Amino acid dipepetide frequency for Streptococcus phage Javan23

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.093AlaAla: 3.093 ± 0.991
0.515AlaCys: 0.515 ± 0.189
3.436AlaAsp: 3.436 ± 0.464
4.639AlaGlu: 4.639 ± 0.485
3.264AlaPhe: 3.264 ± 0.99
4.553AlaGly: 4.553 ± 1.412
0.344AlaHis: 0.344 ± 0.159
5.841AlaIle: 5.841 ± 0.855
6.271AlaLys: 6.271 ± 0.625
5.756AlaLeu: 5.756 ± 1.369
2.405AlaMet: 2.405 ± 0.821
4.037AlaAsn: 4.037 ± 0.633
1.46AlaPro: 1.46 ± 0.375
2.577AlaGln: 2.577 ± 0.496
2.491AlaArg: 2.491 ± 0.45
5.498AlaSer: 5.498 ± 1.252
4.209AlaThr: 4.209 ± 0.681
4.381AlaVal: 4.381 ± 1.47
0.859AlaTrp: 0.859 ± 0.306
2.062AlaTyr: 2.062 ± 0.433
0.0AlaXaa: 0.0 ± 0.0
Cys
0.344CysAla: 0.344 ± 0.159
0.0CysCys: 0.0 ± 0.0
0.258CysAsp: 0.258 ± 0.154
0.773CysGlu: 0.773 ± 0.244
0.43CysPhe: 0.43 ± 0.171
0.515CysGly: 0.515 ± 0.232
0.258CysHis: 0.258 ± 0.153
0.344CysIle: 0.344 ± 0.19
0.601CysLys: 0.601 ± 0.279
0.258CysLeu: 0.258 ± 0.123
0.172CysMet: 0.172 ± 0.118
0.344CysAsn: 0.344 ± 0.17
0.172CysPro: 0.172 ± 0.178
0.086CysGln: 0.086 ± 0.074
0.0CysArg: 0.0 ± 0.0
0.172CysSer: 0.172 ± 0.115
0.172CysThr: 0.172 ± 0.118
0.687CysVal: 0.687 ± 0.246
0.258CysTrp: 0.258 ± 0.145
0.086CysTyr: 0.086 ± 0.08
0.0CysXaa: 0.0 ± 0.0
Asp
4.553AspAla: 4.553 ± 0.685
0.601AspCys: 0.601 ± 0.22
4.123AspAsp: 4.123 ± 0.816
5.24AspGlu: 5.24 ± 0.838
4.037AspPhe: 4.037 ± 0.657
5.841AspGly: 5.841 ± 0.702
0.601AspHis: 0.601 ± 0.219
4.639AspIle: 4.639 ± 0.765
5.927AspLys: 5.927 ± 0.664
6.099AspLeu: 6.099 ± 0.84
1.546AspMet: 1.546 ± 0.281
3.78AspAsn: 3.78 ± 0.648
0.859AspPro: 0.859 ± 0.273
1.46AspGln: 1.46 ± 0.312
2.663AspArg: 2.663 ± 0.555
3.093AspSer: 3.093 ± 0.606
3.522AspThr: 3.522 ± 0.67
3.608AspVal: 3.608 ± 0.538
0.773AspTrp: 0.773 ± 0.265
3.178AspTyr: 3.178 ± 0.625
0.0AspXaa: 0.0 ± 0.0
Glu
3.178GluAla: 3.178 ± 0.581
0.172GluCys: 0.172 ± 0.124
3.093GluAsp: 3.093 ± 0.559
3.952GluGlu: 3.952 ± 0.79
3.093GluPhe: 3.093 ± 0.589
2.319GluGly: 2.319 ± 0.409
1.374GluHis: 1.374 ± 0.441
5.756GluIle: 5.756 ± 0.732
4.982GluLys: 4.982 ± 0.987
6.786GluLeu: 6.786 ± 1.037
1.976GluMet: 1.976 ± 0.359
4.123GluAsn: 4.123 ± 0.664
1.46GluPro: 1.46 ± 0.425
3.608GluGln: 3.608 ± 0.564
3.35GluArg: 3.35 ± 0.627
2.319GluSer: 2.319 ± 0.4
3.952GluThr: 3.952 ± 0.586
4.982GluVal: 4.982 ± 0.82
1.117GluTrp: 1.117 ± 0.293
