Amino acid dipepetide frequency for Human adenovirus C serotype 6 (HAdV-6) (Human adenovirus 6)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.708AlaAla: 10.708 ± 1.764
1.004AlaCys: 1.004 ± 0.348
4.016AlaAsp: 4.016 ± 0.843
4.239AlaGlu: 4.239 ± 0.926
3.235AlaPhe: 3.235 ± 0.542
4.573AlaGly: 4.573 ± 0.868
1.227AlaHis: 1.227 ± 0.275
3.569AlaIle: 3.569 ± 0.622
1.562AlaLys: 1.562 ± 0.423
8.701AlaLeu: 8.701 ± 1.182
1.339AlaMet: 1.339 ± 0.42
3.346AlaAsn: 3.346 ± 0.886
6.358AlaPro: 6.358 ± 1.087
3.235AlaGln: 3.235 ± 0.626
6.358AlaArg: 6.358 ± 0.875
5.466AlaSer: 5.466 ± 0.672
4.796AlaThr: 4.796 ± 0.711
4.796AlaVal: 4.796 ± 0.656
1.115AlaTrp: 1.115 ± 0.343
2.677AlaTyr: 2.677 ± 0.53
0.0AlaXaa: 0.0 ± 0.0
Cys
1.45CysAla: 1.45 ± 0.498
1.115CysCys: 1.115 ± 0.441
0.781CysAsp: 0.781 ± 0.255
0.781CysGlu: 0.781 ± 0.272
0.335CysPhe: 0.335 ± 0.163
2.119CysGly: 2.119 ± 0.52
0.781CysHis: 0.781 ± 0.372
0.446CysIle: 0.446 ± 0.198
0.669CysLys: 0.669 ± 0.254
1.004CysLeu: 1.004 ± 0.26
0.446CysMet: 0.446 ± 0.187
1.115CysAsn: 1.115 ± 0.403
0.446CysPro: 0.446 ± 0.192
0.223CysGln: 0.223 ± 0.15
1.004CysArg: 1.004 ± 0.361
1.339CysSer: 1.339 ± 0.486
1.115CysThr: 1.115 ± 0.389
0.669CysVal: 0.669 ± 0.309
0.335CysTrp: 0.335 ± 0.235
1.339CysTyr: 1.339 ± 0.387
0.0CysXaa: 0.0 ± 0.0
Asp
4.573AspAla: 4.573 ± 0.894
0.781AspCys: 0.781 ± 0.264
3.346AspAsp: 3.346 ± 0.931
4.127AspGlu: 4.127 ± 0.795
2.008AspPhe: 2.008 ± 0.512
3.012AspGly: 3.012 ± 0.686
0.892AspHis: 0.892 ± 0.337
1.673AspIle: 1.673 ± 0.387
2.454AspLys: 2.454 ± 0.478
4.685AspLeu: 4.685 ± 0.649
2.008AspMet: 2.008 ± 0.535
2.008AspAsn: 2.008 ± 0.453
3.123AspPro: 3.123 ± 0.564
1.339AspGln: 1.339 ± 0.336
4.127AspArg: 4.127 ± 0.861
3.681AspSer: 3.681 ± 0.677
2.789AspThr: 2.789 ± 0.526
3.458AspVal: 3.458 ± 0.623
0.669AspTrp: 0.669 ± 0.2
2.789AspTyr: 2.789 ± 0.383
0.112AspXaa: 0.112 ± 0.098
Glu
5.131GluAla: 5.131 ± 0.951
1.339GluCys: 1.339 ± 0.424
4.908GluAsp: 4.908 ± 0.773
8.924GluGlu: 8.924 ± 1.922
1.562GluPhe: 1.562 ± 0.342
3.569GluGly: 3.569 ± 0.672
1.562GluHis: 1.562 ± 0.347
2.566GluIle: 2.566 ± 0.656
2.008GluLys: 2.008 ± 0.492
5.466GluLeu: 5.466 ± 0.697
1.45GluMet: 1.45 ± 0.249
2.008GluAsn: 2.008 ± 0.532
2.789GluPro: 2.789 ± 0.566
3.681GluGln: 3.681 ± 0.589
5.02GluArg: 5.02 ± 1.087
3.346GluSer: 3.346 ± 0.456
3.681GluThr: 3.681 ± 0.55
3.681GluVal: 3.681 ± 0.553
0.669GluTrp: 0.669 ± 0.268
1.339GluTyr: 1.339 ± 0.465
0.0GluXaa: 0.0 ± 0.0
Phe
3.012PheAla: 3.012 ± 0.498
0.446PheCys: 0.446 ± 0.281
2.342PheAsp: 2.342 ± 0.528
2.119PheGlu: 2.119 ± 0.436
1.45PhePhe: 1.45 ± 0.43
0.892PheGly: 0.892 ± 0.292
0.558PheHis: 0.558 ± 0.193
1.115PheIle: 1.115 ± 0.328
1.339PheLys: 1.339 ± 0.443
3.569PheLeu: 3.569 ± 0.655
1.673PheMet: 1.673 ± 0.34
1.339PheAsn: 1.339 ± 0.251
2.566PhePro: 2.566 ± 0.459
2.008PheGln: 2.008 ± 0.323
3.235PheArg: 3.235 ± 0.403
2.454PheSer: 2.454 ± 0.55
2.231PheThr: 2.231 ± 0.435
2.677PheVal: 2.677 ± 0.645
0.112PheTrp: 0.112 ± 0.105
1.896PheTyr: 1.896 ± 0.476
0.0PheXaa: 0.0 ± 0.0
Gly
4.573GlyAla: 4.573 ± 0.639
1.115GlyCys: 1.115 ± 0.374
3.793GlyAsp: 3.793 ± 0.654
2.566GlyGlu: 2.566 ± 0.371
2.677GlyPhe: 2.677 ± 0.4
5.577GlyGly: 5.577 ± 0.768
1.896GlyHis: 1.896 ± 0.496
2.677GlyIle: 2.677 ± 0.483
2.119GlyLys: 2.119 ± 0.538
5.131GlyLeu: 5.131 ± 0.788
1.45GlyMet: 1.45 ± 0.413
3.346GlyAsn: 3.346 ± 0.894
3.012GlyPro: 3.012 ± 0.533
3.012GlyGln: 3.012 ± 0.512
4.239GlyArg: 4.239 ± 0.877
4.127GlySer: 4.127 ± 0.709
3.012GlyThr: 3.012 ± 0.616
4.908GlyVal: 4.908 ± 0.879
0.335GlyTrp: 0.335 ± 0.237
1.562GlyTyr: 1.562 ± 0.474
0.0GlyXaa: 0.0 ± 0.0
His
1.673HisAla: 1.673 ± 0.283
0.892HisCys: 0.892 ± 0.529
0.669HisAsp: 0.669 ± 0.285
1.115HisGlu: 1.115 ± 0.329
0.558HisPhe: 0.558 ± 0.255
1.896HisGly: 1.896 ± 0.397
0.669HisHis: 0.669 ± 0.268
0.892HisIle: 0.892 ± 0.257
0.781HisLys: 0.781 ± 0.301
2.9HisLeu: 2.9 ± 0.462
0.112HisMet: 0.112 ± 0.121
1.45HisAsn: 1.45 ± 0.463
1.673HisPro: 1.673 ± 0.435
0.892HisGln: 0.892 ± 0.281
2.119HisArg: 2.119 ± 0.423
1.45HisSer: 1.45 ± 0.38
1.004HisThr: 1.004 ± 0.219
1.562HisVal: 1.562 ± 0.368
0.446HisTrp: 0.446 ± 0.204
0.558HisTyr: 0.558 ± 0.242
0.0HisXaa: 0.0 ± 0.0
Ile
2.454IleAla: 2.454 ± 0.473
0.669IleCys: 0.669 ± 0.234
1.339IleAsp: 1.339 ± 0.341
1.45IleGlu: 1.45 ± 0.349
0.892IlePhe: 0.892 ± 0.364
2.454IleGly: 2.454 ± 0.601
0.558IleHis: 0.558 ± 0.229
1.785IleIle: 1.785 ± 0.491
2.677IleLys: 2.677 ± 0.673
3.346IleLeu: 3.346 ± 0.801
0.781IleMet: 0.781 ± 0.245
2.566IleAsn: 2.566 ± 0.507
2.008IlePro: 2.008 ± 0.658
1.339IleGln: 1.339 ± 0.352
2.231IleArg: 2.231 ± 0.593
2.454IleSer: 2.454 ± 0.461
3.012IleThr: 3.012 ± 0.771
2.677IleVal: 2.677 ± 0.55
0.558IleTrp: 0.558 ± 0.201
0.892IleTyr: 0.892 ± 0.395
0.0IleXaa: 0.0 ± 0.0
Lys
1.785LysAla: 1.785 ± 0.385
0.892LysCys: 0.892 ± 0.296
2.231LysAsp: 2.231 ± 0.45
2.231LysGlu: 2.231 ± 0.428
1.673LysPhe: 1.673 ± 0.452
2.119LysGly: 2.119 ± 0.718
0.781LysHis: 0.781 ± 0.376
2.454LysIle: 2.454 ± 0.415
3.346LysLys: 3.346 ± 0.92
3.458LysLeu: 3.458 ± 0.831
1.115LysMet: 1.115 ± 0.364
1.115LysAsn: 1.115 ± 0.333
1.673LysPro: 1.673 ± 0.431
1.339LysGln: 1.339 ± 0.371
2.9LysArg: 2.9 ± 0.782
2.566LysSer: 2.566 ± 0.595
2.566LysThr: 2.566 ± 0.675
1.562LysVal: 1.562 ± 0.374
0.335LysTrp: 0.335 ± 0.242
1.45LysTyr: 1.45 ± 0.318
0.0LysXaa: 0.0 ± 0.0
Leu
8.254LeuAla: 8.254 ± 1.074
1.115LeuCys: 1.115 ± 0.409
5.131LeuAsp: 5.131 ± 0.677
5.354LeuGlu: 5.354 ± 0.906
2.008LeuPhe: 2.008 ± 0.379
6.135LeuGly: 6.135 ± 0.69
3.012LeuHis: 3.012 ± 0.544
2.454LeuIle: 2.454 ± 0.589
5.689LeuLys: 5.689 ± 0.852
8.812LeuLeu: 8.812 ± 1.311
2.566LeuMet: 2.566 ± 0.517
4.573LeuAsn: 4.573 ± 0.805
5.577LeuPro: 5.577 ± 0.988
4.573LeuGln: 4.573 ± 0.958
6.916LeuArg: 6.916 ± 1.181
5.02LeuSer: 5.02 ± 0.78
6.023LeuThr: 6.023 ± 1.283
5.02LeuVal: 5.02 ± 0.801
2.119LeuTrp: 2.119 ± 0.387
2.789LeuTyr: 2.789 ± 0.798
0.112LeuXaa: 0.112 ± 0.117
Met
2.231MetAla: 2.231 ± 0.512
0.335MetCys: 0.335 ± 0.179
1.339MetAsp: 1.339 ± 0.352
2.119MetGlu: 2.119 ± 0.346
0.892MetPhe: 0.892 ± 0.328
1.339MetGly: 1.339 ± 0.358
1.115MetHis: 1.115 ± 0.487
0.781MetIle: 0.781 ± 0.278
0.446MetLys: 0.446 ± 0.165
2.677MetLeu: 2.677 ± 0.589
0.892MetMet: 0.892 ± 0.294
0.781MetAsn: 0.781 ± 0.344
1.785MetPro: 1.785 ± 0.429
1.339MetGln: 1.339 ± 0.329
1.562MetArg: 1.562 ± 0.52
1.785MetSer: 1.785 ± 0.449
1.45MetThr: 1.45 ± 0.399
1.785MetVal: 1.785 ± 0.362
0.335MetTrp: 0.335 ± 0.19
1.004MetTyr: 1.004 ± 0.281
0.0MetXaa: 0.0 ± 0.0
Asn
2.677AsnAla: 2.677 ± 0.61
0.892AsnCys: 0.892 ± 0.435
2.454AsnAsp: 2.454 ± 0.575
3.012AsnGlu: 3.012 ± 0.605
2.342AsnPhe: 2.342 ± 0.525
2.677AsnGly: 2.677 ± 1.089
0.446AsnHis: 0.446 ± 0.293
2.342AsnIle: 2.342 ± 0.527
1.004AsnLys: 1.004 ± 0.334
5.131AsnLeu: 5.131 ± 0.745
1.673AsnMet: 1.673 ± 0.636
2.342AsnAsn: 2.342 ± 0.598
3.681AsnPro: 3.681 ± 0.664
1.227AsnGln: 1.227 ± 0.308
2.789AsnArg: 2.789 ± 0.49
4.239AsnSer: 4.239 ± 0.714
2.342AsnThr: 2.342 ± 0.722
2.566AsnVal: 2.566 ± 0.587
0.446AsnTrp: 0.446 ± 0.203
1.896AsnTyr: 1.896 ± 0.573
0.0AsnXaa: 0.0 ± 0.0
Pro
4.35ProAla: 4.35 ± 0.603
0.446ProCys: 0.446 ± 0.2
3.123ProAsp: 3.123 ± 0.319
4.796ProGlu: 4.796 ± 0.82
2.9ProPhe: 2.9 ± 0.575
4.908ProGly: 4.908 ± 0.556
1.004ProHis: 1.004 ± 0.26
1.562ProIle: 1.562 ± 0.335
2.008ProLys: 2.008 ± 0.428
6.023ProLeu: 6.023 ± 1.2
1.45ProMet: 1.45 ± 0.423
3.346ProAsn: 3.346 ± 0.577
8.143ProPro: 8.143 ± 1.709
2.789ProGln: 2.789 ± 0.815
5.02ProArg: 5.02 ± 0.871
5.02ProSer: 5.02 ± 0.878
4.685ProThr: 4.685 ± 0.797
3.681ProVal: 3.681 ± 0.734
0.669ProTrp: 0.669 ± 0.258
1.896ProTyr: 1.896 ± 0.449
0.0ProXaa: 0.0 ± 0.0
Gln
4.35GlnAla: 4.35 ± 0.564
0.669GlnCys: 0.669 ± 0.276
2.119GlnAsp: 2.119 ± 0.396
3.904GlnGlu: 3.904 ± 0.726
1.227GlnPhe: 1.227 ± 0.395
2.566GlnGly: 2.566 ± 0.527
0.892GlnHis: 0.892 ± 0.234
1.673GlnIle: 1.673 ± 0.268
1.339GlnLys: 1.339 ± 0.324
3.681GlnLeu: 3.681 ± 0.579
0.892GlnMet: 0.892 ± 0.315
1.673GlnAsn: 1.673 ± 0.567
4.239GlnPro: 4.239 ± 0.466
3.012GlnGln: 3.012 ± 0.69
3.235GlnArg: 3.235 ± 0.691
2.454GlnSer: 2.454 ± 0.629
2.119GlnThr: 2.119 ± 0.554
3.458GlnVal: 3.458 ± 0.542
0.446GlnTrp: 0.446 ± 0.257
1.004GlnTyr: 1.004 ± 0.382
0.0GlnXaa: 0.0 ± 0.0
Arg
6.804ArgAla: 6.804 ± 0.986
1.673ArgCys: 1.673 ± 0.592
4.127ArgAsp: 4.127 ± 1.013
4.35ArgGlu: 4.35 ± 0.949
2.454ArgPhe: 2.454 ± 0.486
5.02ArgGly: 5.02 ± 0.947
2.566ArgHis: 2.566 ± 0.57
1.896ArgIle: 1.896 ± 0.299
2.119ArgLys: 2.119 ± 0.52
5.577ArgLeu: 5.577 ± 0.934
1.004ArgMet: 1.004 ± 0.296
4.239ArgAsn: 4.239 ± 0.643
5.243ArgPro: 5.243 ± 0.846
4.239ArgGln: 4.239 ± 0.963
8.589ArgArg: 8.589 ± 2.376
4.908ArgSer: 4.908 ± 1.045
3.123ArgThr: 3.123 ± 0.709
3.904ArgVal: 3.904 ± 0.997
1.227ArgTrp: 1.227 ± 0.269
1.45ArgTyr: 1.45 ± 0.346
0.0ArgXaa: 0.0 ± 0.0
Ser
5.243SerAla: 5.243 ± 0.927
1.004SerCys: 1.004 ± 0.255
2.566SerAsp: 2.566 ± 0.364
4.239SerGlu: 4.239 ± 0.839
2.677SerPhe: 2.677 ± 0.559
4.908SerGly: 4.908 ± 0.922
1.673SerHis: 1.673 ± 0.62
2.9SerIle: 2.9 ± 0.557
2.677SerLys: 2.677 ± 0.628
6.47SerLeu: 6.47 ± 1.102
1.45SerMet: 1.45 ± 0.474
3.235SerAsn: 3.235 ± 0.652
5.243SerPro: 5.243 ± 0.88
3.346SerGln: 3.346 ± 0.607
4.239SerArg: 4.239 ± 0.635
5.243SerSer: 5.243 ± 0.978
4.35SerThr: 4.35 ± 0.657
3.569SerVal: 3.569 ± 0.618
1.115SerTrp: 1.115 ± 0.388
2.231SerTyr: 2.231 ± 0.701
0.0SerXaa: 0.0 ± 0.0
Thr
4.796ThrAla: 4.796 ± 0.716
1.227ThrCys: 1.227 ± 0.397
2.9ThrAsp: 2.9 ± 0.537
2.9ThrGlu: 2.9 ± 0.363
3.681ThrPhe: 3.681 ± 0.829
3.235ThrGly: 3.235 ± 0.866
1.45ThrHis: 1.45 ± 0.327
1.896ThrIle: 1.896 ± 0.606
1.673ThrLys: 1.673 ± 0.655
6.023ThrLeu: 6.023 ± 0.77
1.673ThrMet: 1.673 ± 0.476
2.454ThrAsn: 2.454 ± 0.745
4.127ThrPro: 4.127 ± 0.576
1.785ThrGln: 1.785 ± 0.364
3.793ThrArg: 3.793 ± 0.714
3.458ThrSer: 3.458 ± 0.798
4.35ThrThr: 4.35 ± 0.667
4.685ThrVal: 4.685 ± 0.544
0.669ThrTrp: 0.669 ± 0.256
2.566ThrTyr: 2.566 ± 0.518
0.0ThrXaa: 0.0 ± 0.0
Val
5.354ValAla: 5.354 ± 0.789
1.004ValCys: 1.004 ± 0.366
3.235ValAsp: 3.235 ± 0.896
3.681ValGlu: 3.681 ± 0.672
2.789ValPhe: 2.789 ± 0.773
2.119ValGly: 2.119 ± 0.411
1.004ValHis: 1.004 ± 0.316
2.231ValIle: 2.231 ± 0.503
1.115ValLys: 1.115 ± 0.278
5.577ValLeu: 5.577 ± 0.712
2.231ValMet: 2.231 ± 0.388
2.454ValAsn: 2.454 ± 0.481
4.127ValPro: 4.127 ± 0.658
3.123ValGln: 3.123 ± 0.746
4.462ValArg: 4.462 ± 0.693
5.131ValSer: 5.131 ± 1.124
3.904ValThr: 3.904 ± 0.714
3.793ValVal: 3.793 ± 0.765
0.335ValTrp: 0.335 ± 0.17
2.789ValTyr: 2.789 ± 0.457
0.0ValXaa: 0.0 ± 0.0
Trp
0.669TrpAla: 0.669 ± 0.222
0.112TrpCys: 0.112 ± 0.114
0.892TrpAsp: 0.892 ± 0.386
0.892TrpGlu: 0.892 ± 0.293
0.335TrpPhe: 0.335 ± 0.158
0.781TrpGly: 0.781 ± 0.212
0.0TrpHis: 0.0 ± 0.0
0.223TrpIle: 0.223 ± 0.139
0.781TrpLys: 0.781 ± 0.364
0.892TrpLeu: 0.892 ± 0.238
0.446TrpMet: 0.446 ± 0.198
1.115TrpAsn: 1.115 ± 0.434
0.892TrpPro: 0.892 ± 0.395
0.558TrpGln: 0.558 ± 0.251
1.004TrpArg: 1.004 ± 0.372
1.339TrpSer: 1.339 ± 0.305
0.892TrpThr: 0.892 ± 0.366
0.335TrpVal: 0.335 ± 0.175
0.112TrpTrp: 0.112 ± 0.116
0.335TrpTyr: 0.335 ± 0.225
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.231TyrAla: 2.231 ± 0.51
0.781TyrCys: 0.781 ± 0.346
2.342TyrAsp: 2.342 ± 0.516
1.896TyrGlu: 1.896 ± 0.466
1.339TyrPhe: 1.339 ± 0.436
1.227TyrGly: 1.227 ± 0.448
1.227TyrHis: 1.227 ± 0.405
0.892TyrIle: 0.892 ± 0.334
1.785TyrLys: 1.785 ± 0.471
4.127TyrLeu: 4.127 ± 0.742
1.339TyrMet: 1.339 ± 0.522
1.673TyrAsn: 1.673 ± 0.521
1.115TyrPro: 1.115 ± 0.337
1.785TyrGln: 1.785 ± 0.389
1.673TyrArg: 1.673 ± 0.323
2.9TyrSer: 2.9 ± 0.662
1.896TyrThr: 1.896 ± 0.341
1.673TyrVal: 1.673 ± 0.304
0.558TyrTrp: 0.558 ± 0.197
0.446TyrTyr: 0.446 ± 0.222
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.112XaaIle: 0.112 ± 0.098
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.112XaaGln: 0.112 ± 0.117
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 20 proteins (8966 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski