4.076ProArg: 4.076 ± 0.332
4.919ProSer: 4.919 ± 0.333
3.706ProThr: 3.706 ± 0.311
4.531ProVal: 4.531 ± 0.295
0.573ProTrp: 0.573 ± 0.099
1.567ProTyr: 1.567 ± 0.167
0.0ProXaa: 0.0 ± 0.0
Gln
2.358GlnAla: 2.358 ± 0.272
1.095GlnCys: 1.095 ± 0.125
1.55GlnAsp: 1.55 ± 0.155
2.308GlnGlu: 2.308 ± 0.238
1.516GlnPhe: 1.516 ± 0.16
1.263GlnGly: 1.263 ± 0.147
1.465GlnHis: 1.465 ± 0.175
1.752GlnIle: 1.752 ± 0.193
1.718GlnLys: 1.718 ± 0.179
4.161GlnLeu: 4.161 ± 0.365
1.145GlnMet: 1.145 ± 0.145
1.887GlnAsn: 1.887 ± 0.167
2.24GlnPro: 2.24 ± 0.229
2.207GlnGln: 2.207 ± 0.47
2.914GlnArg: 2.914 ± 0.259
1.954GlnSer: 1.954 ± 0.175
2.897GlnThr: 2.897 ± 0.294
2.375GlnVal: 2.375 ± 0.222
0.337GlnTrp: 0.337 ± 0.074
1.381GlnTyr: 1.381 ± 0.157
0.0GlnXaa: 0.0 ± 0.0
Arg
3.622ArgAla: 3.622 ± 0.276
1.634ArgCys: 1.634 ± 0.188
3.571ArgAsp: 3.571 ± 0.283
3.605ArgGlu: 3.605 ± 0.235
2.291ArgPhe: 2.291 ± 0.248
3.487ArgGly: 3.487 ± 0.285
2.712ArgHis: 2.712 ± 0.249
2.712ArgIle: 2.712 ± 0.21
2.965ArgLys: 2.965 ± 0.213
7.075ArgLeu: 7.075 ± 0.41
1.398ArgMet: 1.398 ± 0.125
2.527ArgAsn: 2.527 ± 0.221
3.706ArgPro: 3.706 ± 0.298
2.981ArgGln: 2.981 ± 0.241
5.828ArgArg: 5.828 ± 0.479
4.211ArgSer: 4.211 ± 0.26
3.251ArgThr: 3.251 ± 0.238
4.076ArgVal: 4.076 ± 0.313
1.061ArgTrp: 1.061 ± 0.152
2.661ArgTyr: 2.661 ± 0.206
0.0ArgXaa: 0.0 ± 0.0
Ser
5.138SerAla: 5.138 ± 0.297
1.499SerCys: 1.499 ± 0.164
4.177SerAsp: 4.177 ± 0.326
4.177SerGlu: 4.177 ± 0.205
2.729SerPhe: 2.729 ± 0.186
4.211SerGly: 4.211 ± 0.346
2.173SerHis: 2.173 ± 0.193
3.184SerIle: 3.184 ± 0.227
2.459SerLys: 2.459 ± 0.211
7.058SerLeu: 7.058 ± 0.385
1.769SerMet: 1.769 ± 0.188
2.813SerAsn: 2.813 ± 0.238
4.228SerPro: 4.228 ± 0.342
2.746SerGln: 2.746 ± 0.231
5.239SerArg: 5.239 ± 0.293
7.934SerSer: 7.934 ± 0.658
5.946SerThr: 5.946 ± 0.554
4.683SerVal: 4.683 ± 0.299
0.893SerTrp: 0.893 ± 0.104
2.19SerTyr: 2.19 ± 0.187
0.0SerXaa: 0.0 ± 0.0
Thr
5.373ThrAla: 5.373 ± 0.288
1.887ThrCys: 1.887 ± 0.217
3.083ThrAsp: 3.083 ± 0.254
3.588ThrGlu: 3.588 ± 0.276
3.2ThrPhe: 3.2 ± 0.216
2.779ThrGly: 2.779 ± 0.222
1.954ThrHis: 1.954 ± 0.207
3.066ThrIle: 3.066 ± 0.221
2.897ThrLys: 2.897 ± 0.267
6.131ThrLeu: 6.131 ± 0.45
1.533ThrMet: 1.533 ± 0.154
2.645ThrAsn: 2.645 ± 0.262
4.262ThrPro: 4.262 ± 0.349
2.88ThrGln: 2.88 ± 0.23
3.689ThrArg: 3.689 ± 0.297
6.266ThrSer: 6.266 ± 0.499
7.631ThrThr: 7.631 ± 0.972
6.081ThrVal: 6.081 ± 0.374
0.842ThrTrp: 0.842 ± 0.122
2.291ThrTyr: 2.291 ± 0.195
0.0ThrXaa: 0.0 ± 0.0
Val
4.649ValAla: 4.649 ± 0.293
2.122ValCys: 2.122 ± 0.22
2.914ValAsp: 2.914 ± 0.289
3.352ValGlu: 3.352 ± 0.243
3.706ValPhe: 3.706 ± 0.299
2.965ValGly: 2.965 ± 0.265
1.769ValHis: 1.769 ± 0.17
3.908ValIle: 3.908 ± 0.267
2.813ValLys: 2.813 ± 0.226
7.513ValLeu: 7.513 ± 0.445
2.257ValMet: 2.257 ± 0.219
3.301ValAsn: 3.301 ± 0.219
3.672ValPro: 3.672 ± 0.252
2.611ValGln: 2.611 ± 0.24
4.043ValArg: 4.043 ± 0.273
5.626ValSer: 5.626 ± 0.338
5.677ValThr: 5.677 ± 0.336
4.733ValVal: 4.733 ± 0.294
0.96ValTrp: 0.96 ± 0.137
2.965ValTyr: 2.965 ± 0.26
0.0ValXaa: 0.0 ± 0.0
Trp
0.606TrpAla: 0.606 ± 0.105
0.556TrpCys: 0.556 ± 0.104
0.573TrpAsp: 0.573 ± 0.107
0.758TrpGlu: 0.758 ± 0.104
0.59TrpPhe: 0.59 ± 0.105
0.606TrpGly: 0.606 ± 0.127
0.404TrpHis: 0.404 ± 0.072
0.825TrpIle: 0.825 ± 0.106
0.539TrpLys: 0.539 ± 0.085
1.836TrpLeu: 1.836 ± 0.15
0.337TrpMet: 0.337 ± 0.08
0.404TrpAsn: 0.404 ± 0.083
0.741TrpPro: 0.741 ± 0.111
0.404TrpGln: 0.404 ± 0.085
0.96TrpArg: 0.96 ± 0.18
0.876TrpSer: 0.876 ± 0.108
0.842TrpThr: 0.842 ± 0.12
0.606TrpVal: 0.606 ± 0.095
0.404TrpTrp: 0.404 ± 0.096
0.674TrpTyr: 0.674 ± 0.102
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.021TyrAla: 2.021 ± 0.186
1.162TyrCys: 1.162 ± 0.106
2.004TyrAsp: 2.004 ± 0.199
2.021TyrGlu: 2.021 ± 0.182
1.567TyrPhe: 1.567 ± 0.185
1.769TyrGly: 1.769 ± 0.201
1.213TyrHis: 1.213 ± 0.139
1.735TyrIle: 1.735 ± 0.155
1.381TyrLys: 1.381 ± 0.157
3.689TyrLeu: 3.689 ± 0.225
0.809TyrMet: 0.809 ± 0.117
1.971TyrAsn: 1.971 ± 0.181
1.196TyrPro: 1.196 ± 0.138
1.398TyrGln: 1.398 ± 0.169
2.628TyrArg: 2.628 ± 0.198
2.392TyrSer: 2.392 ± 0.166
2.072TyrThr: 2.072 ± 0.214
3.301TyrVal: 3.301 ± 0.254
0.573TyrTrp: 0.573 ± 0.091
1.297TyrTyr: 1.297 ± 0.154
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 175 proteins (59368 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski