Amino acid dipepetide frequency for Salipiger mucosus DSM 16094

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.756AlaAla: 16.756 ± 0.16	1.202AlaCys: 1.202 ± 0.029	6.754AlaAsp: 6.754 ± 0.078	9.067AlaGlu: 9.067 ± 0.089	4.227AlaPhe: 4.227 ± 0.054	11.262AlaGly: 11.262 ± 0.098	2.359AlaHis: 2.359 ± 0.04	5.189AlaIle: 5.189 ± 0.057	2.914AlaLys: 2.914 ± 0.055	13.933AlaLeu: 13.933 ± 0.104	3.793AlaMet: 3.793 ± 0.05	2.377AlaAsn: 2.377 ± 0.039	6.407AlaPro: 6.407 ± 0.077	4.346AlaGln: 4.346 ± 0.062	10.062AlaArg: 10.062 ± 0.103	5.595AlaSer: 5.595 ± 0.062	5.974AlaThr: 5.974 ± 0.06	8.418AlaVal: 8.418 ± 0.089	1.608AlaTrp: 1.608 ± 0.034	2.483AlaTyr: 2.483 ± 0.037	0.001AlaXaa: 0.001 ± 0.001
Cys	1.087CysAla: 1.087 ± 0.027	0.127CysCys: 0.127 ± 0.01	0.622CysAsp: 0.622 ± 0.019	0.501CysGlu: 0.501 ± 0.017	0.301CysPhe: 0.301 ± 0.013	0.95CysGly: 0.95 ± 0.026	0.286CysHis: 0.286 ± 0.014	0.407CysIle: 0.407 ± 0.015	0.178CysLys: 0.178 ± 0.013	0.859CysLeu: 0.859 ± 0.023	0.181CysMet: 0.181 ± 0.011	0.196CysAsn: 0.196 ± 0.012	0.54CysPro: 0.54 ± 0.02	0.222CysGln: 0.222 ± 0.012	0.657CysArg: 0.657 ± 0.02	0.437CysSer: 0.437 ± 0.015	0.438CysThr: 0.438 ± 0.018	0.621CysVal: 0.621 ± 0.021	0.119CysTrp: 0.119 ± 0.009	0.199CysTyr: 0.199 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	7.435AspAla: 7.435 ± 0.073	0.548AspCys: 0.548 ± 0.02	3.654AspAsp: 3.654 ± 0.068	4.065AspGlu: 4.065 ± 0.053	2.428AspPhe: 2.428 ± 0.037	5.756AspGly: 5.756 ± 0.077	1.375AspHis: 1.375 ± 0.029	2.875AspIle: 2.875 ± 0.047	1.478AspLys: 1.478 ± 0.034	6.295AspLeu: 6.295 ± 0.062	1.708AspMet: 1.708 ± 0.031	1.18AspAsn: 1.18 ± 0.029	3.908AspPro: 3.908 ± 0.053	1.618AspGln: 1.618 ± 0.033	4.899AspArg: 4.899 ± 0.049	2.325AspSer: 2.325 ± 0.042	3.156AspThr: 3.156 ± 0.055	4.156AspVal: 4.156 ± 0.054	1.263AspTrp: 1.263 ± 0.03	1.618AspTyr: 1.618 ± 0.032	0.0AspXaa: 0.0 ± 0.0
Glu	9.49GluAla: 9.49 ± 0.094	0.383GluCys: 0.383 ± 0.015	3.971GluAsp: 3.971 ± 0.051	4.157GluGlu: 4.157 ± 0.062	1.757GluPhe: 1.757 ± 0.033	5.706GluGly: 5.706 ± 0.07	1.323GluHis: 1.323 ± 0.029	3.879GluIle: 3.879 ± 0.047	1.922GluLys: 1.922 ± 0.039	5.522GluLeu: 5.522 ± 0.063	2.0GluMet: 2.0 ± 0.035	1.73GluAsn: 1.73 ± 0.036	2.887GluPro: 2.887 ± 0.046	2.019GluGln: 2.019 ± 0.04	4.894GluArg: 4.894 ± 0.063	2.591GluSer: 2.591 ± 0.043	4.435GluThr: 4.435 ± 0.052	4.781GluVal: 4.781 ± 0.058	0.701GluTrp: 0.701 ± 0.023	1.064GluTyr: 1.064 ± 0.026	0.001GluXaa: 0.001 ± 0.001
Phe	4.195PheAla: 4.195 ± 0.048	0.393PheCys: 0.393 ± 0.016	2.794PheAsp: 2.794 ± 0.045	2.38PheGlu: 2.38 ± 0.036	1.328PhePhe: 1.328 ± 0.036	3.528PheGly: 3.528 ± 0.046	0.791PheHis: 0.791 ± 0.022	1.413PheIle: 1.413 ± 0.031	0.787PheLys: 0.787 ± 0.027	3.3PheLeu: 3.3 ± 0.045	0.828PheMet: 0.828 ± 0.026	0.917PheAsn: 0.917 ± 0.027	1.548PhePro: 1.548 ± 0.031	0.941PheGln: 0.941 ± 0.021	2.488PheArg: 2.488 ± 0.044	2.003PheSer: 2.003 ± 0.035	1.967PheThr: 1.967 ± 0.042	2.664PheVal: 2.664 ± 0.039	0.538PheTrp: 0.538 ± 0.018	0.836PheTyr: 0.836 ± 0.022	0.0PheXaa: 0.0 ± 0.0
Gly	10.512GlyAla: 10.512 ± 0.098	0.885GlyCys: 0.885 ± 0.026	5.159GlyAsp: 5.159 ± 0.083	5.167GlyGlu: 5.167 ± 0.053	3.517GlyPhe: 3.517 ± 0.043	7.955GlyGly: 7.955 ± 0.105	2.062GlyHis: 2.062 ± 0.038	4.333GlyIle: 4.333 ± 0.054	2.638GlyLys: 2.638 ± 0.046	9.379GlyLeu: 9.379 ± 0.079	2.631GlyMet: 2.631 ± 0.042	2.123GlyAsn: 2.123 ± 0.053	3.984GlyPro: 3.984 ± 0.056	3.013GlyGln: 3.013 ± 0.043	6.701GlyArg: 6.701 ± 0.073	4.258GlySer: 4.258 ± 0.057	5.051GlyThr: 5.051 ± 0.073	6.45GlyVal: 6.45 ± 0.059	1.57GlyTrp: 1.57 ± 0.033	2.358GlyTyr: 2.358 ± 0.039	0.001GlyXaa: 0.001 ± 0.001
His	2.469HisAla: 2.469 ± 0.04	0.24HisCys: 0.24 ± 0.012	1.348HisAsp: 1.348 ± 0.031	1.257HisGlu: 1.257 ± 0.027	0.832HisPhe: 0.832 ± 0.024	2.094HisGly: 2.094 ± 0.039	0.602HisHis: 0.602 ± 0.022	0.803HisIle: 0.803 ± 0.022	0.448HisLys: 0.448 ± 0.016	2.122HisLeu: 2.122 ± 0.05	0.537HisMet: 0.537 ± 0.018	0.375HisAsn: 0.375 ± 0.016	1.494HisPro: 1.494 ± 0.032	0.498HisGln: 0.498 ± 0.017	1.614HisArg: 1.614 ± 0.037	0.856HisSer: 0.856 ± 0.022	0.76HisThr: 0.76 ± 0.022	1.651HisVal: 1.651 ± 0.035	0.351HisTrp: 0.351 ± 0.015	0.555HisTyr: 0.555 ± 0.015	0.0HisXaa: 0.0 ± 0.0
Ile	6.337IleAla: 6.337 ± 0.058	0.525IleCys: 0.525 ± 0.018	3.409IleAsp: 3.409 ± 0.047	3.577IleGlu: 3.577 ± 0.051	1.649IlePhe: 1.649 ± 0.034	4.217IleGly: 4.217 ± 0.055	0.866IleHis: 0.866 ± 0.023	1.643IleIle: 1.643 ± 0.043	1.004IleLys: 1.004 ± 0.026	4.229IleLeu: 4.229 ± 0.06	1.013IleMet: 1.013 ± 0.026	1.09IleAsn: 1.09 ± 0.028	2.12IlePro: 2.12 ± 0.038	1.03IleGln: 1.03 ± 0.024	3.254IleArg: 3.254 ± 0.047	2.746IleSer: 2.746 ± 0.05	2.502IleThr: 2.502 ± 0.04	3.59IleVal: 3.59 ± 0.047	0.621IleTrp: 0.621 ± 0.02	0.995IleTyr: 0.995 ± 0.024	0.0IleXaa: 0.0 ± 0.0
Lys	3.296LysAla: 3.296 ± 0.054	0.168LysCys: 0.168 ± 0.009	1.382LysAsp: 1.382 ± 0.033	1.402LysGlu: 1.402 ± 0.034	0.693LysPhe: 0.693 ± 0.023	2.207LysGly: 2.207 ± 0.049	0.51LysHis: 0.51 ± 0.016	1.297LysIle: 1.297 ± 0.034	0.996LysLys: 0.996 ± 0.037	2.504LysLeu: 2.504 ± 0.042	0.727LysMet: 0.727 ± 0.024	0.619LysAsn: 0.619 ± 0.022	1.524LysPro: 1.524 ± 0.031	0.809LysGln: 0.809 ± 0.026	2.044LysArg: 2.044 ± 0.044	1.532LysSer: 1.532 ± 0.033	1.624LysThr: 1.624 ± 0.033	1.942LysVal: 1.942 ± 0.037	0.318LysTrp: 0.318 ± 0.014	0.548LysTyr: 0.548 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	13.117LeuAla: 13.117 ± 0.12	0.958LeuCys: 0.958 ± 0.024	6.228LeuAsp: 6.228 ± 0.06	6.036LeuGlu: 6.036 ± 0.069	3.397LeuPhe: 3.397 ± 0.052	8.601LeuGly: 8.601 ± 0.081	1.941LeuHis: 1.941 ± 0.034	4.324LeuIle: 4.324 ± 0.066	2.733LeuLys: 2.733 ± 0.049	8.74LeuLeu: 8.74 ± 0.107	2.523LeuMet: 2.523 ± 0.037	2.295LeuAsn: 2.295 ± 0.036	5.641LeuPro: 5.641 ± 0.061	2.639LeuGln: 2.639 ± 0.044	7.683LeuArg: 7.683 ± 0.074	6.379LeuSer: 6.379 ± 0.06	5.551LeuThr: 5.551 ± 0.066	7.11LeuVal: 7.11 ± 0.073	1.26LeuTrp: 1.26 ± 0.033	1.932LeuTyr: 1.932 ± 0.035	0.001LeuXaa: 0.001 ± 0.001
Met	3.361MetAla: 3.361 ± 0.049	0.183MetCys: 0.183 ± 0.01	1.407MetAsp: 1.407 ± 0.026	1.454MetGlu: 1.454 ± 0.029	0.753MetPhe: 0.753 ± 0.021	2.213MetGly: 2.213 ± 0.043	0.497MetHis: 0.497 ± 0.017	1.442MetIle: 1.442 ± 0.033	0.943MetLys: 0.943 ± 0.028	2.634MetLeu: 2.634 ± 0.041	0.765MetMet: 0.765 ± 0.027	0.719MetAsn: 0.719 ± 0.021	1.585MetPro: 1.585 ± 0.034	1.0MetGln: 1.0 ± 0.028	2.03MetArg: 2.03 ± 0.033	1.804MetSer: 1.804 ± 0.039	2.242MetThr: 2.242 ± 0.044	1.835MetVal: 1.835 ± 0.033	0.237MetTrp: 0.237 ± 0.012	0.31MetTyr: 0.31 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	2.872AsnAla: 2.872 ± 0.04	0.224AsnCys: 0.224 ± 0.013	1.363AsnAsp: 1.363 ± 0.037	1.199AsnGlu: 1.199 ± 0.033	0.856AsnPhe: 0.856 ± 0.025	2.13AsnGly: 2.13 ± 0.045	0.467AsnHis: 0.467 ± 0.016	1.169AsnIle: 1.169 ± 0.028	0.522AsnLys: 0.522 ± 0.023	2.252AsnLeu: 2.252 ± 0.036	0.625AsnMet: 0.625 ± 0.021	0.556AsnAsn: 0.556 ± 0.019	1.635AsnPro: 1.635 ± 0.034	0.586AsnGln: 0.586 ± 0.018	1.67AsnArg: 1.67 ± 0.035	1.032AsnSer: 1.032 ± 0.026	1.169AsnThr: 1.169 ± 0.028	1.697AsnVal: 1.697 ± 0.03	0.359AsnTrp: 0.359 ± 0.015	0.557AsnTyr: 0.557 ± 0.019	0.0AsnXaa: 0.0 ± 0.0
Pro	6.224ProAla: 6.224 ± 0.07	0.392ProCys: 0.392 ± 0.016	4.079ProAsp: 4.079 ± 0.055	4.99ProGlu: 4.99 ± 0.066	1.888ProPhe: 1.888 ± 0.038	5.256ProGly: 5.256 ± 0.063	1.057ProHis: 1.057 ± 0.027	1.933ProIle: 1.933 ± 0.033	1.358ProLys: 1.358 ± 0.031	4.696ProLeu: 4.696 ± 0.054	1.321ProMet: 1.321 ± 0.032	1.125ProAsn: 1.125 ± 0.022	2.48ProPro: 2.48 ± 0.047	1.641ProGln: 1.641 ± 0.031	3.509ProArg: 3.509 ± 0.052	2.521ProSer: 2.521 ± 0.039	2.254ProThr: 2.254 ± 0.039	4.409ProVal: 4.409 ± 0.052	0.729ProTrp: 0.729 ± 0.023	1.083ProTyr: 1.083 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	3.883GlnAla: 3.883 ± 0.051	0.202GlnCys: 0.202 ± 0.012	1.751GlnAsp: 1.751 ± 0.035	1.731GlnGlu: 1.731 ± 0.037	0.951GlnPhe: 0.951 ± 0.024	2.608GlnGly: 2.608 ± 0.044	0.581GlnHis: 0.581 ± 0.018	1.646GlnIle: 1.646 ± 0.034	0.939GlnLys: 0.939 ± 0.029	2.675GlnLeu: 2.675 ± 0.044	0.917GlnMet: 0.917 ± 0.027	0.726GlnAsn: 0.726 ± 0.021	1.599GlnPro: 1.599 ± 0.033	1.056GlnGln: 1.056 ± 0.032	2.291GlnArg: 2.291 ± 0.038	1.622GlnSer: 1.622 ± 0.032	1.578GlnThr: 1.578 ± 0.029	2.387GlnVal: 2.387 ± 0.038	0.373GlnTrp: 0.373 ± 0.016	0.513GlnTyr: 0.513 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	9.036ArgAla: 9.036 ± 0.087	0.582ArgCys: 0.582 ± 0.018	4.881ArgAsp: 4.881 ± 0.061	4.794ArgGlu: 4.794 ± 0.055	2.84ArgPhe: 2.84 ± 0.04	5.522ArgGly: 5.522 ± 0.068	1.861ArgHis: 1.861 ± 0.04	3.966ArgIle: 3.966 ± 0.055	2.122ArgLys: 2.122 ± 0.046	8.029ArgLeu: 8.029 ± 0.079	2.149ArgMet: 2.149 ± 0.036	1.812ArgAsn: 1.812 ± 0.035	3.905ArgPro: 3.905 ± 0.055	2.418ArgGln: 2.418 ± 0.039	6.415ArgArg: 6.415 ± 0.084	3.538ArgSer: 3.538 ± 0.049	3.271ArgThr: 3.271 ± 0.039	5.181ArgVal: 5.181 ± 0.059	0.985ArgTrp: 0.985 ± 0.026	1.627ArgTyr: 1.627 ± 0.035	0.002ArgXaa: 0.002 ± 0.001
Ser	5.736SerAla: 5.736 ± 0.061	0.442SerCys: 0.442 ± 0.02	3.241SerAsp: 3.241 ± 0.045	3.265SerGlu: 3.265 ± 0.055	2.11SerPhe: 2.11 ± 0.035	5.473SerGly: 5.473 ± 0.064	1.072SerHis: 1.072 ± 0.027	2.238SerIle: 2.238 ± 0.04	1.303SerLys: 1.303 ± 0.034	4.869SerLeu: 4.869 ± 0.058	1.345SerMet: 1.345 ± 0.032	1.229SerAsn: 1.229 ± 0.032	2.524SerPro: 2.524 ± 0.038	1.419SerGln: 1.419 ± 0.029	3.556SerArg: 3.556 ± 0.049	2.664SerSer: 2.664 ± 0.049	2.509SerThr: 2.509 ± 0.038	3.793SerVal: 3.793 ± 0.055	0.75SerTrp: 0.75 ± 0.02	1.257SerTyr: 1.257 ± 0.025	0.001SerXaa: 0.001 ± 0.001
Thr	6.174ThrAla: 6.174 ± 0.075	0.478ThrCys: 0.478 ± 0.02	3.222ThrAsp: 3.222 ± 0.045	3.304ThrGlu: 3.304 ± 0.048	1.934ThrPhe: 1.934 ± 0.038	5.671ThrGly: 5.671 ± 0.065	1.069ThrHis: 1.069 ± 0.026	2.44ThrIle: 2.44 ± 0.038	1.152ThrLys: 1.152 ± 0.027	5.804ThrLeu: 5.804 ± 0.072	1.305ThrMet: 1.305 ± 0.028	1.135ThrAsn: 1.135 ± 0.028	3.452ThrPro: 3.452 ± 0.043	1.5ThrGln: 1.5 ± 0.033	3.816ThrArg: 3.816 ± 0.052	2.594ThrSer: 2.594 ± 0.039	2.803ThrThr: 2.803 ± 0.042	4.223ThrVal: 4.223 ± 0.051	0.738ThrTrp: 0.738 ± 0.025	1.174ThrTyr: 1.174 ± 0.031	0.0ThrXaa: 0.0 ± 0.0
Val	8.84ValAla: 8.84 ± 0.084	0.636ValCys: 0.636 ± 0.02	4.064ValAsp: 4.064 ± 0.051	4.76ValGlu: 4.76 ± 0.05	2.786ValPhe: 2.786 ± 0.046	5.511ValGly: 5.511 ± 0.067	1.393ValHis: 1.393 ± 0.025	3.888ValIle: 3.888 ± 0.049	1.849ValLys: 1.849 ± 0.041	7.472ValLeu: 7.472 ± 0.078	2.124ValMet: 2.124 ± 0.04	1.816ValAsn: 1.816 ± 0.033	3.899ValPro: 3.899 ± 0.046	2.088ValGln: 2.088 ± 0.037	4.551ValArg: 4.551 ± 0.053	4.389ValSer: 4.389 ± 0.06	4.814ValThr: 4.814 ± 0.055	5.651ValVal: 5.651 ± 0.069	0.93ValTrp: 0.93 ± 0.025	1.492ValTyr: 1.492 ± 0.029	0.001ValXaa: 0.001 ± 0.001
Trp	1.366TrpAla: 1.366 ± 0.03	0.139TrpCys: 0.139 ± 0.01	0.787TrpAsp: 0.787 ± 0.024	0.733TrpGlu: 0.733 ± 0.021	0.539TrpPhe: 0.539 ± 0.019	1.007TrpGly: 1.007 ± 0.025	0.329TrpHis: 0.329 ± 0.014	0.678TrpIle: 0.678 ± 0.02	0.412TrpLys: 0.412 ± 0.015	1.635TrpLeu: 1.635 ± 0.036	0.422TrpMet: 0.422 ± 0.016	0.378TrpAsn: 0.378 ± 0.016	0.738TrpPro: 0.738 ± 0.021	0.597TrpGln: 0.597 ± 0.02	1.215TrpArg: 1.215 ± 0.032	0.813TrpSer: 0.813 ± 0.021	0.858TrpThr: 0.858 ± 0.023	0.866TrpVal: 0.866 ± 0.026	0.229TrpTrp: 0.229 ± 0.013	0.282TrpTyr: 0.282 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.536TyrAla: 2.536 ± 0.04	0.22TyrCys: 0.22 ± 0.011	1.622TyrAsp: 1.622 ± 0.037	1.374TyrGlu: 1.374 ± 0.031	0.855TyrPhe: 0.855 ± 0.022	2.082TyrGly: 2.082 ± 0.036	0.464TyrHis: 0.464 ± 0.017	0.855TyrIle: 0.855 ± 0.024	0.441TyrLys: 0.441 ± 0.016	2.138TyrLeu: 2.138 ± 0.039	0.499TyrMet: 0.499 ± 0.016	0.546TyrAsn: 0.546 ± 0.02	1.073TyrPro: 1.073 ± 0.026	0.591TyrGln: 0.591 ± 0.019	1.584TyrArg: 1.584 ± 0.031	1.096TyrSer: 1.096 ± 0.026	1.031TyrThr: 1.031 ± 0.026	1.529TyrVal: 1.529 ± 0.035	0.345TyrTrp: 0.345 ± 0.017	0.543TyrTyr: 0.543 ± 0.02	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.002XaaAla: 0.002 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.001XaaPhe: 0.001 ± 0.001	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.001XaaLys: 0.001 ± 0.001	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.001	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.001	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5583 proteins (1630836 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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