2.062GluTyr: 2.062 ± 0.464
0.0GluXaa: 0.0 ± 0.0
Phe
2.749PheAla: 2.749 ± 0.474
0.344PheCys: 0.344 ± 0.211
4.982PheAsp: 4.982 ± 0.674
3.694PheGlu: 3.694 ± 0.732
0.945PhePhe: 0.945 ± 0.234
2.835PheGly: 2.835 ± 0.505
0.773PheHis: 0.773 ± 0.263
2.405PheIle: 2.405 ± 0.47
3.436PheLys: 3.436 ± 0.604
2.749PheLeu: 2.749 ± 0.454
1.546PheMet: 1.546 ± 0.355
3.178PheAsn: 3.178 ± 0.49
0.344PhePro: 0.344 ± 0.151
1.46PheGln: 1.46 ± 0.418
1.718PheArg: 1.718 ± 0.329
3.952PheSer: 3.952 ± 0.594
2.663PheThr: 2.663 ± 0.449
2.319PheVal: 2.319 ± 0.394
0.086PheTrp: 0.086 ± 0.085
2.233PheTyr: 2.233 ± 0.396
0.0PheXaa: 0.0 ± 0.0
Gly
5.154GlyAla: 5.154 ± 1.343
0.258GlyCys: 0.258 ± 0.15
3.522GlyAsp: 3.522 ± 0.545
2.577GlyGlu: 2.577 ± 0.339
2.749GlyPhe: 2.749 ± 0.575
4.381GlyGly: 4.381 ± 0.471
0.773GlyHis: 0.773 ± 0.204
6.958GlyIle: 6.958 ± 1.532
4.209GlyLys: 4.209 ± 0.544
5.584GlyLeu: 5.584 ± 1.131
1.46GlyMet: 1.46 ± 0.338
4.639GlyAsn: 4.639 ± 0.789
0.172GlyPro: 0.172 ± 0.117
2.749GlyGln: 2.749 ± 0.469
2.835GlyArg: 2.835 ± 0.463
3.694GlySer: 3.694 ± 0.838
4.639GlyThr: 4.639 ± 0.704
4.295GlyVal: 4.295 ± 0.85
1.031GlyTrp: 1.031 ± 0.285
3.093GlyTyr: 3.093 ± 0.584
0.0GlyXaa: 0.0 ± 0.0
His
0.773HisAla: 0.773 ± 0.228
0.258HisCys: 0.258 ± 0.137
0.601HisAsp: 0.601 ± 0.275
0.773HisGlu: 0.773 ± 0.252
0.773HisPhe: 0.773 ± 0.219
0.43HisGly: 0.43 ± 0.176
0.43HisHis: 0.43 ± 0.171
1.117HisIle: 1.117 ± 0.296
1.289HisLys: 1.289 ± 0.299
0.773HisLeu: 0.773 ± 0.3
0.086HisMet: 0.086 ± 0.077
0.601HisAsn: 0.601 ± 0.235
0.687HisPro: 0.687 ± 0.285
0.515HisGln: 0.515 ± 0.205
0.773HisArg: 0.773 ± 0.256
1.117HisSer: 1.117 ± 0.397
0.773HisThr: 0.773 ± 0.241
0.773HisVal: 0.773 ± 0.257
0.172HisTrp: 0.172 ± 0.11
0.601HisTyr: 0.601 ± 0.27
0.0HisXaa: 0.0 ± 0.0
Ile
5.584IleAla: 5.584 ± 1.269
0.258IleCys: 0.258 ± 0.164
6.786IleAsp: 6.786 ± 0.771
5.841IleGlu: 5.841 ± 0.722
2.663IlePhe: 2.663 ± 0.474
6.615IleGly: 6.615 ± 1.036
0.945IleHis: 0.945 ± 0.255
4.553IleIle: 4.553 ± 0.712
6.443IleLys: 6.443 ± 0.953
4.381IleLeu: 4.381 ± 0.494
1.374IleMet: 1.374 ± 0.344
4.639IleAsn: 4.639 ± 0.671
3.007IlePro: 3.007 ± 0.527
2.405IleGln: 2.405 ± 0.599
3.007IleArg: 3.007 ± 0.535
5.584IleSer: 5.584 ± 0.794
6.357IleThr: 6.357 ± 0.727
4.639IleVal: 4.639 ± 0.634
0.945IleTrp: 0.945 ± 0.327
2.577IleTyr: 2.577 ± 0.629
0.0IleXaa: 0.0 ± 0.0
Lys
5.584LysAla: 5.584 ± 0.7
0.43LysCys: 0.43 ± 0.213
4.295LysAsp: 4.295 ± 0.753
6.357LysGlu: 6.357 ± 0.984
2.921LysPhe: 2.921 ± 0.466
5.154LysGly: 5.154 ± 0.736
1.117LysHis: 1.117 ± 0.319
5.326LysIle: 5.326 ± 0.606
6.872LysLys: 6.872 ± 0.992
7.559LysLeu: 7.559 ± 0.932
2.233LysMet: 2.233 ± 0.471
4.639LysAsn: 4.639 ± 0.545
3.007LysPro: 3.007 ± 0.572
3.007LysGln: 3.007 ± 0.471
3.522LysArg: 3.522 ± 0.808
6.099LysSer: 6.099 ± 0.677
4.295LysThr: 4.295 ± 0.566
5.927LysVal: 5.927 ± 0.578
0.859LysTrp: 0.859 ± 0.308
3.35LysTyr: 3.35 ± 0.543
0.0LysXaa: 0.0 ± 0.0
Leu
5.154LeuAla: 5.154 ± 0.755
0.43LeuCys: 0.43 ± 0.181
7.044LeuAsp: 7.044 ± 0.861
5.412LeuGlu: 5.412 ± 0.763
3.952LeuPhe: 3.952 ± 0.594
4.381LeuGly: 4.381 ± 0.862
1.031LeuHis: 1.031 ± 0.398
5.412LeuIle: 5.412 ± 0.616
6.443LeuLys: 6.443 ± 0.811
4.553LeuLeu: 4.553 ± 0.631
1.203LeuMet: 1.203 ± 0.368
5.068LeuAsn: 5.068 ± 0.766
2.835LeuPro: 2.835 ± 0.54
3.264LeuGln: 3.264 ± 0.518
2.491LeuArg: 2.491 ± 0.659
6.271LeuSer: 6.271 ± 0.534
6.7LeuThr: 6.7 ± 0.655
3.522LeuVal: 3.522 ± 0.489
0.601LeuTrp: 0.601 ± 0.269
1.976LeuTyr: 1.976 ± 0.369
0.0LeuXaa: 0.0 ± 0.0
Met
1.46MetAla: 1.46 ± 0.37
0.43MetCys: 0.43 ± 0.193
1.031MetAsp: 1.031 ± 0.351
1.546MetGlu: 1.546 ± 0.325
0.859MetPhe: 0.859 ± 0.22
0.773MetGly: 0.773 ± 0.282
0.344MetHis: 0.344 ± 0.16
2.405MetIle: 2.405 ± 0.51
1.46MetLys: 1.46 ± 0.294
1.632MetLeu: 1.632 ± 0.383
1.374MetMet: 1.374 ± 0.344
1.46MetAsn: 1.46 ± 0.33
0.859MetPro: 0.859 ± 0.209
1.89MetGln: 1.89 ± 0.366
1.031MetArg: 1.031 ± 0.275
2.835MetSer: 2.835 ± 0.566
1.89MetThr: 1.89 ± 0.395
0.773MetVal: 0.773 ± 0.215
0.258MetTrp: 0.258 ± 0.142
0.344MetTyr: 0.344 ± 0.167
0.0MetXaa: 0.0 ± 0.0
Asn
4.123AsnAla: 4.123 ± 0.756
0.344AsnCys: 0.344 ± 0.175
3.866AsnAsp: 3.866 ± 0.654
3.093AsnGlu: 3.093 ± 0.51
2.577AsnPhe: 2.577 ± 0.508
4.725AsnGly: 4.725 ± 0.783
0.687AsnHis: 0.687 ± 0.222
4.725AsnIle: 4.725 ± 0.884
5.756AsnLys: 5.756 ± 0.821
4.295AsnLeu: 4.295 ± 0.854
1.89AsnMet: 1.89 ± 0.296
4.381AsnAsn: 4.381 ± 0.788
2.577AsnPro: 2.577 ± 0.579
2.663AsnGln: 2.663 ± 0.554
2.148AsnArg: 2.148 ± 0.428
3.694AsnSer: 3.694 ± 0.519
3.694AsnThr: 3.694 ± 0.501
3.35AsnVal: 3.35 ± 0.437
0.515AsnTrp: 0.515 ± 0.166
2.148AsnTyr: 2.148 ± 0.479
0.0AsnXaa: 0.0 ± 0.0
Pro
2.062ProAla: 2.062 ± 0.546
0.258ProCys: 0.258 ± 0.159
1.718ProAsp: 1.718 ± 0.406
1.117ProGlu: 1.117 ± 0.344
1.804ProPhe: 1.804 ± 0.473
1.289ProGly: 1.289 ± 0.362
0.515ProHis: 0.515 ± 0.262
1.804ProIle: 1.804 ± 0.442
1.804ProLys: 1.804 ± 0.37
1.89ProLeu: 1.89 ± 0.373
0.601ProMet: 0.601 ± 0.25
1.289ProAsn: 1.289 ± 0.386
0.859ProPro: 0.859 ± 0.197
1.289ProGln: 1.289 ± 0.361
1.031ProArg: 1.031 ± 0.309
1.804ProSer: 1.804 ± 0.462
1.976ProThr: 1.976 ± 0.355
2.319ProVal: 2.319 ± 0.422
0.172ProTrp: 0.172 ± 0.121
1.117ProTyr: 1.117 ± 0.26
0.0ProXaa: 0.0 ± 0.0
Gln
2.835GlnAla: 2.835 ± 0.493
0.344GlnCys: 0.344 ± 0.172
2.148GlnAsp: 2.148 ± 0.369
2.062GlnGlu: 2.062 ± 0.515
1.804GlnPhe: 1.804 ± 0.324
2.663GlnGly: 2.663 ± 0.723
0.601GlnHis: 0.601 ± 0.219
3.78GlnIle: 3.78 ± 0.65
4.295GlnLys: 4.295 ± 0.642
3.178GlnLeu: 3.178 ± 0.454
1.374GlnMet: 1.374 ± 0.251
2.319GlnAsn: 2.319 ± 0.426
1.289GlnPro: 1.289 ± 0.299
2.319GlnGln: 2.319 ± 0.517
1.031GlnArg: 1.031 ± 0.292
3.436GlnSer: 3.436 ± 0.654
2.835GlnThr: 2.835 ± 0.454
2.663GlnVal: 2.663 ± 0.475
0.515GlnTrp: 0.515 ± 0.203
1.203GlnTyr: 1.203 ± 0.36
0.0GlnXaa: 0.0 ± 0.0
Arg
2.405ArgAla: 2.405 ± 0.472
0.0ArgCys: 0.0 ± 0.0
1.546ArgAsp: 1.546 ± 0.327
1.718ArgGlu: 1.718 ± 0.433
1.46ArgPhe: 1.46 ± 0.526
2.148ArgGly: 2.148 ± 0.304
0.687ArgHis: 0.687 ± 0.236
2.148ArgIle: 2.148 ± 0.426
3.608ArgLys: 3.608 ± 0.552
3.608ArgLeu: 3.608 ± 0.559
0.859ArgMet: 0.859 ± 0.277
2.921ArgAsn: 2.921 ± 0.44
0.859ArgPro: 0.859 ± 0.28
1.289ArgGln: 1.289 ± 0.301
1.289ArgArg: 1.289 ± 0.342
2.577ArgSer: 2.577 ± 0.445
1.89ArgThr: 1.89 ± 0.43
2.921ArgVal: 2.921 ± 0.441
0.515ArgTrp: 0.515 ± 0.189
1.718ArgTyr: 1.718 ± 0.394
0.0ArgXaa: 0.0 ± 0.0
Ser
5.412SerAla: 5.412 ± 1.723
0.086SerCys: 0.086 ± 0.089
4.381SerAsp: 4.381 ± 0.66
4.209SerGlu: 4.209 ± 0.706
2.835SerPhe: 2.835 ± 0.417
5.068SerGly: 5.068 ± 1.062
0.344SerHis: 0.344 ± 0.166
5.24SerIle: 5.24 ± 0.69
5.412SerLys: 5.412 ± 0.616
5.927SerLeu: 5.927 ± 0.698
1.632SerMet: 1.632 ± 0.334
4.123SerAsn: 4.123 ± 0.709
1.632SerPro: 1.632 ± 0.315
3.436SerGln: 3.436 ± 0.593
1.89SerArg: 1.89 ± 0.376
4.037SerSer: 4.037 ± 0.694
4.553SerThr: 4.553 ± 0.803
3.608SerVal: 3.608 ± 0.609
1.203SerTrp: 1.203 ± 0.246
2.491SerTyr: 2.491 ± 0.507
0.0SerXaa: 0.0 ± 0.0
Thr
4.982ThrAla: 4.982 ± 1.129
0.172ThrCys: 0.172 ± 0.129
4.123ThrAsp: 4.123 ± 0.594
3.694ThrGlu: 3.694 ± 0.697
3.264ThrPhe: 3.264 ± 0.555
4.037ThrGly: 4.037 ± 0.6
0.945ThrHis: 0.945 ± 0.264
7.474ThrIle: 7.474 ± 1.073
4.553ThrLys: 4.553 ± 0.645
4.811ThrLeu: 4.811 ± 0.541
1.031ThrMet: 1.031 ± 0.256
2.577ThrAsn: 2.577 ± 0.54
2.148ThrPro: 2.148 ± 0.333
3.264ThrGln: 3.264 ± 0.623
1.374ThrArg: 1.374 ± 0.288
4.295ThrSer: 4.295 ± 0.874
2.921ThrThr: 2.921 ± 0.619
5.412ThrVal: 5.412 ± 0.785
0.43ThrTrp: 0.43 ± 0.136
2.319ThrTyr: 2.319 ± 0.434
0.0ThrXaa: 0.0 ± 0.0
Val
5.154ValAla: 5.154 ± 1.187
0.344ValCys: 0.344 ± 0.147
5.154ValAsp: 5.154 ± 0.661
4.209ValGlu: 4.209 ± 0.845
2.577ValPhe: 2.577 ± 0.427
4.295ValGly: 4.295 ± 1.196
0.859ValHis: 0.859 ± 0.266
4.896ValIle: 4.896 ± 0.575
5.068ValLys: 5.068 ± 0.571
3.952ValLeu: 3.952 ± 0.561
0.945ValMet: 0.945 ± 0.328
3.866ValAsn: 3.866 ± 0.523
1.289ValPro: 1.289 ± 0.357
2.319ValGln: 2.319 ± 0.451
1.546ValArg: 1.546 ± 0.365
4.123ValSer: 4.123 ± 0.59
3.866ValThr: 3.866 ± 0.56
3.608ValVal: 3.608 ± 0.597
0.773ValTrp: 0.773 ± 0.277
3.35ValTyr: 3.35 ± 0.609
0.0ValXaa: 0.0 ± 0.0
Trp
0.773TrpAla: 0.773 ± 0.28
0.086TrpCys: 0.086 ± 0.088
0.344TrpAsp: 0.344 ± 0.149
0.515TrpGlu: 0.515 ± 0.216
0.687TrpPhe: 0.687 ± 0.219
0.601TrpGly: 0.601 ± 0.213
0.258TrpHis: 0.258 ± 0.138
1.117TrpIle: 1.117 ± 0.269
1.289TrpLys: 1.289 ± 0.335
0.945TrpLeu: 0.945 ± 0.205
0.344TrpMet: 0.344 ± 0.156
0.601TrpAsn: 0.601 ± 0.192
0.0TrpPro: 0.0 ± 0.0
0.601TrpGln: 0.601 ± 0.232
0.344TrpArg: 0.344 ± 0.168
1.031TrpSer: 1.031 ± 0.29
0.601TrpThr: 0.601 ± 0.347
0.43TrpVal: 0.43 ± 0.177
0.086TrpTrp: 0.086 ± 0.08
0.859TrpTyr: 0.859 ± 0.309
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.319TyrAla: 2.319 ± 0.46
0.601TyrCys: 0.601 ± 0.258
3.694TyrAsp: 3.694 ± 0.549
2.233TyrGlu: 2.233 ± 0.5
1.718TyrPhe: 1.718 ± 0.48
2.148TyrGly: 2.148 ± 0.447
0.43TyrHis: 0.43 ± 0.196
2.663TyrIle: 2.663 ± 0.533
2.835TyrLys: 2.835 ± 0.382
3.007TyrLeu: 3.007 ± 0.639
0.515TyrMet: 0.515 ± 0.221
2.663TyrAsn: 2.663 ± 0.687
1.203TyrPro: 1.203 ± 0.305
2.491TyrGln: 2.491 ± 0.423
1.632TyrArg: 1.632 ± 0.365
1.976TyrSer: 1.976 ± 0.407
2.319TyrThr: 2.319 ± 0.402
1.976TyrVal: 1.976 ± 0.441
0.344TyrTrp: 0.344 ± 0.206
1.89TyrTyr: 1.89 ± 0.445
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 56 proteins (11642 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski