Amino acid dipepetide frequency for Trinickia soli

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.405AlaAla: 18.405 ± 0.163	1.387AlaCys: 1.387 ± 0.034	6.596AlaAsp: 6.596 ± 0.075	6.005AlaGlu: 6.005 ± 0.074	4.521AlaPhe: 4.521 ± 0.056	10.557AlaGly: 10.557 ± 0.102	3.064AlaHis: 3.064 ± 0.047	5.708AlaIle: 5.708 ± 0.062	3.731AlaLys: 3.731 ± 0.061	14.987AlaLeu: 14.987 ± 0.129	3.226AlaMet: 3.226 ± 0.046	3.225AlaAsn: 3.225 ± 0.051	6.338AlaPro: 6.338 ± 0.077	5.849AlaGln: 5.849 ± 0.073	9.794AlaArg: 9.794 ± 0.104	7.697AlaSer: 7.697 ± 0.083	6.507AlaThr: 6.507 ± 0.085	8.894AlaVal: 8.894 ± 0.072	1.717AlaTrp: 1.717 ± 0.037	2.878AlaTyr: 2.878 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	1.392CysAla: 1.392 ± 0.029	0.128CysCys: 0.128 ± 0.01	0.566CysAsp: 0.566 ± 0.018	0.538CysGlu: 0.538 ± 0.017	0.328CysPhe: 0.328 ± 0.013	1.019CysGly: 1.019 ± 0.025	0.23CysHis: 0.23 ± 0.011	0.393CysIle: 0.393 ± 0.016	0.227CysLys: 0.227 ± 0.01	0.802CysLeu: 0.802 ± 0.023	0.192CysMet: 0.192 ± 0.009	0.25CysAsn: 0.25 ± 0.011	0.46CysPro: 0.46 ± 0.016	0.21CysGln: 0.21 ± 0.011	0.65CysArg: 0.65 ± 0.022	0.524CysSer: 0.524 ± 0.019	0.521CysThr: 0.521 ± 0.019	0.841CysVal: 0.841 ± 0.023	0.12CysTrp: 0.12 ± 0.008	0.235CysTyr: 0.235 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	7.93AspAla: 7.93 ± 0.08	0.51AspCys: 0.51 ± 0.015	3.177AspAsp: 3.177 ± 0.056	3.672AspGlu: 3.672 ± 0.051	1.911AspPhe: 1.911 ± 0.032	4.66AspGly: 4.66 ± 0.06	1.127AspHis: 1.127 ± 0.025	2.49AspIle: 2.49 ± 0.041	1.512AspLys: 1.512 ± 0.032	5.021AspLeu: 5.021 ± 0.056	1.136AspMet: 1.136 ± 0.024	1.205AspAsn: 1.205 ± 0.03	2.953AspPro: 2.953 ± 0.047	1.488AspGln: 1.488 ± 0.03	3.525AspArg: 3.525 ± 0.054	2.51AspSer: 2.51 ± 0.038	2.739AspThr: 2.739 ± 0.049	4.34AspVal: 4.34 ± 0.053	0.931AspTrp: 0.931 ± 0.024	1.494AspTyr: 1.494 ± 0.03	0.0AspXaa: 0.0 ± 0.0
Glu	6.852GluAla: 6.852 ± 0.075	0.438GluCys: 0.438 ± 0.016	2.114GluAsp: 2.114 ± 0.037	2.36GluGlu: 2.36 ± 0.047	1.743GluPhe: 1.743 ± 0.032	3.484GluGly: 3.484 ± 0.047	1.524GluHis: 1.524 ± 0.027	2.74GluIle: 2.74 ± 0.046	1.689GluLys: 1.689 ± 0.032	5.385GluLeu: 5.385 ± 0.06	1.188GluMet: 1.188 ± 0.028	1.316GluAsn: 1.316 ± 0.028	2.714GluPro: 2.714 ± 0.042	2.447GluGln: 2.447 ± 0.038	5.427GluArg: 5.427 ± 0.069	2.642GluSer: 2.642 ± 0.038	2.92GluThr: 2.92 ± 0.046	3.499GluVal: 3.499 ± 0.054	0.716GluTrp: 0.716 ± 0.023	1.14GluTyr: 1.14 ± 0.022	0.0GluXaa: 0.0 ± 0.0
Phe	4.81PheAla: 4.81 ± 0.059	0.445PheCys: 0.445 ± 0.017	2.778PheAsp: 2.778 ± 0.039	2.115PheGlu: 2.115 ± 0.035	1.378PhePhe: 1.378 ± 0.033	3.483PheGly: 3.483 ± 0.049	0.756PheHis: 0.756 ± 0.021	1.534PheIle: 1.534 ± 0.027	1.04PheLys: 1.04 ± 0.028	2.842PheLeu: 2.842 ± 0.045	0.742PheMet: 0.742 ± 0.02	1.064PheAsn: 1.064 ± 0.025	1.533PhePro: 1.533 ± 0.032	0.948PheGln: 0.948 ± 0.025	1.957PheArg: 1.957 ± 0.037	2.3PheSer: 2.3 ± 0.037	1.872PheThr: 1.872 ± 0.037	3.197PheVal: 3.197 ± 0.044	0.464PheTrp: 0.464 ± 0.015	0.913PheTyr: 0.913 ± 0.023	0.0PheXaa: 0.0 ± 0.0
Gly	9.935GlyAla: 9.935 ± 0.114	0.874GlyCys: 0.874 ± 0.022	4.022GlyAsp: 4.022 ± 0.054	4.317GlyGlu: 4.317 ± 0.06	3.255GlyPhe: 3.255 ± 0.045	6.788GlyGly: 6.788 ± 0.102	1.966GlyHis: 1.966 ± 0.031	4.125GlyIle: 4.125 ± 0.054	3.017GlyLys: 3.017 ± 0.051	7.733GlyLeu: 7.733 ± 0.071	2.067GlyMet: 2.067 ± 0.039	2.314GlyAsn: 2.314 ± 0.052	3.049GlyPro: 3.049 ± 0.043	2.845GlyGln: 2.845 ± 0.042	5.501GlyArg: 5.501 ± 0.06	4.682GlySer: 4.682 ± 0.072	4.478GlyThr: 4.478 ± 0.086	6.638GlyVal: 6.638 ± 0.072	1.335GlyTrp: 1.335 ± 0.038	2.417GlyTyr: 2.417 ± 0.04	0.0GlyXaa: 0.0 ± 0.0
His	3.257HisAla: 3.257 ± 0.047	0.289HisCys: 0.289 ± 0.013	1.316HisAsp: 1.316 ± 0.03	1.263HisGlu: 1.263 ± 0.028	0.903HisPhe: 0.903 ± 0.024	2.199HisGly: 2.199 ± 0.044	0.605HisHis: 0.605 ± 0.016	0.909HisIle: 0.909 ± 0.021	0.477HisLys: 0.477 ± 0.016	2.184HisLeu: 2.184 ± 0.039	0.504HisMet: 0.504 ± 0.016	0.517HisAsn: 0.517 ± 0.019	1.457HisPro: 1.457 ± 0.027	0.653HisGln: 0.653 ± 0.021	1.735HisArg: 1.735 ± 0.033	1.078HisSer: 1.078 ± 0.026	1.123HisThr: 1.123 ± 0.031	1.857HisVal: 1.857 ± 0.034	0.392HisTrp: 0.392 ± 0.015	0.702HisTyr: 0.702 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	7.05IleAla: 7.05 ± 0.073	0.429IleCys: 0.429 ± 0.015	3.718IleAsp: 3.718 ± 0.049	3.581IleGlu: 3.581 ± 0.053	1.348IlePhe: 1.348 ± 0.029	4.724IleGly: 4.724 ± 0.053	0.904IleHis: 0.904 ± 0.023	1.527IleIle: 1.527 ± 0.034	1.304IleLys: 1.304 ± 0.033	3.083IleLeu: 3.083 ± 0.045	0.724IleMet: 0.724 ± 0.023	1.269IleAsn: 1.269 ± 0.031	1.898IlePro: 1.898 ± 0.037	1.071IleGln: 1.071 ± 0.024	2.664IleArg: 2.664 ± 0.036	2.421IleSer: 2.421 ± 0.041	2.182IleThr: 2.182 ± 0.04	4.519IleVal: 4.519 ± 0.059	0.484IleTrp: 0.484 ± 0.017	0.978IleTyr: 0.978 ± 0.026	0.0IleXaa: 0.0 ± 0.0
Lys	3.49LysAla: 3.49 ± 0.059	0.178LysCys: 0.178 ± 0.01	1.416LysAsp: 1.416 ± 0.039	1.356LysGlu: 1.356 ± 0.034	0.806LysPhe: 0.806 ± 0.021	2.071LysGly: 2.071 ± 0.043	0.704LysHis: 0.704 ± 0.021	1.514LysIle: 1.514 ± 0.035	1.125LysLys: 1.125 ± 0.039	3.207LysLeu: 3.207 ± 0.047	0.75LysMet: 0.75 ± 0.022	0.785LysAsn: 0.785 ± 0.023	1.863LysPro: 1.863 ± 0.038	1.272LysGln: 1.272 ± 0.029	2.404LysArg: 2.404 ± 0.037	1.65LysSer: 1.65 ± 0.034	1.861LysThr: 1.861 ± 0.039	2.092LysVal: 2.092 ± 0.042	0.361LysTrp: 0.361 ± 0.015	0.672LysTyr: 0.672 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	14.363LeuAla: 14.363 ± 0.108	0.981LeuCys: 0.981 ± 0.025	5.93LeuAsp: 5.93 ± 0.065	5.013LeuGlu: 5.013 ± 0.063	3.405LeuPhe: 3.405 ± 0.052	8.016LeuGly: 8.016 ± 0.08	2.26LeuHis: 2.26 ± 0.035	4.405LeuIle: 4.405 ± 0.058	3.066LeuLys: 3.066 ± 0.045	9.554LeuLeu: 9.554 ± 0.097	2.202LeuMet: 2.202 ± 0.034	2.607LeuAsn: 2.607 ± 0.044	5.767LeuPro: 5.767 ± 0.072	3.25LeuGln: 3.25 ± 0.042	7.322LeuArg: 7.322 ± 0.083	6.314LeuSer: 6.314 ± 0.057	5.699LeuThr: 5.699 ± 0.078	7.519LeuVal: 7.519 ± 0.081	1.111LeuTrp: 1.111 ± 0.028	2.175LeuTyr: 2.175 ± 0.041	0.0LeuXaa: 0.0 ± 0.0
Met	2.438MetAla: 2.438 ± 0.038	0.179MetCys: 0.179 ± 0.01	0.933MetAsp: 0.933 ± 0.023	0.901MetGlu: 0.901 ± 0.023	0.709MetPhe: 0.709 ± 0.02	1.526MetGly: 1.526 ± 0.033	0.576MetHis: 0.576 ± 0.019	1.042MetIle: 1.042 ± 0.027	0.963MetLys: 0.963 ± 0.025	2.585MetLeu: 2.585 ± 0.038	0.562MetMet: 0.562 ± 0.019	0.844MetAsn: 0.844 ± 0.02	1.492MetPro: 1.492 ± 0.03	1.051MetGln: 1.051 ± 0.023	1.907MetArg: 1.907 ± 0.036	1.729MetSer: 1.729 ± 0.031	1.645MetThr: 1.645 ± 0.031	1.343MetVal: 1.343 ± 0.03	0.218MetTrp: 0.218 ± 0.011	0.35MetTyr: 0.35 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	3.61AsnAla: 3.61 ± 0.057	0.249AsnCys: 0.249 ± 0.014	1.436AsnAsp: 1.436 ± 0.037	1.365AsnGlu: 1.365 ± 0.028	0.918AsnPhe: 0.918 ± 0.026	2.524AsnGly: 2.524 ± 0.059	0.519AsnHis: 0.519 ± 0.019	1.142AsnIle: 1.142 ± 0.027	0.634AsnLys: 0.634 ± 0.021	2.547AsnLeu: 2.547 ± 0.044	0.535AsnMet: 0.535 ± 0.017	0.761AsnAsn: 0.761 ± 0.025	1.671AsnPro: 1.671 ± 0.029	0.875AsnGln: 0.875 ± 0.023	1.794AsnArg: 1.794 ± 0.029	1.237AsnSer: 1.237 ± 0.032	1.386AsnThr: 1.386 ± 0.036	2.226AsnVal: 2.226 ± 0.044	0.419AsnTrp: 0.419 ± 0.014	0.689AsnTyr: 0.689 ± 0.02	0.0AsnXaa: 0.0 ± 0.0
Pro	6.525ProAla: 6.525 ± 0.075	0.385ProCys: 0.385 ± 0.016	3.168ProAsp: 3.168 ± 0.045	2.898ProGlu: 2.898 ± 0.047	1.958ProPhe: 1.958 ± 0.035	4.266ProGly: 4.266 ± 0.058	1.358ProHis: 1.358 ± 0.032	2.221ProIle: 2.221 ± 0.033	1.396ProLys: 1.396 ± 0.031	5.14ProLeu: 5.14 ± 0.061	1.126ProMet: 1.126 ± 0.026	1.405ProAsn: 1.405 ± 0.031	2.532ProPro: 2.532 ± 0.055	1.888ProGln: 1.888 ± 0.038	3.089ProArg: 3.089 ± 0.048	3.163ProSer: 3.163 ± 0.039	2.747ProThr: 2.747 ± 0.039	4.028ProVal: 4.028 ± 0.052	0.664ProTrp: 0.664 ± 0.021	1.283ProTyr: 1.283 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	4.951GlnAla: 4.951 ± 0.063	0.304GlnCys: 0.304 ± 0.013	1.367GlnAsp: 1.367 ± 0.03	1.412GlnGlu: 1.412 ± 0.031	1.284GlnPhe: 1.284 ± 0.029	2.43GlnGly: 2.43 ± 0.034	0.897GlnHis: 0.897 ± 0.021	1.879GlnIle: 1.879 ± 0.033	0.986GlnLys: 0.986 ± 0.026	3.757GlnLeu: 3.757 ± 0.05	0.984GlnMet: 0.984 ± 0.026	0.909GlnAsn: 0.909 ± 0.027	1.974GlnPro: 1.974 ± 0.038	1.747GlnGln: 1.747 ± 0.043	2.966GlnArg: 2.966 ± 0.044	2.156GlnSer: 2.156 ± 0.034	2.099GlnThr: 2.099 ± 0.037	2.425GlnVal: 2.425 ± 0.038	0.604GlnTrp: 0.604 ± 0.021	0.923GlnTyr: 0.923 ± 0.027	0.0GlnXaa: 0.0 ± 0.0
Arg	8.889ArgAla: 8.889 ± 0.092	0.676ArgCys: 0.676 ± 0.023	3.811ArgAsp: 3.811 ± 0.055	4.558ArgGlu: 4.558 ± 0.056	3.166ArgPhe: 3.166 ± 0.044	4.722ArgGly: 4.722 ± 0.055	1.924ArgHis: 1.924 ± 0.036	3.824ArgIle: 3.824 ± 0.054	2.024ArgLys: 2.024 ± 0.038	7.709ArgLeu: 7.709 ± 0.085	1.898ArgMet: 1.898 ± 0.031	1.87ArgAsn: 1.87 ± 0.032	3.211ArgPro: 3.211 ± 0.045	2.584ArgGln: 2.584 ± 0.043	5.754ArgArg: 5.754 ± 0.074	3.684ArgSer: 3.684 ± 0.046	3.681ArgThr: 3.681 ± 0.051	5.363ArgVal: 5.363 ± 0.06	1.11ArgTrp: 1.11 ± 0.027	2.184ArgTyr: 2.184 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	7.186SerAla: 7.186 ± 0.082	0.473SerCys: 0.473 ± 0.014	2.89SerAsp: 2.89 ± 0.046	2.719SerGlu: 2.719 ± 0.039	2.13SerPhe: 2.13 ± 0.038	5.366SerGly: 5.366 ± 0.08	1.261SerHis: 1.261 ± 0.026	2.757SerIle: 2.757 ± 0.033	1.596SerLys: 1.596 ± 0.033	5.87SerLeu: 5.87 ± 0.06	1.407SerMet: 1.407 ± 0.027	1.649SerAsn: 1.649 ± 0.038	3.036SerPro: 3.036 ± 0.043	1.866SerGln: 1.866 ± 0.039	3.729SerArg: 3.729 ± 0.052	3.483SerSer: 3.483 ± 0.056	3.286SerThr: 3.286 ± 0.055	4.357SerVal: 4.357 ± 0.052	0.696SerTrp: 0.696 ± 0.02	1.362SerTyr: 1.362 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	6.173ThrAla: 6.173 ± 0.083	0.449ThrCys: 0.449 ± 0.018	2.662ThrAsp: 2.662 ± 0.047	2.283ThrGlu: 2.283 ± 0.034	2.038ThrPhe: 2.038 ± 0.038	4.767ThrGly: 4.767 ± 0.071	1.303ThrHis: 1.303 ± 0.033	2.687ThrIle: 2.687 ± 0.049	1.329ThrLys: 1.329 ± 0.032	6.419ThrLeu: 6.419 ± 0.087	1.175ThrMet: 1.175 ± 0.027	1.45ThrAsn: 1.45 ± 0.036	3.429ThrPro: 3.429 ± 0.052	2.035ThrGln: 2.035 ± 0.035	3.669ThrArg: 3.669 ± 0.039	3.106ThrSer: 3.106 ± 0.051	3.02ThrThr: 3.02 ± 0.054	4.294ThrVal: 4.294 ± 0.058	0.655ThrTrp: 0.655 ± 0.02	1.275ThrTyr: 1.275 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	9.779ValAla: 9.779 ± 0.084	0.822ValCys: 0.822 ± 0.023	4.41ValAsp: 4.41 ± 0.052	4.178ValGlu: 4.178 ± 0.053	2.786ValPhe: 2.786 ± 0.042	5.701ValGly: 5.701 ± 0.061	1.513ValHis: 1.513 ± 0.029	3.475ValIle: 3.475 ± 0.049	2.441ValLys: 2.441 ± 0.05	7.752ValLeu: 7.752 ± 0.068	1.787ValMet: 1.787 ± 0.039	2.032ValAsn: 2.032 ± 0.043	3.944ValPro: 3.944 ± 0.057	2.463ValGln: 2.463 ± 0.037	5.422ValArg: 5.422 ± 0.061	4.704ValSer: 4.704 ± 0.059	4.525ValThr: 4.525 ± 0.056	6.322ValVal: 6.322 ± 0.072	0.927ValTrp: 0.927 ± 0.025	1.644ValTyr: 1.644 ± 0.03	0.0ValXaa: 0.0 ± 0.0
Trp	1.184TrpAla: 1.184 ± 0.031	0.15TrpCys: 0.15 ± 0.01	0.605TrpAsp: 0.605 ± 0.018	0.514TrpGlu: 0.514 ± 0.018	0.541TrpPhe: 0.541 ± 0.019	0.847TrpGly: 0.847 ± 0.025	0.405TrpHis: 0.405 ± 0.015	0.68TrpIle: 0.68 ± 0.022	0.408TrpLys: 0.408 ± 0.017	1.888TrpLeu: 1.888 ± 0.041	0.349TrpMet: 0.349 ± 0.016	0.449TrpAsn: 0.449 ± 0.016	0.69TrpPro: 0.69 ± 0.022	0.653TrpGln: 0.653 ± 0.022	1.291TrpArg: 1.291 ± 0.031	0.762TrpSer: 0.762 ± 0.021	0.677TrpThr: 0.677 ± 0.02	0.884TrpVal: 0.884 ± 0.021	0.239TrpTrp: 0.239 ± 0.014	0.306TrpTyr: 0.306 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.87TyrAla: 2.87 ± 0.047	0.28TyrCys: 0.28 ± 0.011	1.417TyrAsp: 1.417 ± 0.036	1.293TyrGlu: 1.293 ± 0.031	1.039TyrPhe: 1.039 ± 0.023	2.208TyrGly: 2.208 ± 0.036	0.525TyrHis: 0.525 ± 0.02	0.825TyrIle: 0.825 ± 0.024	0.611TyrLys: 0.611 ± 0.02	2.493TyrLeu: 2.493 ± 0.039	0.436TyrMet: 0.436 ± 0.017	0.615TyrAsn: 0.615 ± 0.02	1.229TyrPro: 1.229 ± 0.033	0.861TyrGln: 0.861 ± 0.022	2.043TyrArg: 2.043 ± 0.036	1.279TyrSer: 1.279 ± 0.025	1.247TyrThr: 1.247 ± 0.024	1.99TyrVal: 1.99 ± 0.032	0.36TyrTrp: 0.36 ± 0.015	0.692TyrTyr: 0.692 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5348 proteins (1751137 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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