Amino acid dipepetide frequency for Sporolactobacillus shoreae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.991AlaAla: 6.991 ± 0.101	0.677AlaCys: 0.677 ± 0.028	4.154AlaAsp: 4.154 ± 0.065	4.747AlaGlu: 4.747 ± 0.091	3.612AlaPhe: 3.612 ± 0.066	6.062AlaGly: 6.062 ± 0.09	1.525AlaHis: 1.525 ± 0.042	5.539AlaIle: 5.539 ± 0.08	4.235AlaLys: 4.235 ± 0.069	8.061AlaLeu: 8.061 ± 0.103	1.957AlaMet: 1.957 ± 0.049	2.517AlaAsn: 2.517 ± 0.051	2.317AlaPro: 2.317 ± 0.055	2.619AlaGln: 2.619 ± 0.052	3.362AlaArg: 3.362 ± 0.068	4.519AlaSer: 4.519 ± 0.063	3.408AlaThr: 3.408 ± 0.064	5.872AlaVal: 5.872 ± 0.079	0.721AlaTrp: 0.721 ± 0.031	2.466AlaTyr: 2.466 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	0.609CysAla: 0.609 ± 0.027	0.107CysCys: 0.107 ± 0.011	0.443CysAsp: 0.443 ± 0.023	0.393CysGlu: 0.393 ± 0.02	0.408CysPhe: 0.408 ± 0.02	0.871CysGly: 0.871 ± 0.034	0.228CysHis: 0.228 ± 0.015	0.523CysIle: 0.523 ± 0.023	0.312CysLys: 0.312 ± 0.017	0.846CysLeu: 0.846 ± 0.033	0.216CysMet: 0.216 ± 0.015	0.246CysAsn: 0.246 ± 0.016	0.42CysPro: 0.42 ± 0.025	0.243CysGln: 0.243 ± 0.016	0.46CysArg: 0.46 ± 0.023	0.613CysSer: 0.613 ± 0.026	0.453CysThr: 0.453 ± 0.02	0.506CysVal: 0.506 ± 0.025	0.094CysTrp: 0.094 ± 0.011	0.297CysTyr: 0.297 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	3.719AspAla: 3.719 ± 0.065	0.439AspCys: 0.439 ± 0.023	2.638AspAsp: 2.638 ± 0.059	3.872AspGlu: 3.872 ± 0.068	2.506AspPhe: 2.506 ± 0.048	3.512AspGly: 3.512 ± 0.059	1.486AspHis: 1.486 ± 0.035	3.476AspIle: 3.476 ± 0.059	2.9AspLys: 2.9 ± 0.058	5.559AspLeu: 5.559 ± 0.078	1.243AspMet: 1.243 ± 0.034	1.624AspAsn: 1.624 ± 0.041	2.395AspPro: 2.395 ± 0.056	2.667AspGln: 2.667 ± 0.058	3.064AspArg: 3.064 ± 0.063	2.913AspSer: 2.913 ± 0.057	2.479AspThr: 2.479 ± 0.053	3.606AspVal: 3.606 ± 0.065	0.659AspTrp: 0.659 ± 0.024	2.23AspTyr: 2.23 ± 0.047	0.0AspXaa: 0.0 ± 0.0
Glu	4.802GluAla: 4.802 ± 0.076	0.407GluCys: 0.407 ± 0.022	2.959GluAsp: 2.959 ± 0.061	4.532GluGlu: 4.532 ± 0.074	1.965GluPhe: 1.965 ± 0.048	3.574GluGly: 3.574 ± 0.067	1.327GluHis: 1.327 ± 0.034	4.249GluIle: 4.249 ± 0.076	5.752GluLys: 5.752 ± 0.085	5.766GluLeu: 5.766 ± 0.085	1.853GluMet: 1.853 ± 0.044	3.164GluAsn: 3.164 ± 0.061	1.958GluPro: 1.958 ± 0.043	2.629GluGln: 2.629 ± 0.055	3.306GluArg: 3.306 ± 0.062	3.512GluSer: 3.512 ± 0.055	3.483GluThr: 3.483 ± 0.057	3.605GluVal: 3.605 ± 0.062	0.748GluTrp: 0.748 ± 0.029	1.59GluTyr: 1.59 ± 0.041	0.0GluXaa: 0.0 ± 0.0
Phe	3.088PheAla: 3.088 ± 0.064	0.453PheCys: 0.453 ± 0.02	2.595PheAsp: 2.595 ± 0.059	2.338PheGlu: 2.338 ± 0.052	2.57PhePhe: 2.57 ± 0.062	3.418PheGly: 3.418 ± 0.06	1.114PheHis: 1.114 ± 0.037	3.534PheIle: 3.534 ± 0.066	2.251PheLys: 2.251 ± 0.056	4.778PheLeu: 4.778 ± 0.089	1.096PheMet: 1.096 ± 0.036	1.849PheAsn: 1.849 ± 0.043	1.738PhePro: 1.738 ± 0.042	1.634PheGln: 1.634 ± 0.042	1.948PheArg: 1.948 ± 0.045	3.856PheSer: 3.856 ± 0.073	2.354PheThr: 2.354 ± 0.048	2.986PheVal: 2.986 ± 0.064	0.52PheTrp: 0.52 ± 0.024	1.824PheTyr: 1.824 ± 0.046	0.0PheXaa: 0.0 ± 0.0
Gly	5.043GlyAla: 5.043 ± 0.092	0.681GlyCys: 0.681 ± 0.03	3.206GlyAsp: 3.206 ± 0.066	3.886GlyGlu: 3.886 ± 0.067	3.484GlyPhe: 3.484 ± 0.064	4.921GlyGly: 4.921 ± 0.088	1.591GlyHis: 1.591 ± 0.041	5.818GlyIle: 5.818 ± 0.084	5.065GlyLys: 5.065 ± 0.064	7.105GlyLeu: 7.105 ± 0.093	2.103GlyMet: 2.103 ± 0.045	2.736GlyAsn: 2.736 ± 0.053	1.779GlyPro: 1.779 ± 0.037	2.605GlyGln: 2.605 ± 0.048	3.336GlyArg: 3.336 ± 0.063	4.645GlySer: 4.645 ± 0.07	4.263GlyThr: 4.263 ± 0.069	4.719GlyVal: 4.719 ± 0.074	0.91GlyTrp: 0.91 ± 0.032	2.859GlyTyr: 2.859 ± 0.059	0.0GlyXaa: 0.0 ± 0.0
His	1.515HisAla: 1.515 ± 0.039	0.241HisCys: 0.241 ± 0.016	1.091HisAsp: 1.091 ± 0.028	1.287HisGlu: 1.287 ± 0.036	1.27HisPhe: 1.27 ± 0.037	1.499HisGly: 1.499 ± 0.044	0.737HisHis: 0.737 ± 0.033	1.457HisIle: 1.457 ± 0.04	0.962HisLys: 0.962 ± 0.03	2.425HisLeu: 2.425 ± 0.058	0.544HisMet: 0.544 ± 0.022	0.681HisAsn: 0.681 ± 0.023	1.276HisPro: 1.276 ± 0.037	0.983HisGln: 0.983 ± 0.032	1.117HisArg: 1.117 ± 0.034	1.35HisSer: 1.35 ± 0.039	0.973HisThr: 0.973 ± 0.028	1.526HisVal: 1.526 ± 0.039	0.258HisTrp: 0.258 ± 0.018	0.964HisTyr: 0.964 ± 0.034	0.0HisXaa: 0.0 ± 0.0
Ile	5.963IleAla: 5.963 ± 0.08	0.744IleCys: 0.744 ± 0.029	4.227IleAsp: 4.227 ± 0.07	4.327IleGlu: 4.327 ± 0.076	3.26IlePhe: 3.26 ± 0.071	5.833IleGly: 5.833 ± 0.097	1.716IleHis: 1.716 ± 0.043	5.18IleIle: 5.18 ± 0.081	4.011IleLys: 4.011 ± 0.065	7.081IleLeu: 7.081 ± 0.083	1.631IleMet: 1.631 ± 0.046	3.103IleAsn: 3.103 ± 0.066	3.18IlePro: 3.18 ± 0.062	2.543IleGln: 2.543 ± 0.062	3.978IleArg: 3.978 ± 0.067	5.101IleSer: 5.101 ± 0.07	3.783IleThr: 3.783 ± 0.058	5.277IleVal: 5.277 ± 0.085	0.674IleTrp: 0.674 ± 0.031	2.439IleTyr: 2.439 ± 0.046	0.0IleXaa: 0.0 ± 0.0
Lys	4.619LysAla: 4.619 ± 0.066	0.362LysCys: 0.362 ± 0.02	3.295LysAsp: 3.295 ± 0.057	4.643LysGlu: 4.643 ± 0.07	1.805LysPhe: 1.805 ± 0.037	3.938LysGly: 3.938 ± 0.073	1.125LysHis: 1.125 ± 0.035	4.737LysIle: 4.737 ± 0.074	5.885LysLys: 5.885 ± 0.072	5.483LysLeu: 5.483 ± 0.07	2.099LysMet: 2.099 ± 0.043	3.427LysAsn: 3.427 ± 0.064	2.123LysPro: 2.123 ± 0.05	2.681LysGln: 2.681 ± 0.049	3.249LysArg: 3.249 ± 0.06	3.631LysSer: 3.631 ± 0.061	3.627LysThr: 3.627 ± 0.067	4.05LysVal: 4.05 ± 0.068	0.737LysTrp: 0.737 ± 0.029	2.098LysTyr: 2.098 ± 0.049	0.0LysXaa: 0.0 ± 0.0
Leu	7.859LeuAla: 7.859 ± 0.109	0.87LeuCys: 0.87 ± 0.03	5.189LeuAsp: 5.189 ± 0.07	5.447LeuGlu: 5.447 ± 0.085	5.16LeuPhe: 5.16 ± 0.098	6.459LeuGly: 6.459 ± 0.09	1.982LeuHis: 1.982 ± 0.045	8.204LeuIle: 8.204 ± 0.11	6.606LeuLys: 6.606 ± 0.092	10.192LeuLeu: 10.192 ± 0.14	2.647LeuMet: 2.647 ± 0.047	4.601LeuAsn: 4.601 ± 0.076	4.177LeuPro: 4.177 ± 0.063	3.276LeuGln: 3.276 ± 0.062	4.357LeuArg: 4.357 ± 0.067	7.721LeuSer: 7.721 ± 0.096	5.875LeuThr: 5.875 ± 0.075	6.232LeuVal: 6.232 ± 0.072	0.913LeuTrp: 0.913 ± 0.033	3.048LeuTyr: 3.048 ± 0.054	0.0LeuXaa: 0.0 ± 0.0
Met	2.253MetAla: 2.253 ± 0.053	0.157MetCys: 0.157 ± 0.012	1.526MetAsp: 1.526 ± 0.038	1.472MetGlu: 1.472 ± 0.037	0.964MetPhe: 0.964 ± 0.033	1.69MetGly: 1.69 ± 0.045	0.474MetHis: 0.474 ± 0.022	2.314MetIle: 2.314 ± 0.047	2.096MetLys: 2.096 ± 0.043	2.416MetLeu: 2.416 ± 0.047	0.831MetMet: 0.831 ± 0.034	1.442MetAsn: 1.442 ± 0.039	1.114MetPro: 1.114 ± 0.033	0.857MetGln: 0.857 ± 0.028	1.278MetArg: 1.278 ± 0.031	1.641MetSer: 1.641 ± 0.044	1.731MetThr: 1.731 ± 0.044	1.62MetVal: 1.62 ± 0.04	0.179MetTrp: 0.179 ± 0.013	0.618MetTyr: 0.618 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	2.816AsnAla: 2.816 ± 0.052	0.28AsnCys: 0.28 ± 0.017	2.165AsnAsp: 2.165 ± 0.053	2.562AsnGlu: 2.562 ± 0.05	1.701AsnPhe: 1.701 ± 0.04	3.304AsnGly: 3.304 ± 0.064	1.162AsnHis: 1.162 ± 0.038	2.821AsnIle: 2.821 ± 0.054	2.441AsnLys: 2.441 ± 0.058	3.812AsnLeu: 3.812 ± 0.066	1.067AsnMet: 1.067 ± 0.03	1.726AsnAsn: 1.726 ± 0.051	2.103AsnPro: 2.103 ± 0.05	2.076AsnGln: 2.076 ± 0.053	2.145AsnArg: 2.145 ± 0.043	2.351AsnSer: 2.351 ± 0.064	1.985AsnThr: 1.985 ± 0.047	2.821AsnVal: 2.821 ± 0.054	0.523AsnTrp: 0.523 ± 0.023	1.604AsnTyr: 1.604 ± 0.046	0.0AsnXaa: 0.0 ± 0.0
Pro	2.905ProAla: 2.905 ± 0.057	0.241ProCys: 0.241 ± 0.015	2.598ProAsp: 2.598 ± 0.047	3.224ProGlu: 3.224 ± 0.06	2.082ProPhe: 2.082 ± 0.046	2.603ProGly: 2.603 ± 0.055	0.76ProHis: 0.76 ± 0.025	2.549ProIle: 2.549 ± 0.055	2.088ProLys: 2.088 ± 0.048	3.694ProLeu: 3.694 ± 0.065	0.848ProMet: 0.848 ± 0.027	1.415ProAsn: 1.415 ± 0.038	1.012ProPro: 1.012 ± 0.034	1.213ProGln: 1.213 ± 0.037	1.301ProArg: 1.301 ± 0.034	2.471ProSer: 2.471 ± 0.056	1.825ProThr: 1.825 ± 0.049	3.329ProVal: 3.329 ± 0.057	0.386ProTrp: 0.386 ± 0.021	1.401ProTyr: 1.401 ± 0.046	0.0ProXaa: 0.0 ± 0.0
Gln	3.17GlnAla: 3.17 ± 0.062	0.227GlnCys: 0.227 ± 0.014	1.624GlnAsp: 1.624 ± 0.046	2.074GlnGlu: 2.074 ± 0.056	1.57GlnPhe: 1.57 ± 0.036	2.24GlnGly: 2.24 ± 0.047	0.685GlnHis: 0.685 ± 0.026	2.884GlnIle: 2.884 ± 0.066	2.84GlnLys: 2.84 ± 0.052	4.166GlnLeu: 4.166 ± 0.068	1.296GlnMet: 1.296 ± 0.036	1.776GlnAsn: 1.776 ± 0.042	1.429GlnPro: 1.429 ± 0.037	1.641GlnGln: 1.641 ± 0.049	1.632GlnArg: 1.632 ± 0.042	2.628GlnSer: 2.628 ± 0.053	2.221GlnThr: 2.221 ± 0.051	2.432GlnVal: 2.432 ± 0.051	0.432GlnTrp: 0.432 ± 0.023	1.186GlnTyr: 1.186 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	3.147ArgAla: 3.147 ± 0.065	0.343ArgCys: 0.343 ± 0.019	2.519ArgAsp: 2.519 ± 0.048	3.268ArgGlu: 3.268 ± 0.062	2.207ArgPhe: 2.207 ± 0.046	2.68ArgGly: 2.68 ± 0.049	1.06ArgHis: 1.06 ± 0.033	3.695ArgIle: 3.695 ± 0.068	3.423ArgLys: 3.423 ± 0.063	5.102ArgLeu: 5.102 ± 0.08	1.481ArgMet: 1.481 ± 0.042	2.039ArgAsn: 2.039 ± 0.048	1.695ArgPro: 1.695 ± 0.044	2.165ArgGln: 2.165 ± 0.049	2.847ArgArg: 2.847 ± 0.059	2.838ArgSer: 2.838 ± 0.051	2.674ArgThr: 2.674 ± 0.05	2.926ArgVal: 2.926 ± 0.057	0.498ArgTrp: 0.498 ± 0.022	1.737ArgTyr: 1.737 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	4.69SerAla: 4.69 ± 0.066	0.501SerCys: 0.501 ± 0.025	3.764SerAsp: 3.764 ± 0.076	4.113SerGlu: 4.113 ± 0.069	3.295SerPhe: 3.295 ± 0.06	5.792SerGly: 5.792 ± 0.087	1.377SerHis: 1.377 ± 0.041	4.635SerIle: 4.635 ± 0.065	3.524SerLys: 3.524 ± 0.063	6.675SerLeu: 6.675 ± 0.089	1.696SerMet: 1.696 ± 0.048	2.318SerAsn: 2.318 ± 0.054	2.275SerPro: 2.275 ± 0.06	2.274SerGln: 2.274 ± 0.055	3.075SerArg: 3.075 ± 0.062	4.433SerSer: 4.433 ± 0.1	3.155SerThr: 3.155 ± 0.061	4.899SerVal: 4.899 ± 0.065	0.711SerTrp: 0.711 ± 0.026	2.262SerTyr: 2.262 ± 0.048	0.0SerXaa: 0.0 ± 0.0
Thr	4.284ThrAla: 4.284 ± 0.065	0.441ThrCys: 0.441 ± 0.02	3.025ThrAsp: 3.025 ± 0.05	3.084ThrGlu: 3.084 ± 0.046	2.551ThrPhe: 2.551 ± 0.057	4.653ThrGly: 4.653 ± 0.082	1.114ThrHis: 1.114 ± 0.031	3.959ThrIle: 3.959 ± 0.056	2.775ThrLys: 2.775 ± 0.059	5.718ThrLeu: 5.718 ± 0.089	1.269ThrMet: 1.269 ± 0.033	2.001ThrAsn: 2.001 ± 0.051	2.219ThrPro: 2.219 ± 0.046	1.635ThrGln: 1.635 ± 0.04	2.117ThrArg: 2.117 ± 0.044	3.259ThrSer: 3.259 ± 0.063	2.706ThrThr: 2.706 ± 0.058	4.486ThrVal: 4.486 ± 0.073	0.519ThrTrp: 0.519 ± 0.025	1.773ThrTyr: 1.773 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	5.011ValAla: 5.011 ± 0.075	0.691ValCys: 0.691 ± 0.028	3.568ValAsp: 3.568 ± 0.071	3.522ValGlu: 3.522 ± 0.067	3.123ValPhe: 3.123 ± 0.059	4.434ValGly: 4.434 ± 0.07	1.478ValHis: 1.478 ± 0.042	5.4ValIle: 5.4 ± 0.081	3.934ValLys: 3.934 ± 0.066	6.989ValLeu: 6.989 ± 0.09	1.705ValMet: 1.705 ± 0.047	2.928ValAsn: 2.928 ± 0.053	2.916ValPro: 2.916 ± 0.059	2.334ValGln: 2.334 ± 0.048	3.404ValArg: 3.404 ± 0.062	5.112ValSer: 5.112 ± 0.082	4.229ValThr: 4.229 ± 0.076	4.525ValVal: 4.525 ± 0.083	0.681ValTrp: 0.681 ± 0.029	2.176ValTyr: 2.176 ± 0.049	0.0ValXaa: 0.0 ± 0.0
Trp	0.678TrpAla: 0.678 ± 0.028	0.08TrpCys: 0.08 ± 0.009	0.518TrpAsp: 0.518 ± 0.022	0.536TrpGlu: 0.536 ± 0.024	0.531TrpPhe: 0.531 ± 0.02	0.73TrpGly: 0.73 ± 0.027	0.246TrpHis: 0.246 ± 0.016	0.903TrpIle: 0.903 ± 0.033	0.723TrpLys: 0.723 ± 0.03	1.247TrpLeu: 1.247 ± 0.034	0.337TrpMet: 0.337 ± 0.018	0.558TrpAsn: 0.558 ± 0.023	0.333TrpPro: 0.333 ± 0.018	0.417TrpGln: 0.417 ± 0.02	0.542TrpArg: 0.542 ± 0.023	0.653TrpSer: 0.653 ± 0.03	0.571TrpThr: 0.571 ± 0.024	0.636TrpVal: 0.636 ± 0.026	0.155TrpTrp: 0.155 ± 0.012	0.368TrpTyr: 0.368 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.197TyrAla: 2.197 ± 0.051	0.345TyrCys: 0.345 ± 0.018	1.881TyrAsp: 1.881 ± 0.047	1.856TyrGlu: 1.856 ± 0.041	1.88TyrPhe: 1.88 ± 0.044	2.542TyrGly: 2.542 ± 0.052	0.967TyrHis: 0.967 ± 0.033	2.174TyrIle: 2.174 ± 0.046	1.79TyrLys: 1.79 ± 0.042	3.701TyrLeu: 3.701 ± 0.064	0.755TyrMet: 0.755 ± 0.027	1.316TyrAsn: 1.316 ± 0.041	1.489TyrPro: 1.489 ± 0.039	1.659TyrGln: 1.659 ± 0.043	1.825TyrArg: 1.825 ± 0.041	2.22TyrSer: 2.22 ± 0.047	1.793TyrThr: 1.793 ± 0.044	2.109TyrVal: 2.109 ± 0.045	0.443TyrTrp: 0.443 ± 0.019	1.347TyrTyr: 1.347 ± 0.048	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3461 proteins (1011389 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---