Amino acid dipepetide frequency for Dissulfurirhabdus thermomarina

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	22.425AlaAla: 22.425 ± 0.368	1.675AlaCys: 1.675 ± 0.055	6.314AlaAsp: 6.314 ± 0.099	8.71AlaGlu: 8.71 ± 0.122	4.548AlaPhe: 4.548 ± 0.09	13.171AlaGly: 13.171 ± 0.193	2.129AlaHis: 2.129 ± 0.054	3.434AlaIle: 3.434 ± 0.079	2.759AlaLys: 2.759 ± 0.073	13.862AlaLeu: 13.862 ± 0.199	2.654AlaMet: 2.654 ± 0.061	1.851AlaAsn: 1.851 ± 0.06	6.745AlaPro: 6.745 ± 0.115	2.286AlaGln: 2.286 ± 0.062	11.677AlaArg: 11.677 ± 0.177	4.046AlaSer: 4.046 ± 0.076	4.284AlaThr: 4.284 ± 0.074	10.64AlaVal: 10.64 ± 0.117	1.907AlaTrp: 1.907 ± 0.058	2.736AlaTyr: 2.736 ± 0.071	0.0AlaXaa: 0.0 ± 0.0
Cys	1.115CysAla: 1.115 ± 0.045	0.177CysCys: 0.177 ± 0.017	0.485CysAsp: 0.485 ± 0.027	0.534CysGlu: 0.534 ± 0.029	0.402CysPhe: 0.402 ± 0.023	1.361CysGly: 1.361 ± 0.053	0.794CysHis: 0.794 ± 0.075	0.399CysIle: 0.399 ± 0.023	0.191CysLys: 0.191 ± 0.017	1.462CysLeu: 1.462 ± 0.054	0.187CysMet: 0.187 ± 0.016	0.247CysAsn: 0.247 ± 0.019	0.974CysPro: 0.974 ± 0.04	0.261CysGln: 0.261 ± 0.019	1.339CysArg: 1.339 ± 0.044	0.48CysSer: 0.48 ± 0.027	0.581CysThr: 0.581 ± 0.031	0.658CysVal: 0.658 ± 0.033	0.122CysTrp: 0.122 ± 0.014	0.296CysTyr: 0.296 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	5.284AspAla: 5.284 ± 0.097	0.581AspCys: 0.581 ± 0.029	2.509AspAsp: 2.509 ± 0.076	3.347AspGlu: 3.347 ± 0.074	2.281AspPhe: 2.281 ± 0.058	4.491AspGly: 4.491 ± 0.081	1.135AspHis: 1.135 ± 0.047	2.424AspIle: 2.424 ± 0.066	1.128AspLys: 1.128 ± 0.046	7.096AspLeu: 7.096 ± 0.114	0.911AspMet: 0.911 ± 0.033	0.894AspAsn: 0.894 ± 0.04	4.544AspPro: 4.544 ± 0.085	1.185AspGln: 1.185 ± 0.046	5.423AspArg: 5.423 ± 0.094	1.349AspSer: 1.349 ± 0.049	2.002AspThr: 2.002 ± 0.052	4.109AspVal: 4.109 ± 0.072	0.758AspTrp: 0.758 ± 0.036	1.444AspTyr: 1.444 ± 0.049	0.0AspXaa: 0.0 ± 0.0
Glu	10.961GluAla: 10.961 ± 0.175	0.539GluCys: 0.539 ± 0.03	3.246GluAsp: 3.246 ± 0.074	4.783GluGlu: 4.783 ± 0.104	1.623GluPhe: 1.623 ± 0.043	6.031GluGly: 6.031 ± 0.106	1.067GluHis: 1.067 ± 0.037	3.854GluIle: 3.854 ± 0.076	2.432GluLys: 2.432 ± 0.074	6.193GluLeu: 6.193 ± 0.103	1.475GluMet: 1.475 ± 0.044	1.226GluAsn: 1.226 ± 0.041	2.858GluPro: 2.858 ± 0.069	1.425GluGln: 1.425 ± 0.059	6.335GluArg: 6.335 ± 0.11	1.934GluSer: 1.934 ± 0.052	3.574GluThr: 3.574 ± 0.076	6.143GluVal: 6.143 ± 0.104	0.729GluTrp: 0.729 ± 0.034	1.07GluTyr: 1.07 ± 0.035	0.0GluXaa: 0.0 ± 0.0
Phe	3.356PheAla: 3.356 ± 0.075	0.524PheCys: 0.524 ± 0.026	2.149PheAsp: 2.149 ± 0.057	2.172PheGlu: 2.172 ± 0.049	1.665PhePhe: 1.665 ± 0.047	3.122PheGly: 3.122 ± 0.072	0.872PheHis: 0.872 ± 0.037	1.133PheIle: 1.133 ± 0.043	0.81PheLys: 0.81 ± 0.035	4.232PheLeu: 4.232 ± 0.092	0.634PheMet: 0.634 ± 0.03	0.792PheAsn: 0.792 ± 0.031	1.938PhePro: 1.938 ± 0.048	0.955PheGln: 0.955 ± 0.036	3.329PheArg: 3.329 ± 0.07	1.831PheSer: 1.831 ± 0.048	1.856PheThr: 1.856 ± 0.057	2.62PheVal: 2.62 ± 0.054	0.534PheTrp: 0.534 ± 0.027	0.931PheTyr: 0.931 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	10.362GlyAla: 10.362 ± 0.151	1.399GlyCys: 1.399 ± 0.053	4.452GlyAsp: 4.452 ± 0.08	5.753GlyGlu: 5.753 ± 0.09	3.192GlyPhe: 3.192 ± 0.072	9.031GlyGly: 9.031 ± 0.131	2.042GlyHis: 2.042 ± 0.052	3.992GlyIle: 3.992 ± 0.071	2.659GlyLys: 2.659 ± 0.068	10.29GlyLeu: 10.29 ± 0.144	2.081GlyMet: 2.081 ± 0.057	1.555GlyAsn: 1.555 ± 0.047	5.018GlyPro: 5.018 ± 0.099	1.996GlyGln: 1.996 ± 0.052	9.971GlyArg: 9.971 ± 0.15	3.366GlySer: 3.366 ± 0.07	4.708GlyThr: 4.708 ± 0.091	6.834GlyVal: 6.834 ± 0.105	1.337GlyTrp: 1.337 ± 0.053	2.228GlyTyr: 2.228 ± 0.057	0.0GlyXaa: 0.0 ± 0.0
His	1.951HisAla: 1.951 ± 0.061	0.304HisCys: 0.304 ± 0.022	1.039HisAsp: 1.039 ± 0.046	1.196HisGlu: 1.196 ± 0.036	0.788HisPhe: 0.788 ± 0.034	2.058HisGly: 2.058 ± 0.06	0.607HisHis: 0.607 ± 0.032	0.749HisIle: 0.749 ± 0.031	0.495HisLys: 0.495 ± 0.029	2.523HisLeu: 2.523 ± 0.059	0.377HisMet: 0.377 ± 0.021	0.49HisAsn: 0.49 ± 0.026	1.887HisPro: 1.887 ± 0.051	0.493HisGln: 0.493 ± 0.021	2.25HisArg: 2.25 ± 0.055	0.714HisSer: 0.714 ± 0.033	0.769HisThr: 0.769 ± 0.036	1.618HisVal: 1.618 ± 0.054	0.25HisTrp: 0.25 ± 0.02	0.613HisTyr: 0.613 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	3.606IleAla: 3.606 ± 0.077	0.428IleCys: 0.428 ± 0.025	2.184IleAsp: 2.184 ± 0.06	2.549IleGlu: 2.549 ± 0.068	1.291IlePhe: 1.291 ± 0.04	3.235IleGly: 3.235 ± 0.069	0.958IleHis: 0.958 ± 0.041	1.191IleIle: 1.191 ± 0.048	0.998IleLys: 0.998 ± 0.042	4.577IleLeu: 4.577 ± 0.086	0.572IleMet: 0.572 ± 0.03	0.831IleAsn: 0.831 ± 0.04	2.388IlePro: 2.388 ± 0.057	1.157IleGln: 1.157 ± 0.041	4.087IleArg: 4.087 ± 0.086	1.8IleSer: 1.8 ± 0.053	1.718IleThr: 1.718 ± 0.055	2.746IleVal: 2.746 ± 0.075	0.341IleTrp: 0.341 ± 0.018	0.925IleTyr: 0.925 ± 0.035	0.0IleXaa: 0.0 ± 0.0
Lys	3.596LysAla: 3.596 ± 0.087	0.26LysCys: 0.26 ± 0.021	1.539LysAsp: 1.539 ± 0.054	1.87LysGlu: 1.87 ± 0.07	0.672LysPhe: 0.672 ± 0.031	2.68LysGly: 2.68 ± 0.072	0.417LysHis: 0.417 ± 0.028	1.413LysIle: 1.413 ± 0.059	1.389LysLys: 1.389 ± 0.062	1.911LysLeu: 1.911 ± 0.058	0.604LysMet: 0.604 ± 0.029	0.686LysAsn: 0.686 ± 0.035	1.236LysPro: 1.236 ± 0.046	0.575LysGln: 0.575 ± 0.033	2.1LysArg: 2.1 ± 0.061	1.08LysSer: 1.08 ± 0.038	1.475LysThr: 1.475 ± 0.046	2.485LysVal: 2.485 ± 0.073	0.25LysTrp: 0.25 ± 0.02	0.63LysTyr: 0.63 ± 0.033	0.0LysXaa: 0.0 ± 0.0
Leu	16.145LeuAla: 16.145 ± 0.227	1.245LeuCys: 1.245 ± 0.039	6.738LeuAsp: 6.738 ± 0.102	8.142LeuGlu: 8.142 ± 0.128	3.872LeuPhe: 3.872 ± 0.077	9.322LeuGly: 9.322 ± 0.122	2.305LeuHis: 2.305 ± 0.05	2.811LeuIle: 2.811 ± 0.062	3.026LeuLys: 3.026 ± 0.086	11.591LeuLeu: 11.591 ± 0.173	1.7LeuMet: 1.7 ± 0.056	1.898LeuAsn: 1.898 ± 0.057	6.183LeuPro: 6.183 ± 0.096	2.572LeuGln: 2.572 ± 0.064	9.989LeuArg: 9.989 ± 0.124	5.259LeuSer: 5.259 ± 0.089	4.348LeuThr: 4.348 ± 0.072	9.384LeuVal: 9.384 ± 0.132	1.209LeuTrp: 1.209 ± 0.045	2.295LeuTyr: 2.295 ± 0.057	0.0LeuXaa: 0.0 ± 0.0
Met	2.636MetAla: 2.636 ± 0.053	0.149MetCys: 0.149 ± 0.015	1.253MetAsp: 1.253 ± 0.043	1.616MetGlu: 1.616 ± 0.045	0.429MetPhe: 0.429 ± 0.027	1.683MetGly: 1.683 ± 0.053	0.325MetHis: 0.325 ± 0.019	0.707MetIle: 0.707 ± 0.031	0.972MetLys: 0.972 ± 0.038	1.535MetLeu: 1.535 ± 0.05	0.351MetMet: 0.351 ± 0.023	0.615MetAsn: 0.615 ± 0.026	1.098MetPro: 1.098 ± 0.033	0.39MetGln: 0.39 ± 0.023	1.332MetArg: 1.332 ± 0.044	0.912MetSer: 0.912 ± 0.04	1.106MetThr: 1.106 ± 0.041	1.435MetVal: 1.435 ± 0.045	0.14MetTrp: 0.14 ± 0.014	0.238MetTyr: 0.238 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	1.96AsnAla: 1.96 ± 0.053	0.24AsnCys: 0.24 ± 0.02	0.898AsnAsp: 0.898 ± 0.036	0.873AsnGlu: 0.873 ± 0.038	0.737AsnPhe: 0.737 ± 0.033	1.488AsnGly: 1.488 ± 0.047	0.389AsnHis: 0.389 ± 0.022	0.994AsnIle: 0.994 ± 0.04	0.511AsnLys: 0.511 ± 0.027	2.45AsnLeu: 2.45 ± 0.057	0.402AsnMet: 0.402 ± 0.024	0.428AsnAsn: 0.428 ± 0.025	1.518AsnPro: 1.518 ± 0.043	0.441AsnGln: 0.441 ± 0.025	1.743AsnArg: 1.743 ± 0.05	0.654AsnSer: 0.654 ± 0.03	0.788AsnThr: 0.788 ± 0.033	1.605AsnVal: 1.605 ± 0.052	0.289AsnTrp: 0.289 ± 0.021	0.52AsnTyr: 0.52 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	8.126ProAla: 8.126 ± 0.126	0.589ProCys: 0.589 ± 0.03	3.746ProAsp: 3.746 ± 0.067	5.343ProGlu: 5.343 ± 0.1	2.09ProPhe: 2.09 ± 0.052	7.726ProGly: 7.726 ± 0.126	1.049ProHis: 1.049 ± 0.04	1.519ProIle: 1.519 ± 0.046	1.332ProLys: 1.332 ± 0.048	5.233ProLeu: 5.233 ± 0.089	1.068ProMet: 1.068 ± 0.036	0.953ProAsn: 0.953 ± 0.039	4.398ProPro: 4.398 ± 0.103	0.911ProGln: 0.911 ± 0.036	4.203ProArg: 4.203 ± 0.074	2.272ProSer: 2.272 ± 0.053	2.008ProThr: 2.008 ± 0.046	5.255ProVal: 5.255 ± 0.091	0.814ProTrp: 0.814 ± 0.035	1.332ProTyr: 1.332 ± 0.044	0.0ProXaa: 0.0 ± 0.0
Gln	3.331GlnAla: 3.331 ± 0.079	0.256GlnCys: 0.256 ± 0.021	1.189GlnAsp: 1.189 ± 0.042	1.652GlnGlu: 1.652 ± 0.054	0.647GlnPhe: 0.647 ± 0.025	1.985GlnGly: 1.985 ± 0.049	0.398GlnHis: 0.398 ± 0.025	0.951GlnIle: 0.951 ± 0.043	0.82GlnLys: 0.82 ± 0.036	1.904GlnLeu: 1.904 ± 0.059	0.507GlnMet: 0.507 ± 0.024	0.504GlnAsn: 0.504 ± 0.026	0.993GlnPro: 0.993 ± 0.039	0.613GlnGln: 0.613 ± 0.035	1.942GlnArg: 1.942 ± 0.055	0.746GlnSer: 0.746 ± 0.037	0.931GlnThr: 0.931 ± 0.04	2.299GlnVal: 2.299 ± 0.057	0.26GlnTrp: 0.26 ± 0.018	0.435GlnTyr: 0.435 ± 0.027	0.0GlnXaa: 0.0 ± 0.0
Arg	10.251ArgAla: 10.251 ± 0.159	1.122ArgCys: 1.122 ± 0.043	4.426ArgAsp: 4.426 ± 0.071	6.752ArgGlu: 6.752 ± 0.109	3.595ArgPhe: 3.595 ± 0.076	6.708ArgGly: 6.708 ± 0.106	2.34ArgHis: 2.34 ± 0.054	4.345ArgIle: 4.345 ± 0.087	2.464ArgLys: 2.464 ± 0.072	12.176ArgLeu: 12.176 ± 0.159	1.915ArgMet: 1.915 ± 0.051	1.75ArgAsn: 1.75 ± 0.051	5.982ArgPro: 5.982 ± 0.1	2.245ArgGln: 2.245 ± 0.061	11.681ArgArg: 11.681 ± 0.169	3.472ArgSer: 3.472 ± 0.073	3.606ArgThr: 3.606 ± 0.065	7.497ArgVal: 7.497 ± 0.109	1.241ArgTrp: 1.241 ± 0.045	2.459ArgTyr: 2.459 ± 0.061	0.0ArgXaa: 0.0 ± 0.0
Ser	4.257SerAla: 4.257 ± 0.078	0.512SerCys: 0.512 ± 0.027	1.83SerAsp: 1.83 ± 0.048	2.035SerGlu: 2.035 ± 0.058	1.423SerPhe: 1.423 ± 0.045	4.408SerGly: 4.408 ± 0.085	0.714SerHis: 0.714 ± 0.03	1.552SerIle: 1.552 ± 0.048	0.893SerLys: 0.893 ± 0.043	4.262SerLeu: 4.262 ± 0.076	0.767SerMet: 0.767 ± 0.031	0.733SerAsn: 0.733 ± 0.034	2.585SerPro: 2.585 ± 0.057	0.909SerGln: 0.909 ± 0.037	3.463SerArg: 3.463 ± 0.059	1.61SerSer: 1.61 ± 0.058	1.777SerThr: 1.777 ± 0.048	2.935SerVal: 2.935 ± 0.067	0.555SerTrp: 0.555 ± 0.03	0.994SerTyr: 0.994 ± 0.036	0.0SerXaa: 0.0 ± 0.0
Thr	5.263ThrAla: 5.263 ± 0.096	0.642ThrCys: 0.642 ± 0.031	2.249ThrAsp: 2.249 ± 0.061	2.293ThrGlu: 2.293 ± 0.056	1.666ThrPhe: 1.666 ± 0.049	4.946ThrGly: 4.946 ± 0.082	0.879ThrHis: 0.879 ± 0.036	1.539ThrIle: 1.539 ± 0.052	0.928ThrLys: 0.928 ± 0.041	5.017ThrLeu: 5.017 ± 0.088	0.662ThrMet: 0.662 ± 0.033	0.866ThrAsn: 0.866 ± 0.035	3.103ThrPro: 3.103 ± 0.057	0.814ThrGln: 0.814 ± 0.033	3.539ThrArg: 3.539 ± 0.071	1.731ThrSer: 1.731 ± 0.054	2.191ThrThr: 2.191 ± 0.061	3.756ThrVal: 3.756 ± 0.07	0.638ThrTrp: 0.638 ± 0.033	1.211ThrTyr: 1.211 ± 0.044	0.0ThrXaa: 0.0 ± 0.0
Val	9.703ValAla: 9.703 ± 0.137	0.906ValCys: 0.906 ± 0.043	4.609ValAsp: 4.609 ± 0.092	5.675ValGlu: 5.675 ± 0.099	3.16ValPhe: 3.16 ± 0.063	5.689ValGly: 5.689 ± 0.104	1.83ValHis: 1.83 ± 0.052	3.181ValIle: 3.181 ± 0.082	2.113ValLys: 2.113 ± 0.063	9.598ValLeu: 9.598 ± 0.126	1.415ValMet: 1.415 ± 0.047	1.737ValAsn: 1.737 ± 0.051	4.66ValPro: 4.66 ± 0.097	2.107ValGln: 2.107 ± 0.059	7.779ValArg: 7.779 ± 0.105	3.586ValSer: 3.586 ± 0.08	4.48ValThr: 4.48 ± 0.082	7.625ValVal: 7.625 ± 0.112	0.737ValTrp: 0.737 ± 0.036	1.649ValTyr: 1.649 ± 0.047	0.0ValXaa: 0.0 ± 0.0
Trp	1.263TrpAla: 1.263 ± 0.049	0.17TrpCys: 0.17 ± 0.015	0.628TrpAsp: 0.628 ± 0.03	0.76TrpGlu: 0.76 ± 0.03	0.465TrpPhe: 0.465 ± 0.026	1.0TrpGly: 1.0 ± 0.045	0.35TrpHis: 0.35 ± 0.022	0.694TrpIle: 0.694 ± 0.032	0.369TrpLys: 0.369 ± 0.024	1.309TrpLeu: 1.309 ± 0.045	0.315TrpMet: 0.315 ± 0.022	0.32TrpAsn: 0.32 ± 0.02	0.684TrpPro: 0.684 ± 0.039	0.365TrpGln: 0.365 ± 0.025	1.389TrpArg: 1.389 ± 0.047	0.537TrpSer: 0.537 ± 0.027	0.688TrpThr: 0.688 ± 0.031	0.864TrpVal: 0.864 ± 0.036	0.261TrpTrp: 0.261 ± 0.02	0.276TrpTyr: 0.276 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.263TyrAla: 2.263 ± 0.062	0.346TyrCys: 0.346 ± 0.021	1.414TyrAsp: 1.414 ± 0.064	1.443TyrGlu: 1.443 ± 0.046	0.909TyrPhe: 0.909 ± 0.038	2.133TyrGly: 2.133 ± 0.063	0.572TyrHis: 0.572 ± 0.028	0.697TyrIle: 0.697 ± 0.034	0.578TyrLys: 0.578 ± 0.03	2.813TyrLeu: 2.813 ± 0.061	0.325TyrMet: 0.325 ± 0.022	0.555TyrAsn: 0.555 ± 0.029	1.178TyrPro: 1.178 ± 0.043	0.665TyrGln: 0.665 ± 0.032	2.455TyrArg: 2.455 ± 0.06	0.833TyrSer: 0.833 ± 0.033	1.042TyrThr: 1.042 ± 0.036	1.729TyrVal: 1.729 ± 0.053	0.335TyrTrp: 0.335 ± 0.021	0.725TyrTyr: 0.725 ± 0.035	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2522 proteins (769361 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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