Amino acid dipepetide frequency for Actinomyces sp. oral taxon 448 str. F0400

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
20.237AlaAla: 20.237 ± 0.23
1.277AlaCys: 1.277 ± 0.042
8.856AlaAsp: 8.856 ± 0.123
7.381AlaGlu: 7.381 ± 0.125
3.094AlaPhe: 3.094 ± 0.061
13.844AlaGly: 13.844 ± 0.168
2.463AlaHis: 2.463 ± 0.054
4.443AlaIle: 4.443 ± 0.08
1.796AlaLys: 1.796 ± 0.057
14.281AlaLeu: 14.281 ± 0.166
2.704AlaMet: 2.704 ± 0.056
1.85AlaAsn: 1.85 ± 0.048
7.518AlaPro: 7.518 ± 0.123
3.705AlaGln: 3.705 ± 0.076
11.55AlaArg: 11.55 ± 0.185
8.175AlaSer: 8.175 ± 0.134
7.096AlaThr: 7.096 ± 0.096
12.222AlaVal: 12.222 ± 0.141
2.063AlaTrp: 2.063 ± 0.051
2.251AlaTyr: 2.251 ± 0.056
0.0AlaXaa: 0.0 ± 0.0
Cys
1.138CysAla: 1.138 ± 0.039
0.111CysCys: 0.111 ± 0.011
0.464CysAsp: 0.464 ± 0.026
0.432CysGlu: 0.432 ± 0.023
0.223CysPhe: 0.223 ± 0.019
0.919CysGly: 0.919 ± 0.035
0.165CysHis: 0.165 ± 0.015
0.226CysIle: 0.226 ± 0.02
0.072CysLys: 0.072 ± 0.008
0.9CysLeu: 0.9 ± 0.033
0.127CysMet: 0.127 ± 0.012
0.121CysAsn: 0.121 ± 0.014
0.461CysPro: 0.461 ± 0.03
0.177CysGln: 0.177 ± 0.015
0.584CysArg: 0.584 ± 0.029
0.478CysSer: 0.478 ± 0.025
0.541CysThr: 0.541 ± 0.027
0.641CysVal: 0.641 ± 0.027
0.137CysTrp: 0.137 ± 0.015
0.17CysTyr: 0.17 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
8.784AspAla: 8.784 ± 0.133
0.381AspCys: 0.381 ± 0.02
4.488AspAsp: 4.488 ± 0.086
4.205AspGlu: 4.205 ± 0.082
1.458AspPhe: 1.458 ± 0.046
6.357AspGly: 6.357 ± 0.106
1.303AspHis: 1.303 ± 0.044
2.065AspIle: 2.065 ± 0.056
0.914AspLys: 0.914 ± 0.036
6.3AspLeu: 6.3 ± 0.099
1.014AspMet: 1.014 ± 0.038
0.91AspAsn: 0.91 ± 0.038
4.468AspPro: 4.468 ± 0.084
1.517AspGln: 1.517 ± 0.045
4.463AspArg: 4.463 ± 0.088
3.242AspSer: 3.242 ± 0.072
2.891AspThr: 2.891 ± 0.066
5.709AspVal: 5.709 ± 0.095
0.844AspTrp: 0.844 ± 0.031
1.392AspTyr: 1.392 ± 0.051
0.0AspXaa: 0.0 ± 0.0
Glu
7.627GluAla: 7.627 ± 0.126
0.35GluCys: 0.35 ± 0.022
3.36GluAsp: 3.36 ± 0.073
3.325GluGlu: 3.325 ± 0.081
1.068GluPhe: 1.068 ± 0.034
4.138GluGly: 4.138 ± 0.078
1.334GluHis: 1.334 ± 0.045
2.46GluIle: 2.46 ± 0.063
1.04GluLys: 1.04 ± 0.043
5.594GluLeu: 5.594 ± 0.099
1.04GluMet: 1.04 ± 0.04
1.073GluAsn: 1.073 ± 0.038
3.16GluPro: 3.16 ± 0.075
1.852GluGln: 1.852 ± 0.052
5.327GluArg: 5.327 ± 0.096
2.772GluSer: 2.772 ± 0.062
2.903GluThr: 2.903 ± 0.057
4.385GluVal: 4.385 ± 0.09
0.592GluTrp: 0.592 ± 0.028
0.941GluTyr: 0.941 ± 0.031
0.0GluXaa: 0.0 ± 0.0
Phe
2.895PheAla: 2.895 ± 0.069
0.226PheCys: 0.226 ± 0.016
1.73PheAsp: 1.73 ± 0.045
1.288PheGlu: 1.288 ± 0.038
0.858PhePhe: 0.858 ± 0.044
2.304PheGly: 2.304 ± 0.062
0.532PheHis: 0.532 ± 0.026
1.084PheIle: 1.084 ± 0.037
0.456PheLys: 0.456 ± 0.029
2.361PheLeu: 2.361 ± 0.06
0.478PheMet: 0.478 ± 0.024
0.563PheAsn: 0.563 ± 0.028
1.117PhePro: 1.117 ± 0.039
0.568PheGln: 0.568 ± 0.028
1.447PheArg: 1.447 ± 0.045
1.628PheSer: 1.628 ± 0.047
1.813PheThr: 1.813 ± 0.049
2.068PheVal: 2.068 ± 0.053
0.369PheTrp: 0.369 ± 0.025
0.577PheTyr: 0.577 ± 0.024
0.0PheXaa: 0.0 ± 0.0
Gly
12.316GlyAla: 12.316 ± 0.154
0.784GlyCys: 0.784 ± 0.034
4.856GlyAsp: 4.856 ± 0.089
4.958GlyGlu: 4.958 ± 0.083
2.418GlyPhe: 2.418 ± 0.063
8.638GlyGly: 8.638 ± 0.14
1.86GlyHis: 1.86 ± 0.069
3.741GlyIle: 3.741 ± 0.076
1.604GlyLys: 1.604 ± 0.048
9.257GlyLeu: 9.257 ± 0.126
2.117GlyMet: 2.117 ± 0.046
1.491GlyAsn: 1.491 ± 0.041
4.999GlyPro: 4.999 ± 0.096
2.44GlyGln: 2.44 ± 0.053
8.496GlyArg: 8.496 ± 0.121
5.755GlySer: 5.755 ± 0.117
6.016GlyThr: 6.016 ± 0.095
7.654GlyVal: 7.654 ± 0.105
1.594GlyTrp: 1.594 ± 0.045
2.018GlyTyr: 2.018 ± 0.053
0.0GlyXaa: 0.0 ± 0.0
His
2.464HisAla: 2.464 ± 0.086
0.17HisCys: 0.17 ± 0.015
1.346HisAsp: 1.346 ± 0.044
1.22HisGlu: 1.22 ± 0.033
0.39HisPhe: 0.39 ± 0.021
1.95HisGly: 1.95 ± 0.048
0.557HisHis: 0.557 ± 0.029
0.593HisIle: 0.593 ± 0.026
0.243HisLys: 0.243 ± 0.018
2.17HisLeu: 2.17 ± 0.048
0.384HisMet: 0.384 ± 0.024
0.407HisAsn: 0.407 ± 0.026
1.417HisPro: 1.417 ± 0.045
0.487HisGln: 0.487 ± 0.03
1.851HisArg: 1.851 ± 0.051
0.984HisSer: 0.984 ± 0.037
0.903HisThr: 0.903 ± 0.044
1.721HisVal: 1.721 ± 0.042
0.308HisTrp: 0.308 ± 0.019
0.439HisTyr: 0.439 ± 0.02
0.0HisXaa: 0.0 ± 0.0
Ile
5.259IleAla: 5.259 ± 0.087
0.332IleCys: 0.332 ± 0.018
2.987IleAsp: 2.987 ± 0.063
2.398IleGlu: 2.398 ± 0.061
0.96IlePhe: 0.96 ± 0.038
3.971IleGly: 3.971 ± 0.083
0.733IleHis: 0.733 ± 0.027
1.795IleIle: 1.795 ± 0.06
0.685IleLys: 0.685 ± 0.037
3.418IleLeu: 3.418 ± 0.068
0.816IleMet: 0.816 ± 0.033
0.839IleAsn: 0.839 ± 0.035
2.032IlePro: 2.032 ± 0.054
0.781IleGln: 0.781 ± 0.031
2.283IleArg: 2.283 ± 0.056
2.186IleSer: 2.186 ± 0.062
2.597IleThr: 2.597 ± 0.064
3.783IleVal: 3.783 ± 0.075
0.396IleTrp: 0.396 ± 0.025
0.602IleTyr: 0.602 ± 0.027
0.0IleXaa: 0.0 ± 0.0
Lys
1.998LysAla: 1.998 ± 0.063
0.078LysCys: 0.078 ± 0.01
1.123LysAsp: 1.123 ± 0.04
0.957LysGlu: 0.957 ± 0.034
0.332LysPhe: 0.332 ± 0.023
1.424LysGly: 1.424 ± 0.042
0.285LysHis: 0.285 ± 0.021
0.755LysIle: 0.755 ± 0.037
0.573LysLys: 0.573 ± 0.029
1.101LysLeu: 1.101 ± 0.035
0.279LysMet: 0.279 ± 0.017
0.462LysAsn: 0.462 ± 0.023
0.819LysPro: 0.819 ± 0.037
0.469LysGln: 0.469 ± 0.025
1.369LysArg: 1.369 ± 0.043
0.878LysSer: 0.878 ± 0.033
1.106LysThr: 1.106 ± 0.04
1.283LysVal: 1.283 ± 0.045
0.164LysTrp: 0.164 ± 0.013
0.323LysTyr: 0.323 ± 0.022
0.0LysXaa: 0.0 ± 0.0
Leu
14.732LeuAla: 14.732 ± 0.172
0.722LeuCys: 0.722 ± 0.026
6.436LeuAsp: 6.436 ± 0.112
4.816LeuGlu: 4.816 ± 0.081
2.177LeuPhe: 2.177 ± 0.062
8.845LeuGly: 8.845 ± 0.117
1.961LeuHis: 1.961 ± 0.051
4.029LeuIle: 4.029 ± 0.082
1.565LeuLys: 1.565 ± 0.049
10.006LeuLeu: 10.006 ± 0.138
1.921LeuMet: 1.921 ± 0.055
1.708LeuAsn: 1.708 ± 0.046
5.496LeuPro: 5.496 ± 0.087
1.816LeuGln: 1.816 ± 0.044
7.485LeuArg: 7.485 ± 0.11
5.693LeuSer: 5.693 ± 0.098
7.369LeuThr: 7.369 ± 0.103
9.108LeuVal: 9.108 ± 0.131
1.144LeuTrp: 1.144 ± 0.039
1.476LeuTyr: 1.476 ± 0.04
0.0LeuXaa: 0.0 ± 0.0
Met
2.376MetAla: 2.376 ± 0.056
0.158MetCys: 0.158 ± 0.014
1.009MetAsp: 1.009 ± 0.036
0.826MetGlu: 0.826 ± 0.034
0.492MetPhe: 0.492 ± 0.025
1.621MetGly: 1.621 ± 0.046
0.354MetHis: 0.354 ± 0.021
0.893MetIle: 0.893 ± 0.037
0.381MetLys: 0.381 ± 0.02
1.97MetLeu: 1.97 ± 0.046
0.427MetMet: 0.427 ± 0.023
0.543MetAsn: 0.543 ± 0.027
1.293MetPro: 1.293 ± 0.038
0.395MetGln: 0.395 ± 0.021
1.723MetArg: 1.723 ± 0.046
1.86MetSer: 1.86 ± 0.048
1.849MetThr: 1.849 ± 0.045
1.605MetVal: 1.605 ± 0.043
0.224MetTrp: 0.224 ± 0.016
0.303MetTyr: 0.303 ± 0.019
0.0MetXaa: 0.0 ± 0.0
Asn
2.217AsnAla: 2.217 ± 0.05
0.13AsnCys: 0.13 ± 0.012
1.111AsnAsp: 1.111 ± 0.04
0.946AsnGlu: 0.946 ± 0.035
0.411AsnPhe: 0.411 ± 0.024
1.732AsnGly: 1.732 ± 0.052
0.426AsnHis: 0.426 ± 0.024
0.745AsnIle: 0.745 ± 0.032
0.392AsnLys: 0.392 ± 0.025
1.78AsnLeu: 1.78 ± 0.045
0.288AsnMet: 0.288 ± 0.019
0.438AsnAsn: 0.438 ± 0.027
1.297AsnPro: 1.297 ± 0.041
0.521AsnGln: 0.521 ± 0.029
1.332AsnArg: 1.332 ± 0.046
0.843AsnSer: 0.843 ± 0.036
1.002AsnThr: 1.002 ± 0.037
1.405AsnVal: 1.405 ± 0.043
0.262AsnTrp: 0.262 ± 0.019
0.383AsnTyr: 0.383 ± 0.024
0.0AsnXaa: 0.0 ± 0.0
Pro
8.542ProAla: 8.542 ± 0.143
0.352ProCys: 0.352 ± 0.021
4.428ProAsp: 4.428 ± 0.071
3.633ProGlu: 3.633 ± 0.076
1.335ProPhe: 1.335 ± 0.04
5.935ProGly: 5.935 ± 0.09
1.128ProHis: 1.128 ± 0.037
1.682ProIle: 1.682 ± 0.045
0.708ProLys: 0.708 ± 0.032
4.67ProLeu: 4.67 ± 0.09
1.1ProMet: 1.1 ± 0.041
0.847ProAsn: 0.847 ± 0.037
2.919ProPro: 2.919 ± 0.082
1.543ProGln: 1.543 ± 0.048
4.213ProArg: 4.213 ± 0.099
3.766ProSer: 3.766 ± 0.082
3.696ProThr: 3.696 ± 0.082
5.206ProVal: 5.206 ± 0.089
0.878ProTrp: 0.878 ± 0.03
1.056ProTyr: 1.056 ± 0.038
0.0ProXaa: 0.0 ± 0.0
Gln
3.454GlnAla: 3.454 ± 0.079
0.191GlnCys: 0.191 ± 0.017
1.424GlnAsp: 1.424 ± 0.039
1.353GlnGlu: 1.353 ± 0.046
0.52GlnPhe: 0.52 ± 0.025
2.004GlnGly: 2.004 ± 0.053
0.514GlnHis: 0.514 ± 0.025
1.222GlnIle: 1.222 ± 0.041
0.428GlnLys: 0.428 ± 0.022
2.167GlnLeu: 2.167 ± 0.052
0.622GlnMet: 0.622 ± 0.03
0.515GlnAsn: 0.515 ± 0.029
1.312GlnPro: 1.312 ± 0.051
0.882GlnGln: 0.882 ± 0.035
2.184GlnArg: 2.184 ± 0.054
1.275GlnSer: 1.275 ± 0.042
1.506GlnThr: 1.506 ± 0.045
2.405GlnVal: 2.405 ± 0.06
0.469GlnTrp: 0.469 ± 0.023
0.587GlnTyr: 0.587 ± 0.029
0.0GlnXaa: 0.0 ± 0.0
Arg
11.197ArgAla: 11.197 ± 0.166
0.592ArgCys: 0.592 ± 0.027
4.153ArgAsp: 4.153 ± 0.087
4.501ArgGlu: 4.501 ± 0.079
2.036ArgPhe: 2.036 ± 0.054
6.137ArgGly: 6.137 ± 0.113
1.74ArgHis: 1.74 ± 0.043
3.453ArgIle: 3.453 ± 0.069
1.203ArgLys: 1.203 ± 0.039
8.39ArgLeu: 8.39 ± 0.13
1.916ArgMet: 1.916 ± 0.049
1.301ArgAsn: 1.301 ± 0.039
4.952ArgPro: 4.952 ± 0.098
1.989ArgGln: 1.989 ± 0.052
9.014ArgArg: 9.014 ± 0.157
5.065ArgSer: 5.065 ± 0.083
5.546ArgThr: 5.546 ± 0.09
6.333ArgVal: 6.333 ± 0.107
1.265ArgTrp: 1.265 ± 0.046
1.604ArgTyr: 1.604 ± 0.044
0.0ArgXaa: 0.0 ± 0.0
Ser
8.238SerAla: 8.238 ± 0.129
0.507SerCys: 0.507 ± 0.028
3.229SerAsp: 3.229 ± 0.077
2.708SerGlu: 2.708 ± 0.06
1.762SerPhe: 1.762 ± 0.052
6.248SerGly: 6.248 ± 0.099
1.164SerHis: 1.164 ± 0.052
2.111SerIle: 2.111 ± 0.056
0.947SerLys: 0.947 ± 0.037
5.48SerLeu: 5.48 ± 0.084
1.422SerMet: 1.422 ± 0.047
1.078SerAsn: 1.078 ± 0.042
3.713SerPro: 3.713 ± 0.074
1.707SerGln: 1.707 ± 0.047
4.731SerArg: 4.731 ± 0.082
4.368SerSer: 4.368 ± 0.1
4.105SerThr: 4.105 ± 0.082
4.455SerVal: 4.455 ± 0.084
1.03SerTrp: 1.03 ± 0.033
1.227SerTyr: 1.227 ± 0.045
0.0SerXaa: 0.0 ± 0.0
Thr
8.755ThrAla: 8.755 ± 0.132
0.538ThrCys: 0.538 ± 0.03
3.941ThrAsp: 3.941 ± 0.08
2.642ThrGlu: 2.642 ± 0.06
1.56ThrPhe: 1.56 ± 0.043
6.741ThrGly: 6.741 ± 0.113
1.116ThrHis: 1.116 ± 0.038
2.594ThrIle: 2.594 ± 0.062
0.854ThrLys: 0.854 ± 0.032
5.551ThrLeu: 5.551 ± 0.086
1.285ThrMet: 1.285 ± 0.04
1.16ThrAsn: 1.16 ± 0.043
3.923ThrPro: 3.923 ± 0.083
1.468ThrGln: 1.468 ± 0.046
4.567ThrArg: 4.567 ± 0.079
3.919ThrSer: 3.919 ± 0.081
4.561ThrThr: 4.561 ± 0.097
5.828ThrVal: 5.828 ± 0.102
1.046ThrTrp: 1.046 ± 0.035
1.266ThrTyr: 1.266 ± 0.041
0.0ThrXaa: 0.0 ± 0.0
Val
10.675ValAla: 10.675 ± 0.126
0.845ValCys: 0.845 ± 0.035
5.682ValAsp: 5.682 ± 0.087
4.877ValGlu: 4.877 ± 0.093
2.21ValPhe: 2.21 ± 0.063
7.309ValGly: 7.309 ± 0.103
1.737ValHis: 1.737 ± 0.044
3.682ValIle: 3.682 ± 0.076
1.334ValLys: 1.334 ± 0.049
9.52ValLeu: 9.52 ± 0.133
1.697ValMet: 1.697 ± 0.047
1.583ValAsn: 1.583 ± 0.044
5.087ValPro: 5.087 ± 0.076
1.784ValGln: 1.784 ± 0.05
6.88ValArg: 6.88 ± 0.105
5.259ValSer: 5.259 ± 0.083
5.672ValThr: 5.672 ± 0.111
9.087ValVal: 9.087 ± 0.14
1.1ValTrp: 1.1 ± 0.036
1.511ValTyr: 1.511 ± 0.045
0.0ValXaa: 0.0 ± 0.0
Trp
1.676TrpAla: 1.676 ± 0.046
0.179TrpCys: 0.179 ± 0.016
0.827TrpAsp: 0.827 ± 0.027
0.717TrpGlu: 0.717 ± 0.034
0.473TrpPhe: 0.473 ± 0.024
1.034TrpGly: 1.034 ± 0.037
0.291TrpHis: 0.291 ± 0.018
0.65TrpIle: 0.65 ± 0.032
0.236TrpLys: 0.236 ± 0.017
1.543TrpLeu: 1.543 ± 0.042
0.358TrpMet: 0.358 ± 0.02
0.395TrpAsn: 0.395 ± 0.021
0.679TrpPro: 0.679 ± 0.027
0.414TrpGln: 0.414 ± 0.021
1.352TrpArg: 1.352 ± 0.042
0.943TrpSer: 0.943 ± 0.037
1.014TrpThr: 1.014 ± 0.04
1.062TrpVal: 1.062 ± 0.036
0.363TrpTrp: 0.363 ± 0.025
0.328TrpTyr: 0.328 ± 0.021
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.226TyrAla: 2.226 ± 0.051
0.165TyrCys: 0.165 ± 0.015
1.259TyrAsp: 1.259 ± 0.043
1.161TyrGlu: 1.161 ± 0.037
0.589TyrPhe: 0.589 ± 0.03
1.86TyrGly: 1.86 ± 0.046
0.345TyrHis: 0.345 ± 0.023
0.631TyrIle: 0.631 ± 0.031
0.347TyrLys: 0.347 ± 0.021
2.043TyrLeu: 2.043 ± 0.055
0.306TyrMet: 0.306 ± 0.022
0.374TyrAsn: 0.374 ± 0.022
0.975TyrPro: 0.975 ± 0.037
0.52TyrGln: 0.52 ± 0.026
1.534TyrArg: 1.534 ± 0.046
1.137TyrSer: 1.137 ± 0.043
1.127TyrThr: 1.127 ± 0.038
1.571TyrVal: 1.571 ± 0.051
0.285TyrTrp: 0.285 ± 0.019
0.453TyrTyr: 0.453 ± 0.022
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2518 proteins (817327 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski