Amino acid dipepetide frequency for Alfalfa latent virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.824AlaAla: 3.824 ± 1.246
0.765AlaCys: 0.765 ± 0.592
6.119AlaAsp: 6.119 ± 1.984
6.501AlaGlu: 6.501 ± 3.081
3.059AlaPhe: 3.059 ± 1.085
2.677AlaGly: 2.677 ± 1.064
0.382AlaHis: 0.382 ± 0.202
5.736AlaIle: 5.736 ± 2.478
5.736AlaLys: 5.736 ± 3.001
8.413AlaLeu: 8.413 ± 2.567
1.147AlaMet: 1.147 ± 0.531
2.677AlaAsn: 2.677 ± 0.905
1.53AlaPro: 1.53 ± 1.173
1.147AlaGln: 1.147 ± 0.629
4.589AlaArg: 4.589 ± 1.628
3.824AlaSer: 3.824 ± 2.678
2.294AlaThr: 2.294 ± 0.511
5.736AlaVal: 5.736 ± 1.072
0.382AlaTrp: 0.382 ± 0.783
1.147AlaTyr: 1.147 ± 0.605
0.0AlaXaa: 0.0 ± 0.0
Cys
2.294CysAla: 2.294 ± 1.17
1.147CysCys: 1.147 ± 1.466
0.765CysAsp: 0.765 ± 0.681
3.059CysGlu: 3.059 ± 1.175
1.53CysPhe: 1.53 ± 0.639
2.294CysGly: 2.294 ± 0.511
0.0CysHis: 0.0 ± 0.0
0.765CysIle: 0.765 ± 0.403
0.765CysLys: 0.765 ± 0.403
1.53CysLeu: 1.53 ± 1.043
0.765CysMet: 0.765 ± 0.529
0.765CysAsn: 0.765 ± 0.403
0.382CysPro: 0.382 ± 0.708
1.147CysGln: 1.147 ± 1.104
2.294CysArg: 2.294 ± 0.75
2.294CysSer: 2.294 ± 2.811
2.294CysThr: 2.294 ± 2.053
1.912CysVal: 1.912 ± 1.009
0.0CysTrp: 0.0 ± 0.0
0.382CysTyr: 0.382 ± 0.202
0.0CysXaa: 0.0 ± 0.0
Asp
4.207AspAla: 4.207 ± 2.16
2.294AspCys: 2.294 ± 1.21
3.824AspAsp: 3.824 ± 1.441
3.824AspGlu: 3.824 ± 0.829
3.059AspPhe: 3.059 ± 0.903
3.059AspGly: 3.059 ± 1.251
3.442AspHis: 3.442 ± 1.335
2.294AspIle: 2.294 ± 1.21
2.677AspLys: 2.677 ± 1.619
5.736AspLeu: 5.736 ± 1.478
1.147AspMet: 1.147 ± 0.605
3.059AspAsn: 3.059 ± 1.165
1.912AspPro: 1.912 ± 1.009
1.53AspGln: 1.53 ± 0.807
2.677AspArg: 2.677 ± 0.905
2.677AspSer: 2.677 ± 1.602
1.147AspThr: 1.147 ± 0.605
2.677AspVal: 2.677 ± 1.619
1.53AspTrp: 1.53 ± 0.639
2.294AspTyr: 2.294 ± 0.824
0.0AspXaa: 0.0 ± 0.0
Glu
6.501GluAla: 6.501 ± 1.618
2.677GluCys: 2.677 ± 0.495
3.059GluAsp: 3.059 ± 1.129
6.501GluGlu: 6.501 ± 2.803
5.354GluPhe: 5.354 ± 2.667
5.736GluGly: 5.736 ± 1.036
0.765GluHis: 0.765 ± 0.403
4.589GluIle: 4.589 ± 1.647
5.736GluLys: 5.736 ± 1.284
6.883GluLeu: 6.883 ± 2.334
0.765GluMet: 0.765 ± 0.403
2.677GluAsn: 2.677 ± 0.905
2.677GluPro: 2.677 ± 1.971
3.824GluGln: 3.824 ± 2.228
4.971GluArg: 4.971 ± 1.002
5.736GluSer: 5.736 ± 1.763
0.765GluThr: 0.765 ± 0.592
6.501GluVal: 6.501 ± 2.344
0.765GluTrp: 0.765 ± 0.403
3.442GluTyr: 3.442 ± 1.067
0.0GluXaa: 0.0 ± 0.0
Phe
2.677PheAla: 2.677 ± 1.651
0.765PheCys: 0.765 ± 0.403
3.059PheAsp: 3.059 ± 0.903
6.501PheGlu: 6.501 ± 2.605
2.294PhePhe: 2.294 ± 0.75
4.207PheGly: 4.207 ± 1.093
0.765PheHis: 0.765 ± 0.681
3.442PheIle: 3.442 ± 1.548
1.912PheLys: 1.912 ± 1.152
7.648PheLeu: 7.648 ± 2.527
1.147PheMet: 1.147 ± 0.605
1.912PheAsn: 1.912 ± 0.623
1.53PhePro: 1.53 ± 0.639
2.294PheGln: 2.294 ± 1.403
2.677PheArg: 2.677 ± 0.967
5.736PheSer: 5.736 ± 1.014
4.207PheThr: 4.207 ± 1.452
2.294PheVal: 2.294 ± 0.75
0.765PheTrp: 0.765 ± 0.592
2.294PheTyr: 2.294 ± 1.061
0.0PheXaa: 0.0 ± 0.0
Gly
3.824GlyAla: 3.824 ± 1.86
1.912GlyCys: 1.912 ± 2.143
4.971GlyAsp: 4.971 ± 1.389
4.589GlyGlu: 4.589 ± 1.725
3.059GlyPhe: 3.059 ± 2.209
3.059GlyGly: 3.059 ± 1.251
0.0GlyHis: 0.0 ± 0.0
1.912GlyIle: 1.912 ± 1.009
4.971GlyLys: 4.971 ± 2.046
6.883GlyLeu: 6.883 ± 0.882
0.765GlyMet: 0.765 ± 0.592
2.294GlyAsn: 2.294 ± 1.21
1.147GlyPro: 1.147 ± 1.004
1.53GlyGln: 1.53 ± 0.807
3.824GlyArg: 3.824 ± 0.993
4.971GlySer: 4.971 ± 1.92
2.677GlyThr: 2.677 ± 1.003
5.354GlyVal: 5.354 ± 2.332
1.147GlyTrp: 1.147 ± 1.29
1.912GlyTyr: 1.912 ± 1.009
0.0GlyXaa: 0.0 ± 0.0
His
1.53HisAla: 1.53 ± 1.269
0.0HisCys: 0.0 ± 0.0
0.765HisAsp: 0.765 ± 0.403
0.765HisGlu: 0.765 ± 0.403
0.382HisPhe: 0.382 ± 0.202
0.765HisGly: 0.765 ± 1.087
1.147HisHis: 1.147 ± 0.629
1.147HisIle: 1.147 ± 0.605
1.147HisLys: 1.147 ± 0.892
4.207HisLeu: 4.207 ± 2.219
0.0HisMet: 0.0 ± 0.0
1.53HisAsn: 1.53 ± 0.639
0.382HisPro: 0.382 ± 0.202
0.382HisGln: 0.382 ± 0.202
2.677HisArg: 2.677 ± 1.971
3.824HisSer: 3.824 ± 1.438
0.382HisThr: 0.382 ± 0.202
1.147HisVal: 1.147 ± 1.319
0.382HisTrp: 0.382 ± 0.202
0.765HisTyr: 0.765 ± 0.403
0.0HisXaa: 0.0 ± 0.0
Ile
4.589IleAla: 4.589 ± 1.176
2.294IleCys: 2.294 ± 0.824
4.589IleAsp: 4.589 ± 0.78
4.971IleGlu: 4.971 ± 1.339
2.677IlePhe: 2.677 ± 1.064
2.677IleGly: 2.677 ± 2.15
1.53IleHis: 1.53 ± 2.174
4.589IleIle: 4.589 ± 2.137
4.589IleLys: 4.589 ± 1.609
4.207IleLeu: 4.207 ± 1.567
1.912IleMet: 1.912 ± 0.954
1.53IleAsn: 1.53 ± 0.543
1.912IlePro: 1.912 ± 1.009
1.912IleGln: 1.912 ± 2.311
2.677IleArg: 2.677 ± 1.011
4.971IleSer: 4.971 ± 0.952
1.53IleThr: 1.53 ± 0.732
4.207IleVal: 4.207 ± 2.045
0.382IleTrp: 0.382 ± 0.708
1.53IleTyr: 1.53 ± 0.807
0.0IleXaa: 0.0 ± 0.0
Lys
4.207LysAla: 4.207 ± 1.631
1.53LysCys: 1.53 ± 0.732
3.442LysAsp: 3.442 ± 0.677
3.442LysGlu: 3.442 ± 1.593
4.207LysPhe: 4.207 ± 1.013
3.442LysGly: 3.442 ± 0.769
0.765LysHis: 0.765 ± 0.403
3.824LysIle: 3.824 ± 1.523
3.824LysLys: 3.824 ± 1.441
8.413LysLeu: 8.413 ± 2.076
0.765LysMet: 0.765 ± 1.189
3.059LysAsn: 3.059 ± 1.92
1.912LysPro: 1.912 ± 0.709
2.677LysGln: 2.677 ± 0.905
4.207LysArg: 4.207 ± 1.631
5.736LysSer: 5.736 ± 1.978
3.059LysThr: 3.059 ± 0.977
4.971LysVal: 4.971 ± 1.253
0.382LysTrp: 0.382 ± 0.202
0.382LysTyr: 0.382 ± 0.202
0.0LysXaa: 0.0 ± 0.0
Leu
5.354LeuAla: 5.354 ± 3.019
2.294LeuCys: 2.294 ± 1.035
4.589LeuAsp: 4.589 ± 1.021
9.178LeuGlu: 9.178 ± 2.055
4.971LeuPhe: 4.971 ± 1.892
6.883LeuGly: 6.883 ± 1.572
3.442LeuHis: 3.442 ± 1.815
8.795LeuIle: 8.795 ± 1.812
10.325LeuLys: 10.325 ± 2.131
8.795LeuLeu: 8.795 ± 1.934
3.059LeuMet: 3.059 ± 1.129
4.589LeuAsn: 4.589 ± 1.725
4.971LeuPro: 4.971 ± 1.829
3.442LeuGln: 3.442 ± 1.545
5.354LeuArg: 5.354 ± 0.813
4.589LeuSer: 4.589 ± 1.725
6.883LeuThr: 6.883 ± 2.2
6.119LeuVal: 6.119 ± 1.95
0.0LeuTrp: 0.0 ± 0.0
1.53LeuTyr: 1.53 ± 1.043
0.0LeuXaa: 0.0 ± 0.0
Met
3.059MetAla: 3.059 ± 1.085
0.382MetCys: 0.382 ± 0.202
1.147MetAsp: 1.147 ± 0.629
2.677MetGlu: 2.677 ± 1.412
0.382MetPhe: 0.382 ± 0.708
0.382MetGly: 0.382 ± 0.202
0.765MetHis: 0.765 ± 0.592
0.0MetIle: 0.0 ± 0.0
0.765MetLys: 0.765 ± 0.592
2.294MetLeu: 2.294 ± 0.824
0.0MetMet: 0.0 ± 0.0
0.765MetAsn: 0.765 ± 0.403
1.53MetPro: 1.53 ± 1.173
0.765MetGln: 0.765 ± 1.195
1.147MetArg: 1.147 ± 0.605
0.382MetSer: 0.382 ± 0.202
1.147MetThr: 1.147 ± 0.605
1.147MetVal: 1.147 ± 0.605
0.0MetTrp: 0.0 ± 0.0
0.382MetTyr: 0.382 ± 0.708
0.0MetXaa: 0.0 ± 0.0
Asn
2.677AsnAla: 2.677 ± 0.905
1.53AsnCys: 1.53 ± 0.639
1.147AsnAsp: 1.147 ± 0.531
3.059AsnGlu: 3.059 ± 1.614
2.294AsnPhe: 2.294 ± 1.21
2.677AsnGly: 2.677 ± 1.055
0.765AsnHis: 0.765 ± 0.403
1.53AsnIle: 1.53 ± 2.45
1.912AsnLys: 1.912 ± 0.709
5.736AsnLeu: 5.736 ± 1.747
1.53AsnMet: 1.53 ± 0.542
2.677AsnAsn: 2.677 ± 4.741
2.677AsnPro: 2.677 ± 1.619
1.147AsnGln: 1.147 ± 1.787
2.677AsnArg: 2.677 ± 1.412
3.824AsnSer: 3.824 ± 3.674
1.53AsnThr: 1.53 ± 0.732
0.765AsnVal: 0.765 ± 0.403
1.53AsnTrp: 1.53 ± 1.173
3.059AsnTyr: 3.059 ± 1.085
0.0AsnXaa: 0.0 ± 0.0
Pro
1.53ProAla: 1.53 ± 1.185
0.382ProCys: 0.382 ± 0.202
1.912ProAsp: 1.912 ± 1.295
4.589ProGlu: 4.589 ± 2.195
1.912ProPhe: 1.912 ± 0.709
1.912ProGly: 1.912 ± 0.709
1.53ProHis: 1.53 ± 2.174
2.677ProIle: 2.677 ± 1.166
2.677ProLys: 2.677 ± 1.412
2.294ProLeu: 2.294 ± 0.987
0.0ProMet: 0.0 ± 0.0
2.677ProAsn: 2.677 ± 3.433
2.294ProPro: 2.294 ± 1.507
1.147ProGln: 1.147 ± 0.531
1.147ProArg: 1.147 ± 0.605
1.147ProSer: 1.147 ± 0.629
1.912ProThr: 1.912 ± 2.113
1.147ProVal: 1.147 ± 1.004
0.382ProTrp: 0.382 ± 0.202
1.912ProTyr: 1.912 ± 1.009
0.0ProXaa: 0.0 ± 0.0
Gln
1.912GlnAla: 1.912 ± 2.143
1.53GlnCys: 1.53 ± 1.389
1.912GlnAsp: 1.912 ± 0.623
1.912GlnGlu: 1.912 ± 0.709
1.53GlnPhe: 1.53 ± 0.639
1.912GlnGly: 1.912 ± 0.623
0.382GlnHis: 0.382 ± 0.202
2.294GlnIle: 2.294 ± 1.21
1.912GlnLys: 1.912 ± 1.879
3.442GlnLeu: 3.442 ± 1.826
0.765GlnMet: 0.765 ± 0.592
1.53GlnAsn: 1.53 ± 0.807
1.147GlnPro: 1.147 ± 0.531
1.147GlnGln: 1.147 ± 2.124
0.765GlnArg: 0.765 ± 0.681
2.677GlnSer: 2.677 ± 0.905
0.765GlnThr: 0.765 ± 0.403
1.912GlnVal: 1.912 ± 2.236
0.382GlnTrp: 0.382 ± 0.202
0.765GlnTyr: 0.765 ± 1.087
0.0GlnXaa: 0.0 ± 0.0
Arg
6.883ArgAla: 6.883 ± 1.46
1.53ArgCys: 1.53 ± 0.807
2.677ArgAsp: 2.677 ± 0.876
3.442ArgGlu: 3.442 ± 1.015
6.119ArgPhe: 6.119 ± 1.561
3.824ArgGly: 3.824 ± 1.373
0.765ArgHis: 0.765 ± 0.403
1.147ArgIle: 1.147 ± 0.531
1.912ArgLys: 1.912 ± 0.623
4.207ArgLeu: 4.207 ± 0.999
0.765ArgMet: 0.765 ± 0.403
1.912ArgAsn: 1.912 ± 0.598
1.147ArgPro: 1.147 ± 1.29
1.912ArgGln: 1.912 ± 0.623
1.912ArgArg: 1.912 ± 1.42
5.736ArgSer: 5.736 ± 1.652
1.912ArgThr: 1.912 ± 1.045
2.677ArgVal: 2.677 ± 0.967
0.765ArgTrp: 0.765 ± 0.403
3.824ArgTyr: 3.824 ± 1.246
0.0ArgXaa: 0.0 ± 0.0
Ser
3.059SerAla: 3.059 ± 1.076
1.147SerCys: 1.147 ± 2.034
4.971SerAsp: 4.971 ± 1.651
3.442SerGlu: 3.442 ± 3.0
3.442SerPhe: 3.442 ± 0.961
5.354SerGly: 5.354 ± 1.934
2.294SerHis: 2.294 ± 0.824
4.589SerIle: 4.589 ± 2.801
8.031SerLys: 8.031 ± 2.044
8.031SerLeu: 8.031 ± 2.044
1.53SerMet: 1.53 ± 0.601
3.442SerAsn: 3.442 ± 2.212
3.442SerPro: 3.442 ± 1.004
1.147SerGln: 1.147 ± 0.605
2.677SerArg: 2.677 ± 1.064
6.119SerSer: 6.119 ± 2.395
1.912SerThr: 1.912 ± 0.598
4.589SerVal: 4.589 ± 4.568
0.0SerTrp: 0.0 ± 0.0
2.294SerTyr: 2.294 ± 0.987
0.0SerXaa: 0.0 ± 0.0
Thr
2.294ThrAla: 2.294 ± 1.956
0.382ThrCys: 0.382 ± 0.783
1.53ThrAsp: 1.53 ± 0.732
3.824ThrGlu: 3.824 ± 1.418
5.736ThrPhe: 5.736 ± 1.747
2.677ThrGly: 2.677 ± 1.1
2.677ThrHis: 2.677 ± 0.495
2.294ThrIle: 2.294 ± 1.035
1.912ThrLys: 1.912 ± 0.95
4.971ThrLeu: 4.971 ± 1.614
1.147ThrMet: 1.147 ± 0.605
1.912ThrAsn: 1.912 ± 1.107
0.765ThrPro: 0.765 ± 1.087
0.0ThrGln: 0.0 ± 0.0
2.677ThrArg: 2.677 ± 1.011
2.677ThrSer: 2.677 ± 2.695
1.53ThrThr: 1.53 ± 0.807
1.147ThrVal: 1.147 ± 1.104
0.382ThrTrp: 0.382 ± 0.708
1.53ThrTyr: 1.53 ± 0.807
0.0ThrXaa: 0.0 ± 0.0
Val
3.824ValAla: 3.824 ± 1.827
2.294ValCys: 2.294 ± 1.403
2.294ValAsp: 2.294 ± 1.257
4.971ValGlu: 4.971 ± 2.017
4.207ValPhe: 4.207 ± 2.045
4.589ValGly: 4.589 ± 1.407
1.53ValHis: 1.53 ± 0.639
5.354ValIle: 5.354 ± 2.719
3.059ValLys: 3.059 ± 1.727
6.883ValLeu: 6.883 ± 2.707
0.382ValMet: 0.382 ± 0.202
3.059ValAsn: 3.059 ± 1.085
2.677ValPro: 2.677 ± 2.04
3.059ValGln: 3.059 ± 1.175
2.677ValArg: 2.677 ± 1.061
1.912ValSer: 1.912 ± 0.598
3.059ValThr: 3.059 ± 1.074
4.207ValVal: 4.207 ± 1.949
0.382ValTrp: 0.382 ± 0.202
0.382ValTyr: 0.382 ± 0.202
0.0ValXaa: 0.0 ± 0.0
Trp
0.765TrpAla: 0.765 ± 0.592
0.382TrpCys: 0.382 ± 0.202
0.765TrpAsp: 0.765 ± 0.592
0.765TrpGlu: 0.765 ± 1.066
1.147TrpPhe: 1.147 ± 1.004
0.0TrpGly: 0.0 ± 0.0
0.382TrpHis: 0.382 ± 0.202
0.382TrpIle: 0.382 ± 0.202
0.0TrpLys: 0.0 ± 0.0
1.53TrpLeu: 1.53 ± 0.807
0.0TrpMet: 0.0 ± 0.0
0.765TrpAsn: 0.765 ± 1.416
0.382TrpPro: 0.382 ± 0.202
0.0TrpGln: 0.0 ± 0.0
0.382TrpArg: 0.382 ± 0.708
0.382TrpSer: 0.382 ± 0.202
0.765TrpThr: 0.765 ± 0.681
1.147TrpVal: 1.147 ± 0.605
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.677TyrAla: 2.677 ± 1.1
1.147TyrCys: 1.147 ± 0.531
1.53TyrAsp: 1.53 ± 0.807
1.912TyrGlu: 1.912 ± 1.009
0.765TyrPhe: 0.765 ± 0.403
2.677TyrGly: 2.677 ± 1.412
0.0TyrHis: 0.0 ± 0.0
1.912TyrIle: 1.912 ± 0.709
0.765TyrLys: 0.765 ± 0.403
3.059TyrLeu: 3.059 ± 1.165
1.147TyrMet: 1.147 ± 0.531
1.912TyrAsn: 1.912 ± 1.152
0.765TyrPro: 0.765 ± 0.592
0.382TyrGln: 0.382 ± 0.202
3.059TyrArg: 3.059 ± 1.165
2.294TyrSer: 2.294 ± 1.21
2.294TyrThr: 2.294 ± 1.17
1.147TyrVal: 1.147 ± 0.531
0.382TyrTrp: 0.382 ± 0.202
1.147TyrTyr: 1.147 ± 0.605
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5 proteins (2616 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski