Amino acid dipepetide frequency for Murmansk poxvirus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.101AlaAla: 2.101 ± 0.226
0.796AlaCys: 0.796 ± 0.142
1.735AlaAsp: 1.735 ± 0.143
1.544AlaGlu: 1.544 ± 0.197
1.496AlaPhe: 1.496 ± 0.146
1.433AlaGly: 1.433 ± 0.175
0.366AlaHis: 0.366 ± 0.072
3.327AlaIle: 3.327 ± 0.22
2.404AlaLys: 2.404 ± 0.194
3.2AlaLeu: 3.2 ± 0.217
0.732AlaMet: 0.732 ± 0.106
2.038AlaAsn: 2.038 ± 0.189
0.812AlaPro: 0.812 ± 0.145
0.462AlaGln: 0.462 ± 0.089
1.162AlaArg: 1.162 ± 0.144
3.009AlaSer: 3.009 ± 0.279
1.926AlaThr: 1.926 ± 0.199
2.261AlaVal: 2.261 ± 0.167
0.207AlaTrp: 0.207 ± 0.057
1.894AlaTyr: 1.894 ± 0.165
0.0AlaXaa: 0.0 ± 0.0
Cys
0.653CysAla: 0.653 ± 0.12
0.605CysCys: 0.605 ± 0.098
1.465CysAsp: 1.465 ± 0.155
0.987CysGlu: 0.987 ± 0.118
0.7CysPhe: 0.7 ± 0.112
1.035CysGly: 1.035 ± 0.121
0.494CysHis: 0.494 ± 0.099
2.245CysIle: 2.245 ± 0.209
1.608CysLys: 1.608 ± 0.187
1.512CysLeu: 1.512 ± 0.176
0.589CysMet: 0.589 ± 0.093
2.022CysAsn: 2.022 ± 0.201
0.78CysPro: 0.78 ± 0.134
0.398CysGln: 0.398 ± 0.088
0.748CysArg: 0.748 ± 0.12
1.576CysSer: 1.576 ± 0.153
1.226CysThr: 1.226 ± 0.174
1.178CysVal: 1.178 ± 0.146
0.207CysTrp: 0.207 ± 0.056
1.321CysTyr: 1.321 ± 0.156
0.0CysXaa: 0.0 ± 0.0
Asp
2.197AspAla: 2.197 ± 0.162
1.226AspCys: 1.226 ± 0.176
5.604AspAsp: 5.604 ± 0.425
4.235AspGlu: 4.235 ± 0.357
2.722AspPhe: 2.722 ± 0.199
2.722AspGly: 2.722 ± 0.241
0.907AspHis: 0.907 ± 0.108
9.058AspIle: 9.058 ± 0.475
5.413AspLys: 5.413 ± 0.279
5.062AspLeu: 5.062 ± 0.339
1.608AspMet: 1.608 ± 0.142
5.556AspAsn: 5.556 ± 0.331
1.417AspPro: 1.417 ± 0.123
1.035AspGln: 1.035 ± 0.129
2.165AspArg: 2.165 ± 0.22
4.314AspSer: 4.314 ± 0.241
4.235AspThr: 4.235 ± 0.275
4.537AspVal: 4.537 ± 0.263
0.414AspTrp: 0.414 ± 0.092
3.63AspTyr: 3.63 ± 0.231
0.0AspXaa: 0.0 ± 0.0
Glu
1.624GluAla: 1.624 ± 0.171
1.258GluCys: 1.258 ± 0.143
3.725GluAsp: 3.725 ± 0.257
3.248GluGlu: 3.248 ± 0.281
2.977GluPhe: 2.977 ± 0.208
1.56GluGly: 1.56 ± 0.166
1.114GluHis: 1.114 ± 0.134
4.983GluIle: 4.983 ± 0.315
4.489GluLys: 4.489 ± 0.42
5.556GluLeu: 5.556 ± 0.367
1.433GluMet: 1.433 ± 0.156
3.709GluAsn: 3.709 ± 0.287
1.799GluPro: 1.799 ± 0.176
1.13GluGln: 1.13 ± 0.162
2.324GluArg: 2.324 ± 0.308
3.646GluSer: 3.646 ± 0.262
3.311GluThr: 3.311 ± 0.243
2.483GluVal: 2.483 ± 0.217
0.43GluTrp: 0.43 ± 0.069
3.773GluTyr: 3.773 ± 0.252
0.0GluXaa: 0.0 ± 0.0
Phe
1.13PheAla: 1.13 ± 0.167
1.051PheCys: 1.051 ± 0.167
2.834PheAsp: 2.834 ± 0.201
2.245PheGlu: 2.245 ± 0.18
1.879PhePhe: 1.879 ± 0.193
2.181PheGly: 2.181 ± 0.191
0.86PheHis: 0.86 ± 0.136
5.508PheIle: 5.508 ± 0.279
3.216PheLys: 3.216 ± 0.2
3.725PheLeu: 3.725 ± 0.253
1.337PheMet: 1.337 ± 0.149
3.55PheAsn: 3.55 ± 0.235
1.369PhePro: 1.369 ± 0.154
0.812PheGln: 0.812 ± 0.121
1.926PheArg: 1.926 ± 0.154
3.805PheSer: 3.805 ± 0.268
2.897PheThr: 2.897 ± 0.232
2.866PheVal: 2.866 ± 0.233
0.398PheTrp: 0.398 ± 0.084
2.181PheTyr: 2.181 ± 0.188
0.0PheXaa: 0.0 ± 0.0
Gly
1.767GlyAla: 1.767 ± 0.171
0.669GlyCys: 0.669 ± 0.099
2.786GlyAsp: 2.786 ± 0.24
2.07GlyGlu: 2.07 ± 0.17
1.942GlyPhe: 1.942 ± 0.182
2.276GlyGly: 2.276 ± 0.239
0.685GlyHis: 0.685 ± 0.091
3.884GlyIle: 3.884 ± 0.25
3.248GlyLys: 3.248 ± 0.215
2.531GlyLeu: 2.531 ± 0.172
0.796GlyMet: 0.796 ± 0.117
3.2GlyAsn: 3.2 ± 0.213
0.716GlyPro: 0.716 ± 0.112
0.494GlyGln: 0.494 ± 0.081
1.433GlyArg: 1.433 ± 0.17
2.866GlySer: 2.866 ± 0.216
2.372GlyThr: 2.372 ± 0.192
2.483GlyVal: 2.483 ± 0.19
0.255GlyTrp: 0.255 ± 0.058
2.372GlyTyr: 2.372 ± 0.231
0.0GlyXaa: 0.0 ± 0.0
His
0.748HisAla: 0.748 ± 0.087
0.605HisCys: 0.605 ± 0.094
1.194HisAsp: 1.194 ± 0.138
0.923HisGlu: 0.923 ± 0.104
0.78HisPhe: 0.78 ± 0.123
0.78HisGly: 0.78 ± 0.113
0.573HisHis: 0.573 ± 0.105
2.372HisIle: 2.372 ± 0.188
1.369HisLys: 1.369 ± 0.142
1.735HisLeu: 1.735 ± 0.173
0.525HisMet: 0.525 ± 0.079
1.496HisAsn: 1.496 ± 0.15
0.685HisPro: 0.685 ± 0.117
0.446HisGln: 0.446 ± 0.076
0.891HisArg: 0.891 ± 0.127
1.242HisSer: 1.242 ± 0.131
1.242HisThr: 1.242 ± 0.136
1.465HisVal: 1.465 ± 0.145
0.127HisTrp: 0.127 ± 0.042
0.955HisTyr: 0.955 ± 0.136
0.0HisXaa: 0.0 ± 0.0
Ile
3.184IleAla: 3.184 ± 0.25
1.735IleCys: 1.735 ± 0.169
7.721IleAsp: 7.721 ± 0.352
5.094IleGlu: 5.094 ± 0.335
4.044IlePhe: 4.044 ± 0.267
3.884IleGly: 3.884 ± 0.227
2.038IleHis: 2.038 ± 0.183
9.902IleIle: 9.902 ± 0.401
8.581IleLys: 8.581 ± 0.484
8.421IleLeu: 8.421 ± 0.355
2.42IleMet: 2.42 ± 0.206
9.122IleAsn: 9.122 ± 0.446
3.455IlePro: 3.455 ± 0.185
2.054IleGln: 2.054 ± 0.174
3.741IleArg: 3.741 ± 0.234
8.453IleSer: 8.453 ± 0.412
5.429IleThr: 5.429 ± 0.314
5.874IleVal: 5.874 ± 0.321
0.478IleTrp: 0.478 ± 0.083
5.015IleTyr: 5.015 ± 0.317
0.0IleXaa: 0.0 ± 0.0
Lys
2.181LysAla: 2.181 ± 0.208
1.99LysCys: 1.99 ± 0.245
5.588LysAsp: 5.588 ± 0.399
4.728LysGlu: 4.728 ± 0.291
3.486LysPhe: 3.486 ± 0.261
2.34LysGly: 2.34 ± 0.164
2.101LysHis: 2.101 ± 0.168
7.036LysIle: 7.036 ± 0.392
6.734LysLys: 6.734 ± 0.395
7.801LysLeu: 7.801 ± 0.329
2.197LysMet: 2.197 ± 0.167
6.002LysAsn: 6.002 ± 0.391
2.117LysPro: 2.117 ± 0.204
2.197LysGln: 2.197 ± 0.16
3.407LysArg: 3.407 ± 0.246
5.842LysSer: 5.842 ± 0.276
4.617LysThr: 4.617 ± 0.304
4.155LysVal: 4.155 ± 0.333
0.812LysTrp: 0.812 ± 0.115
5.492LysTyr: 5.492 ± 0.366
0.0LysXaa: 0.0 ± 0.0
Leu
2.945LeuAla: 2.945 ± 0.188
1.719LeuCys: 1.719 ± 0.167
5.986LeuAsp: 5.986 ± 0.384
5.222LeuGlu: 5.222 ± 0.456
4.712LeuPhe: 4.712 ± 0.323
3.057LeuGly: 3.057 ± 0.237
1.926LeuHis: 1.926 ± 0.241
7.514LeuIle: 7.514 ± 0.344
6.113LeuLys: 6.113 ± 0.339
8.39LeuLeu: 8.39 ± 0.425
2.213LeuMet: 2.213 ± 0.212
5.381LeuAsn: 5.381 ± 0.311
3.168LeuPro: 3.168 ± 0.282
1.926LeuGln: 1.926 ± 0.187
3.057LeuArg: 3.057 ± 0.247
7.291LeuSer: 7.291 ± 0.341
4.855LeuThr: 4.855 ± 0.313
5.19LeuVal: 5.19 ± 0.338
0.446LeuTrp: 0.446 ± 0.107
4.442LeuTyr: 4.442 ± 0.28
0.0LeuXaa: 0.0 ± 0.0
Met
1.289MetAla: 1.289 ± 0.16
0.382MetCys: 0.382 ± 0.093
1.99MetAsp: 1.99 ± 0.176
1.656MetGlu: 1.656 ± 0.144
1.289MetPhe: 1.289 ± 0.145
0.78MetGly: 0.78 ± 0.126
0.414MetHis: 0.414 ± 0.08
2.452MetIle: 2.452 ± 0.174
1.958MetLys: 1.958 ± 0.167
2.483MetLeu: 2.483 ± 0.175
0.621MetMet: 0.621 ± 0.093
1.783MetAsn: 1.783 ± 0.17
0.78MetPro: 0.78 ± 0.128
0.478MetGln: 0.478 ± 0.072
1.067MetArg: 1.067 ± 0.151
1.926MetSer: 1.926 ± 0.179
1.353MetThr: 1.353 ± 0.138
1.242MetVal: 1.242 ± 0.13
0.111MetTrp: 0.111 ± 0.036
1.608MetTyr: 1.608 ± 0.159
0.0MetXaa: 0.0 ± 0.0
Asn
2.054AsnAla: 2.054 ± 0.168
1.305AsnCys: 1.305 ± 0.188
5.842AsnAsp: 5.842 ± 0.341
4.489AsnGlu: 4.489 ± 0.27
2.929AsnPhe: 2.929 ± 0.219
3.343AsnGly: 3.343 ± 0.292
1.672AsnHis: 1.672 ± 0.142
8.565AsnIle: 8.565 ± 0.507
6.925AsnLys: 6.925 ± 0.293
4.855AsnLeu: 4.855 ± 0.358
2.197AsnMet: 2.197 ± 0.166
7.944AsnAsn: 7.944 ± 0.484
2.531AsnPro: 2.531 ± 0.182
1.528AsnGln: 1.528 ± 0.15
2.977AsnArg: 2.977 ± 0.244
4.617AsnSer: 4.617 ± 0.233
5.46AsnThr: 5.46 ± 0.317
4.569AsnVal: 4.569 ± 0.225
0.509AsnTrp: 0.509 ± 0.083
3.805AsnTyr: 3.805 ± 0.262
0.0AsnXaa: 0.0 ± 0.0
Pro
1.114ProAla: 1.114 ± 0.143
0.637ProCys: 0.637 ± 0.098
1.831ProAsp: 1.831 ± 0.176
2.165ProGlu: 2.165 ± 0.173
1.465ProPhe: 1.465 ± 0.139
1.289ProGly: 1.289 ± 0.164
0.541ProHis: 0.541 ± 0.1
2.961ProIle: 2.961 ± 0.196
2.261ProLys: 2.261 ± 0.18
2.945ProLeu: 2.945 ± 0.248
0.669ProMet: 0.669 ± 0.108
2.149ProAsn: 2.149 ± 0.196
1.528ProPro: 1.528 ± 0.244
0.7ProGln: 0.7 ± 0.122
1.465ProArg: 1.465 ± 0.215
2.213ProSer: 2.213 ± 0.213
1.863ProThr: 1.863 ± 0.16
1.958ProVal: 1.958 ± 0.17
0.35ProTrp: 0.35 ± 0.077
1.608ProTyr: 1.608 ± 0.164
0.0ProXaa: 0.0 ± 0.0
Gln
0.605GlnAla: 0.605 ± 0.11
0.748GlnCys: 0.748 ± 0.129
1.083GlnAsp: 1.083 ± 0.151
1.194GlnGlu: 1.194 ± 0.141
0.7GlnPhe: 0.7 ± 0.096
0.605GlnGly: 0.605 ± 0.105
0.557GlnHis: 0.557 ± 0.102
1.465GlnIle: 1.465 ± 0.149
1.465GlnLys: 1.465 ± 0.167
2.229GlnLeu: 2.229 ± 0.185
0.605GlnMet: 0.605 ± 0.095
1.13GlnAsn: 1.13 ± 0.11
0.716GlnPro: 0.716 ± 0.099
0.669GlnGln: 0.669 ± 0.128
1.003GlnArg: 1.003 ± 0.127
1.512GlnSer: 1.512 ± 0.14
1.21GlnThr: 1.21 ± 0.124
0.907GlnVal: 0.907 ± 0.121
0.287GlnTrp: 0.287 ± 0.061
1.305GlnTyr: 1.305 ± 0.144
0.0GlnXaa: 0.0 ± 0.0
Arg
0.748ArgAla: 0.748 ± 0.086
1.003ArgCys: 1.003 ± 0.129
2.324ArgAsp: 2.324 ± 0.173
1.847ArgGlu: 1.847 ± 0.283
1.974ArgPhe: 1.974 ± 0.158
1.783ArgGly: 1.783 ± 0.161
1.067ArgHis: 1.067 ± 0.121
3.423ArgIle: 3.423 ± 0.25
3.295ArgLys: 3.295 ± 0.264
3.677ArgLeu: 3.677 ± 0.295
0.876ArgMet: 0.876 ± 0.096
2.834ArgAsn: 2.834 ± 0.224
1.146ArgPro: 1.146 ± 0.16
0.955ArgGln: 0.955 ± 0.135
2.213ArgArg: 2.213 ± 0.241
2.515ArgSer: 2.515 ± 0.227
1.879ArgThr: 1.879 ± 0.195
2.404ArgVal: 2.404 ± 0.197
0.446ArgTrp: 0.446 ± 0.081
2.706ArgTyr: 2.706 ± 0.169
0.0ArgXaa: 0.0 ± 0.0
Ser
2.483SerAla: 2.483 ± 0.21
1.417SerCys: 1.417 ± 0.149
4.84SerAsp: 4.84 ± 0.357
3.757SerGlu: 3.757 ± 0.275
3.486SerPhe: 3.486 ± 0.234
3.041SerGly: 3.041 ± 0.237
1.433SerHis: 1.433 ± 0.156
7.53SerIle: 7.53 ± 0.293
6.463SerLys: 6.463 ± 0.303
6.575SerLeu: 6.575 ± 0.322
2.149SerMet: 2.149 ± 0.191
5.699SerAsn: 5.699 ± 0.325
2.165SerPro: 2.165 ± 0.2
1.703SerGln: 1.703 ± 0.217
2.945SerArg: 2.945 ± 0.204
6.527SerSer: 6.527 ± 0.488
4.155SerThr: 4.155 ± 0.29
4.457SerVal: 4.457 ± 0.27
0.414SerTrp: 0.414 ± 0.075
4.251SerTyr: 4.251 ± 0.28
0.0SerXaa: 0.0 ± 0.0
Thr
2.038ThrAla: 2.038 ± 0.184
1.385ThrCys: 1.385 ± 0.172
3.661ThrAsp: 3.661 ± 0.221
2.945ThrGlu: 2.945 ± 0.201
2.913ThrPhe: 2.913 ± 0.236
2.038ThrGly: 2.038 ± 0.215
1.353ThrHis: 1.353 ± 0.166
5.731ThrIle: 5.731 ± 0.27
4.871ThrLys: 4.871 ± 0.269
4.919ThrLeu: 4.919 ± 0.258
1.21ThrMet: 1.21 ± 0.141
4.107ThrAsn: 4.107 ± 0.219
2.595ThrPro: 2.595 ± 0.243
0.923ThrGln: 0.923 ± 0.125
2.292ThrArg: 2.292 ± 0.186
4.696ThrSer: 4.696 ± 0.293
4.059ThrThr: 4.059 ± 0.34
3.789ThrVal: 3.789 ± 0.253
0.446ThrTrp: 0.446 ± 0.071
2.834ThrTyr: 2.834 ± 0.221
0.0ThrXaa: 0.0 ± 0.0
Val
2.149ValAla: 2.149 ± 0.163
1.401ValCys: 1.401 ± 0.141
3.709ValAsp: 3.709 ± 0.234
3.263ValGlu: 3.263 ± 0.222
3.168ValPhe: 3.168 ± 0.273
1.831ValGly: 1.831 ± 0.213
0.828ValHis: 0.828 ± 0.105
5.572ValIle: 5.572 ± 0.286
5.19ValLys: 5.19 ± 0.285
4.537ValLeu: 4.537 ± 0.266
1.576ValMet: 1.576 ± 0.174
4.68ValAsn: 4.68 ± 0.273
2.07ValPro: 2.07 ± 0.205
1.051ValGln: 1.051 ± 0.124
2.245ValArg: 2.245 ± 0.183
4.919ValSer: 4.919 ± 0.298
3.407ValThr: 3.407 ± 0.239
3.693ValVal: 3.693 ± 0.326
0.255ValTrp: 0.255 ± 0.072
3.518ValTyr: 3.518 ± 0.258
0.0ValXaa: 0.0 ± 0.0
Trp
0.175TrpAla: 0.175 ± 0.054
0.127TrpCys: 0.127 ± 0.043
0.414TrpAsp: 0.414 ± 0.085
0.462TrpGlu: 0.462 ± 0.078
0.414TrpPhe: 0.414 ± 0.087
0.271TrpGly: 0.271 ± 0.063
0.048TrpHis: 0.048 ± 0.026
0.716TrpIle: 0.716 ± 0.096
0.86TrpLys: 0.86 ± 0.118
0.637TrpLeu: 0.637 ± 0.098
0.302TrpMet: 0.302 ± 0.064
0.525TrpAsn: 0.525 ± 0.097
0.191TrpPro: 0.191 ± 0.057
0.096TrpGln: 0.096 ± 0.042
0.255TrpArg: 0.255 ± 0.065
0.462TrpSer: 0.462 ± 0.085
0.35TrpThr: 0.35 ± 0.071
0.382TrpVal: 0.382 ± 0.081
0.032TrpTrp: 0.032 ± 0.021
0.366TrpTyr: 0.366 ± 0.078
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.719TyrAla: 1.719 ± 0.172
1.289TyrCys: 1.289 ± 0.13
3.725TyrAsp: 3.725 ± 0.236
2.499TyrGlu: 2.499 ± 0.24
2.69TyrPhe: 2.69 ± 0.183
2.595TyrGly: 2.595 ± 0.237
1.178TyrHis: 1.178 ± 0.114
6.4TyrIle: 6.4 ± 0.299
4.362TyrLys: 4.362 ± 0.299
4.76TyrLeu: 4.76 ± 0.307
1.592TyrMet: 1.592 ± 0.174
5.19TyrAsn: 5.19 ± 0.38
1.672TyrPro: 1.672 ± 0.168
0.939TyrGln: 0.939 ± 0.111
1.799TyrArg: 1.799 ± 0.175
4.059TyrSer: 4.059 ± 0.28
2.961TyrThr: 2.961 ± 0.224
3.184TyrVal: 3.184 ± 0.212
0.462TyrTrp: 0.462 ± 0.098
3.216TyrTyr: 3.216 ± 0.257
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 202 proteins (62817 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski