Amino acid dipepetide frequency for Blackberry vein banding-associated virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.035AlaAla: 5.035 ± 0.662
1.119AlaCys: 1.119 ± 0.376
3.17AlaAsp: 3.17 ± 0.682
2.984AlaGlu: 2.984 ± 0.93
2.611AlaPhe: 2.611 ± 0.888
4.289AlaGly: 4.289 ± 0.925
0.559AlaHis: 0.559 ± 0.351
4.103AlaIle: 4.103 ± 1.256
3.543AlaLys: 3.543 ± 0.99
8.765AlaLeu: 8.765 ± 1.021
1.492AlaMet: 1.492 ± 0.301
3.17AlaAsn: 3.17 ± 0.733
2.424AlaPro: 2.424 ± 1.121
1.865AlaGln: 1.865 ± 0.5
3.916AlaArg: 3.916 ± 1.049
5.035AlaSer: 5.035 ± 0.545
2.984AlaThr: 2.984 ± 0.847
8.392AlaVal: 8.392 ± 1.158
0.746AlaTrp: 0.746 ± 0.495
3.17AlaTyr: 3.17 ± 0.952
0.0AlaXaa: 0.0 ± 0.0
Cys
1.119CysAla: 1.119 ± 0.374
0.0CysCys: 0.0 ± 0.0
1.678CysAsp: 1.678 ± 0.349
1.119CysGlu: 1.119 ± 0.387
1.678CysPhe: 1.678 ± 0.556
2.238CysGly: 2.238 ± 0.488
0.186CysHis: 0.186 ± 0.117
0.746CysIle: 0.746 ± 0.228
0.932CysLys: 0.932 ± 0.407
1.305CysLeu: 1.305 ± 0.562
0.186CysMet: 0.186 ± 0.117
0.932CysAsn: 0.932 ± 0.586
0.373CysPro: 0.373 ± 0.234
0.559CysGln: 0.559 ± 0.267
1.119CysArg: 1.119 ± 0.352
1.305CysSer: 1.305 ± 0.409
1.492CysThr: 1.492 ± 0.554
1.492CysVal: 1.492 ± 0.537
0.373CysTrp: 0.373 ± 0.229
1.119CysTyr: 1.119 ± 0.219
0.0CysXaa: 0.0 ± 0.0
Asp
2.984AspAla: 2.984 ± 0.779
0.746AspCys: 0.746 ± 0.359
4.476AspAsp: 4.476 ± 0.82
3.17AspGlu: 3.17 ± 0.862
1.865AspPhe: 1.865 ± 0.598
2.984AspGly: 2.984 ± 0.689
0.186AspHis: 0.186 ± 0.117
3.916AspIle: 3.916 ± 1.074
2.424AspLys: 2.424 ± 0.889
4.662AspLeu: 4.662 ± 0.862
2.051AspMet: 2.051 ± 0.635
3.357AspAsn: 3.357 ± 0.744
2.424AspPro: 2.424 ± 0.715
0.746AspGln: 0.746 ± 0.415
2.424AspArg: 2.424 ± 0.607
4.849AspSer: 4.849 ± 1.022
2.797AspThr: 2.797 ± 0.896
6.154AspVal: 6.154 ± 1.071
0.373AspTrp: 0.373 ± 0.214
1.865AspTyr: 1.865 ± 0.495
0.0AspXaa: 0.0 ± 0.0
Glu
3.916GluAla: 3.916 ± 0.616
0.559GluCys: 0.559 ± 0.351
2.611GluAsp: 2.611 ± 0.618
2.797GluGlu: 2.797 ± 0.829
1.865GluPhe: 1.865 ± 0.665
4.849GluGly: 4.849 ± 0.826
0.0GluHis: 0.0 ± 0.0
2.424GluIle: 2.424 ± 0.54
5.222GluLys: 5.222 ± 1.138
5.595GluLeu: 5.595 ± 1.33
1.492GluMet: 1.492 ± 0.425
2.051GluAsn: 2.051 ± 1.124
1.492GluPro: 1.492 ± 0.457
1.865GluGln: 1.865 ± 0.494
4.103GluArg: 4.103 ± 1.28
4.103GluSer: 4.103 ± 0.765
2.797GluThr: 2.797 ± 0.612
6.9GluVal: 6.9 ± 1.028
0.186GluTrp: 0.186 ± 0.226
2.051GluTyr: 2.051 ± 0.431
0.0GluXaa: 0.0 ± 0.0
Phe
1.865PheAla: 1.865 ± 0.635
1.305PheCys: 1.305 ± 0.676
2.238PheAsp: 2.238 ± 0.463
1.865PheGlu: 1.865 ± 0.811
1.305PhePhe: 1.305 ± 0.426
2.238PheGly: 2.238 ± 0.438
0.746PheHis: 0.746 ± 0.316
2.051PheIle: 2.051 ± 0.635
2.424PheLys: 2.424 ± 0.754
4.662PheLeu: 4.662 ± 1.395
1.492PheMet: 1.492 ± 0.36
2.051PheAsn: 2.051 ± 0.457
1.865PhePro: 1.865 ± 0.538
0.373PheGln: 0.373 ± 0.175
2.797PheArg: 2.797 ± 0.54
4.849PheSer: 4.849 ± 0.796
1.678PheThr: 1.678 ± 0.627
3.73PheVal: 3.73 ± 0.856
0.0PheTrp: 0.0 ± 0.0
1.865PheTyr: 1.865 ± 0.559
0.0PheXaa: 0.0 ± 0.0
Gly
3.17GlyAla: 3.17 ± 0.649
2.797GlyCys: 2.797 ± 0.937
5.035GlyAsp: 5.035 ± 0.554
4.103GlyGlu: 4.103 ± 0.849
2.984GlyPhe: 2.984 ± 0.599
5.968GlyGly: 5.968 ± 1.782
0.559GlyHis: 0.559 ± 0.234
2.424GlyIle: 2.424 ± 0.719
5.781GlyLys: 5.781 ± 1.386
5.781GlyLeu: 5.781 ± 0.753
1.119GlyMet: 1.119 ± 0.459
2.238GlyAsn: 2.238 ± 0.738
0.746GlyPro: 0.746 ± 0.41
1.492GlyGln: 1.492 ± 0.496
3.73GlyArg: 3.73 ± 0.788
5.968GlySer: 5.968 ± 0.749
3.916GlyThr: 3.916 ± 0.944
6.714GlyVal: 6.714 ± 1.358
1.119GlyTrp: 1.119 ± 0.306
2.051GlyTyr: 2.051 ± 0.666
0.0GlyXaa: 0.0 ± 0.0
His
1.119HisAla: 1.119 ± 0.378
0.373HisCys: 0.373 ± 0.234
0.932HisAsp: 0.932 ± 0.409
1.305HisGlu: 1.305 ± 0.378
0.373HisPhe: 0.373 ± 0.193
1.305HisGly: 1.305 ± 0.275
0.373HisHis: 0.373 ± 0.234
0.373HisIle: 0.373 ± 0.194
0.746HisLys: 0.746 ± 0.483
1.119HisLeu: 1.119 ± 0.356
0.0HisMet: 0.0 ± 0.0
0.932HisAsn: 0.932 ± 0.412
0.932HisPro: 0.932 ± 0.282
0.186HisGln: 0.186 ± 0.117
0.373HisArg: 0.373 ± 0.234
0.746HisSer: 0.746 ± 0.468
0.373HisThr: 0.373 ± 0.234
1.305HisVal: 1.305 ± 0.621
0.0HisTrp: 0.0 ± 0.0
0.0HisTyr: 0.0 ± 0.0
0.0HisXaa: 0.0 ± 0.0
Ile
2.984IleAla: 2.984 ± 0.638
0.186IleCys: 0.186 ± 0.211
2.051IleAsp: 2.051 ± 0.837
1.678IleGlu: 1.678 ± 0.688
2.611IlePhe: 2.611 ± 0.421
2.238IleGly: 2.238 ± 0.534
0.746IleHis: 0.746 ± 0.228
1.678IleIle: 1.678 ± 0.424
3.73IleLys: 3.73 ± 0.985
3.916IleLeu: 3.916 ± 1.128
0.559IleMet: 0.559 ± 0.243
2.424IleAsn: 2.424 ± 0.627
2.238IlePro: 2.238 ± 0.619
0.746IleGln: 0.746 ± 0.249
2.611IleArg: 2.611 ± 0.611
3.73IleSer: 3.73 ± 0.855
2.238IleThr: 2.238 ± 0.549
4.103IleVal: 4.103 ± 0.72
0.186IleTrp: 0.186 ± 0.296
1.678IleTyr: 1.678 ± 0.551
0.0IleXaa: 0.0 ± 0.0
Lys
4.289LysAla: 4.289 ± 0.96
1.119LysCys: 1.119 ± 0.41
2.797LysAsp: 2.797 ± 1.056
5.035LysGlu: 5.035 ± 0.751
1.678LysPhe: 1.678 ± 0.585
4.849LysGly: 4.849 ± 1.191
0.932LysHis: 0.932 ± 0.488
3.73LysIle: 3.73 ± 0.762
2.984LysLys: 2.984 ± 1.138
5.968LysLeu: 5.968 ± 1.171
1.119LysMet: 1.119 ± 0.489
1.305LysAsn: 1.305 ± 0.406
2.984LysPro: 2.984 ± 0.878
0.746LysGln: 0.746 ± 0.286
3.916LysArg: 3.916 ± 0.674
3.73LysSer: 3.73 ± 0.847
3.17LysThr: 3.17 ± 0.909
7.273LysVal: 7.273 ± 1.451
0.186LysTrp: 0.186 ± 0.117
2.238LysTyr: 2.238 ± 0.996
0.0LysXaa: 0.0 ± 0.0
Leu
6.9LeuAla: 6.9 ± 0.922
3.73LeuCys: 3.73 ± 0.53
5.781LeuAsp: 5.781 ± 1.333
4.103LeuGlu: 4.103 ± 1.21
3.17LeuPhe: 3.17 ± 0.973
5.781LeuGly: 5.781 ± 0.818
1.305LeuHis: 1.305 ± 0.373
3.17LeuIle: 3.17 ± 0.944
6.527LeuLys: 6.527 ± 0.947
9.511LeuLeu: 9.511 ± 1.181
1.678LeuMet: 1.678 ± 0.684
3.357LeuAsn: 3.357 ± 0.94
4.103LeuPro: 4.103 ± 0.758
2.611LeuGln: 2.611 ± 1.066
6.341LeuArg: 6.341 ± 1.337
8.019LeuSer: 8.019 ± 1.681
7.273LeuThr: 7.273 ± 1.544
9.325LeuVal: 9.325 ± 1.478
0.559LeuTrp: 0.559 ± 0.243
3.17LeuTyr: 3.17 ± 1.074
0.0LeuXaa: 0.0 ± 0.0
Met
2.238MetAla: 2.238 ± 0.75
0.0MetCys: 0.0 ± 0.0
1.678MetAsp: 1.678 ± 0.217
1.119MetGlu: 1.119 ± 0.435
0.932MetPhe: 0.932 ± 0.442
1.305MetGly: 1.305 ± 0.424
0.746MetHis: 0.746 ± 0.468
1.119MetIle: 1.119 ± 0.372
1.305MetLys: 1.305 ± 0.28
1.678MetLeu: 1.678 ± 0.672
0.932MetMet: 0.932 ± 0.306
0.373MetAsn: 0.373 ± 0.175
0.186MetPro: 0.186 ± 0.117
0.373MetGln: 0.373 ± 0.193
1.119MetArg: 1.119 ± 0.43
1.678MetSer: 1.678 ± 0.307
1.305MetThr: 1.305 ± 0.489
3.17MetVal: 3.17 ± 0.973
0.373MetTrp: 0.373 ± 0.281
0.373MetTyr: 0.373 ± 0.214
0.0MetXaa: 0.0 ± 0.0
Asn
3.73AsnAla: 3.73 ± 0.795
0.559AsnCys: 0.559 ± 0.234
1.119AsnAsp: 1.119 ± 0.381
2.797AsnGlu: 2.797 ± 1.111
3.73AsnPhe: 3.73 ± 1.105
2.238AsnGly: 2.238 ± 0.835
0.559AsnHis: 0.559 ± 0.288
1.492AsnIle: 1.492 ± 0.504
1.119AsnLys: 1.119 ± 0.588
2.797AsnLeu: 2.797 ± 0.892
0.186AsnMet: 0.186 ± 0.117
1.678AsnAsn: 1.678 ± 0.575
2.051AsnPro: 2.051 ± 0.501
0.746AsnGln: 0.746 ± 0.35
2.424AsnArg: 2.424 ± 0.324
3.17AsnSer: 3.17 ± 0.597
3.357AsnThr: 3.357 ± 1.02
2.424AsnVal: 2.424 ± 0.646
0.373AsnTrp: 0.373 ± 0.315
0.746AsnTyr: 0.746 ± 0.458
0.0AsnXaa: 0.0 ± 0.0
Pro
3.17ProAla: 3.17 ± 0.601
0.373ProCys: 0.373 ± 0.316
1.865ProAsp: 1.865 ± 0.424
2.238ProGlu: 2.238 ± 0.803
1.492ProPhe: 1.492 ± 0.353
2.611ProGly: 2.611 ± 0.687
0.373ProHis: 0.373 ± 0.234
1.492ProIle: 1.492 ± 0.494
2.238ProLys: 2.238 ± 0.534
2.238ProLeu: 2.238 ± 0.587
0.559ProMet: 0.559 ± 0.346
0.746ProAsn: 0.746 ± 0.495
2.051ProPro: 2.051 ± 0.779
0.746ProGln: 0.746 ± 0.341
2.611ProArg: 2.611 ± 0.629
3.73ProSer: 3.73 ± 0.634
3.357ProThr: 3.357 ± 0.445
4.476ProVal: 4.476 ± 1.243
0.0ProTrp: 0.0 ± 0.0
2.051ProTyr: 2.051 ± 0.527
0.0ProXaa: 0.0 ± 0.0
Gln
1.865GlnAla: 1.865 ± 0.515
0.373GlnCys: 0.373 ± 0.234
0.746GlnAsp: 0.746 ± 0.336
1.119GlnGlu: 1.119 ± 0.271
0.373GlnPhe: 0.373 ± 0.214
1.492GlnGly: 1.492 ± 0.521
0.373GlnHis: 0.373 ± 0.232
0.932GlnIle: 0.932 ± 0.226
1.678GlnLys: 1.678 ± 0.688
1.119GlnLeu: 1.119 ± 0.395
1.119GlnMet: 1.119 ± 0.64
0.373GlnAsn: 0.373 ± 0.318
1.119GlnPro: 1.119 ± 0.369
0.373GlnGln: 0.373 ± 0.234
1.865GlnArg: 1.865 ± 0.646
1.119GlnSer: 1.119 ± 0.505
1.492GlnThr: 1.492 ± 0.424
2.051GlnVal: 2.051 ± 0.471
0.0GlnTrp: 0.0 ± 0.0
0.559GlnTyr: 0.559 ± 0.294
0.0GlnXaa: 0.0 ± 0.0
Arg
3.73ArgAla: 3.73 ± 0.837
2.051ArgCys: 2.051 ± 0.829
2.424ArgAsp: 2.424 ± 0.585
3.17ArgGlu: 3.17 ± 0.844
1.305ArgPhe: 1.305 ± 0.705
4.849ArgGly: 4.849 ± 0.916
0.932ArgHis: 0.932 ± 0.294
2.424ArgIle: 2.424 ± 0.704
2.984ArgLys: 2.984 ± 0.395
7.087ArgLeu: 7.087 ± 1.022
1.678ArgMet: 1.678 ± 0.65
1.678ArgAsn: 1.678 ± 0.411
2.797ArgPro: 2.797 ± 0.718
1.119ArgGln: 1.119 ± 0.485
5.035ArgArg: 5.035 ± 1.037
7.273ArgSer: 7.273 ± 1.347
4.662ArgThr: 4.662 ± 0.753
7.087ArgVal: 7.087 ± 1.199
0.746ArgTrp: 0.746 ± 0.356
1.678ArgTyr: 1.678 ± 0.528
0.0ArgXaa: 0.0 ± 0.0
Ser
4.289SerAla: 4.289 ± 0.551
1.119SerCys: 1.119 ± 0.537
3.916SerAsp: 3.916 ± 0.804
4.662SerGlu: 4.662 ± 0.736
3.357SerPhe: 3.357 ± 0.663
5.781SerGly: 5.781 ± 0.935
0.746SerHis: 0.746 ± 0.38
2.611SerIle: 2.611 ± 0.899
5.222SerLys: 5.222 ± 0.76
10.257SerLeu: 10.257 ± 1.476
0.932SerMet: 0.932 ± 0.409
2.984SerAsn: 2.984 ± 0.358
1.305SerPro: 1.305 ± 0.402
2.611SerGln: 2.611 ± 0.878
6.527SerArg: 6.527 ± 1.157
6.9SerSer: 6.9 ± 0.894
6.527SerThr: 6.527 ± 1.303
9.698SerVal: 9.698 ± 1.258
0.186SerTrp: 0.186 ± 0.201
3.357SerTyr: 3.357 ± 0.787
0.0SerXaa: 0.0 ± 0.0
Thr
5.781ThrAla: 5.781 ± 0.938
0.746ThrCys: 0.746 ± 0.249
2.797ThrAsp: 2.797 ± 0.826
3.357ThrGlu: 3.357 ± 0.722
3.73ThrPhe: 3.73 ± 0.547
3.916ThrGly: 3.916 ± 0.923
0.932ThrHis: 0.932 ± 0.274
4.103ThrIle: 4.103 ± 1.164
1.865ThrLys: 1.865 ± 0.752
7.833ThrLeu: 7.833 ± 3.133
0.932ThrMet: 0.932 ± 0.411
1.305ThrAsn: 1.305 ± 0.569
2.611ThrPro: 2.611 ± 0.992
0.932ThrGln: 0.932 ± 0.449
4.103ThrArg: 4.103 ± 1.447
3.916ThrSer: 3.916 ± 0.608
3.73ThrThr: 3.73 ± 0.99
5.595ThrVal: 5.595 ± 0.658
0.373ThrTrp: 0.373 ± 0.322
2.984ThrTyr: 2.984 ± 0.588
0.0ThrXaa: 0.0 ± 0.0
Val
8.765ValAla: 8.765 ± 0.755
1.492ValCys: 1.492 ± 0.658
5.408ValAsp: 5.408 ± 0.658
7.46ValGlu: 7.46 ± 0.981
4.476ValPhe: 4.476 ± 0.56
6.714ValGly: 6.714 ± 1.332
1.119ValHis: 1.119 ± 0.522
2.611ValIle: 2.611 ± 0.773
6.341ValLys: 6.341 ± 0.876
8.392ValLeu: 8.392 ± 1.415
2.424ValMet: 2.424 ± 0.559
4.103ValAsn: 4.103 ± 0.567
4.849ValPro: 4.849 ± 0.807
1.865ValGln: 1.865 ± 0.794
6.9ValArg: 6.9 ± 1.221
8.579ValSer: 8.579 ± 1.17
5.035ValThr: 5.035 ± 1.074
12.122ValVal: 12.122 ± 1.676
1.492ValTrp: 1.492 ± 0.666
5.222ValTyr: 5.222 ± 1.147
0.0ValXaa: 0.0 ± 0.0
Trp
0.373TrpAla: 0.373 ± 0.229
0.186TrpCys: 0.186 ± 0.117
0.559TrpAsp: 0.559 ± 0.22
0.373TrpGlu: 0.373 ± 0.229
0.746TrpPhe: 0.746 ± 0.343
0.373TrpGly: 0.373 ± 0.234
0.0TrpHis: 0.0 ± 0.0
0.0TrpIle: 0.0 ± 0.0
0.373TrpLys: 0.373 ± 0.214
0.746TrpLeu: 0.746 ± 0.483
0.186TrpMet: 0.186 ± 0.207
0.559TrpAsn: 0.559 ± 0.456
0.373TrpPro: 0.373 ± 0.193
0.0TrpGln: 0.0 ± 0.0
0.373TrpArg: 0.373 ± 0.325
0.373TrpSer: 0.373 ± 0.281
0.559TrpThr: 0.559 ± 0.243
0.746TrpVal: 0.746 ± 0.235
0.0TrpTrp: 0.0 ± 0.0
0.559TrpTyr: 0.559 ± 0.313
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.051TyrAla: 2.051 ± 0.764
1.119TyrCys: 1.119 ± 0.44
3.17TyrAsp: 3.17 ± 1.082
2.424TyrGlu: 2.424 ± 0.671
1.119TyrPhe: 1.119 ± 0.364
1.678TyrGly: 1.678 ± 0.36
1.492TyrHis: 1.492 ± 0.496
0.932TyrIle: 0.932 ± 0.523
2.611TyrLys: 2.611 ± 0.545
2.984TyrLeu: 2.984 ± 0.757
1.678TyrMet: 1.678 ± 0.65
1.678TyrAsn: 1.678 ± 0.409
1.492TyrPro: 1.492 ± 0.443
0.186TyrGln: 0.186 ± 0.252
2.424TyrArg: 2.424 ± 0.532
3.916TyrSer: 3.916 ± 1.009
2.984TyrThr: 2.984 ± 0.613
2.611TyrVal: 2.611 ± 0.461
0.186TyrTrp: 0.186 ± 0.117
1.865TyrTyr: 1.865 ± 0.972
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 11 proteins (5363 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski