Amino acid dipepetide frequency for Aspergillus saccharolyticus JOP 1030-1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.898AlaAla: 9.898 ± 0.068	1.129AlaCys: 1.129 ± 0.017	4.34AlaAsp: 4.34 ± 0.031	5.334AlaGlu: 5.334 ± 0.048	3.092AlaPhe: 3.092 ± 0.036	6.03AlaGly: 6.03 ± 0.043	1.992AlaHis: 1.992 ± 0.023	4.194AlaIle: 4.194 ± 0.032	3.59AlaLys: 3.59 ± 0.029	8.093AlaLeu: 8.093 ± 0.051	1.977AlaMet: 1.977 ± 0.021	2.81AlaAsn: 2.81 ± 0.028	4.857AlaPro: 4.857 ± 0.046	3.638AlaGln: 3.638 ± 0.028	5.294AlaArg: 5.294 ± 0.038	7.549AlaSer: 7.549 ± 0.052	5.671AlaThr: 5.671 ± 0.039	5.624AlaVal: 5.624 ± 0.036	1.209AlaTrp: 1.209 ± 0.016	2.245AlaTyr: 2.245 ± 0.024	0.0AlaXaa: 0.0 ± 0.0
Cys	1.009CysAla: 1.009 ± 0.016	0.273CysCys: 0.273 ± 0.01	0.67CysAsp: 0.67 ± 0.013	0.612CysGlu: 0.612 ± 0.012	0.557CysPhe: 0.557 ± 0.012	0.925CysGly: 0.925 ± 0.016	0.363CysHis: 0.363 ± 0.01	0.706CysIle: 0.706 ± 0.014	0.452CysLys: 0.452 ± 0.012	1.392CysLeu: 1.392 ± 0.02	0.281CysMet: 0.281 ± 0.008	0.413CysAsn: 0.413 ± 0.011	0.679CysPro: 0.679 ± 0.015	0.465CysGln: 0.465 ± 0.01	0.838CysArg: 0.838 ± 0.017	0.992CysSer: 0.992 ± 0.018	0.718CysThr: 0.718 ± 0.014	0.842CysVal: 0.842 ± 0.014	0.209CysTrp: 0.209 ± 0.005	0.379CysTyr: 0.379 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	4.705AspAla: 4.705 ± 0.028	0.639AspCys: 0.639 ± 0.013	3.852AspAsp: 3.852 ± 0.045	4.284AspGlu: 4.284 ± 0.036	2.084AspPhe: 2.084 ± 0.023	3.764AspGly: 3.764 ± 0.032	1.333AspHis: 1.333 ± 0.018	2.777AspIle: 2.777 ± 0.027	2.028AspLys: 2.028 ± 0.022	5.185AspLeu: 5.185 ± 0.034	1.143AspMet: 1.143 ± 0.014	1.738AspAsn: 1.738 ± 0.022	3.33AspPro: 3.33 ± 0.028	1.882AspGln: 1.882 ± 0.022	3.162AspArg: 3.162 ± 0.035	4.044AspSer: 4.044 ± 0.035	2.883AspThr: 2.883 ± 0.027	3.406AspVal: 3.406 ± 0.028	0.875AspTrp: 0.875 ± 0.015	1.645AspTyr: 1.645 ± 0.019	0.0AspXaa: 0.0 ± 0.0
Glu	5.438GluAla: 5.438 ± 0.041	0.605GluCys: 0.605 ± 0.012	4.002GluAsp: 4.002 ± 0.034	5.575GluGlu: 5.575 ± 0.057	1.904GluPhe: 1.904 ± 0.023	3.769GluGly: 3.769 ± 0.032	1.425GluHis: 1.425 ± 0.019	2.993GluIle: 2.993 ± 0.026	3.318GluLys: 3.318 ± 0.033	5.243GluLeu: 5.243 ± 0.042	1.44GluMet: 1.44 ± 0.017	2.106GluAsn: 2.106 ± 0.021	2.763GluPro: 2.763 ± 0.039	2.597GluGln: 2.597 ± 0.028	3.943GluArg: 3.943 ± 0.039	4.27GluSer: 4.27 ± 0.038	3.549GluThr: 3.549 ± 0.026	3.661GluVal: 3.661 ± 0.035	0.873GluTrp: 0.873 ± 0.015	1.671GluTyr: 1.671 ± 0.019	0.0GluXaa: 0.0 ± 0.0
Phe	3.051PheAla: 3.051 ± 0.032	0.592PheCys: 0.592 ± 0.013	2.195PheAsp: 2.195 ± 0.024	2.042PheGlu: 2.042 ± 0.021	1.646PhePhe: 1.646 ± 0.023	2.683PheGly: 2.683 ± 0.032	0.961PheHis: 0.961 ± 0.016	1.72PheIle: 1.72 ± 0.021	1.282PheLys: 1.282 ± 0.017	3.646PheLeu: 3.646 ± 0.032	0.735PheMet: 0.735 ± 0.013	1.312PheAsn: 1.312 ± 0.019	2.004PhePro: 2.004 ± 0.021	1.405PheGln: 1.405 ± 0.017	2.011PheArg: 2.011 ± 0.021	2.983PheSer: 2.983 ± 0.027	2.141PheThr: 2.141 ± 0.022	2.426PheVal: 2.426 ± 0.025	0.643PheTrp: 0.643 ± 0.013	1.127PheTyr: 1.127 ± 0.019	0.0PheXaa: 0.0 ± 0.0
Gly	5.351GlyAla: 5.351 ± 0.046	0.9GlyCys: 0.9 ± 0.015	3.437GlyAsp: 3.437 ± 0.032	3.659GlyGlu: 3.659 ± 0.029	2.73GlyPhe: 2.73 ± 0.028	5.675GlyGly: 5.675 ± 0.065	1.655GlyHis: 1.655 ± 0.02	3.318GlyIle: 3.318 ± 0.029	3.051GlyLys: 3.051 ± 0.03	6.312GlyLeu: 6.312 ± 0.038	1.539GlyMet: 1.539 ± 0.019	2.248GlyAsn: 2.248 ± 0.026	3.302GlyPro: 3.302 ± 0.029	2.537GlyGln: 2.537 ± 0.026	4.194GlyArg: 4.194 ± 0.032	5.706GlySer: 5.706 ± 0.04	3.86GlyThr: 3.86 ± 0.029	4.458GlyVal: 4.458 ± 0.037	1.186GlyTrp: 1.186 ± 0.018	2.132GlyTyr: 2.132 ± 0.028	0.0GlyXaa: 0.0 ± 0.0
His	2.036HisAla: 2.036 ± 0.021	0.346HisCys: 0.346 ± 0.008	1.342HisAsp: 1.342 ± 0.017	1.421HisGlu: 1.421 ± 0.02	0.934HisPhe: 0.934 ± 0.015	1.76HisGly: 1.76 ± 0.02	1.043HisHis: 1.043 ± 0.021	1.245HisIle: 1.245 ± 0.015	0.844HisLys: 0.844 ± 0.014	2.471HisLeu: 2.471 ± 0.026	0.493HisMet: 0.493 ± 0.01	0.866HisAsn: 0.866 ± 0.013	1.843HisPro: 1.843 ± 0.023	1.09HisGln: 1.09 ± 0.017	1.743HisArg: 1.743 ± 0.02	1.929HisSer: 1.929 ± 0.022	1.338HisThr: 1.338 ± 0.019	1.424HisVal: 1.424 ± 0.015	0.373HisTrp: 0.373 ± 0.009	0.754HisTyr: 0.754 ± 0.015	0.0HisXaa: 0.0 ± 0.0
Ile	4.149IleAla: 4.149 ± 0.036	0.768IleCys: 0.768 ± 0.014	2.72IleAsp: 2.72 ± 0.024	2.694IleGlu: 2.694 ± 0.029	1.939IlePhe: 1.939 ± 0.025	3.006IleGly: 3.006 ± 0.031	1.264IleHis: 1.264 ± 0.017	2.399IleIle: 2.399 ± 0.027	1.899IleLys: 1.899 ± 0.022	4.594IleLeu: 4.594 ± 0.037	0.939IleMet: 0.939 ± 0.015	1.677IleAsn: 1.677 ± 0.022	3.119IlePro: 3.119 ± 0.024	1.895IleGln: 1.895 ± 0.021	2.81IleArg: 2.81 ± 0.022	3.739IleSer: 3.739 ± 0.029	2.795IleThr: 2.795 ± 0.024	3.101IleVal: 3.101 ± 0.031	0.69IleTrp: 0.69 ± 0.012	1.448IleTyr: 1.448 ± 0.018	0.0IleXaa: 0.0 ± 0.0
Lys	3.77LysAla: 3.77 ± 0.034	0.457LysCys: 0.457 ± 0.01	2.33LysAsp: 2.33 ± 0.026	3.012LysGlu: 3.012 ± 0.03	1.231LysPhe: 1.231 ± 0.015	2.642LysGly: 2.642 ± 0.026	1.06LysHis: 1.06 ± 0.015	1.995LysIle: 1.995 ± 0.02	2.817LysLys: 2.817 ± 0.039	3.747LysLeu: 3.747 ± 0.03	0.883LysMet: 0.883 ± 0.016	1.497LysAsn: 1.497 ± 0.017	2.512LysPro: 2.512 ± 0.026	1.762LysGln: 1.762 ± 0.02	3.151LysArg: 3.151 ± 0.03	3.1LysSer: 3.1 ± 0.025	2.506LysThr: 2.506 ± 0.025	2.57LysVal: 2.57 ± 0.026	0.57LysTrp: 0.57 ± 0.011	1.258LysTyr: 1.258 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	8.25LeuAla: 8.25 ± 0.045	1.299LeuCys: 1.299 ± 0.019	5.212LeuAsp: 5.212 ± 0.039	5.573LeuGlu: 5.573 ± 0.043	3.427LeuPhe: 3.427 ± 0.033	6.071LeuGly: 6.071 ± 0.042	2.43LeuHis: 2.43 ± 0.025	4.024LeuIle: 4.024 ± 0.035	3.856LeuLys: 3.856 ± 0.034	9.003LeuLeu: 9.003 ± 0.072	1.826LeuMet: 1.826 ± 0.019	3.175LeuAsn: 3.175 ± 0.025	5.677LeuPro: 5.677 ± 0.042	4.073LeuGln: 4.073 ± 0.033	6.143LeuArg: 6.143 ± 0.038	7.617LeuSer: 7.617 ± 0.044	5.206LeuThr: 5.206 ± 0.031	5.736LeuVal: 5.736 ± 0.042	1.255LeuTrp: 1.255 ± 0.019	2.507LeuTyr: 2.507 ± 0.026	0.0LeuXaa: 0.0 ± 0.0
Met	2.094MetAla: 2.094 ± 0.02	0.254MetCys: 0.254 ± 0.008	1.164MetAsp: 1.164 ± 0.016	1.245MetGlu: 1.245 ± 0.015	0.709MetPhe: 0.709 ± 0.014	1.407MetGly: 1.407 ± 0.016	0.492MetHis: 0.492 ± 0.01	0.995MetIle: 0.995 ± 0.018	0.921MetLys: 0.921 ± 0.014	1.843MetLeu: 1.843 ± 0.021	0.574MetMet: 0.574 ± 0.012	0.767MetAsn: 0.767 ± 0.014	1.178MetPro: 1.178 ± 0.016	0.899MetGln: 0.899 ± 0.015	1.295MetArg: 1.295 ± 0.017	1.807MetSer: 1.807 ± 0.02	1.295MetThr: 1.295 ± 0.014	1.345MetVal: 1.345 ± 0.017	0.25MetTrp: 0.25 ± 0.008	0.517MetTyr: 0.517 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	2.986AsnAla: 2.986 ± 0.031	0.432AsnCys: 0.432 ± 0.01	1.756AsnAsp: 1.756 ± 0.018	1.877AsnGlu: 1.877 ± 0.024	1.239AsnPhe: 1.239 ± 0.017	2.602AsnGly: 2.602 ± 0.026	0.891AsnHis: 0.891 ± 0.015	1.812AsnIle: 1.812 ± 0.021	1.344AsnLys: 1.344 ± 0.017	3.193AsnLeu: 3.193 ± 0.025	0.741AsnMet: 0.741 ± 0.013	1.395AsnAsn: 1.395 ± 0.02	2.438AsnPro: 2.438 ± 0.024	1.305AsnGln: 1.305 ± 0.016	1.922AsnArg: 1.922 ± 0.021	2.564AsnSer: 2.564 ± 0.028	2.081AsnThr: 2.081 ± 0.021	2.169AsnVal: 2.169 ± 0.023	0.529AsnTrp: 0.529 ± 0.012	1.038AsnTyr: 1.038 ± 0.017	0.0AsnXaa: 0.0 ± 0.0
Pro	5.659ProAla: 5.659 ± 0.048	0.579ProCys: 0.579 ± 0.012	3.153ProAsp: 3.153 ± 0.031	3.801ProGlu: 3.801 ± 0.035	2.074ProPhe: 2.074 ± 0.021	3.89ProGly: 3.89 ± 0.037	1.475ProHis: 1.475 ± 0.02	2.465ProIle: 2.465 ± 0.023	2.308ProLys: 2.308 ± 0.024	4.958ProLeu: 4.958 ± 0.038	1.07ProMet: 1.07 ± 0.015	2.004ProAsn: 2.004 ± 0.022	5.139ProPro: 5.139 ± 0.076	2.498ProGln: 2.498 ± 0.031	3.572ProArg: 3.572 ± 0.035	6.163ProSer: 6.163 ± 0.057	4.152ProThr: 4.152 ± 0.037	3.723ProVal: 3.723 ± 0.034	0.775ProTrp: 0.775 ± 0.013	1.555ProTyr: 1.555 ± 0.02	0.0ProXaa: 0.0 ± 0.0
Gln	3.635GlnAla: 3.635 ± 0.03	0.484GlnCys: 0.484 ± 0.013	2.003GlnAsp: 2.003 ± 0.023	2.478GlnGlu: 2.478 ± 0.026	1.322GlnPhe: 1.322 ± 0.016	2.442GlnGly: 2.442 ± 0.027	1.143GlnHis: 1.143 ± 0.019	1.927GlnIle: 1.927 ± 0.024	1.872GlnLys: 1.872 ± 0.022	3.645GlnLeu: 3.645 ± 0.029	0.884GlnMet: 0.884 ± 0.015	1.453GlnAsn: 1.453 ± 0.019	2.707GlnPro: 2.707 ± 0.036	2.767GlnGln: 2.767 ± 0.051	2.819GlnArg: 2.819 ± 0.027	3.233GlnSer: 3.233 ± 0.032	2.474GlnThr: 2.474 ± 0.025	2.249GlnVal: 2.249 ± 0.024	0.574GlnTrp: 0.574 ± 0.01	1.197GlnTyr: 1.197 ± 0.014	0.0GlnXaa: 0.0 ± 0.0
Arg	5.029ArgAla: 5.029 ± 0.032	0.793ArgCys: 0.793 ± 0.014	3.355ArgAsp: 3.355 ± 0.038	3.99ArgGlu: 3.99 ± 0.036	2.268ArgPhe: 2.268 ± 0.023	3.812ArgGly: 3.812 ± 0.029	1.659ArgHis: 1.659 ± 0.021	2.924ArgIle: 2.924 ± 0.027	3.322ArgLys: 3.322 ± 0.03	5.887ArgLeu: 5.887 ± 0.036	1.329ArgMet: 1.329 ± 0.018	2.173ArgAsn: 2.173 ± 0.024	3.625ArgPro: 3.625 ± 0.032	2.774ArgGln: 2.774 ± 0.028	5.419ArgArg: 5.419 ± 0.05	5.032ArgSer: 5.032 ± 0.045	3.46ArgThr: 3.46 ± 0.031	3.636ArgVal: 3.636 ± 0.031	0.999ArgTrp: 0.999 ± 0.015	1.768ArgTyr: 1.768 ± 0.018	0.0ArgXaa: 0.0 ± 0.0
Ser	7.12SerAla: 7.12 ± 0.042	0.948SerCys: 0.948 ± 0.016	4.186SerAsp: 4.186 ± 0.034	4.146SerGlu: 4.146 ± 0.035	3.043SerPhe: 3.043 ± 0.026	5.483SerGly: 5.483 ± 0.041	2.05SerHis: 2.05 ± 0.024	3.876SerIle: 3.876 ± 0.029	3.304SerLys: 3.304 ± 0.031	7.567SerLeu: 7.567 ± 0.043	1.685SerMet: 1.685 ± 0.019	2.789SerAsn: 2.789 ± 0.025	5.646SerPro: 5.646 ± 0.05	3.358SerGln: 3.358 ± 0.031	5.168SerArg: 5.168 ± 0.05	9.374SerSer: 9.374 ± 0.087	5.869SerThr: 5.869 ± 0.049	4.714SerVal: 4.714 ± 0.035	1.136SerTrp: 1.136 ± 0.017	2.106SerTyr: 2.106 ± 0.021	0.0SerXaa: 0.0 ± 0.0
Thr	5.569ThrAla: 5.569 ± 0.039	0.764ThrCys: 0.764 ± 0.015	2.87ThrAsp: 2.87 ± 0.025	3.122ThrGlu: 3.122 ± 0.029	2.224ThrPhe: 2.224 ± 0.022	4.254ThrGly: 4.254 ± 0.036	1.396ThrHis: 1.396 ± 0.018	3.117ThrIle: 3.117 ± 0.026	2.314ThrLys: 2.314 ± 0.024	5.51ThrLeu: 5.51 ± 0.036	1.195ThrMet: 1.195 ± 0.016	2.07ThrAsn: 2.07 ± 0.023	4.383ThrPro: 4.383 ± 0.044	2.194ThrGln: 2.194 ± 0.022	3.328ThrArg: 3.328 ± 0.027	5.475ThrSer: 5.475 ± 0.046	4.947ThrThr: 4.947 ± 0.054	3.984ThrVal: 3.984 ± 0.03	0.836ThrTrp: 0.836 ± 0.013	1.683ThrTyr: 1.683 ± 0.019	0.0ThrXaa: 0.0 ± 0.0
Val	5.414ValAla: 5.414 ± 0.038	0.881ValCys: 0.881 ± 0.015	3.66ValAsp: 3.66 ± 0.031	3.857ValGlu: 3.857 ± 0.033	2.462ValPhe: 2.462 ± 0.025	4.055ValGly: 4.055 ± 0.036	1.486ValHis: 1.486 ± 0.017	2.979ValIle: 2.979 ± 0.026	2.6ValLys: 2.6 ± 0.027	5.83ValLeu: 5.83 ± 0.041	1.316ValMet: 1.316 ± 0.019	2.146ValAsn: 2.146 ± 0.025	3.633ValPro: 3.633 ± 0.029	2.462ValGln: 2.462 ± 0.025	3.693ValArg: 3.693 ± 0.03	4.8ValSer: 4.8 ± 0.033	3.667ValThr: 3.667 ± 0.038	4.444ValVal: 4.444 ± 0.038	0.89ValTrp: 0.89 ± 0.015	1.823ValTyr: 1.823 ± 0.02	0.0ValXaa: 0.0 ± 0.0
Trp	1.13TrpAla: 1.13 ± 0.018	0.198TrpCys: 0.198 ± 0.007	0.88TrpAsp: 0.88 ± 0.015	0.849TrpGlu: 0.849 ± 0.014	0.545TrpPhe: 0.545 ± 0.011	0.93TrpGly: 0.93 ± 0.016	0.362TrpHis: 0.362 ± 0.008	0.752TrpIle: 0.752 ± 0.011	0.743TrpLys: 0.743 ± 0.013	1.381TrpLeu: 1.381 ± 0.017	0.382TrpMet: 0.382 ± 0.009	0.603TrpAsn: 0.603 ± 0.013	0.6TrpPro: 0.6 ± 0.013	0.577TrpGln: 0.577 ± 0.01	1.006TrpArg: 1.006 ± 0.015	1.075TrpSer: 1.075 ± 0.017	0.956TrpThr: 0.956 ± 0.014	0.922TrpVal: 0.922 ± 0.015	0.287TrpTrp: 0.287 ± 0.009	0.428TrpTyr: 0.428 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.276TyrAla: 2.276 ± 0.025	0.434TyrCys: 0.434 ± 0.009	1.63TyrAsp: 1.63 ± 0.018	1.577TyrGlu: 1.577 ± 0.021	1.175TyrPhe: 1.175 ± 0.017	2.051TyrGly: 2.051 ± 0.027	0.813TyrHis: 0.813 ± 0.014	1.426TyrIle: 1.426 ± 0.018	1.005TyrLys: 1.005 ± 0.016	2.86TyrLeu: 2.86 ± 0.025	0.62TyrMet: 0.62 ± 0.012	1.074TyrAsn: 1.074 ± 0.016	1.578TyrPro: 1.578 ± 0.02	1.13TyrGln: 1.13 ± 0.016	1.74TyrArg: 1.74 ± 0.021	2.118TyrSer: 2.118 ± 0.022	1.666TyrThr: 1.666 ± 0.021	1.661TyrVal: 1.661 ± 0.02	0.447TyrTrp: 0.447 ± 0.011	0.99TyrTyr: 0.99 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.003XaaXaa: 0.003 ± 0.002

Statistics based on 10061 proteins (4793634 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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