Amino acid dipepetide frequency for Streptococcus satellite phage Javan404

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.008AlaAla: 1.008 ± 0.472
0.672AlaCys: 0.672 ± 0.431
5.376AlaAsp: 5.376 ± 1.257
4.032AlaGlu: 4.032 ± 1.149
2.016AlaPhe: 2.016 ± 0.697
1.68AlaGly: 1.68 ± 0.64
0.336AlaHis: 0.336 ± 0.271
5.04AlaIle: 5.04 ± 1.738
6.384AlaLys: 6.384 ± 1.78
5.04AlaLeu: 5.04 ± 0.957
2.688AlaMet: 2.688 ± 0.802
1.68AlaAsn: 1.68 ± 0.793
0.672AlaPro: 0.672 ± 0.392
2.016AlaGln: 2.016 ± 1.223
1.344AlaArg: 1.344 ± 0.863
3.696AlaSer: 3.696 ± 1.318
3.36AlaThr: 3.36 ± 1.433
3.024AlaVal: 3.024 ± 1.099
0.0AlaTrp: 0.0 ± 0.0
1.68AlaTyr: 1.68 ± 0.611
0.0AlaXaa: 0.0 ± 0.0
Cys
0.672CysAla: 0.672 ± 0.601
0.0CysCys: 0.0 ± 0.0
0.336CysAsp: 0.336 ± 0.374
1.008CysGlu: 1.008 ± 0.671
0.336CysPhe: 0.336 ± 0.252
1.008CysGly: 1.008 ± 0.444
0.336CysHis: 0.336 ± 0.301
1.008CysIle: 1.008 ± 0.756
0.336CysLys: 0.336 ± 0.332
1.008CysLeu: 1.008 ± 0.822
0.0CysMet: 0.0 ± 0.0
0.0CysAsn: 0.0 ± 0.0
0.0CysPro: 0.0 ± 0.0
0.0CysGln: 0.0 ± 0.0
0.0CysArg: 0.0 ± 0.0
0.336CysSer: 0.336 ± 0.373
0.336CysThr: 0.336 ± 0.324
0.672CysVal: 0.672 ± 0.406
0.0CysTrp: 0.0 ± 0.0
0.336CysTyr: 0.336 ± 0.252
0.0CysXaa: 0.0 ± 0.0
Asp
2.352AspAla: 2.352 ± 0.895
0.672AspCys: 0.672 ± 0.392
5.04AspAsp: 5.04 ± 1.755
6.048AspGlu: 6.048 ± 1.424
4.368AspPhe: 4.368 ± 1.371
2.352AspGly: 2.352 ± 0.8
1.008AspHis: 1.008 ± 0.424
7.056AspIle: 7.056 ± 1.962
5.04AspLys: 5.04 ± 1.752
6.048AspLeu: 6.048 ± 1.831
1.008AspMet: 1.008 ± 0.522
5.376AspAsn: 5.376 ± 0.928
0.672AspPro: 0.672 ± 0.35
3.024AspGln: 3.024 ± 0.856
1.344AspArg: 1.344 ± 0.523
1.008AspSer: 1.008 ± 0.533
2.688AspThr: 2.688 ± 0.668
3.696AspVal: 3.696 ± 0.993
0.0AspTrp: 0.0 ± 0.0
5.04AspTyr: 5.04 ± 0.97
0.0AspXaa: 0.0 ± 0.0
Glu
6.048GluAla: 6.048 ± 1.248
0.672GluCys: 0.672 ± 0.414
4.704GluAsp: 4.704 ± 1.029
9.745GluGlu: 9.745 ± 2.508
3.36GluPhe: 3.36 ± 1.211
1.68GluGly: 1.68 ± 0.683
0.672GluHis: 0.672 ± 0.494
5.712GluIle: 5.712 ± 1.453
8.401GluLys: 8.401 ± 1.854
13.105GluLeu: 13.105 ± 1.887
3.36GluMet: 3.36 ± 0.803
7.392GluAsn: 7.392 ± 1.734
2.352GluPro: 2.352 ± 0.913
2.688GluGln: 2.688 ± 0.613
4.704GluArg: 4.704 ± 1.219
2.352GluSer: 2.352 ± 0.657
2.688GluThr: 2.688 ± 0.634
3.696GluVal: 3.696 ± 1.06
0.672GluTrp: 0.672 ± 0.418
3.696GluTyr: 3.696 ± 0.815
0.0GluXaa: 0.0 ± 0.0
Phe
1.68PheAla: 1.68 ± 0.653
0.336PheCys: 0.336 ± 0.324
3.36PheAsp: 3.36 ± 0.856
4.704PheGlu: 4.704 ± 1.084
3.024PhePhe: 3.024 ± 0.97
2.016PheGly: 2.016 ± 0.522
0.336PheHis: 0.336 ± 0.301
3.36PheIle: 3.36 ± 1.112
3.024PheLys: 3.024 ± 0.673
5.712PheLeu: 5.712 ± 1.275
0.336PheMet: 0.336 ± 0.326
2.352PheAsn: 2.352 ± 0.84
0.0PhePro: 0.0 ± 0.0
1.344PheGln: 1.344 ± 0.765
2.016PheArg: 2.016 ± 0.803
3.36PheSer: 3.36 ± 1.18
2.352PheThr: 2.352 ± 0.784
3.36PheVal: 3.36 ± 1.226
0.336PheTrp: 0.336 ± 0.252
1.008PheTyr: 1.008 ± 0.56
0.0PheXaa: 0.0 ± 0.0
Gly
2.352GlyAla: 2.352 ± 0.581
0.672GlyCys: 0.672 ± 0.504
1.68GlyAsp: 1.68 ± 1.027
3.36GlyGlu: 3.36 ± 1.118
0.672GlyPhe: 0.672 ± 0.402
2.688GlyGly: 2.688 ± 0.862
0.672GlyHis: 0.672 ± 0.601
4.704GlyIle: 4.704 ± 1.019
4.032GlyLys: 4.032 ± 0.988
5.712GlyLeu: 5.712 ± 1.439
1.344GlyMet: 1.344 ± 0.77
2.016GlyAsn: 2.016 ± 0.784
0.0GlyPro: 0.0 ± 0.0
1.344GlyGln: 1.344 ± 0.587
1.008GlyArg: 1.008 ± 0.412
2.688GlySer: 2.688 ± 0.729
2.352GlyThr: 2.352 ± 0.701
2.352GlyVal: 2.352 ± 0.907
0.672GlyTrp: 0.672 ± 0.355
2.016GlyTyr: 2.016 ± 0.706
0.0GlyXaa: 0.0 ± 0.0
His
1.344HisAla: 1.344 ± 0.863
0.0HisCys: 0.0 ± 0.0
1.008HisAsp: 1.008 ± 0.46
0.672HisGlu: 0.672 ± 0.536
0.672HisPhe: 0.672 ± 0.468
0.0HisGly: 0.0 ± 0.0
0.672HisHis: 0.672 ± 0.538
1.344HisIle: 1.344 ± 0.621
0.336HisLys: 0.336 ± 0.271
1.008HisLeu: 1.008 ± 0.524
1.008HisMet: 1.008 ± 0.833
0.336HisAsn: 0.336 ± 0.326
0.336HisPro: 0.336 ± 0.252
0.336HisGln: 0.336 ± 0.271
0.0HisArg: 0.0 ± 0.0
0.336HisSer: 0.336 ± 0.318
0.672HisThr: 0.672 ± 0.418
0.672HisVal: 0.672 ± 0.369
0.336HisTrp: 0.336 ± 0.373
0.336HisTyr: 0.336 ± 0.271
0.0HisXaa: 0.0 ± 0.0
Ile
6.048IleAla: 6.048 ± 1.722
1.008IleCys: 1.008 ± 0.618
7.392IleAsp: 7.392 ± 2.039
7.056IleGlu: 7.056 ± 1.914
4.368IlePhe: 4.368 ± 1.598
4.368IleGly: 4.368 ± 0.929
0.336IleHis: 0.336 ± 0.252
8.065IleIle: 8.065 ± 1.569
6.384IleLys: 6.384 ± 1.476
7.056IleLeu: 7.056 ± 1.63
0.672IleMet: 0.672 ± 0.495
4.704IleAsn: 4.704 ± 1.29
1.008IlePro: 1.008 ± 0.465
4.368IleGln: 4.368 ± 0.997
2.016IleArg: 2.016 ± 0.736
9.745IleSer: 9.745 ± 1.809
4.368IleThr: 4.368 ± 1.163
6.048IleVal: 6.048 ± 1.639
0.0IleTrp: 0.0 ± 0.0
1.68IleTyr: 1.68 ± 0.485
0.0IleXaa: 0.0 ± 0.0
Lys
5.376LysAla: 5.376 ± 1.72
0.336LysCys: 0.336 ± 0.373
4.704LysAsp: 4.704 ± 1.544
10.417LysGlu: 10.417 ± 1.639
3.36LysPhe: 3.36 ± 1.261
2.016LysGly: 2.016 ± 0.737
1.68LysHis: 1.68 ± 0.831
9.073LysIle: 9.073 ± 1.455
9.073LysLys: 9.073 ± 1.462
7.728LysLeu: 7.728 ± 1.524
3.696LysMet: 3.696 ± 1.031
5.712LysAsn: 5.712 ± 1.512
2.016LysPro: 2.016 ± 0.545
5.712LysGln: 5.712 ± 1.517
3.36LysArg: 3.36 ± 0.68
6.72LysSer: 6.72 ± 1.279
9.073LysThr: 9.073 ± 1.398
7.056LysVal: 7.056 ± 1.599
0.0LysTrp: 0.0 ± 0.0
2.352LysTyr: 2.352 ± 0.85
0.0LysXaa: 0.0 ± 0.0
Leu
4.704LeuAla: 4.704 ± 0.972
0.672LeuCys: 0.672 ± 0.406
7.392LeuAsp: 7.392 ± 1.104
8.737LeuGlu: 8.737 ± 2.272
5.376LeuPhe: 5.376 ± 1.13
7.056LeuGly: 7.056 ± 2.22
1.008LeuHis: 1.008 ± 0.622
10.753LeuIle: 10.753 ± 1.973
10.081LeuLys: 10.081 ± 1.799
9.745LeuLeu: 9.745 ± 1.552
2.016LeuMet: 2.016 ± 0.707
6.048LeuAsn: 6.048 ± 1.258
2.016LeuPro: 2.016 ± 0.73
6.048LeuGln: 6.048 ± 1.504
3.36LeuArg: 3.36 ± 0.927
4.032LeuSer: 4.032 ± 0.999
5.712LeuThr: 5.712 ± 1.124
5.04LeuVal: 5.04 ± 1.461
0.336LeuTrp: 0.336 ± 0.301
3.024LeuTyr: 3.024 ± 0.996
0.0LeuXaa: 0.0 ± 0.0
Met
1.68MetAla: 1.68 ± 0.814
0.336MetCys: 0.336 ± 0.301
1.008MetAsp: 1.008 ± 0.53
2.016MetGlu: 2.016 ± 0.748
0.0MetPhe: 0.0 ± 0.0
0.672MetGly: 0.672 ± 0.392
1.344MetHis: 1.344 ± 0.877
2.688MetIle: 2.688 ± 1.3
3.36MetLys: 3.36 ± 1.127
2.352MetLeu: 2.352 ± 0.902
1.008MetMet: 1.008 ± 0.424
2.688MetAsn: 2.688 ± 0.647
0.0MetPro: 0.0 ± 0.0
1.68MetGln: 1.68 ± 0.706
0.336MetArg: 0.336 ± 0.301
1.008MetSer: 1.008 ± 1.016
1.008MetThr: 1.008 ± 0.619
1.008MetVal: 1.008 ± 0.496
0.336MetTrp: 0.336 ± 0.271
0.672MetTyr: 0.672 ± 0.428
0.0MetXaa: 0.0 ± 0.0
Asn
4.032AsnAla: 4.032 ± 0.897
0.0AsnCys: 0.0 ± 0.0
2.352AsnAsp: 2.352 ± 0.832
5.04AsnGlu: 5.04 ± 1.225
2.352AsnPhe: 2.352 ± 0.827
2.352AsnGly: 2.352 ± 1.114
0.672AsnHis: 0.672 ± 0.407
5.04AsnIle: 5.04 ± 1.3
7.392AsnLys: 7.392 ± 1.455
7.056AsnLeu: 7.056 ± 1.467
1.008AsnMet: 1.008 ± 0.817
4.704AsnAsn: 4.704 ± 1.518
1.344AsnPro: 1.344 ± 0.553
2.352AsnGln: 2.352 ± 0.927
2.688AsnArg: 2.688 ± 0.852
3.024AsnSer: 3.024 ± 0.987
2.016AsnThr: 2.016 ± 0.78
2.016AsnVal: 2.016 ± 0.842
1.008AsnTrp: 1.008 ± 0.545
3.36AsnTyr: 3.36 ± 0.86
0.0AsnXaa: 0.0 ± 0.0
Pro
0.672ProAla: 0.672 ± 0.405
0.0ProCys: 0.0 ± 0.0
1.344ProAsp: 1.344 ± 0.706
2.352ProGlu: 2.352 ± 0.712
1.344ProPhe: 1.344 ± 0.509
0.0ProGly: 0.0 ± 0.0
0.0ProHis: 0.0 ± 0.0
0.672ProIle: 0.672 ± 0.355
1.008ProLys: 1.008 ± 0.698
2.352ProLeu: 2.352 ± 0.982
0.0ProMet: 0.0 ± 0.0
1.008ProAsn: 1.008 ± 0.585
1.008ProPro: 1.008 ± 0.513
0.672ProGln: 0.672 ± 0.455
2.016ProArg: 2.016 ± 0.906
2.016ProSer: 2.016 ± 0.503
1.68ProThr: 1.68 ± 0.625
1.344ProVal: 1.344 ± 0.791
0.0ProTrp: 0.0 ± 0.0
1.008ProTyr: 1.008 ± 0.505
0.0ProXaa: 0.0 ± 0.0
Gln
2.688GlnAla: 2.688 ± 0.689
1.008GlnCys: 1.008 ± 0.575
3.024GlnAsp: 3.024 ± 1.019
3.024GlnGlu: 3.024 ± 0.952
1.68GlnPhe: 1.68 ± 0.673
3.696GlnGly: 3.696 ± 0.961
0.0GlnHis: 0.0 ± 0.0
3.696GlnIle: 3.696 ± 1.332
5.376GlnLys: 5.376 ± 1.094
4.368GlnLeu: 4.368 ± 1.267
1.68GlnMet: 1.68 ± 0.716
1.68GlnAsn: 1.68 ± 0.629
1.344GlnPro: 1.344 ± 0.523
0.672GlnGln: 0.672 ± 0.418
1.344GlnArg: 1.344 ± 0.403
2.016GlnSer: 2.016 ± 0.839
2.352GlnThr: 2.352 ± 1.358
1.344GlnVal: 1.344 ± 0.585
0.336GlnTrp: 0.336 ± 0.342
3.024GlnTyr: 3.024 ± 1.158
0.0GlnXaa: 0.0 ± 0.0
Arg
1.344ArgAla: 1.344 ± 0.737
0.0ArgCys: 0.0 ± 0.0
2.352ArgAsp: 2.352 ± 0.871
3.696ArgGlu: 3.696 ± 1.126
1.344ArgPhe: 1.344 ± 0.548
1.008ArgGly: 1.008 ± 0.495
0.672ArgHis: 0.672 ± 0.331
2.688ArgIle: 2.688 ± 1.09
2.688ArgLys: 2.688 ± 0.869
3.36ArgLeu: 3.36 ± 1.024
0.672ArgMet: 0.672 ± 0.405
1.344ArgAsn: 1.344 ± 0.498
1.68ArgPro: 1.68 ± 0.564
3.36ArgGln: 3.36 ± 1.085
1.344ArgArg: 1.344 ± 0.498
2.352ArgSer: 2.352 ± 0.736
2.016ArgThr: 2.016 ± 0.635
2.016ArgVal: 2.016 ± 0.63
1.344ArgTrp: 1.344 ± 0.565
1.344ArgTyr: 1.344 ± 0.557
0.0ArgXaa: 0.0 ± 0.0
Ser
4.032SerAla: 4.032 ± 1.765
0.672SerCys: 0.672 ± 0.355
4.032SerAsp: 4.032 ± 0.883
3.696SerGlu: 3.696 ± 1.093
0.672SerPhe: 0.672 ± 0.355
2.688SerGly: 2.688 ± 0.772
1.68SerHis: 1.68 ± 0.566
5.376SerIle: 5.376 ± 1.141
7.056SerLys: 7.056 ± 1.536
3.36SerLeu: 3.36 ± 0.973
1.344SerMet: 1.344 ± 0.595
2.352SerAsn: 2.352 ± 0.708
1.344SerPro: 1.344 ± 0.714
2.352SerGln: 2.352 ± 0.615
2.688SerArg: 2.688 ± 0.846
3.696SerSer: 3.696 ± 1.453
3.024SerThr: 3.024 ± 1.136
2.352SerVal: 2.352 ± 1.061
0.672SerTrp: 0.672 ± 0.636
6.048SerTyr: 6.048 ± 1.469
0.0SerXaa: 0.0 ± 0.0
Thr
1.68ThrAla: 1.68 ± 0.695
0.0ThrCys: 0.0 ± 0.0
2.352ThrAsp: 2.352 ± 0.879
5.376ThrGlu: 5.376 ± 1.053
1.68ThrPhe: 1.68 ± 0.708
2.688ThrGly: 2.688 ± 0.874
0.336ThrHis: 0.336 ± 0.301
4.704ThrIle: 4.704 ± 1.266
5.712ThrLys: 5.712 ± 1.123
5.712ThrLeu: 5.712 ± 1.776
1.008ThrMet: 1.008 ± 0.713
4.032ThrAsn: 4.032 ± 1.136
1.344ThrPro: 1.344 ± 0.556
2.352ThrGln: 2.352 ± 0.963
2.688ThrArg: 2.688 ± 0.742
1.68ThrSer: 1.68 ± 0.603
2.688ThrThr: 2.688 ± 0.906
2.688ThrVal: 2.688 ± 1.194
0.336ThrTrp: 0.336 ± 0.252
2.688ThrTyr: 2.688 ± 0.833
0.0ThrXaa: 0.0 ± 0.0
Val
2.016ValAla: 2.016 ± 0.758
0.672ValCys: 0.672 ± 0.406
3.36ValAsp: 3.36 ± 0.806
2.688ValGlu: 2.688 ± 0.995
2.352ValPhe: 2.352 ± 0.907
1.68ValGly: 1.68 ± 0.657
0.0ValHis: 0.0 ± 0.0
2.352ValIle: 2.352 ± 1.186
5.04ValLys: 5.04 ± 1.357
7.392ValLeu: 7.392 ± 1.051
1.008ValMet: 1.008 ± 0.491
4.032ValAsn: 4.032 ± 0.657
2.688ValPro: 2.688 ± 1.056
2.016ValGln: 2.016 ± 0.834
1.008ValArg: 1.008 ± 0.603
5.376ValSer: 5.376 ± 1.106
2.688ValThr: 2.688 ± 0.752
2.352ValVal: 2.352 ± 0.842
0.336ValTrp: 0.336 ± 0.252
3.36ValTyr: 3.36 ± 1.153
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
1.68TrpGlu: 1.68 ± 0.559
0.672TrpPhe: 0.672 ± 0.501
0.672TrpGly: 0.672 ± 0.35
0.0TrpHis: 0.0 ± 0.0
0.672TrpIle: 0.672 ± 0.524
0.336TrpLys: 0.336 ± 0.283
0.672TrpLeu: 0.672 ± 0.387
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
0.336TrpPro: 0.336 ± 0.326
0.336TrpGln: 0.336 ± 0.373
0.336TrpArg: 0.336 ± 0.252
0.672TrpSer: 0.672 ± 0.331
0.0TrpThr: 0.0 ± 0.0
0.0TrpVal: 0.0 ± 0.0
0.0TrpTrp: 0.0 ± 0.0
0.672TrpTyr: 0.672 ± 0.35
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.016TyrAla: 2.016 ± 1.703
0.0TyrCys: 0.0 ± 0.0
3.024TyrAsp: 3.024 ± 0.701
2.352TyrGlu: 2.352 ± 0.999
4.368TyrPhe: 4.368 ± 1.274
2.016TyrGly: 2.016 ± 0.752
0.0TyrHis: 0.0 ± 0.0
2.688TyrIle: 2.688 ± 1.075
8.401TyrLys: 8.401 ± 1.693
4.368TyrLeu: 4.368 ± 1.074
1.008TyrMet: 1.008 ± 0.49
2.352TyrAsn: 2.352 ± 0.956
0.336TyrPro: 0.336 ± 0.332
1.68TyrGln: 1.68 ± 0.64
3.024TyrArg: 3.024 ± 0.981
3.024TyrSer: 3.024 ± 0.823
0.672TyrThr: 0.672 ± 0.457
1.68TyrVal: 1.68 ± 0.62
0.336TyrTrp: 0.336 ± 0.283
1.68TyrTyr: 1.68 ± 0.536
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 20 proteins (2977 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski