Amino acid dipepetide frequency for Dehalogenimonas lykanthroporepellens (strain ATCC BAA-1523 / JCM 15061 / BL-DC-9)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.199AlaAla: 10.199 ± 0.26
1.125AlaCys: 1.125 ± 0.054
5.824AlaAsp: 5.824 ± 0.127
7.72AlaGlu: 7.72 ± 0.166
3.161AlaPhe: 3.161 ± 0.1
9.528AlaGly: 9.528 ± 0.168
1.508AlaHis: 1.508 ± 0.055
5.464AlaIle: 5.464 ± 0.113
3.205AlaLys: 3.205 ± 0.089
9.57AlaLeu: 9.57 ± 0.159
2.508AlaMet: 2.508 ± 0.071
2.51AlaAsn: 2.51 ± 0.074
3.346AlaPro: 3.346 ± 0.085
2.68AlaGln: 2.68 ± 0.069
6.382AlaArg: 6.382 ± 0.139
4.905AlaSer: 4.905 ± 0.113
4.812AlaThr: 4.812 ± 0.113
8.789AlaVal: 8.789 ± 0.166
1.02AlaTrp: 1.02 ± 0.051
2.265AlaTyr: 2.265 ± 0.075
0.0AlaXaa: 0.0 ± 0.0
Cys
0.832CysAla: 0.832 ± 0.045
0.161CysCys: 0.161 ± 0.021
0.547CysAsp: 0.547 ± 0.038
0.455CysGlu: 0.455 ± 0.032
0.379CysPhe: 0.379 ± 0.029
1.343CysGly: 1.343 ± 0.063
0.404CysHis: 0.404 ± 0.036
0.503CysIle: 0.503 ± 0.032
0.367CysLys: 0.367 ± 0.027
1.045CysLeu: 1.045 ± 0.048
0.176CysMet: 0.176 ± 0.018
0.339CysAsn: 0.339 ± 0.031
0.916CysPro: 0.916 ± 0.052
0.369CysGln: 0.369 ± 0.03
1.083CysArg: 1.083 ± 0.054
0.572CysSer: 0.572 ± 0.038
0.484CysThr: 0.484 ± 0.031
0.629CysVal: 0.629 ± 0.039
0.098CysTrp: 0.098 ± 0.015
0.333CysTyr: 0.333 ± 0.029
0.0CysXaa: 0.0 ± 0.0
Asp
4.747AspAla: 4.747 ± 0.103
0.589AspCys: 0.589 ± 0.039
3.052AspAsp: 3.052 ± 0.099
4.027AspGlu: 4.027 ± 0.087
2.365AspPhe: 2.365 ± 0.074
4.349AspGly: 4.349 ± 0.092
0.905AspHis: 0.905 ± 0.046
4.712AspIle: 4.712 ± 0.093
2.464AspLys: 2.464 ± 0.083
5.198AspLeu: 5.198 ± 0.111
1.351AspMet: 1.351 ± 0.062
1.906AspAsn: 1.906 ± 0.065
2.495AspPro: 2.495 ± 0.074
1.399AspGln: 1.399 ± 0.062
3.677AspArg: 3.677 ± 0.096
2.914AspSer: 2.914 ± 0.08
3.059AspThr: 3.059 ± 0.091
3.402AspVal: 3.402 ± 0.09
0.807AspTrp: 0.807 ± 0.042
2.03AspTyr: 2.03 ± 0.067
0.0AspXaa: 0.0 ± 0.0
Glu
6.901GluAla: 6.901 ± 0.16
0.626GluCys: 0.626 ± 0.043
3.0GluAsp: 3.0 ± 0.092
4.622GluGlu: 4.622 ± 0.102
2.453GluPhe: 2.453 ± 0.084
4.104GluGly: 4.104 ± 0.085
1.299GluHis: 1.299 ± 0.054
4.689GluIle: 4.689 ± 0.114
3.914GluLys: 3.914 ± 0.101
7.463GluLeu: 7.463 ± 0.148
1.823GluMet: 1.823 ± 0.06
2.294GluAsn: 2.294 ± 0.071
2.661GluPro: 2.661 ± 0.08
2.552GluGln: 2.552 ± 0.08
4.274GluArg: 4.274 ± 0.105
3.446GluSer: 3.446 ± 0.086
3.966GluThr: 3.966 ± 0.094
4.632GluVal: 4.632 ± 0.11
0.75GluTrp: 0.75 ± 0.041
2.074GluTyr: 2.074 ± 0.062
0.0GluXaa: 0.0 ± 0.0
Phe
3.011PheAla: 3.011 ± 0.081
0.488PheCys: 0.488 ± 0.035
2.432PheAsp: 2.432 ± 0.072
2.118PheGlu: 2.118 ± 0.072
1.485PhePhe: 1.485 ± 0.058
3.275PheGly: 3.275 ± 0.105
0.742PheHis: 0.742 ± 0.038
2.652PheIle: 2.652 ± 0.074
1.59PheLys: 1.59 ± 0.061
3.342PheLeu: 3.342 ± 0.095
0.853PheMet: 0.853 ± 0.042
1.561PheAsn: 1.561 ± 0.062
1.682PhePro: 1.682 ± 0.057
1.169PheGln: 1.169 ± 0.055
2.219PheArg: 2.219 ± 0.081
2.307PheSer: 2.307 ± 0.074
2.21PheThr: 2.21 ± 0.075
2.284PheVal: 2.284 ± 0.069
0.461PheTrp: 0.461 ± 0.033
1.071PheTyr: 1.071 ± 0.045
0.0PheXaa: 0.0 ± 0.0
Gly
6.918GlyAla: 6.918 ± 0.142
1.056GlyCys: 1.056 ± 0.056
4.138GlyAsp: 4.138 ± 0.102
4.919GlyGlu: 4.919 ± 0.097
3.377GlyPhe: 3.377 ± 0.075
6.193GlyGly: 6.193 ± 0.154
1.814GlyHis: 1.814 ± 0.064
5.711GlyIle: 5.711 ± 0.118
4.027GlyLys: 4.027 ± 0.093
8.73GlyLeu: 8.73 ± 0.155
2.233GlyMet: 2.233 ± 0.066
2.665GlyAsn: 2.665 ± 0.085
2.407GlyPro: 2.407 ± 0.073
2.782GlyGln: 2.782 ± 0.08
5.709GlyArg: 5.709 ± 0.112
4.31GlySer: 4.31 ± 0.106
4.268GlyThr: 4.268 ± 0.108
6.013GlyVal: 6.013 ± 0.096
1.083GlyTrp: 1.083 ± 0.056
2.696GlyTyr: 2.696 ± 0.071
0.0GlyXaa: 0.0 ± 0.0
His
1.404HisAla: 1.404 ± 0.048
0.272HisCys: 0.272 ± 0.024
1.037HisAsp: 1.037 ± 0.046
1.05HisGlu: 1.05 ± 0.046
0.83HisPhe: 0.83 ± 0.041
1.534HisGly: 1.534 ± 0.055
0.534HisHis: 0.534 ± 0.036
1.188HisIle: 1.188 ± 0.047
0.675HisLys: 0.675 ± 0.04
2.108HisLeu: 2.108 ± 0.063
0.352HisMet: 0.352 ± 0.025
0.677HisAsn: 0.677 ± 0.039
1.263HisPro: 1.263 ± 0.056
0.754HisGln: 0.754 ± 0.041
1.542HisArg: 1.542 ± 0.066
1.083HisSer: 1.083 ± 0.045
0.941HisThr: 0.941 ± 0.048
0.983HisVal: 0.983 ± 0.049
0.241HisTrp: 0.241 ± 0.023
0.643HisTyr: 0.643 ± 0.038
0.0HisXaa: 0.0 ± 0.0
Ile
6.239IleAla: 6.239 ± 0.12
0.737IleCys: 0.737 ± 0.041
4.226IleAsp: 4.226 ± 0.107
4.305IleGlu: 4.305 ± 0.089
2.187IlePhe: 2.187 ± 0.074
5.194IleGly: 5.194 ± 0.111
1.213IleHis: 1.213 ± 0.05
4.643IleIle: 4.643 ± 0.122
2.86IleLys: 2.86 ± 0.083
5.504IleLeu: 5.504 ± 0.121
1.527IleMet: 1.527 ± 0.057
2.231IleAsn: 2.231 ± 0.079
2.99IlePro: 2.99 ± 0.072
1.787IleGln: 1.787 ± 0.069
3.895IleArg: 3.895 ± 0.109
3.847IleSer: 3.847 ± 0.098
4.102IleThr: 4.102 ± 0.113
4.27IleVal: 4.27 ± 0.1
0.633IleTrp: 0.633 ± 0.037
1.663IleTyr: 1.663 ± 0.052
0.0IleXaa: 0.0 ± 0.0
Lys
4.398LysAla: 4.398 ± 0.129
0.467LysCys: 0.467 ± 0.033
2.267LysAsp: 2.267 ± 0.083
2.998LysGlu: 2.998 ± 0.095
1.268LysPhe: 1.268 ± 0.051
3.006LysGly: 3.006 ± 0.086
0.742LysHis: 0.742 ± 0.041
2.684LysIle: 2.684 ± 0.095
2.541LysLys: 2.541 ± 0.088
4.368LysLeu: 4.368 ± 0.103
1.194LysMet: 1.194 ± 0.05
1.653LysAsn: 1.653 ± 0.06
2.309LysPro: 2.309 ± 0.077
1.559LysGln: 1.559 ± 0.056
2.594LysArg: 2.594 ± 0.07
2.602LysSer: 2.602 ± 0.068
2.791LysThr: 2.791 ± 0.079
3.099LysVal: 3.099 ± 0.094
0.415LysTrp: 0.415 ± 0.03
1.238LysTyr: 1.238 ± 0.052
0.0LysXaa: 0.0 ± 0.0
Leu
11.022LeuAla: 11.022 ± 0.178
0.941LeuCys: 0.941 ± 0.051
5.558LeuAsp: 5.558 ± 0.103
7.002LeuGlu: 7.002 ± 0.136
3.478LeuPhe: 3.478 ± 0.092
7.603LeuGly: 7.603 ± 0.144
1.552LeuHis: 1.552 ± 0.051
5.611LeuIle: 5.611 ± 0.129
5.502LeuLys: 5.502 ± 0.103
9.224LeuLeu: 9.224 ± 0.187
2.055LeuMet: 2.055 ± 0.073
3.44LeuAsn: 3.44 ± 0.089
5.204LeuPro: 5.204 ± 0.094
2.367LeuGln: 2.367 ± 0.068
5.743LeuArg: 5.743 ± 0.111
6.811LeuSer: 6.811 ± 0.131
6.195LeuThr: 6.195 ± 0.124
7.115LeuVal: 7.115 ± 0.137
0.897LeuTrp: 0.897 ± 0.053
2.162LeuTyr: 2.162 ± 0.071
0.0LeuXaa: 0.0 ± 0.0
Met
2.778MetAla: 2.778 ± 0.08
0.174MetCys: 0.174 ± 0.02
1.221MetAsp: 1.221 ± 0.053
1.544MetGlu: 1.544 ± 0.06
0.664MetPhe: 0.664 ± 0.036
1.791MetGly: 1.791 ± 0.068
0.297MetHis: 0.297 ± 0.024
1.253MetIle: 1.253 ± 0.055
1.508MetLys: 1.508 ± 0.055
2.181MetLeu: 2.181 ± 0.064
0.608MetMet: 0.608 ± 0.039
0.97MetAsn: 0.97 ± 0.045
1.284MetPro: 1.284 ± 0.045
0.534MetGln: 0.534 ± 0.036
1.272MetArg: 1.272 ± 0.054
1.739MetSer: 1.739 ± 0.065
1.636MetThr: 1.636 ± 0.053
1.946MetVal: 1.946 ± 0.062
0.168MetTrp: 0.168 ± 0.021
0.503MetTyr: 0.503 ± 0.032
0.0MetXaa: 0.0 ± 0.0
Asn
2.64AsnAla: 2.64 ± 0.081
0.404AsnCys: 0.404 ± 0.031
1.751AsnAsp: 1.751 ± 0.062
1.858AsnGlu: 1.858 ± 0.07
1.15AsnPhe: 1.15 ± 0.052
2.613AsnGly: 2.613 ± 0.076
0.683AsnHis: 0.683 ± 0.04
2.455AsnIle: 2.455 ± 0.079
1.448AsnLys: 1.448 ± 0.06
3.402AsnLeu: 3.402 ± 0.092
0.834AsnMet: 0.834 ± 0.039
1.232AsnAsn: 1.232 ± 0.055
2.206AsnPro: 2.206 ± 0.068
1.184AsnGln: 1.184 ± 0.048
2.42AsnArg: 2.42 ± 0.081
1.819AsnSer: 1.819 ± 0.065
1.762AsnThr: 1.762 ± 0.062
2.057AsnVal: 2.057 ± 0.068
0.39AsnTrp: 0.39 ± 0.032
0.972AsnTyr: 0.972 ± 0.042
0.0AsnXaa: 0.0 ± 0.0
Pro
4.605ProAla: 4.605 ± 0.108
0.396ProCys: 0.396 ± 0.028
3.245ProAsp: 3.245 ± 0.098
4.377ProGlu: 4.377 ± 0.091
1.768ProPhe: 1.768 ± 0.065
4.289ProGly: 4.289 ± 0.11
0.888ProHis: 0.888 ± 0.041
2.011ProIle: 2.011 ± 0.071
1.534ProLys: 1.534 ± 0.067
4.127ProLeu: 4.127 ± 0.087
0.936ProMet: 0.936 ± 0.039
1.387ProAsn: 1.387 ± 0.058
2.032ProPro: 2.032 ± 0.075
1.429ProGln: 1.429 ± 0.055
2.374ProArg: 2.374 ± 0.076
2.554ProSer: 2.554 ± 0.074
2.208ProThr: 2.208 ± 0.062
4.341ProVal: 4.341 ± 0.102
0.53ProTrp: 0.53 ± 0.039
1.075ProTyr: 1.075 ± 0.045
0.0ProXaa: 0.0 ± 0.0
Gln
3.786GlnAla: 3.786 ± 0.096
0.297GlnCys: 0.297 ± 0.028
1.437GlnAsp: 1.437 ± 0.061
2.166GlnGlu: 2.166 ± 0.08
1.027GlnPhe: 1.027 ± 0.043
2.122GlnGly: 2.122 ± 0.063
0.559GlnHis: 0.559 ± 0.031
1.881GlnIle: 1.881 ± 0.059
1.506GlnLys: 1.506 ± 0.061
3.04GlnLeu: 3.04 ± 0.081
0.807GlnMet: 0.807 ± 0.039
1.018GlnAsn: 1.018 ± 0.048
1.513GlnPro: 1.513 ± 0.06
1.18GlnGln: 1.18 ± 0.051
1.911GlnArg: 1.911 ± 0.06
1.915GlnSer: 1.915 ± 0.07
1.72GlnThr: 1.72 ± 0.06
2.462GlnVal: 2.462 ± 0.076
0.323GlnTrp: 0.323 ± 0.024
0.781GlnTyr: 0.781 ± 0.044
0.0GlnXaa: 0.0 ± 0.0
Arg
4.873ArgAla: 4.873 ± 0.108
0.773ArgCys: 0.773 ± 0.045
3.367ArgAsp: 3.367 ± 0.092
4.59ArgGlu: 4.59 ± 0.114
2.493ArgPhe: 2.493 ± 0.069
4.016ArgGly: 4.016 ± 0.111
1.684ArgHis: 1.684 ± 0.071
4.008ArgIle: 4.008 ± 0.097
2.914ArgLys: 2.914 ± 0.081
7.869ArgLeu: 7.869 ± 0.148
1.619ArgMet: 1.619 ± 0.058
2.11ArgAsn: 2.11 ± 0.071
2.864ArgPro: 2.864 ± 0.08
3.055ArgGln: 3.055 ± 0.081
5.428ArgArg: 5.428 ± 0.137
3.061ArgSer: 3.061 ± 0.085
3.036ArgThr: 3.036 ± 0.072
4.599ArgVal: 4.599 ± 0.11
0.687ArgTrp: 0.687 ± 0.041
2.229ArgTyr: 2.229 ± 0.065
0.0ArgXaa: 0.0 ± 0.0
Ser
5.694SerAla: 5.694 ± 0.14
0.587SerCys: 0.587 ± 0.036
2.772SerAsp: 2.772 ± 0.073
3.208SerGlu: 3.208 ± 0.088
2.277SerPhe: 2.277 ± 0.066
5.914SerGly: 5.914 ± 0.123
1.182SerHis: 1.182 ± 0.048
3.138SerIle: 3.138 ± 0.079
1.869SerLys: 1.869 ± 0.059
6.159SerLeu: 6.159 ± 0.13
1.318SerMet: 1.318 ± 0.052
1.659SerAsn: 1.659 ± 0.062
2.751SerPro: 2.751 ± 0.077
1.98SerGln: 1.98 ± 0.063
4.085SerArg: 4.085 ± 0.092
3.182SerSer: 3.182 ± 0.102
2.709SerThr: 2.709 ± 0.08
4.238SerVal: 4.238 ± 0.095
0.597SerTrp: 0.597 ± 0.035
1.519SerTyr: 1.519 ± 0.06
0.0SerXaa: 0.0 ± 0.0
Thr
6.166ThrAla: 6.166 ± 0.111
0.566ThrCys: 0.566 ± 0.034
3.423ThrAsp: 3.423 ± 0.089
3.769ThrGlu: 3.769 ± 0.091
1.944ThrPhe: 1.944 ± 0.065
5.898ThrGly: 5.898 ± 0.117
0.987ThrHis: 0.987 ± 0.047
3.459ThrIle: 3.459 ± 0.098
1.622ThrLys: 1.622 ± 0.057
5.166ThrLeu: 5.166 ± 0.109
1.112ThrMet: 1.112 ± 0.049
1.55ThrAsn: 1.55 ± 0.072
3.109ThrPro: 3.109 ± 0.087
1.316ThrGln: 1.316 ± 0.048
3.356ThrArg: 3.356 ± 0.086
2.87ThrSer: 2.87 ± 0.085
3.025ThrThr: 3.025 ± 0.093
4.488ThrVal: 4.488 ± 0.104
0.545ThrTrp: 0.545 ± 0.041
1.215ThrTyr: 1.215 ± 0.05
0.0ThrXaa: 0.0 ± 0.0
Val
7.341ValAla: 7.341 ± 0.119
0.874ValCys: 0.874 ± 0.048
3.909ValAsp: 3.909 ± 0.1
4.586ValGlu: 4.586 ± 0.088
2.998ValPhe: 2.998 ± 0.094
5.204ValGly: 5.204 ± 0.127
1.144ValHis: 1.144 ± 0.047
5.866ValIle: 5.866 ± 0.133
3.348ValLys: 3.348 ± 0.084
6.518ValLeu: 6.518 ± 0.118
1.932ValMet: 1.932 ± 0.062
2.623ValAsn: 2.623 ± 0.078
3.26ValPro: 3.26 ± 0.086
1.603ValGln: 1.603 ± 0.065
4.224ValArg: 4.224 ± 0.083
4.724ValSer: 4.724 ± 0.096
4.867ValThr: 4.867 ± 0.115
5.732ValVal: 5.732 ± 0.119
0.807ValTrp: 0.807 ± 0.043
1.833ValTyr: 1.833 ± 0.058
0.0ValXaa: 0.0 ± 0.0
Trp
0.83TrpAla: 0.83 ± 0.039
0.082TrpCys: 0.082 ± 0.015
0.574TrpAsp: 0.574 ± 0.041
0.677TrpGlu: 0.677 ± 0.041
0.411TrpPhe: 0.411 ± 0.033
0.786TrpGly: 0.786 ± 0.048
0.272TrpHis: 0.272 ± 0.024
0.547TrpIle: 0.547 ± 0.039
0.421TrpLys: 0.421 ± 0.03
1.462TrpLeu: 1.462 ± 0.071
0.293TrpMet: 0.293 ± 0.026
0.463TrpAsn: 0.463 ± 0.033
0.48TrpPro: 0.48 ± 0.036
0.603TrpGln: 0.603 ± 0.038
0.834TrpArg: 0.834 ± 0.049
0.522TrpSer: 0.522 ± 0.037
0.497TrpThr: 0.497 ± 0.036
0.704TrpVal: 0.704 ± 0.036
0.22TrpTrp: 0.22 ± 0.023
0.339TrpTyr: 0.339 ± 0.03
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.139TyrAla: 2.139 ± 0.078
0.419TyrCys: 0.419 ± 0.033
1.668TyrAsp: 1.668 ± 0.06
1.552TyrGlu: 1.552 ± 0.058
1.234TyrPhe: 1.234 ± 0.051
2.288TyrGly: 2.288 ± 0.064
0.698TyrHis: 0.698 ± 0.04
1.578TyrIle: 1.578 ± 0.062
0.878TyrLys: 0.878 ± 0.046
3.004TyrLeu: 3.004 ± 0.083
0.538TyrMet: 0.538 ± 0.038
0.991TyrAsn: 0.991 ± 0.054
1.335TyrPro: 1.335 ± 0.058
1.15TyrGln: 1.15 ± 0.047
2.256TyrArg: 2.256 ± 0.068
1.657TyrSer: 1.657 ± 0.066
1.299TyrThr: 1.299 ± 0.052
1.613TyrVal: 1.613 ± 0.066
0.346TyrTrp: 0.346 ± 0.031
0.962TyrTyr: 0.962 ± 0.049
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1619 proteins (477317 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski