Amino acid dipepetide frequency for Ruminiclostridium cellulolyticum (strain ATCC 35319 / DSM 5812 / JCM 6584 / H10) (Clostridium cellulolyticum)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.274AlaAla: 5.274 ± 0.097	0.8AlaCys: 0.8 ± 0.031	3.649AlaAsp: 3.649 ± 0.054	4.179AlaGlu: 4.179 ± 0.07	2.678AlaPhe: 2.678 ± 0.05	5.103AlaGly: 5.103 ± 0.09	0.846AlaHis: 0.846 ± 0.026	5.189AlaIle: 5.189 ± 0.084	4.611AlaLys: 4.611 ± 0.073	5.715AlaLeu: 5.715 ± 0.082	1.731AlaMet: 1.731 ± 0.04	2.922AlaAsn: 2.922 ± 0.057	1.729AlaPro: 1.729 ± 0.046	1.911AlaGln: 1.911 ± 0.039	2.368AlaArg: 2.368 ± 0.045	3.895AlaSer: 3.895 ± 0.069	3.092AlaThr: 3.092 ± 0.11	5.431AlaVal: 5.431 ± 0.074	0.534AlaTrp: 0.534 ± 0.021	2.374AlaTyr: 2.374 ± 0.044	0.0AlaXaa: 0.0 ± 0.0
Cys	0.727CysAla: 0.727 ± 0.027	0.217CysCys: 0.217 ± 0.016	0.68CysAsp: 0.68 ± 0.024	0.73CysGlu: 0.73 ± 0.025	0.535CysPhe: 0.535 ± 0.02	1.113CysGly: 1.113 ± 0.031	0.222CysHis: 0.222 ± 0.014	1.098CysIle: 1.098 ± 0.034	0.837CysLys: 0.837 ± 0.028	0.977CysLeu: 0.977 ± 0.029	0.358CysMet: 0.358 ± 0.021	0.687CysAsn: 0.687 ± 0.025	0.491CysPro: 0.491 ± 0.021	0.294CysGln: 0.294 ± 0.017	0.534CysArg: 0.534 ± 0.025	0.915CysSer: 0.915 ± 0.031	0.631CysThr: 0.631 ± 0.027	0.723CysVal: 0.723 ± 0.024	0.134CysTrp: 0.134 ± 0.012	0.452CysTyr: 0.452 ± 0.022	0.0CysXaa: 0.0 ± 0.0
Asp	3.281AspAla: 3.281 ± 0.062	0.7AspCys: 0.7 ± 0.025	2.601AspAsp: 2.601 ± 0.06	3.986AspGlu: 3.986 ± 0.072	2.749AspPhe: 2.749 ± 0.052	3.992AspGly: 3.992 ± 0.077	0.651AspHis: 0.651 ± 0.024	5.853AspIle: 5.853 ± 0.084	4.521AspLys: 4.521 ± 0.063	4.422AspLeu: 4.422 ± 0.065	1.554AspMet: 1.554 ± 0.038	3.113AspAsn: 3.113 ± 0.053	1.694AspPro: 1.694 ± 0.049	1.03AspGln: 1.03 ± 0.029	2.092AspArg: 2.092 ± 0.045	3.811AspSer: 3.811 ± 0.062	3.069AspThr: 3.069 ± 0.062	3.538AspVal: 3.538 ± 0.054	0.62AspTrp: 0.62 ± 0.023	2.602AspTyr: 2.602 ± 0.049	0.0AspXaa: 0.0 ± 0.0
Glu	4.282GluAla: 4.282 ± 0.073	0.735GluCys: 0.735 ± 0.025	3.377GluAsp: 3.377 ± 0.062	4.751GluGlu: 4.751 ± 0.084	2.663GluPhe: 2.663 ± 0.047	3.733GluGly: 3.733 ± 0.057	1.025GluHis: 1.025 ± 0.036	6.133GluIle: 6.133 ± 0.081	6.169GluLys: 6.169 ± 0.086	6.312GluLeu: 6.312 ± 0.083	1.879GluMet: 1.879 ± 0.038	4.411GluAsn: 4.411 ± 0.07	1.634GluPro: 1.634 ± 0.039	2.317GluGln: 2.317 ± 0.053	2.621GluArg: 2.621 ± 0.052	3.513GluSer: 3.513 ± 0.063	3.209GluThr: 3.209 ± 0.052	4.216GluVal: 4.216 ± 0.073	0.561GluTrp: 0.561 ± 0.024	2.903GluTyr: 2.903 ± 0.06	0.0GluXaa: 0.0 ± 0.0
Phe	2.565PheAla: 2.565 ± 0.051	0.601PheCys: 0.601 ± 0.023	2.728PheAsp: 2.728 ± 0.055	2.808PheGlu: 2.808 ± 0.053	1.904PhePhe: 1.904 ± 0.048	2.932PheGly: 2.932 ± 0.058	0.561PheHis: 0.561 ± 0.025	3.677PheIle: 3.677 ± 0.062	3.235PheLys: 3.235 ± 0.062	3.503PheLeu: 3.503 ± 0.07	1.039PheMet: 1.039 ± 0.035	2.362PheAsn: 2.362 ± 0.054	1.322PhePro: 1.322 ± 0.036	1.009PheGln: 1.009 ± 0.029	1.504PheArg: 1.504 ± 0.04	3.308PheSer: 3.308 ± 0.053	2.553PheThr: 2.553 ± 0.055	2.627PheVal: 2.627 ± 0.052	0.364PheTrp: 0.364 ± 0.017	1.74PheTyr: 1.74 ± 0.041	0.0PheXaa: 0.0 ± 0.0
Gly	4.178GlyAla: 4.178 ± 0.073	0.93GlyCys: 0.93 ± 0.033	3.655GlyAsp: 3.655 ± 0.072	4.096GlyGlu: 4.096 ± 0.064	3.203GlyPhe: 3.203 ± 0.051	4.81GlyGly: 4.81 ± 0.092	1.06GlyHis: 1.06 ± 0.028	6.466GlyIle: 6.466 ± 0.081	5.516GlyLys: 5.516 ± 0.071	5.777GlyLeu: 5.777 ± 0.087	1.968GlyMet: 1.968 ± 0.046	3.685GlyAsn: 3.685 ± 0.075	1.378GlyPro: 1.378 ± 0.036	1.984GlyGln: 1.984 ± 0.046	2.676GlyArg: 2.676 ± 0.051	4.369GlySer: 4.369 ± 0.084	4.387GlyThr: 4.387 ± 0.096	4.775GlyVal: 4.775 ± 0.07	0.69GlyTrp: 0.69 ± 0.027	3.122GlyTyr: 3.122 ± 0.061	0.0GlyXaa: 0.0 ± 0.0
His	0.755HisAla: 0.755 ± 0.026	0.239HisCys: 0.239 ± 0.013	0.775HisAsp: 0.775 ± 0.025	0.864HisGlu: 0.864 ± 0.031	0.657HisPhe: 0.657 ± 0.024	1.091HisGly: 1.091 ± 0.031	0.313HisHis: 0.313 ± 0.02	1.292HisIle: 1.292 ± 0.035	1.016HisLys: 1.016 ± 0.027	1.248HisLeu: 1.248 ± 0.035	0.379HisMet: 0.379 ± 0.017	0.766HisAsn: 0.766 ± 0.028	0.733HisPro: 0.733 ± 0.028	0.424HisGln: 0.424 ± 0.019	0.631HisArg: 0.631 ± 0.026	0.923HisSer: 0.923 ± 0.03	0.773HisThr: 0.773 ± 0.029	0.837HisVal: 0.837 ± 0.023	0.156HisTrp: 0.156 ± 0.011	0.602HisTyr: 0.602 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	5.491IleAla: 5.491 ± 0.073	1.175IleCys: 1.175 ± 0.032	5.294IleAsp: 5.294 ± 0.065	5.618IleGlu: 5.618 ± 0.07	3.444IlePhe: 3.444 ± 0.07	5.366IleGly: 5.366 ± 0.069	1.288IleHis: 1.288 ± 0.037	7.214IleIle: 7.214 ± 0.091	6.728IleLys: 6.728 ± 0.085	7.445IleLeu: 7.445 ± 0.106	2.056IleMet: 2.056 ± 0.044	5.201IleAsn: 5.201 ± 0.075	3.414IlePro: 3.414 ± 0.059	2.449IleGln: 2.449 ± 0.055	3.264IleArg: 3.264 ± 0.054	6.564IleSer: 6.564 ± 0.099	5.006IleThr: 5.006 ± 0.08	5.526IleVal: 5.526 ± 0.07	0.598IleTrp: 0.598 ± 0.028	3.057IleTyr: 3.057 ± 0.052	0.0IleXaa: 0.0 ± 0.0
Lys	5.122LysAla: 5.122 ± 0.084	0.796LysCys: 0.796 ± 0.03	4.503LysAsp: 4.503 ± 0.068	5.911LysGlu: 5.911 ± 0.09	2.454LysPhe: 2.454 ± 0.05	4.85LysGly: 4.85 ± 0.065	1.1LysHis: 1.1 ± 0.027	6.341LysIle: 6.341 ± 0.082	6.523LysLys: 6.523 ± 0.085	6.776LysLeu: 6.776 ± 0.083	2.1LysMet: 2.1 ± 0.042	5.057LysAsn: 5.057 ± 0.076	2.449LysPro: 2.449 ± 0.045	2.547LysGln: 2.547 ± 0.056	2.974LysArg: 2.974 ± 0.049	4.895LysSer: 4.895 ± 0.072	4.363LysThr: 4.363 ± 0.071	5.264LysVal: 5.264 ± 0.091	0.688LysTrp: 0.688 ± 0.024	3.576LysTyr: 3.576 ± 0.068	0.0LysXaa: 0.0 ± 0.0
Leu	5.479LeuAla: 5.479 ± 0.081	1.131LeuCys: 1.131 ± 0.028	4.909LeuAsp: 4.909 ± 0.058	5.801LeuGlu: 5.801 ± 0.086	3.683LeuPhe: 3.683 ± 0.065	5.8LeuGly: 5.8 ± 0.067	1.263LeuHis: 1.263 ± 0.036	6.857LeuIle: 6.857 ± 0.093	7.582LeuLys: 7.582 ± 0.091	7.938LeuLeu: 7.938 ± 0.116	2.232LeuMet: 2.232 ± 0.045	4.948LeuAsn: 4.948 ± 0.07	3.235LeuPro: 3.235 ± 0.064	2.529LeuGln: 2.529 ± 0.045	3.302LeuArg: 3.302 ± 0.056	6.606LeuSer: 6.606 ± 0.083	4.971LeuThr: 4.971 ± 0.074	5.494LeuVal: 5.494 ± 0.071	0.701LeuTrp: 0.701 ± 0.03	3.325LeuTyr: 3.325 ± 0.06	0.0LeuXaa: 0.0 ± 0.0
Met	1.889MetAla: 1.889 ± 0.048	0.301MetCys: 0.301 ± 0.016	1.583MetAsp: 1.583 ± 0.037	1.785MetGlu: 1.785 ± 0.042	0.991MetPhe: 0.991 ± 0.03	1.837MetGly: 1.837 ± 0.049	0.362MetHis: 0.362 ± 0.019	1.88MetIle: 1.88 ± 0.044	2.185MetLys: 2.185 ± 0.05	2.463MetLeu: 2.463 ± 0.051	0.579MetMet: 0.579 ± 0.022	1.41MetAsn: 1.41 ± 0.033	0.996MetPro: 0.996 ± 0.029	0.834MetGln: 0.834 ± 0.029	0.925MetArg: 0.925 ± 0.03	1.796MetSer: 1.796 ± 0.043	1.314MetThr: 1.314 ± 0.035	1.746MetVal: 1.746 ± 0.033	0.182MetTrp: 0.182 ± 0.014	0.873MetTyr: 0.873 ± 0.029	0.0MetXaa: 0.0 ± 0.0
Asn	3.216AsnAla: 3.216 ± 0.059	0.668AsnCys: 0.668 ± 0.023	2.869AsnAsp: 2.869 ± 0.049	3.584AsnGlu: 3.584 ± 0.062	2.173AsnPhe: 2.173 ± 0.052	4.12AsnGly: 4.12 ± 0.066	0.748AsnHis: 0.748 ± 0.026	5.576AsnIle: 5.576 ± 0.077	4.261AsnLys: 4.261 ± 0.071	4.647AsnLeu: 4.647 ± 0.066	1.483AsnMet: 1.483 ± 0.036	3.451AsnAsn: 3.451 ± 0.065	2.348AsnPro: 2.348 ± 0.043	1.664AsnGln: 1.664 ± 0.035	2.212AsnArg: 2.212 ± 0.044	4.017AsnSer: 4.017 ± 0.065	3.301AsnThr: 3.301 ± 0.069	3.534AsnVal: 3.534 ± 0.064	0.552AsnTrp: 0.552 ± 0.027	2.287AsnTyr: 2.287 ± 0.048	0.0AsnXaa: 0.0 ± 0.0
Pro	2.198ProAla: 2.198 ± 0.05	0.369ProCys: 0.369 ± 0.018	2.205ProAsp: 2.205 ± 0.044	2.629ProGlu: 2.629 ± 0.048	1.527ProPhe: 1.527 ± 0.037	2.338ProGly: 2.338 ± 0.047	0.545ProHis: 0.545 ± 0.024	2.382ProIle: 2.382 ± 0.054	2.142ProLys: 2.142 ± 0.048	2.714ProLeu: 2.714 ± 0.055	0.748ProMet: 0.748 ± 0.024	1.542ProAsn: 1.542 ± 0.037	0.844ProPro: 0.844 ± 0.029	1.147ProGln: 1.147 ± 0.037	0.953ProArg: 0.953 ± 0.028	2.16ProSer: 2.16 ± 0.046	1.661ProThr: 1.661 ± 0.05	2.852ProVal: 2.852 ± 0.07	0.329ProTrp: 0.329 ± 0.017	1.381ProTyr: 1.381 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	1.939GlnAla: 1.939 ± 0.043	0.31GlnCys: 0.31 ± 0.016	1.416GlnAsp: 1.416 ± 0.036	1.98GlnGlu: 1.98 ± 0.056	1.126GlnPhe: 1.126 ± 0.029	1.758GlnGly: 1.758 ± 0.042	0.417GlnHis: 0.417 ± 0.019	2.486GlnIle: 2.486 ± 0.049	2.647GlnLys: 2.647 ± 0.054	2.773GlnLeu: 2.773 ± 0.06	0.864GlnMet: 0.864 ± 0.029	1.793GlnAsn: 1.793 ± 0.045	0.905GlnPro: 0.905 ± 0.031	1.124GlnGln: 1.124 ± 0.037	1.265GlnArg: 1.265 ± 0.037	1.87GlnSer: 1.87 ± 0.04	1.547GlnThr: 1.547 ± 0.04	1.853GlnVal: 1.853 ± 0.04	0.306GlnTrp: 0.306 ± 0.018	1.325GlnTyr: 1.325 ± 0.037	0.0GlnXaa: 0.0 ± 0.0
Arg	2.196ArgAla: 2.196 ± 0.045	0.422ArgCys: 0.422 ± 0.022	2.008ArgAsp: 2.008 ± 0.046	2.881ArgGlu: 2.881 ± 0.06	1.677ArgPhe: 1.677 ± 0.039	2.129ArgGly: 2.129 ± 0.05	0.614ArgHis: 0.614 ± 0.024	3.577ArgIle: 3.577 ± 0.063	3.025ArgLys: 3.025 ± 0.052	3.616ArgLeu: 3.616 ± 0.062	1.058ArgMet: 1.058 ± 0.032	2.177ArgAsn: 2.177 ± 0.046	1.207ArgPro: 1.207 ± 0.04	1.312ArgGln: 1.312 ± 0.033	1.572ArgArg: 1.572 ± 0.046	1.975ArgSer: 1.975 ± 0.043	2.004ArgThr: 2.004 ± 0.038	2.468ArgVal: 2.468 ± 0.052	0.339ArgTrp: 0.339 ± 0.017	1.592ArgTyr: 1.592 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	4.128SerAla: 4.128 ± 0.068	0.756SerCys: 0.756 ± 0.028	3.79SerAsp: 3.79 ± 0.066	4.337SerGlu: 4.337 ± 0.053	3.152SerPhe: 3.152 ± 0.051	5.396SerGly: 5.396 ± 0.079	1.009SerHis: 1.009 ± 0.033	5.809SerIle: 5.809 ± 0.075	4.857SerLys: 4.857 ± 0.07	5.854SerLeu: 5.854 ± 0.083	1.72SerMet: 1.72 ± 0.038	3.543SerAsn: 3.543 ± 0.059	1.98SerPro: 1.98 ± 0.041	2.181SerGln: 2.181 ± 0.049	2.615SerArg: 2.615 ± 0.046	4.907SerSer: 4.907 ± 0.095	3.659SerThr: 3.659 ± 0.07	4.764SerVal: 4.764 ± 0.082	0.618SerTrp: 0.618 ± 0.027	2.628SerTyr: 2.628 ± 0.057	0.0SerXaa: 0.0 ± 0.0
Thr	4.184ThrAla: 4.184 ± 0.084	0.557ThrCys: 0.557 ± 0.026	3.263ThrAsp: 3.263 ± 0.062	3.342ThrGlu: 3.342 ± 0.059	2.277ThrPhe: 2.277 ± 0.052	4.773ThrGly: 4.773 ± 0.089	0.796ThrHis: 0.796 ± 0.03	4.609ThrIle: 4.609 ± 0.076	3.578ThrLys: 3.578 ± 0.063	4.932ThrLeu: 4.932 ± 0.077	1.236ThrMet: 1.236 ± 0.037	2.707ThrAsn: 2.707 ± 0.06	2.228ThrPro: 2.228 ± 0.07	1.549ThrGln: 1.549 ± 0.039	1.92ThrArg: 1.92 ± 0.041	3.557ThrSer: 3.557 ± 0.065	3.085ThrThr: 3.085 ± 0.09	4.375ThrVal: 4.375 ± 0.095	0.493ThrTrp: 0.493 ± 0.028	2.15ThrTyr: 2.15 ± 0.049	0.0ThrXaa: 0.0 ± 0.0
Val	4.299ValAla: 4.299 ± 0.082	0.944ValCys: 0.944 ± 0.029	3.755ValAsp: 3.755 ± 0.062	4.217ValGlu: 4.217 ± 0.062	3.093ValPhe: 3.093 ± 0.063	4.202ValGly: 4.202 ± 0.072	0.906ValHis: 0.906 ± 0.03	5.647ValIle: 5.647 ± 0.078	5.118ValLys: 5.118 ± 0.073	6.343ValLeu: 6.343 ± 0.078	1.687ValMet: 1.687 ± 0.037	3.848ValAsn: 3.848 ± 0.069	2.381ValPro: 2.381 ± 0.053	1.909ValGln: 1.909 ± 0.045	2.373ValArg: 2.373 ± 0.055	5.033ValSer: 5.033 ± 0.062	4.027ValThr: 4.027 ± 0.109	4.657ValVal: 4.657 ± 0.077	0.613ValTrp: 0.613 ± 0.022	2.55ValTyr: 2.55 ± 0.052	0.0ValXaa: 0.0 ± 0.0
Trp	0.577TrpAla: 0.577 ± 0.022	0.141TrpCys: 0.141 ± 0.011	0.586TrpAsp: 0.586 ± 0.026	0.601TrpGlu: 0.601 ± 0.026	0.395TrpPhe: 0.395 ± 0.02	0.664TrpGly: 0.664 ± 0.029	0.168TrpHis: 0.168 ± 0.013	0.601TrpIle: 0.601 ± 0.025	0.637TrpLys: 0.637 ± 0.031	0.79TrpLeu: 0.79 ± 0.03	0.24TrpMet: 0.24 ± 0.016	0.578TrpAsn: 0.578 ± 0.024	0.237TrpPro: 0.237 ± 0.015	0.334TrpGln: 0.334 ± 0.019	0.363TrpArg: 0.363 ± 0.018	0.659TrpSer: 0.659 ± 0.027	0.455TrpThr: 0.455 ± 0.025	0.501TrpVal: 0.501 ± 0.02	0.116TrpTrp: 0.116 ± 0.011	0.373TrpTyr: 0.373 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.254TyrAla: 2.254 ± 0.055	0.562TyrCys: 0.562 ± 0.027	2.233TyrAsp: 2.233 ± 0.049	2.343TyrGlu: 2.343 ± 0.054	1.963TyrPhe: 1.963 ± 0.047	2.717TyrGly: 2.717 ± 0.054	0.582TyrHis: 0.582 ± 0.027	3.516TyrIle: 3.516 ± 0.065	3.1TyrLys: 3.1 ± 0.058	3.541TyrLeu: 3.541 ± 0.064	1.019TyrMet: 1.019 ± 0.037	2.508TyrAsn: 2.508 ± 0.05	1.461TyrPro: 1.461 ± 0.044	1.155TyrGln: 1.155 ± 0.033	1.683TyrArg: 1.683 ± 0.045	2.93TyrSer: 2.93 ± 0.062	2.504TyrThr: 2.504 ± 0.07	2.422TyrVal: 2.422 ± 0.055	0.421TyrTrp: 0.421 ± 0.023	1.773TyrTyr: 1.773 ± 0.057	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3287 proteins (1145150 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---