Amino acid dipepetide frequency for Hubei mosquito virus 2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.784AlaAla: 6.784 ± 2.622
1.357AlaCys: 1.357 ± 0.558
2.714AlaAsp: 2.714 ± 1.286
1.357AlaGlu: 1.357 ± 0.558
5.427AlaPhe: 5.427 ± 1.375
2.714AlaGly: 2.714 ± 1.115
0.678AlaHis: 0.678 ± 0.486
1.357AlaIle: 1.357 ± 0.74
4.071AlaLys: 4.071 ± 1.625
5.427AlaLeu: 5.427 ± 1.375
3.392AlaMet: 3.392 ± 1.64
2.035AlaAsn: 2.035 ± 1.124
8.141AlaPro: 8.141 ± 2.93
3.392AlaGln: 3.392 ± 0.718
3.392AlaArg: 3.392 ± 0.718
2.035AlaSer: 2.035 ± 0.8
2.035AlaThr: 2.035 ± 0.732
8.141AlaVal: 8.141 ± 1.911
1.357AlaTrp: 1.357 ± 1.324
0.678AlaTyr: 0.678 ± 0.662
0.0AlaXaa: 0.0 ± 0.0
Cys
0.678CysAla: 0.678 ± 0.52
1.357CysCys: 1.357 ± 0.971
0.678CysAsp: 0.678 ± 0.662
1.357CysGlu: 1.357 ± 1.04
1.357CysPhe: 1.357 ± 0.558
0.678CysGly: 0.678 ± 0.662
0.0CysHis: 0.0 ± 0.0
0.678CysIle: 0.678 ± 0.486
0.0CysLys: 0.0 ± 0.0
1.357CysLeu: 1.357 ± 1.324
0.678CysMet: 0.678 ± 0.662
0.0CysAsn: 0.0 ± 0.0
0.0CysPro: 0.0 ± 0.0
0.678CysGln: 0.678 ± 0.52
2.035CysArg: 2.035 ± 0.809
0.678CysSer: 0.678 ± 0.486
2.035CysThr: 2.035 ± 0.732
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
1.357CysTyr: 1.357 ± 1.324
0.0CysXaa: 0.0 ± 0.0
Asp
2.035AspAla: 2.035 ± 0.732
0.0AspCys: 0.0 ± 0.0
3.392AspAsp: 3.392 ± 1.795
3.392AspGlu: 3.392 ± 2.428
0.678AspPhe: 0.678 ± 0.52
6.106AspGly: 6.106 ± 2.489
0.0AspHis: 0.0 ± 0.0
2.714AspIle: 2.714 ± 1.546
4.071AspLys: 4.071 ± 2.302
3.392AspLeu: 3.392 ± 0.751
0.678AspMet: 0.678 ± 0.52
2.035AspAsn: 2.035 ± 0.8
4.071AspPro: 4.071 ± 0.446
2.714AspGln: 2.714 ± 0.627
4.749AspArg: 4.749 ± 1.75
4.071AspSer: 4.071 ± 1.228
2.714AspThr: 2.714 ± 1.932
4.071AspVal: 4.071 ± 1.31
1.357AspTrp: 1.357 ± 0.74
2.714AspTyr: 2.714 ± 1.213
0.0AspXaa: 0.0 ± 0.0
Glu
4.749GluAla: 4.749 ± 2.004
0.678GluCys: 0.678 ± 0.52
6.784GluAsp: 6.784 ± 1.911
3.392GluGlu: 3.392 ± 1.083
2.035GluPhe: 2.035 ± 1.124
2.714GluGly: 2.714 ± 0.819
0.678GluHis: 0.678 ± 0.486
6.106GluIle: 6.106 ± 1.012
2.035GluLys: 2.035 ± 1.457
5.427GluLeu: 5.427 ± 1.044
0.0GluMet: 0.0 ± 0.0
1.357GluAsn: 1.357 ± 0.558
2.714GluPro: 2.714 ± 0.934
0.678GluGln: 0.678 ± 0.486
0.678GluArg: 0.678 ± 0.662
3.392GluSer: 3.392 ± 2.428
3.392GluThr: 3.392 ± 0.246
3.392GluVal: 3.392 ± 1.083
0.678GluTrp: 0.678 ± 0.662
2.035GluTyr: 2.035 ± 0.8
0.0GluXaa: 0.0 ± 0.0
Phe
2.714PheAla: 2.714 ± 1.758
2.035PheCys: 2.035 ± 0.286
4.071PheAsp: 4.071 ± 0.573
2.714PheGlu: 2.714 ± 0.934
0.0PhePhe: 0.0 ± 0.0
3.392PheGly: 3.392 ± 0.751
0.0PheHis: 0.0 ± 0.0
2.035PheIle: 2.035 ± 1.124
2.035PheLys: 2.035 ± 1.305
4.749PheLeu: 4.749 ± 1.102
0.0PheMet: 0.0 ± 0.0
3.392PheAsn: 3.392 ± 0.246
2.035PhePro: 2.035 ± 0.286
2.035PheGln: 2.035 ± 0.732
0.678PheArg: 0.678 ± 0.486
1.357PheSer: 1.357 ± 0.409
0.678PheThr: 0.678 ± 0.486
3.392PheVal: 3.392 ± 0.718
2.035PheTrp: 2.035 ± 0.732
2.714PheTyr: 2.714 ± 1.173
0.0PheXaa: 0.0 ± 0.0
Gly
3.392GlyAla: 3.392 ± 1.661
0.678GlyCys: 0.678 ± 0.662
2.714GlyAsp: 2.714 ± 0.627
2.035GlyGlu: 2.035 ± 0.286
3.392GlyPhe: 3.392 ± 1.661
2.035GlyGly: 2.035 ± 0.809
0.678GlyHis: 0.678 ± 0.52
3.392GlyIle: 3.392 ± 1.083
3.392GlyLys: 3.392 ± 1.116
2.714GlyLeu: 2.714 ± 1.942
1.357GlyMet: 1.357 ± 0.971
2.035GlyAsn: 2.035 ± 0.809
3.392GlyPro: 3.392 ± 0.246
2.714GlyGln: 2.714 ± 1.942
4.749GlyArg: 4.749 ± 1.102
8.141GlySer: 8.141 ± 3.06
3.392GlyThr: 3.392 ± 1.012
4.749GlyVal: 4.749 ± 1.213
2.035GlyTrp: 2.035 ± 1.986
3.392GlyTyr: 3.392 ± 0.718
0.0GlyXaa: 0.0 ± 0.0
His
0.0HisAla: 0.0 ± 0.0
0.0HisCys: 0.0 ± 0.0
0.0HisAsp: 0.0 ± 0.0
1.357HisGlu: 1.357 ± 0.409
0.678HisPhe: 0.678 ± 0.52
1.357HisGly: 1.357 ± 0.971
0.0HisHis: 0.0 ± 0.0
0.678HisIle: 0.678 ± 0.486
2.035HisLys: 2.035 ± 0.809
2.035HisLeu: 2.035 ± 1.457
0.678HisMet: 0.678 ± 0.53
0.678HisAsn: 0.678 ± 0.52
0.678HisPro: 0.678 ± 0.486
0.0HisGln: 0.0 ± 0.0
0.0HisArg: 0.0 ± 0.0
0.0HisSer: 0.0 ± 0.0
0.678HisThr: 0.678 ± 0.662
1.357HisVal: 1.357 ± 0.558
0.0HisTrp: 0.0 ± 0.0
2.714HisTyr: 2.714 ± 0.296
0.0HisXaa: 0.0 ± 0.0
Ile
2.714IleAla: 2.714 ± 1.213
0.678IleCys: 0.678 ± 0.662
4.071IleAsp: 4.071 ± 1.31
2.035IleGlu: 2.035 ± 0.732
2.714IlePhe: 2.714 ± 0.627
2.714IleGly: 2.714 ± 0.296
1.357IleHis: 1.357 ± 0.409
0.678IleIle: 0.678 ± 0.662
2.035IleLys: 2.035 ± 0.732
6.784IleLeu: 6.784 ± 2.024
1.357IleMet: 1.357 ± 0.558
1.357IleAsn: 1.357 ± 0.409
0.678IlePro: 0.678 ± 0.52
2.714IleGln: 2.714 ± 0.934
3.392IleArg: 3.392 ± 1.791
4.749IleSer: 4.749 ± 0.825
2.714IleThr: 2.714 ± 0.819
4.749IleVal: 4.749 ± 1.895
0.678IleTrp: 0.678 ± 0.52
1.357IleTyr: 1.357 ± 0.971
0.0IleXaa: 0.0 ± 0.0
Lys
2.714LysAla: 2.714 ± 1.173
0.0LysCys: 0.0 ± 0.0
2.714LysAsp: 2.714 ± 2.08
4.071LysGlu: 4.071 ± 1.465
3.392LysPhe: 3.392 ± 1.012
2.714LysGly: 2.714 ± 0.296
1.357LysHis: 1.357 ± 0.409
3.392LysIle: 3.392 ± 1.661
4.749LysLys: 4.749 ± 0.9
6.784LysLeu: 6.784 ± 2.253
0.0LysMet: 0.0 ± 0.0
1.357LysAsn: 1.357 ± 1.04
0.678LysPro: 0.678 ± 0.486
4.749LysGln: 4.749 ± 2.518
4.071LysArg: 4.071 ± 1.228
2.035LysSer: 2.035 ± 1.124
2.714LysThr: 2.714 ± 0.296
4.749LysVal: 4.749 ± 1.717
0.0LysTrp: 0.0 ± 0.0
1.357LysTyr: 1.357 ± 0.409
0.0LysXaa: 0.0 ± 0.0
Leu
6.106LeuAla: 6.106 ± 1.856
0.0LeuCys: 0.0 ± 0.0
6.784LeuAsp: 6.784 ± 1.916
7.463LeuGlu: 7.463 ± 1.571
6.106LeuPhe: 6.106 ± 1.802
6.784LeuGly: 6.784 ± 0.532
0.678LeuHis: 0.678 ± 0.662
3.392LeuIle: 3.392 ± 1.012
4.749LeuLys: 4.749 ± 0.9
4.071LeuLeu: 4.071 ± 2.255
0.678LeuMet: 0.678 ± 0.52
3.392LeuAsn: 3.392 ± 1.116
3.392LeuPro: 3.392 ± 1.302
2.035LeuGln: 2.035 ± 0.8
2.035LeuArg: 2.035 ± 1.124
5.427LeuSer: 5.427 ± 2.033
5.427LeuThr: 5.427 ± 0.592
10.176LeuVal: 10.176 ± 3.063
0.678LeuTrp: 0.678 ± 0.662
0.678LeuTyr: 0.678 ± 0.662
0.0LeuXaa: 0.0 ± 0.0
Met
2.035MetAla: 2.035 ± 0.286
0.0MetCys: 0.0 ± 0.0
0.0MetAsp: 0.0 ± 0.0
2.035MetGlu: 2.035 ± 1.457
0.678MetPhe: 0.678 ± 0.486
1.357MetGly: 1.357 ± 0.409
0.678MetHis: 0.678 ± 0.486
2.035MetIle: 2.035 ± 0.732
2.714MetLys: 2.714 ± 1.932
2.035MetLeu: 2.035 ± 0.809
0.678MetMet: 0.678 ± 0.662
0.678MetAsn: 0.678 ± 0.662
1.357MetPro: 1.357 ± 0.409
0.0MetGln: 0.0 ± 0.0
0.678MetArg: 0.678 ± 0.486
1.357MetSer: 1.357 ± 1.04
1.357MetThr: 1.357 ± 0.409
2.714MetVal: 2.714 ± 1.213
0.0MetTrp: 0.0 ± 0.0
2.714MetTyr: 2.714 ± 0.296
0.0MetXaa: 0.0 ± 0.0
Asn
1.357AsnAla: 1.357 ± 0.74
0.0AsnCys: 0.0 ± 0.0
1.357AsnAsp: 1.357 ± 0.409
2.035AsnGlu: 2.035 ± 0.809
1.357AsnPhe: 1.357 ± 1.04
2.035AsnGly: 2.035 ± 0.732
0.0AsnHis: 0.0 ± 0.0
1.357AsnIle: 1.357 ± 0.409
0.678AsnLys: 0.678 ± 0.52
2.035AsnLeu: 2.035 ± 1.124
1.357AsnMet: 1.357 ± 0.971
0.678AsnAsn: 0.678 ± 0.662
2.714AsnPro: 2.714 ± 0.934
1.357AsnGln: 1.357 ± 0.558
4.749AsnArg: 4.749 ± 1.276
2.714AsnSer: 2.714 ± 1.758
0.678AsnThr: 0.678 ± 0.52
6.106AsnVal: 6.106 ± 2.4
1.357AsnTrp: 1.357 ± 0.74
2.035AsnTyr: 2.035 ± 0.8
0.0AsnXaa: 0.0 ± 0.0
Pro
6.784ProAla: 6.784 ± 1.195
2.035ProCys: 2.035 ± 0.286
1.357ProAsp: 1.357 ± 0.74
2.714ProGlu: 2.714 ± 0.627
0.678ProPhe: 0.678 ± 0.486
2.035ProGly: 2.035 ± 0.809
2.035ProHis: 2.035 ± 1.305
2.035ProIle: 2.035 ± 0.809
0.678ProLys: 0.678 ± 0.662
3.392ProLeu: 3.392 ± 1.64
1.357ProMet: 1.357 ± 0.558
1.357ProAsn: 1.357 ± 0.409
12.89ProPro: 12.89 ± 5.876
2.714ProGln: 2.714 ± 0.296
3.392ProArg: 3.392 ± 1.083
4.071ProSer: 4.071 ± 1.228
2.035ProThr: 2.035 ± 0.732
8.82ProVal: 8.82 ± 1.093
1.357ProTrp: 1.357 ± 0.74
5.427ProTyr: 5.427 ± 1.044
0.0ProXaa: 0.0 ± 0.0
Gln
2.035GlnAla: 2.035 ± 0.732
0.678GlnCys: 0.678 ± 0.486
0.678GlnAsp: 0.678 ± 0.662
2.714GlnGlu: 2.714 ± 0.934
2.714GlnPhe: 2.714 ± 0.296
3.392GlnGly: 3.392 ± 0.751
1.357GlnHis: 1.357 ± 0.558
3.392GlnIle: 3.392 ± 2.03
2.714GlnLys: 2.714 ± 0.296
4.749GlnLeu: 4.749 ± 1.75
0.678GlnMet: 0.678 ± 0.428
3.392GlnAsn: 3.392 ± 1.302
3.392GlnPro: 3.392 ± 0.718
4.071GlnGln: 4.071 ± 0.758
2.035GlnArg: 2.035 ± 0.732
2.714GlnSer: 2.714 ± 0.296
0.678GlnThr: 0.678 ± 0.662
2.714GlnVal: 2.714 ± 1.286
0.0GlnTrp: 0.0 ± 0.0
4.071GlnTyr: 4.071 ± 0.758
0.678GlnXaa: 0.678 ± 0.52
Arg
3.392ArgAla: 3.392 ± 1.302
1.357ArgCys: 1.357 ± 0.74
3.392ArgAsp: 3.392 ± 1.083
3.392ArgGlu: 3.392 ± 1.661
2.714ArgPhe: 2.714 ± 1.758
3.392ArgGly: 3.392 ± 0.718
1.357ArgHis: 1.357 ± 0.971
2.035ArgIle: 2.035 ± 1.095
4.071ArgLys: 4.071 ± 1.6
5.427ArgLeu: 5.427 ± 3.091
1.357ArgMet: 1.357 ± 1.04
2.714ArgAsn: 2.714 ± 0.819
2.714ArgPro: 2.714 ± 0.627
5.427ArgGln: 5.427 ± 0.592
2.714ArgArg: 2.714 ± 0.296
4.749ArgSer: 4.749 ± 0.612
4.071ArgThr: 4.071 ± 0.446
6.106ArgVal: 6.106 ± 0.859
0.0ArgTrp: 0.0 ± 0.0
0.0ArgTyr: 0.0 ± 0.0
0.0ArgXaa: 0.0 ± 0.0
Ser
6.784SerAla: 6.784 ± 1.33
0.678SerCys: 0.678 ± 0.52
4.071SerAsp: 4.071 ± 1.625
2.035SerGlu: 2.035 ± 0.732
1.357SerPhe: 1.357 ± 0.971
6.106SerGly: 6.106 ± 1.856
2.035SerHis: 2.035 ± 0.809
2.714SerIle: 2.714 ± 0.296
2.714SerLys: 2.714 ± 0.819
3.392SerLeu: 3.392 ± 1.594
3.392SerMet: 3.392 ± 0.983
2.035SerAsn: 2.035 ± 1.095
4.071SerPro: 4.071 ± 1.31
3.392SerGln: 3.392 ± 1.116
4.749SerArg: 4.749 ± 1.276
4.749SerSer: 4.749 ± 1.544
3.392SerThr: 3.392 ± 0.751
4.749SerVal: 4.749 ± 1.895
1.357SerTrp: 1.357 ± 0.409
1.357SerTyr: 1.357 ± 0.74
0.0SerXaa: 0.0 ± 0.0
Thr
2.035ThrAla: 2.035 ± 0.8
1.357ThrCys: 1.357 ± 0.558
0.678ThrAsp: 0.678 ± 0.52
1.357ThrGlu: 1.357 ± 0.971
1.357ThrPhe: 1.357 ± 0.558
2.035ThrGly: 2.035 ± 0.732
0.678ThrHis: 0.678 ± 0.486
4.749ThrIle: 4.749 ± 0.612
3.392ThrLys: 3.392 ± 1.16
2.035ThrLeu: 2.035 ± 0.286
2.714ThrMet: 2.714 ± 1.173
1.357ThrAsn: 1.357 ± 1.04
4.071ThrPro: 4.071 ± 0.573
2.035ThrGln: 2.035 ± 0.732
4.749ThrArg: 4.749 ± 1.253
4.071ThrSer: 4.071 ± 2.115
3.392ThrThr: 3.392 ± 1.083
4.749ThrVal: 4.749 ± 2.742
0.0ThrTrp: 0.0 ± 0.0
3.392ThrTyr: 3.392 ± 1.302
0.0ThrXaa: 0.0 ± 0.0
Val
8.141ValAla: 8.141 ± 1.882
1.357ValCys: 1.357 ± 0.558
6.784ValAsp: 6.784 ± 1.614
3.392ValGlu: 3.392 ± 1.661
4.071ValPhe: 4.071 ± 0.446
5.427ValGly: 5.427 ± 1.255
0.0ValHis: 0.0 ± 0.0
4.749ValIle: 4.749 ± 1.464
5.427ValLys: 5.427 ± 3.517
8.141ValLeu: 8.141 ± 1.769
2.035ValMet: 2.035 ± 1.124
4.071ValAsn: 4.071 ± 0.793
7.463ValPro: 7.463 ± 3.066
4.749ValGln: 4.749 ± 1.213
5.427ValArg: 5.427 ± 2.173
4.749ValSer: 4.749 ± 1.213
5.427ValThr: 5.427 ± 0.804
5.427ValVal: 5.427 ± 1.375
3.392ValTrp: 3.392 ± 0.246
2.714ValTyr: 2.714 ± 1.173
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.0TrpCys: 0.0 ± 0.0
1.357TrpAsp: 1.357 ± 1.324
0.0TrpGlu: 0.0 ± 0.0
0.678TrpPhe: 0.678 ± 0.662
0.0TrpGly: 0.0 ± 0.0
0.0TrpHis: 0.0 ± 0.0
2.035TrpIle: 2.035 ± 1.305
0.0TrpLys: 0.0 ± 0.0
2.035TrpLeu: 2.035 ± 0.286
0.0TrpMet: 0.0 ± 0.0
0.678TrpAsn: 0.678 ± 0.52
0.678TrpPro: 0.678 ± 0.52
2.714TrpGln: 2.714 ± 0.296
2.035TrpArg: 2.035 ± 0.286
0.678TrpSer: 0.678 ± 0.662
0.678TrpThr: 0.678 ± 0.662
2.035TrpVal: 2.035 ± 1.124
0.678TrpTrp: 0.678 ± 0.662
2.035TrpTyr: 2.035 ± 0.8
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.035TyrAla: 2.035 ± 0.732
1.357TyrCys: 1.357 ± 0.558
1.357TyrAsp: 1.357 ± 0.409
4.071TyrGlu: 4.071 ± 0.758
0.678TyrPhe: 0.678 ± 0.52
2.714TyrGly: 2.714 ± 0.296
2.035TyrHis: 2.035 ± 1.457
0.0TyrIle: 0.0 ± 0.0
2.035TyrLys: 2.035 ± 1.457
4.071TyrLeu: 4.071 ± 1.349
2.035TyrMet: 2.035 ± 0.732
1.357TyrAsn: 1.357 ± 1.04
2.035TyrPro: 2.035 ± 0.286
0.678TyrGln: 0.678 ± 0.662
4.071TyrArg: 4.071 ± 0.446
3.392TyrSer: 3.392 ± 1.116
2.714TyrThr: 2.714 ± 1.173
4.749TyrVal: 4.749 ± 1.213
1.357TyrTrp: 1.357 ± 0.558
2.035TyrTyr: 2.035 ± 1.095
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.678XaaGly: 0.678 ± 0.52
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3 proteins (1475 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski