Amino acid dipepetide frequency for Desulfobacula toluolica (strain DSM 7467 / Tol2)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.896AlaAla: 5.896 ± 0.087	1.161AlaCys: 1.161 ± 0.034	3.896AlaAsp: 3.896 ± 0.057	3.546AlaGlu: 3.546 ± 0.056	3.31AlaPhe: 3.31 ± 0.057	5.787AlaGly: 5.787 ± 0.074	1.287AlaHis: 1.287 ± 0.029	5.02AlaIle: 5.02 ± 0.066	4.598AlaLys: 4.598 ± 0.064	7.017AlaLeu: 7.017 ± 0.081	2.269AlaMet: 2.269 ± 0.039	2.565AlaAsn: 2.565 ± 0.044	1.92AlaPro: 1.92 ± 0.039	2.448AlaGln: 2.448 ± 0.043	3.175AlaArg: 3.175 ± 0.055	4.143AlaSer: 4.143 ± 0.058	3.112AlaThr: 3.112 ± 0.048	5.308AlaVal: 5.308 ± 0.064	0.705AlaTrp: 0.705 ± 0.023	2.111AlaTyr: 2.111 ± 0.037	0.0AlaXaa: 0.0 ± 0.0
Cys	0.915CysAla: 0.915 ± 0.024	0.271CysCys: 0.271 ± 0.015	0.74CysAsp: 0.74 ± 0.024	0.682CysGlu: 0.682 ± 0.021	0.761CysPhe: 0.761 ± 0.026	1.224CysGly: 1.224 ± 0.034	0.441CysHis: 0.441 ± 0.026	0.898CysIle: 0.898 ± 0.024	0.783CysLys: 0.783 ± 0.024	1.254CysLeu: 1.254 ± 0.028	0.361CysMet: 0.361 ± 0.014	0.548CysAsn: 0.548 ± 0.019	0.792CysPro: 0.792 ± 0.028	0.401CysGln: 0.401 ± 0.016	0.729CysArg: 0.729 ± 0.025	0.951CysSer: 0.951 ± 0.024	0.652CysThr: 0.652 ± 0.024	0.885CysVal: 0.885 ± 0.025	0.13CysTrp: 0.13 ± 0.009	0.392CysTyr: 0.392 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	3.79AspAla: 3.79 ± 0.053	0.669AspCys: 0.669 ± 0.023	3.118AspAsp: 3.118 ± 0.068	3.707AspGlu: 3.707 ± 0.054	2.99AspPhe: 2.99 ± 0.045	3.214AspGly: 3.214 ± 0.067	1.328AspHis: 1.328 ± 0.03	5.453AspIle: 5.453 ± 0.067	4.147AspLys: 4.147 ± 0.061	5.942AspLeu: 5.942 ± 0.068	1.703AspMet: 1.703 ± 0.034	2.438AspAsn: 2.438 ± 0.052	2.524AspPro: 2.524 ± 0.046	2.127AspGln: 2.127 ± 0.039	2.469AspArg: 2.469 ± 0.044	3.041AspSer: 3.041 ± 0.054	2.947AspThr: 2.947 ± 0.066	3.406AspVal: 3.406 ± 0.058	0.606AspTrp: 0.606 ± 0.021	2.029AspTyr: 2.029 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	4.092GluAla: 4.092 ± 0.06	0.601GluCys: 0.601 ± 0.022	3.374GluAsp: 3.374 ± 0.054	3.886GluGlu: 3.886 ± 0.072	2.664GluPhe: 2.664 ± 0.042	3.019GluGly: 3.019 ± 0.054	1.141GluHis: 1.141 ± 0.029	5.339GluIle: 5.339 ± 0.067	6.788GluLys: 6.788 ± 0.087	5.667GluLeu: 5.667 ± 0.068	1.761GluMet: 1.761 ± 0.038	3.849GluAsn: 3.849 ± 0.054	1.905GluPro: 1.905 ± 0.044	2.559GluGln: 2.559 ± 0.043	2.544GluArg: 2.544 ± 0.05	3.432GluSer: 3.432 ± 0.055	3.633GluThr: 3.633 ± 0.051	3.134GluVal: 3.134 ± 0.056	0.538GluTrp: 0.538 ± 0.02	2.071GluTyr: 2.071 ± 0.033	0.0GluXaa: 0.0 ± 0.0
Phe	2.92PheAla: 2.92 ± 0.046	0.766PheCys: 0.766 ± 0.021	3.029PheAsp: 3.029 ± 0.047	2.94PheGlu: 2.94 ± 0.044	2.953PhePhe: 2.953 ± 0.06	3.144PheGly: 3.144 ± 0.051	0.998PheHis: 0.998 ± 0.026	3.657PheIle: 3.657 ± 0.061	3.489PheLys: 3.489 ± 0.06	4.617PheLeu: 4.617 ± 0.07	1.257PheMet: 1.257 ± 0.029	2.253PheAsn: 2.253 ± 0.045	1.761PhePro: 1.761 ± 0.035	1.539PheGln: 1.539 ± 0.028	1.785PheArg: 1.785 ± 0.034	3.841PheSer: 3.841 ± 0.054	2.327PheThr: 2.327 ± 0.042	2.848PheVal: 2.848 ± 0.045	0.5PheTrp: 0.5 ± 0.023	1.648PheTyr: 1.648 ± 0.038	0.0PheXaa: 0.0 ± 0.0
Gly	4.452GlyAla: 4.452 ± 0.074	1.144GlyCys: 1.144 ± 0.034	3.145GlyAsp: 3.145 ± 0.073	3.558GlyGlu: 3.558 ± 0.057	3.659GlyPhe: 3.659 ± 0.054	4.577GlyGly: 4.577 ± 0.206	1.408GlyHis: 1.408 ± 0.031	6.159GlyIle: 6.159 ± 0.08	5.227GlyLys: 5.227 ± 0.07	6.287GlyLeu: 6.287 ± 0.078	2.166GlyMet: 2.166 ± 0.043	2.845GlyAsn: 2.845 ± 0.059	1.819GlyPro: 1.819 ± 0.039	2.111GlyGln: 2.111 ± 0.042	2.954GlyArg: 2.954 ± 0.049	4.055GlySer: 4.055 ± 0.081	3.7GlyThr: 3.7 ± 0.06	4.402GlyVal: 4.402 ± 0.054	0.752GlyTrp: 0.752 ± 0.026	2.535GlyTyr: 2.535 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	1.346HisAla: 1.346 ± 0.034	0.338HisCys: 0.338 ± 0.014	1.17HisAsp: 1.17 ± 0.029	1.208HisGlu: 1.208 ± 0.032	0.974HisPhe: 0.974 ± 0.029	1.387HisGly: 1.387 ± 0.03	0.553HisHis: 0.553 ± 0.018	1.758HisIle: 1.758 ± 0.036	1.263HisLys: 1.263 ± 0.026	2.079HisLeu: 2.079 ± 0.038	0.546HisMet: 0.546 ± 0.02	0.842HisAsn: 0.842 ± 0.023	1.096HisPro: 1.096 ± 0.028	0.729HisGln: 0.729 ± 0.024	0.843HisArg: 0.843 ± 0.027	1.165HisSer: 1.165 ± 0.026	1.086HisThr: 1.086 ± 0.026	1.162HisVal: 1.162 ± 0.028	0.21HisTrp: 0.21 ± 0.012	0.709HisTyr: 0.709 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	5.536IleAla: 5.536 ± 0.072	1.199IleCys: 1.199 ± 0.03	4.893IleAsp: 4.893 ± 0.058	5.482IleGlu: 5.482 ± 0.061	3.729IlePhe: 3.729 ± 0.054	4.992IleGly: 4.992 ± 0.067	1.725IleHis: 1.725 ± 0.038	6.332IleIle: 6.332 ± 0.077	6.519IleLys: 6.519 ± 0.081	7.765IleLeu: 7.765 ± 0.081	1.893IleMet: 1.893 ± 0.04	3.94IleAsn: 3.94 ± 0.054	3.665IlePro: 3.665 ± 0.057	2.697IleGln: 2.697 ± 0.045	3.606IleArg: 3.606 ± 0.055	5.659IleSer: 5.659 ± 0.073	4.377IleThr: 4.377 ± 0.066	4.793IleVal: 4.793 ± 0.061	0.593IleTrp: 0.593 ± 0.02	2.163IleTyr: 2.163 ± 0.041	0.0IleXaa: 0.0 ± 0.0
Lys	5.364LysAla: 5.364 ± 0.073	0.724LysCys: 0.724 ± 0.026	4.533LysAsp: 4.533 ± 0.052	5.501LysGlu: 5.501 ± 0.073	2.626LysPhe: 2.626 ± 0.047	4.928LysGly: 4.928 ± 0.058	1.382LysHis: 1.382 ± 0.034	6.897LysIle: 6.897 ± 0.071	8.314LysLys: 8.314 ± 0.104	5.792LysLeu: 5.792 ± 0.066	2.028LysMet: 2.028 ± 0.039	4.817LysAsn: 4.817 ± 0.058	2.729LysPro: 2.729 ± 0.043	3.132LysGln: 3.132 ± 0.052	3.286LysArg: 3.286 ± 0.053	4.238LysSer: 4.238 ± 0.054	5.078LysThr: 5.078 ± 0.064	3.844LysVal: 3.844 ± 0.059	0.632LysTrp: 0.632 ± 0.024	2.196LysTyr: 2.196 ± 0.044	0.0LysXaa: 0.0 ± 0.0
Leu	6.778LeuAla: 6.778 ± 0.071	1.313LeuCys: 1.313 ± 0.032	5.563LeuAsp: 5.563 ± 0.061	6.369LeuGlu: 6.369 ± 0.082	4.851LeuPhe: 4.851 ± 0.067	5.957LeuGly: 5.957 ± 0.072	1.621LeuHis: 1.621 ± 0.034	7.007LeuIle: 7.007 ± 0.081	8.166LeuLys: 8.166 ± 0.085	8.605LeuLeu: 8.605 ± 0.091	2.46LeuMet: 2.46 ± 0.037	4.665LeuAsn: 4.665 ± 0.065	4.067LeuPro: 4.067 ± 0.053	2.589LeuGln: 2.589 ± 0.045	3.512LeuArg: 3.512 ± 0.051	6.992LeuSer: 6.992 ± 0.074	5.084LeuThr: 5.084 ± 0.062	5.608LeuVal: 5.608 ± 0.078	0.825LeuTrp: 0.825 ± 0.027	2.722LeuTyr: 2.722 ± 0.04	0.0LeuXaa: 0.0 ± 0.0
Met	2.435MetAla: 2.435 ± 0.046	0.271MetCys: 0.271 ± 0.013	1.898MetAsp: 1.898 ± 0.036	2.034MetGlu: 2.034 ± 0.04	0.975MetPhe: 0.975 ± 0.026	2.103MetGly: 2.103 ± 0.041	0.435MetHis: 0.435 ± 0.015	2.222MetIle: 2.222 ± 0.035	2.132MetLys: 2.132 ± 0.041	2.212MetLeu: 2.212 ± 0.036	0.737MetMet: 0.737 ± 0.025	1.347MetAsn: 1.347 ± 0.033	1.205MetPro: 1.205 ± 0.029	0.804MetGln: 0.804 ± 0.023	1.003MetArg: 1.003 ± 0.024	1.487MetSer: 1.487 ± 0.029	1.602MetThr: 1.602 ± 0.038	1.924MetVal: 1.924 ± 0.044	0.165MetTrp: 0.165 ± 0.01	0.568MetTyr: 0.568 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	3.007AsnAla: 3.007 ± 0.047	0.663AsnCys: 0.663 ± 0.02	2.418AsnAsp: 2.418 ± 0.056	2.519AsnGlu: 2.519 ± 0.045	2.053AsnPhe: 2.053 ± 0.034	2.875AsnGly: 2.875 ± 0.051	1.06AsnHis: 1.06 ± 0.026	4.369AsnIle: 4.369 ± 0.059	3.402AsnLys: 3.402 ± 0.053	4.628AsnLeu: 4.628 ± 0.061	1.219AsnMet: 1.219 ± 0.031	2.243AsnAsn: 2.243 ± 0.044	2.351AsnPro: 2.351 ± 0.044	1.838AsnGln: 1.838 ± 0.037	2.339AsnArg: 2.339 ± 0.04	2.711AsnSer: 2.711 ± 0.047	2.365AsnThr: 2.365 ± 0.046	2.416AsnVal: 2.416 ± 0.043	0.482AsnTrp: 0.482 ± 0.018	1.487AsnTyr: 1.487 ± 0.036	0.0AsnXaa: 0.0 ± 0.0
Pro	2.539ProAla: 2.539 ± 0.047	0.518ProCys: 0.518 ± 0.02	3.137ProAsp: 3.137 ± 0.054	3.408ProGlu: 3.408 ± 0.052	2.055ProPhe: 2.055 ± 0.041	3.161ProGly: 3.161 ± 0.051	0.758ProHis: 0.758 ± 0.026	2.318ProIle: 2.318 ± 0.047	2.275ProLys: 2.275 ± 0.043	3.496ProLeu: 3.496 ± 0.055	0.94ProMet: 0.94 ± 0.025	1.296ProAsn: 1.296 ± 0.034	1.281ProPro: 1.281 ± 0.032	1.151ProGln: 1.151 ± 0.032	1.337ProArg: 1.337 ± 0.032	2.16ProSer: 2.16 ± 0.034	1.541ProThr: 1.541 ± 0.033	3.426ProVal: 3.426 ± 0.05	0.447ProTrp: 0.447 ± 0.016	1.247ProTyr: 1.247 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	2.785GlnAla: 2.785 ± 0.043	0.389GlnCys: 0.389 ± 0.017	1.819GlnAsp: 1.819 ± 0.037	2.182GlnGlu: 2.182 ± 0.043	1.34GlnPhe: 1.34 ± 0.033	2.258GlnGly: 2.258 ± 0.044	0.589GlnHis: 0.589 ± 0.021	3.093GlnIle: 3.093 ± 0.049	3.131GlnLys: 3.131 ± 0.052	3.021GlnLeu: 3.021 ± 0.043	1.064GlnMet: 1.064 ± 0.027	1.77GlnAsn: 1.77 ± 0.032	0.984GlnPro: 0.984 ± 0.03	1.274GlnGln: 1.274 ± 0.036	1.359GlnArg: 1.359 ± 0.029	1.934GlnSer: 1.934 ± 0.039	2.175GlnThr: 2.175 ± 0.038	2.221GlnVal: 2.221 ± 0.036	0.422GlnTrp: 0.422 ± 0.016	1.081GlnTyr: 1.081 ± 0.027	0.0GlnXaa: 0.0 ± 0.0
Arg	2.565ArgAla: 2.565 ± 0.042	0.562ArgCys: 0.562 ± 0.021	2.217ArgAsp: 2.217 ± 0.044	2.683ArgGlu: 2.683 ± 0.049	2.286ArgPhe: 2.286 ± 0.041	2.197ArgGly: 2.197 ± 0.041	1.018ArgHis: 1.018 ± 0.03	3.859ArgIle: 3.859 ± 0.062	3.228ArgLys: 3.228 ± 0.058	4.576ArgLeu: 4.576 ± 0.065	1.23ArgMet: 1.23 ± 0.031	1.887ArgAsn: 1.887 ± 0.035	1.539ArgPro: 1.539 ± 0.029	1.949ArgGln: 1.949 ± 0.038	1.779ArgArg: 1.779 ± 0.039	2.428ArgSer: 2.428 ± 0.042	1.995ArgThr: 1.995 ± 0.038	2.724ArgVal: 2.724 ± 0.048	0.389ArgTrp: 0.389 ± 0.017	1.536ArgTyr: 1.536 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	3.988SerAla: 3.988 ± 0.056	0.886SerCys: 0.886 ± 0.022	3.522SerAsp: 3.522 ± 0.055	3.408SerGlu: 3.408 ± 0.045	3.322SerPhe: 3.322 ± 0.057	5.024SerGly: 5.024 ± 0.075	1.376SerHis: 1.376 ± 0.034	4.994SerIle: 4.994 ± 0.061	4.355SerLys: 4.355 ± 0.06	6.133SerLeu: 6.133 ± 0.064	1.781SerMet: 1.781 ± 0.032	2.54SerAsn: 2.54 ± 0.046	2.386SerPro: 2.386 ± 0.046	2.123SerGln: 2.123 ± 0.044	3.05SerArg: 3.05 ± 0.053	4.123SerSer: 4.123 ± 0.062	2.735SerThr: 2.735 ± 0.055	3.958SerVal: 3.958 ± 0.054	0.674SerTrp: 0.674 ± 0.022	1.891SerTyr: 1.891 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	4.023ThrAla: 4.023 ± 0.051	0.718ThrCys: 0.718 ± 0.021	3.182ThrAsp: 3.182 ± 0.05	2.511ThrGlu: 2.511 ± 0.042	2.217ThrPhe: 2.217 ± 0.036	4.835ThrGly: 4.835 ± 0.063	1.144ThrHis: 1.144 ± 0.03	4.374ThrIle: 4.374 ± 0.059	3.052ThrLys: 3.052 ± 0.046	5.32ThrLeu: 5.32 ± 0.06	1.259ThrMet: 1.259 ± 0.029	2.032ThrAsn: 2.032 ± 0.036	2.39ThrPro: 2.39 ± 0.042	1.894ThrGln: 1.894 ± 0.039	2.433ThrArg: 2.433 ± 0.039	3.084ThrSer: 3.084 ± 0.052	2.633ThrThr: 2.633 ± 0.048	3.354ThrVal: 3.354 ± 0.05	0.497ThrTrp: 0.497 ± 0.019	1.544ThrTyr: 1.544 ± 0.031	0.0ThrXaa: 0.0 ± 0.0
Val	4.225ValAla: 4.225 ± 0.057	0.998ValCys: 0.998 ± 0.028	3.528ValAsp: 3.528 ± 0.048	3.888ValGlu: 3.888 ± 0.061	3.35ValPhe: 3.35 ± 0.052	3.539ValGly: 3.539 ± 0.048	1.152ValHis: 1.152 ± 0.027	4.928ValIle: 4.928 ± 0.066	4.4ValLys: 4.4 ± 0.065	6.21ValLeu: 6.21 ± 0.068	1.847ValMet: 1.847 ± 0.038	2.69ValAsn: 2.69 ± 0.044	2.341ValPro: 2.341 ± 0.042	1.947ValGln: 1.947 ± 0.042	2.505ValArg: 2.505 ± 0.041	4.294ValSer: 4.294 ± 0.053	3.335ValThr: 3.335 ± 0.05	4.083ValVal: 4.083 ± 0.062	0.561ValTrp: 0.561 ± 0.018	1.825ValTyr: 1.825 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	0.622TrpAla: 0.622 ± 0.022	0.147TrpCys: 0.147 ± 0.01	0.548TrpAsp: 0.548 ± 0.019	0.61TrpGlu: 0.61 ± 0.019	0.506TrpPhe: 0.506 ± 0.019	0.613TrpGly: 0.613 ± 0.023	0.232TrpHis: 0.232 ± 0.013	0.774TrpIle: 0.774 ± 0.025	0.706TrpLys: 0.706 ± 0.022	0.939TrpLeu: 0.939 ± 0.029	0.297TrpMet: 0.297 ± 0.014	0.515TrpAsn: 0.515 ± 0.021	0.348TrpPro: 0.348 ± 0.016	0.398TrpGln: 0.398 ± 0.019	0.384TrpArg: 0.384 ± 0.016	0.518TrpSer: 0.518 ± 0.021	0.461TrpThr: 0.461 ± 0.017	0.555TrpVal: 0.555 ± 0.021	0.132TrpTrp: 0.132 ± 0.01	0.297TrpTyr: 0.297 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.995TyrAla: 1.995 ± 0.038	0.47TyrCys: 0.47 ± 0.018	1.917TyrAsp: 1.917 ± 0.04	1.877TyrGlu: 1.877 ± 0.036	1.652TyrPhe: 1.652 ± 0.037	2.123TyrGly: 2.123 ± 0.036	0.814TyrHis: 0.814 ± 0.022	2.11TyrIle: 2.11 ± 0.039	2.064TyrLys: 2.064 ± 0.04	3.193TyrLeu: 3.193 ± 0.055	0.74TyrMet: 0.74 ± 0.023	1.363TyrAsn: 1.363 ± 0.032	1.387TyrPro: 1.387 ± 0.032	1.186TyrGln: 1.186 ± 0.029	1.554TyrArg: 1.554 ± 0.034	2.012TyrSer: 2.012 ± 0.045	1.655TyrThr: 1.655 ± 0.035	1.595TyrVal: 1.595 ± 0.03	0.345TyrTrp: 0.345 ± 0.017	1.124TyrTyr: 1.124 ± 0.032	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4189 proteins (1459019 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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