Amino acid dipepetide frequency for Marinospirillum alkaliphilum DSM 21637

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.643AlaAla: 11.643 ± 0.149	1.165AlaCys: 1.165 ± 0.038	5.473AlaAsp: 5.473 ± 0.079	7.109AlaGlu: 7.109 ± 0.09	3.696AlaPhe: 3.696 ± 0.074	8.155AlaGly: 8.155 ± 0.116	1.826AlaHis: 1.826 ± 0.047	4.771AlaIle: 4.771 ± 0.074	2.415AlaLys: 2.415 ± 0.06	12.859AlaLeu: 12.859 ± 0.141	2.647AlaMet: 2.647 ± 0.055	2.534AlaAsn: 2.534 ± 0.053	3.557AlaPro: 3.557 ± 0.069	4.183AlaGln: 4.183 ± 0.077	6.821AlaArg: 6.821 ± 0.091	5.94AlaSer: 5.94 ± 0.099	4.697AlaThr: 4.697 ± 0.065	6.747AlaVal: 6.747 ± 0.094	1.376AlaTrp: 1.376 ± 0.044	2.144AlaTyr: 2.144 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	0.721CysAla: 0.721 ± 0.03	0.153CysCys: 0.153 ± 0.014	0.5CysAsp: 0.5 ± 0.024	0.536CysGlu: 0.536 ± 0.026	0.411CysPhe: 0.411 ± 0.023	0.831CysGly: 0.831 ± 0.032	0.324CysHis: 0.324 ± 0.022	0.506CysIle: 0.506 ± 0.024	0.303CysLys: 0.303 ± 0.02	1.018CysLeu: 1.018 ± 0.033	0.229CysMet: 0.229 ± 0.016	0.314CysAsn: 0.314 ± 0.017	0.525CysPro: 0.525 ± 0.026	0.464CysGln: 0.464 ± 0.027	0.617CysArg: 0.617 ± 0.027	0.571CysSer: 0.571 ± 0.023	0.433CysThr: 0.433 ± 0.025	0.604CysVal: 0.604 ± 0.024	0.14CysTrp: 0.14 ± 0.013	0.268CysTyr: 0.268 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	5.522AspAla: 5.522 ± 0.084	0.458AspCys: 0.458 ± 0.024	2.675AspAsp: 2.675 ± 0.056	3.706AspGlu: 3.706 ± 0.071	2.284AspPhe: 2.284 ± 0.052	3.573AspGly: 3.573 ± 0.065	1.249AspHis: 1.249 ± 0.038	2.671AspIle: 2.671 ± 0.064	1.736AspLys: 1.736 ± 0.049	6.357AspLeu: 6.357 ± 0.088	1.169AspMet: 1.169 ± 0.036	1.466AspAsn: 1.466 ± 0.039	2.655AspPro: 2.655 ± 0.059	3.018AspGln: 3.018 ± 0.063	3.154AspArg: 3.154 ± 0.055	2.513AspSer: 2.513 ± 0.049	2.422AspThr: 2.422 ± 0.046	3.226AspVal: 3.226 ± 0.06	1.067AspTrp: 1.067 ± 0.039	1.728AspTyr: 1.728 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	6.862GluAla: 6.862 ± 0.113	0.411GluCys: 0.411 ± 0.019	2.892GluAsp: 2.892 ± 0.06	3.603GluGlu: 3.603 ± 0.066	1.875GluPhe: 1.875 ± 0.044	4.063GluGly: 4.063 ± 0.077	1.487GluHis: 1.487 ± 0.04	3.082GluIle: 3.082 ± 0.067	2.709GluLys: 2.709 ± 0.058	7.575GluLeu: 7.575 ± 0.114	1.545GluMet: 1.545 ± 0.041	1.817GluAsn: 1.817 ± 0.045	2.364GluPro: 2.364 ± 0.056	4.861GluGln: 4.861 ± 0.091	4.308GluArg: 4.308 ± 0.077	2.924GluSer: 2.924 ± 0.048	3.102GluThr: 3.102 ± 0.058	4.635GluVal: 4.635 ± 0.07	0.765GluTrp: 0.765 ± 0.035	1.342GluTyr: 1.342 ± 0.04	0.0GluXaa: 0.0 ± 0.0
Phe	3.48PheAla: 3.48 ± 0.072	0.45PheCys: 0.45 ± 0.021	2.258PheAsp: 2.258 ± 0.054	2.06PheGlu: 2.06 ± 0.048	1.5PhePhe: 1.5 ± 0.041	2.797PheGly: 2.797 ± 0.054	0.834PheHis: 0.834 ± 0.028	1.974PheIle: 1.974 ± 0.052	1.126PheLys: 1.126 ± 0.038	3.404PheLeu: 3.404 ± 0.067	1.032PheMet: 1.032 ± 0.036	1.404PheAsn: 1.404 ± 0.043	1.462PhePro: 1.462 ± 0.043	1.344PheGln: 1.344 ± 0.037	2.098PheArg: 2.098 ± 0.049	2.591PheSer: 2.591 ± 0.056	2.007PheThr: 2.007 ± 0.048	2.379PheVal: 2.379 ± 0.056	0.568PheTrp: 0.568 ± 0.026	1.136PheTyr: 1.136 ± 0.039	0.0PheXaa: 0.0 ± 0.0
Gly	5.724GlyAla: 5.724 ± 0.083	0.922GlyCys: 0.922 ± 0.036	3.633GlyAsp: 3.633 ± 0.072	4.55GlyGlu: 4.55 ± 0.073	3.218GlyPhe: 3.218 ± 0.063	5.371GlyGly: 5.371 ± 0.109	1.88GlyHis: 1.88 ± 0.045	4.311GlyIle: 4.311 ± 0.068	3.25GlyLys: 3.25 ± 0.075	8.753GlyLeu: 8.753 ± 0.105	2.285GlyMet: 2.285 ± 0.047	2.098GlyAsn: 2.098 ± 0.071	1.994GlyPro: 1.994 ± 0.05	4.112GlyGln: 4.112 ± 0.078	4.598GlyArg: 4.598 ± 0.068	4.292GlySer: 4.292 ± 0.085	3.178GlyThr: 3.178 ± 0.079	5.415GlyVal: 5.415 ± 0.082	1.343GlyTrp: 1.343 ± 0.041	2.431GlyTyr: 2.431 ± 0.06	0.0GlyXaa: 0.0 ± 0.0
His	2.075HisAla: 2.075 ± 0.042	0.273HisCys: 0.273 ± 0.016	1.072HisAsp: 1.072 ± 0.033	1.324HisGlu: 1.324 ± 0.043	1.105HisPhe: 1.105 ± 0.035	1.614HisGly: 1.614 ± 0.047	0.778HisHis: 0.778 ± 0.025	0.969HisIle: 0.969 ± 0.031	0.71HisLys: 0.71 ± 0.027	3.244HisLeu: 3.244 ± 0.062	0.435HisMet: 0.435 ± 0.019	0.649HisAsn: 0.649 ± 0.027	1.706HisPro: 1.706 ± 0.046	1.8HisGln: 1.8 ± 0.051	1.553HisArg: 1.553 ± 0.041	1.163HisSer: 1.163 ± 0.033	1.012HisThr: 1.012 ± 0.031	1.021HisVal: 1.021 ± 0.033	0.532HisTrp: 0.532 ± 0.026	0.851HisTyr: 0.851 ± 0.031	0.0HisXaa: 0.0 ± 0.0
Ile	4.643IleAla: 4.643 ± 0.085	0.515IleCys: 0.515 ± 0.022	2.67IleAsp: 2.67 ± 0.062	3.335IleGlu: 3.335 ± 0.065	1.613IlePhe: 1.613 ± 0.049	3.89IleGly: 3.89 ± 0.078	1.315IleHis: 1.315 ± 0.038	2.297IleIle: 2.297 ± 0.056	1.894IleLys: 1.894 ± 0.047	4.718IleLeu: 4.718 ± 0.08	1.004IleMet: 1.004 ± 0.034	2.267IleAsn: 2.267 ± 0.052	2.259IlePro: 2.259 ± 0.055	2.259IleGln: 2.259 ± 0.051	3.442IleArg: 3.442 ± 0.059	3.355IleSer: 3.355 ± 0.058	3.109IleThr: 3.109 ± 0.06	2.434IleVal: 2.434 ± 0.051	0.568IleTrp: 0.568 ± 0.024	1.246IleTyr: 1.246 ± 0.038	0.0IleXaa: 0.0 ± 0.0
Lys	3.762LysAla: 3.762 ± 0.07	0.205LysCys: 0.205 ± 0.015	1.871LysAsp: 1.871 ± 0.05	1.945LysGlu: 1.945 ± 0.055	0.732LysPhe: 0.732 ± 0.027	2.595LysGly: 2.595 ± 0.062	0.788LysHis: 0.788 ± 0.03	1.728LysIle: 1.728 ± 0.048	1.748LysLys: 1.748 ± 0.057	3.765LysLeu: 3.765 ± 0.067	0.863LysMet: 0.863 ± 0.032	1.155LysAsn: 1.155 ± 0.037	1.959LysPro: 1.959 ± 0.051	1.809LysGln: 1.809 ± 0.056	2.157LysArg: 2.157 ± 0.046	1.795LysSer: 1.795 ± 0.052	1.897LysThr: 1.897 ± 0.051	2.591LysVal: 2.591 ± 0.058	0.277LysTrp: 0.277 ± 0.017	0.67LysTyr: 0.67 ± 0.027	0.0LysXaa: 0.0 ± 0.0
Leu	13.584LeuAla: 13.584 ± 0.156	0.949LeuCys: 0.949 ± 0.034	6.973LeuAsp: 6.973 ± 0.096	7.542LeuGlu: 7.542 ± 0.124	3.889LeuPhe: 3.889 ± 0.076	8.364LeuGly: 8.364 ± 0.107	2.739LeuHis: 2.739 ± 0.062	5.853LeuIle: 5.853 ± 0.09	4.826LeuLys: 4.826 ± 0.071	17.579LeuLeu: 17.579 ± 0.279	3.073LeuMet: 3.073 ± 0.07	3.956LeuAsn: 3.956 ± 0.071	6.749LeuPro: 6.749 ± 0.102	7.503LeuGln: 7.503 ± 0.141	6.815LeuArg: 6.815 ± 0.104	6.801LeuSer: 6.801 ± 0.089	6.215LeuThr: 6.215 ± 0.098	8.91LeuVal: 8.91 ± 0.113	1.377LeuTrp: 1.377 ± 0.041	2.418LeuTyr: 2.418 ± 0.054	0.0LeuXaa: 0.0 ± 0.0
Met	2.683MetAla: 2.683 ± 0.049	0.141MetCys: 0.141 ± 0.012	1.389MetAsp: 1.389 ± 0.04	1.301MetGlu: 1.301 ± 0.028	0.67MetPhe: 0.67 ± 0.027	1.817MetGly: 1.817 ± 0.045	0.577MetHis: 0.577 ± 0.024	1.205MetIle: 1.205 ± 0.04	1.15MetLys: 1.15 ± 0.034	2.733MetLeu: 2.733 ± 0.061	0.667MetMet: 0.667 ± 0.027	1.029MetAsn: 1.029 ± 0.032	1.289MetPro: 1.289 ± 0.034	1.536MetGln: 1.536 ± 0.036	1.287MetArg: 1.287 ± 0.044	1.615MetSer: 1.615 ± 0.047	1.551MetThr: 1.551 ± 0.039	1.529MetVal: 1.529 ± 0.039	0.175MetTrp: 0.175 ± 0.013	0.376MetTyr: 0.376 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	2.936AsnAla: 2.936 ± 0.069	0.288AsnCys: 0.288 ± 0.02	1.319AsnAsp: 1.319 ± 0.044	1.629AsnGlu: 1.629 ± 0.047	1.083AsnPhe: 1.083 ± 0.035	1.999AsnGly: 1.999 ± 0.065	0.747AsnHis: 0.747 ± 0.026	1.568AsnIle: 1.568 ± 0.047	1.079AsnLys: 1.079 ± 0.038	3.782AsnLeu: 3.782 ± 0.061	0.699AsnMet: 0.699 ± 0.028	1.142AsnAsn: 1.142 ± 0.055	2.203AsnPro: 2.203 ± 0.043	1.81AsnGln: 1.81 ± 0.046	2.268AsnArg: 2.268 ± 0.054	1.59AsnSer: 1.59 ± 0.053	1.747AsnThr: 1.747 ± 0.059	1.502AsnVal: 1.502 ± 0.051	0.488AsnTrp: 0.488 ± 0.022	0.737AsnTyr: 0.737 ± 0.03	0.0AsnXaa: 0.0 ± 0.0
Pro	4.814ProAla: 4.814 ± 0.093	0.359ProCys: 0.359 ± 0.019	3.247ProAsp: 3.247 ± 0.054	4.057ProGlu: 4.057 ± 0.069	1.663ProPhe: 1.663 ± 0.044	3.82ProGly: 3.82 ± 0.071	0.985ProHis: 0.985 ± 0.034	1.763ProIle: 1.763 ± 0.042	1.262ProLys: 1.262 ± 0.035	5.84ProLeu: 5.84 ± 0.098	1.068ProMet: 1.068 ± 0.031	1.073ProAsn: 1.073 ± 0.035	1.899ProPro: 1.899 ± 0.049	2.133ProGln: 2.133 ± 0.046	2.399ProArg: 2.399 ± 0.053	2.248ProSer: 2.248 ± 0.05	1.946ProThr: 1.946 ± 0.044	4.016ProVal: 4.016 ± 0.066	0.735ProTrp: 0.735 ± 0.029	1.0ProTyr: 1.0 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	6.502GlnAla: 6.502 ± 0.098	0.358GlnCys: 0.358 ± 0.02	2.4GlnAsp: 2.4 ± 0.051	2.786GlnGlu: 2.786 ± 0.064	1.301GlnPhe: 1.301 ± 0.04	4.052GlnGly: 4.052 ± 0.071	1.449GlnHis: 1.449 ± 0.046	2.239GlnIle: 2.239 ± 0.051	1.655GlnLys: 1.655 ± 0.05	8.261GlnLeu: 8.261 ± 0.156	1.269GlnMet: 1.269 ± 0.035	1.195GlnAsn: 1.195 ± 0.039	3.168GlnPro: 3.168 ± 0.068	6.099GlnGln: 6.099 ± 0.14	3.95GlnArg: 3.95 ± 0.088	2.477GlnSer: 2.477 ± 0.051	2.356GlnThr: 2.356 ± 0.062	4.271GlnVal: 4.271 ± 0.071	0.827GlnTrp: 0.827 ± 0.033	0.886GlnTyr: 0.886 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	4.889ArgAla: 4.889 ± 0.086	0.611ArgCys: 0.611 ± 0.025	3.272ArgAsp: 3.272 ± 0.054	4.239ArgGlu: 4.239 ± 0.081	2.67ArgPhe: 2.67 ± 0.056	3.688ArgGly: 3.688 ± 0.06	1.849ArgHis: 1.849 ± 0.047	3.635ArgIle: 3.635 ± 0.061	2.298ArgLys: 2.298 ± 0.05	8.571ArgLeu: 8.571 ± 0.104	1.793ArgMet: 1.793 ± 0.047	2.114ArgAsn: 2.114 ± 0.048	2.538ArgPro: 2.538 ± 0.052	4.037ArgGln: 4.037 ± 0.081	4.115ArgArg: 4.115 ± 0.082	3.358ArgSer: 3.358 ± 0.061	2.698ArgThr: 2.698 ± 0.051	4.37ArgVal: 4.37 ± 0.074	1.025ArgTrp: 1.025 ± 0.041	1.9ArgTyr: 1.9 ± 0.047	0.0ArgXaa: 0.0 ± 0.0
Ser	4.887SerAla: 4.887 ± 0.072	0.589SerCys: 0.589 ± 0.023	2.843SerAsp: 2.843 ± 0.06	3.25SerGlu: 3.25 ± 0.051	2.137SerPhe: 2.137 ± 0.049	5.111SerGly: 5.111 ± 0.095	1.453SerHis: 1.453 ± 0.038	2.803SerIle: 2.803 ± 0.055	1.698SerLys: 1.698 ± 0.045	7.217SerLeu: 7.217 ± 0.093	1.426SerMet: 1.426 ± 0.035	1.741SerAsn: 1.741 ± 0.052	2.359SerPro: 2.359 ± 0.05	2.582SerGln: 2.582 ± 0.048	3.909SerArg: 3.909 ± 0.067	3.605SerSer: 3.605 ± 0.078	2.544SerThr: 2.544 ± 0.062	3.515SerVal: 3.515 ± 0.059	0.863SerTrp: 0.863 ± 0.029	1.388SerTyr: 1.388 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	5.141ThrAla: 5.141 ± 0.077	0.514ThrCys: 0.514 ± 0.022	2.615ThrAsp: 2.615 ± 0.057	3.037ThrGlu: 3.037 ± 0.056	1.75ThrPhe: 1.75 ± 0.045	4.641ThrGly: 4.641 ± 0.09	1.176ThrHis: 1.176 ± 0.042	1.795ThrIle: 1.795 ± 0.053	0.946ThrLys: 0.946 ± 0.03	7.134ThrLeu: 7.134 ± 0.097	0.708ThrMet: 0.708 ± 0.03	1.274ThrAsn: 1.274 ± 0.044	2.962ThrPro: 2.962 ± 0.059	2.149ThrGln: 2.149 ± 0.055	3.297ThrArg: 3.297 ± 0.062	2.965ThrSer: 2.965 ± 0.059	2.616ThrThr: 2.616 ± 0.067	2.67ThrVal: 2.67 ± 0.06	0.558ThrTrp: 0.558 ± 0.025	1.057ThrTyr: 1.057 ± 0.035	0.001ThrXaa: 0.001 ± 0.001
Val	6.867ValAla: 6.867 ± 0.103	0.679ValCys: 0.679 ± 0.028	3.835ValAsp: 3.835 ± 0.066	4.397ValGlu: 4.397 ± 0.071	2.799ValPhe: 2.799 ± 0.056	4.347ValGly: 4.347 ± 0.078	1.428ValHis: 1.428 ± 0.044	3.954ValIle: 3.954 ± 0.069	2.331ValLys: 2.331 ± 0.05	7.571ValLeu: 7.571 ± 0.096	1.899ValMet: 1.899 ± 0.046	2.254ValAsn: 2.254 ± 0.051	2.705ValPro: 2.705 ± 0.057	2.949ValGln: 2.949 ± 0.056	4.026ValArg: 4.026 ± 0.071	4.017ValSer: 4.017 ± 0.062	3.721ValThr: 3.721 ± 0.064	5.135ValVal: 5.135 ± 0.097	0.808ValTrp: 0.808 ± 0.03	1.65ValTyr: 1.65 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	0.87TrpAla: 0.87 ± 0.03	0.162TrpCys: 0.162 ± 0.011	0.521TrpAsp: 0.521 ± 0.022	0.551TrpGlu: 0.551 ± 0.025	0.514TrpPhe: 0.514 ± 0.027	0.817TrpGly: 0.817 ± 0.032	0.389TrpHis: 0.389 ± 0.021	0.692TrpIle: 0.692 ± 0.03	0.418TrpLys: 0.418 ± 0.019	2.55TrpLeu: 2.55 ± 0.072	0.417TrpMet: 0.417 ± 0.02	0.406TrpAsn: 0.406 ± 0.021	0.722TrpPro: 0.722 ± 0.032	1.342TrpGln: 1.342 ± 0.045	0.952TrpArg: 0.952 ± 0.034	0.729TrpSer: 0.729 ± 0.03	0.535TrpThr: 0.535 ± 0.024	0.993TrpVal: 0.993 ± 0.035	0.241TrpTrp: 0.241 ± 0.016	0.321TrpTyr: 0.321 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.153TyrAla: 2.153 ± 0.046	0.266TyrCys: 0.266 ± 0.016	1.189TyrAsp: 1.189 ± 0.039	1.264TyrGlu: 1.264 ± 0.034	0.995TyrPhe: 0.995 ± 0.036	1.817TyrGly: 1.817 ± 0.046	0.612TyrHis: 0.612 ± 0.023	1.018TyrIle: 1.018 ± 0.035	0.758TyrLys: 0.758 ± 0.033	3.186TyrLeu: 3.186 ± 0.066	0.49TyrMet: 0.49 ± 0.022	0.727TyrAsn: 0.727 ± 0.033	1.25TyrPro: 1.25 ± 0.037	1.514TyrGln: 1.514 ± 0.039	1.902TyrArg: 1.902 ± 0.051	1.372TyrSer: 1.372 ± 0.041	1.219TyrThr: 1.219 ± 0.035	1.409TyrVal: 1.409 ± 0.037	0.408TyrTrp: 0.408 ± 0.02	0.667TyrTyr: 0.667 ± 0.03	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.001XaaHis: 0.001 ± 0.001	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.002XaaXaa: 0.002 ± 0.002

Statistics based on 2894 proteins (963687 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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