Amino acid dipepetide frequency for Marinovum algicola DG 898

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
18.216AlaAla: 18.216 ± 0.159
1.229AlaCys: 1.229 ± 0.03
6.856AlaAsp: 6.856 ± 0.073
9.05AlaGlu: 9.05 ± 0.097
4.219AlaPhe: 4.219 ± 0.058
11.396AlaGly: 11.396 ± 0.094
2.38AlaHis: 2.38 ± 0.039
5.652AlaIle: 5.652 ± 0.06
3.394AlaLys: 3.394 ± 0.057
14.691AlaLeu: 14.691 ± 0.118
3.822AlaMet: 3.822 ± 0.052
2.619AlaAsn: 2.619 ± 0.041
6.307AlaPro: 6.307 ± 0.087
4.529AlaGln: 4.529 ± 0.057
10.026AlaArg: 10.026 ± 0.119
5.478AlaSer: 5.478 ± 0.063
5.93AlaThr: 5.93 ± 0.066
8.664AlaVal: 8.664 ± 0.081
1.503AlaTrp: 1.503 ± 0.034
2.506AlaTyr: 2.506 ± 0.04
0.0AlaXaa: 0.0 ± 0.0
Cys
1.21CysAla: 1.21 ± 0.029
0.133CysCys: 0.133 ± 0.01
0.672CysAsp: 0.672 ± 0.021
0.469CysGlu: 0.469 ± 0.018
0.327CysPhe: 0.327 ± 0.015
1.008CysGly: 1.008 ± 0.026
0.292CysHis: 0.292 ± 0.014
0.366CysIle: 0.366 ± 0.016
0.206CysLys: 0.206 ± 0.012
0.891CysLeu: 0.891 ± 0.026
0.161CysMet: 0.161 ± 0.01
0.226CysAsn: 0.226 ± 0.01
0.512CysPro: 0.512 ± 0.02
0.264CysGln: 0.264 ± 0.013
0.604CysArg: 0.604 ± 0.021
0.412CysSer: 0.412 ± 0.016
0.478CysThr: 0.478 ± 0.018
0.624CysVal: 0.624 ± 0.02
0.124CysTrp: 0.124 ± 0.009
0.225CysTyr: 0.225 ± 0.012
0.0CysXaa: 0.0 ± 0.0
Asp
7.069AspAla: 7.069 ± 0.075
0.542AspCys: 0.542 ± 0.021
3.308AspAsp: 3.308 ± 0.059
3.473AspGlu: 3.473 ± 0.128
2.352AspPhe: 2.352 ± 0.042
5.566AspGly: 5.566 ± 0.071
1.418AspHis: 1.418 ± 0.032
3.012AspIle: 3.012 ± 0.042
1.658AspLys: 1.658 ± 0.033
6.377AspLeu: 6.377 ± 0.069
1.566AspMet: 1.566 ± 0.033
1.32AspAsn: 1.32 ± 0.031
3.669AspPro: 3.669 ± 0.053
1.784AspGln: 1.784 ± 0.035
4.597AspArg: 4.597 ± 0.06
2.227AspSer: 2.227 ± 0.041
2.893AspThr: 2.893 ± 0.047
4.088AspVal: 4.088 ± 0.056
1.22AspTrp: 1.22 ± 0.031
1.533AspTyr: 1.533 ± 0.035
0.0AspXaa: 0.0 ± 0.0
Glu
8.951GluAla: 8.951 ± 0.1
0.395GluCys: 0.395 ± 0.016
3.547GluAsp: 3.547 ± 0.058
3.723GluGlu: 3.723 ± 0.06
1.863GluPhe: 1.863 ± 0.037
4.857GluGly: 4.857 ± 0.11
1.105GluHis: 1.105 ± 0.027
3.928GluIle: 3.928 ± 0.046
1.993GluLys: 1.993 ± 0.042
5.231GluLeu: 5.231 ± 0.06
1.926GluMet: 1.926 ± 0.039
1.668GluAsn: 1.668 ± 0.036
2.513GluPro: 2.513 ± 0.045
1.859GluGln: 1.859 ± 0.035
4.173GluArg: 4.173 ± 0.057
2.212GluSer: 2.212 ± 0.045
4.221GluThr: 4.221 ± 0.061
4.545GluVal: 4.545 ± 0.049
0.664GluTrp: 0.664 ± 0.023
1.043GluTyr: 1.043 ± 0.026
0.0GluXaa: 0.0 ± 0.0
Phe
4.624PheAla: 4.624 ± 0.056
0.445PheCys: 0.445 ± 0.016
3.007PheAsp: 3.007 ± 0.049
2.186PheGlu: 2.186 ± 0.04
1.43PhePhe: 1.43 ± 0.031
3.721PheGly: 3.721 ± 0.054
0.768PheHis: 0.768 ± 0.022
1.555PheIle: 1.555 ± 0.036
0.849PheLys: 0.849 ± 0.026
3.533PheLeu: 3.533 ± 0.052
0.818PheMet: 0.818 ± 0.024
0.985PheAsn: 0.985 ± 0.026
1.578PhePro: 1.578 ± 0.028
1.032PheGln: 1.032 ± 0.024
2.277PheArg: 2.277 ± 0.041
1.973PheSer: 1.973 ± 0.039
1.984PheThr: 1.984 ± 0.038
2.738PheVal: 2.738 ± 0.044
0.565PheTrp: 0.565 ± 0.024
0.908PheTyr: 0.908 ± 0.024
0.0PheXaa: 0.0 ± 0.0
Gly
10.518GlyAla: 10.518 ± 0.094
0.9GlyCys: 0.9 ± 0.025
4.771GlyAsp: 4.771 ± 0.083
4.775GlyGlu: 4.775 ± 0.058
3.863GlyPhe: 3.863 ± 0.052
7.678GlyGly: 7.678 ± 0.109
2.003GlyHis: 2.003 ± 0.036
4.373GlyIle: 4.373 ± 0.058
2.954GlyLys: 2.954 ± 0.047
9.652GlyLeu: 9.652 ± 0.09
2.628GlyMet: 2.628 ± 0.044
2.145GlyAsn: 2.145 ± 0.063
3.928GlyPro: 3.928 ± 0.044
3.197GlyGln: 3.197 ± 0.05
6.161GlyArg: 6.161 ± 0.066
4.18GlySer: 4.18 ± 0.078
4.669GlyThr: 4.669 ± 0.06
6.415GlyVal: 6.415 ± 0.069
1.53GlyTrp: 1.53 ± 0.034
2.363GlyTyr: 2.363 ± 0.044
0.0GlyXaa: 0.0 ± 0.0
His
2.33HisAla: 2.33 ± 0.042
0.264HisCys: 0.264 ± 0.012
1.35HisAsp: 1.35 ± 0.03
1.08HisGlu: 1.08 ± 0.028
0.877HisPhe: 0.877 ± 0.025
1.982HisGly: 1.982 ± 0.042
0.529HisHis: 0.529 ± 0.021
0.957HisIle: 0.957 ± 0.023
0.494HisLys: 0.494 ± 0.021
2.097HisLeu: 2.097 ± 0.042
0.546HisMet: 0.546 ± 0.019
0.46HisAsn: 0.46 ± 0.018
1.393HisPro: 1.393 ± 0.033
0.593HisGln: 0.593 ± 0.021
1.439HisArg: 1.439 ± 0.032
0.905HisSer: 0.905 ± 0.026
0.776HisThr: 0.776 ± 0.023
1.593HisVal: 1.593 ± 0.034
0.391HisTrp: 0.391 ± 0.017
0.565HisTyr: 0.565 ± 0.021
0.0HisXaa: 0.0 ± 0.0
Ile
7.001IleAla: 7.001 ± 0.074
0.618IleCys: 0.618 ± 0.02
3.469IleAsp: 3.469 ± 0.05
3.429IleGlu: 3.429 ± 0.048
1.704IlePhe: 1.704 ± 0.037
4.746IleGly: 4.746 ± 0.06
0.884IleHis: 0.884 ± 0.024
1.98IleIle: 1.98 ± 0.044
1.271IleLys: 1.271 ± 0.026
4.669IleLeu: 4.669 ± 0.058
0.965IleMet: 0.965 ± 0.027
1.283IleAsn: 1.283 ± 0.032
2.224IlePro: 2.224 ± 0.042
1.105IleGln: 1.105 ± 0.029
3.133IleArg: 3.133 ± 0.05
2.843IleSer: 2.843 ± 0.047
2.774IleThr: 2.774 ± 0.039
3.669IleVal: 3.669 ± 0.055
0.697IleTrp: 0.697 ± 0.022
1.103IleTyr: 1.103 ± 0.028
0.0IleXaa: 0.0 ± 0.0
Lys
3.632LysAla: 3.632 ± 0.059
0.162LysCys: 0.162 ± 0.011
1.498LysAsp: 1.498 ± 0.035
1.42LysGlu: 1.42 ± 0.031
0.854LysPhe: 0.854 ± 0.026
2.434LysGly: 2.434 ± 0.05
0.581LysHis: 0.581 ± 0.018
1.441LysIle: 1.441 ± 0.034
1.015LysLys: 1.015 ± 0.032
2.806LysLeu: 2.806 ± 0.044
0.781LysMet: 0.781 ± 0.023
0.702LysAsn: 0.702 ± 0.024
1.728LysPro: 1.728 ± 0.039
0.828LysGln: 0.828 ± 0.026
2.084LysArg: 2.084 ± 0.045
1.709LysSer: 1.709 ± 0.035
1.801LysThr: 1.801 ± 0.034
2.171LysVal: 2.171 ± 0.046
0.36LysTrp: 0.36 ± 0.015
0.595LysTyr: 0.595 ± 0.021
0.0LysXaa: 0.0 ± 0.0
Leu
13.991LeuAla: 13.991 ± 0.121
1.013LeuCys: 1.013 ± 0.027
6.04LeuAsp: 6.04 ± 0.068
5.478LeuGlu: 5.478 ± 0.058
3.513LeuPhe: 3.513 ± 0.052
8.817LeuGly: 8.817 ± 0.091
2.02LeuHis: 2.02 ± 0.037
5.128LeuIle: 5.128 ± 0.074
2.973LeuLys: 2.973 ± 0.052
9.265LeuLeu: 9.265 ± 0.109
2.575LeuMet: 2.575 ± 0.045
2.478LeuAsn: 2.478 ± 0.043
5.823LeuPro: 5.823 ± 0.062
2.599LeuGln: 2.599 ± 0.039
7.564LeuArg: 7.564 ± 0.082
6.272LeuSer: 6.272 ± 0.061
6.034LeuThr: 6.034 ± 0.068
6.969LeuVal: 6.969 ± 0.072
1.322LeuTrp: 1.322 ± 0.031
2.002LeuTyr: 2.002 ± 0.036
0.0LeuXaa: 0.0 ± 0.0
Met
3.514MetAla: 3.514 ± 0.046
0.201MetCys: 0.201 ± 0.011
1.283MetAsp: 1.283 ± 0.03
1.269MetGlu: 1.269 ± 0.029
0.809MetPhe: 0.809 ± 0.023
2.19MetGly: 2.19 ± 0.041
0.455MetHis: 0.455 ± 0.017
1.584MetIle: 1.584 ± 0.029
0.99MetLys: 0.99 ± 0.026
2.541MetLeu: 2.541 ± 0.045
0.754MetMet: 0.754 ± 0.028
0.763MetAsn: 0.763 ± 0.02
1.467MetPro: 1.467 ± 0.034
0.996MetGln: 0.996 ± 0.023
1.849MetArg: 1.849 ± 0.035
1.754MetSer: 1.754 ± 0.03
2.148MetThr: 2.148 ± 0.036
1.827MetVal: 1.827 ± 0.035
0.224MetTrp: 0.224 ± 0.014
0.37MetTyr: 0.37 ± 0.017
0.0MetXaa: 0.0 ± 0.0
Asn
3.001AsnAla: 3.001 ± 0.048
0.248AsnCys: 0.248 ± 0.013
1.388AsnAsp: 1.388 ± 0.042
1.17AsnGlu: 1.17 ± 0.064
0.949AsnPhe: 0.949 ± 0.022
2.234AsnGly: 2.234 ± 0.053
0.478AsnHis: 0.478 ± 0.016
1.285AsnIle: 1.285 ± 0.029
0.596AsnLys: 0.596 ± 0.02
2.413AsnLeu: 2.413 ± 0.039
0.672AsnMet: 0.672 ± 0.02
0.602AsnAsn: 0.602 ± 0.019
1.77AsnPro: 1.77 ± 0.04
0.643AsnGln: 0.643 ± 0.022
1.662AsnArg: 1.662 ± 0.031
1.116AsnSer: 1.116 ± 0.028
1.276AsnThr: 1.276 ± 0.026
1.707AsnVal: 1.707 ± 0.035
0.425AsnTrp: 0.425 ± 0.018
0.634AsnTyr: 0.634 ± 0.023
0.0AsnXaa: 0.0 ± 0.0
Pro
6.216ProAla: 6.216 ± 0.071
0.367ProCys: 0.367 ± 0.014
3.756ProAsp: 3.756 ± 0.055
4.787ProGlu: 4.787 ± 0.064
1.892ProPhe: 1.892 ± 0.035
5.011ProGly: 5.011 ± 0.064
1.056ProHis: 1.056 ± 0.026
2.156ProIle: 2.156 ± 0.039
1.478ProLys: 1.478 ± 0.034
4.886ProLeu: 4.886 ± 0.061
1.299ProMet: 1.299 ± 0.031
1.164ProAsn: 1.164 ± 0.027
2.46ProPro: 2.46 ± 0.048
1.712ProGln: 1.712 ± 0.038
3.075ProArg: 3.075 ± 0.045
2.255ProSer: 2.255 ± 0.037
2.196ProThr: 2.196 ± 0.036
4.363ProVal: 4.363 ± 0.054
0.706ProTrp: 0.706 ± 0.022
1.163ProTyr: 1.163 ± 0.029
0.0ProXaa: 0.0 ± 0.0
Gln
4.243GlnAla: 4.243 ± 0.055
0.22GlnCys: 0.22 ± 0.012
1.674GlnAsp: 1.674 ± 0.035
1.801GlnGlu: 1.801 ± 0.038
1.052GlnPhe: 1.052 ± 0.024
2.699GlnGly: 2.699 ± 0.042
0.55GlnHis: 0.55 ± 0.019
1.786GlnIle: 1.786 ± 0.036
0.993GlnLys: 0.993 ± 0.026
2.727GlnLeu: 2.727 ± 0.047
1.053GlnMet: 1.053 ± 0.029
0.803GlnAsn: 0.803 ± 0.022
1.624GlnPro: 1.624 ± 0.034
1.09GlnGln: 1.09 ± 0.029
2.197GlnArg: 2.197 ± 0.041
1.717GlnSer: 1.717 ± 0.034
1.739GlnThr: 1.739 ± 0.033
2.462GlnVal: 2.462 ± 0.04
0.387GlnTrp: 0.387 ± 0.014
0.557GlnTyr: 0.557 ± 0.019
0.0GlnXaa: 0.0 ± 0.0
Arg
8.946ArgAla: 8.946 ± 0.1
0.526ArgCys: 0.526 ± 0.02
4.581ArgAsp: 4.581 ± 0.06
3.963ArgGlu: 3.963 ± 0.053
2.704ArgPhe: 2.704 ± 0.045
5.08ArgGly: 5.08 ± 0.063
1.766ArgHis: 1.766 ± 0.034
3.951ArgIle: 3.951 ± 0.05
2.226ArgLys: 2.226 ± 0.036
7.768ArgLeu: 7.768 ± 0.081
1.998ArgMet: 1.998 ± 0.038
1.784ArgAsn: 1.784 ± 0.036
3.539ArgPro: 3.539 ± 0.046
2.543ArgGln: 2.543 ± 0.049
5.582ArgArg: 5.582 ± 0.083
3.193ArgSer: 3.193 ± 0.052
2.966ArgThr: 2.966 ± 0.044
4.825ArgVal: 4.825 ± 0.062
0.95ArgTrp: 0.95 ± 0.029
1.591ArgTyr: 1.591 ± 0.036
0.0ArgXaa: 0.0 ± 0.0
Ser
5.654SerAla: 5.654 ± 0.065
0.428SerCys: 0.428 ± 0.017
3.187SerAsp: 3.187 ± 0.052
2.933SerGlu: 2.933 ± 0.043
2.215SerPhe: 2.215 ± 0.039
5.436SerGly: 5.436 ± 0.086
1.069SerHis: 1.069 ± 0.032
2.226SerIle: 2.226 ± 0.039
1.357SerLys: 1.357 ± 0.036
4.748SerLeu: 4.748 ± 0.055
1.243SerMet: 1.243 ± 0.029
1.231SerAsn: 1.231 ± 0.031
2.393SerPro: 2.393 ± 0.04
1.573SerGln: 1.573 ± 0.032
3.311SerArg: 3.311 ± 0.043
2.303SerSer: 2.303 ± 0.04
2.328SerThr: 2.328 ± 0.038
3.569SerVal: 3.569 ± 0.051
0.7SerTrp: 0.7 ± 0.022
1.276SerTyr: 1.276 ± 0.032
0.0SerXaa: 0.0 ± 0.0
Thr
6.416ThrAla: 6.416 ± 0.072
0.51ThrCys: 0.51 ± 0.018
3.042ThrAsp: 3.042 ± 0.044
3.156ThrGlu: 3.156 ± 0.047
1.941ThrPhe: 1.941 ± 0.039
5.553ThrGly: 5.553 ± 0.059
1.082ThrHis: 1.082 ± 0.028
2.426ThrIle: 2.426 ± 0.04
1.225ThrLys: 1.225 ± 0.032
5.964ThrLeu: 5.964 ± 0.077
1.197ThrMet: 1.197 ± 0.025
1.187ThrAsn: 1.187 ± 0.031
3.558ThrPro: 3.558 ± 0.049
1.413ThrGln: 1.413 ± 0.033
3.676ThrArg: 3.676 ± 0.052
2.61ThrSer: 2.61 ± 0.04
2.66ThrThr: 2.66 ± 0.05
4.013ThrVal: 4.013 ± 0.058
0.703ThrTrp: 0.703 ± 0.025
1.202ThrTyr: 1.202 ± 0.031
0.0ThrXaa: 0.0 ± 0.0
Val
8.997ValAla: 8.997 ± 0.078
0.615ValCys: 0.615 ± 0.019
3.874ValAsp: 3.874 ± 0.051
4.33ValGlu: 4.33 ± 0.047
2.951ValPhe: 2.951 ± 0.042
5.216ValGly: 5.216 ± 0.064
1.31ValHis: 1.31 ± 0.029
4.23ValIle: 4.23 ± 0.055
1.913ValLys: 1.913 ± 0.039
7.636ValLeu: 7.636 ± 0.082
2.052ValMet: 2.052 ± 0.034
1.884ValAsn: 1.884 ± 0.038
3.671ValPro: 3.671 ± 0.05
2.198ValGln: 2.198 ± 0.034
4.32ValArg: 4.32 ± 0.049
4.163ValSer: 4.163 ± 0.056
4.836ValThr: 4.836 ± 0.051
5.578ValVal: 5.578 ± 0.06
0.93ValTrp: 0.93 ± 0.027
1.464ValTyr: 1.464 ± 0.032
0.0ValXaa: 0.0 ± 0.0
Trp
1.404TrpAla: 1.404 ± 0.032
0.141TrpCys: 0.141 ± 0.01
0.745TrpAsp: 0.745 ± 0.026
0.665TrpGlu: 0.665 ± 0.02
0.543TrpPhe: 0.543 ± 0.021
1.015TrpGly: 1.015 ± 0.03
0.351TrpHis: 0.351 ± 0.018
0.647TrpIle: 0.647 ± 0.02
0.46TrpLys: 0.46 ± 0.016
1.674TrpLeu: 1.674 ± 0.036
0.456TrpMet: 0.456 ± 0.018
0.427TrpAsn: 0.427 ± 0.019
0.744TrpPro: 0.744 ± 0.02
0.73TrpGln: 0.73 ± 0.024
1.153TrpArg: 1.153 ± 0.029
0.765TrpSer: 0.765 ± 0.024
0.745TrpThr: 0.745 ± 0.025
0.826TrpVal: 0.826 ± 0.024
0.217TrpTrp: 0.217 ± 0.011
0.269TrpTyr: 0.269 ± 0.014
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.538TyrAla: 2.538 ± 0.043
0.246TyrCys: 0.246 ± 0.011
1.625TyrAsp: 1.625 ± 0.034
1.258TyrGlu: 1.258 ± 0.031
0.921TyrPhe: 0.921 ± 0.024
2.063TyrGly: 2.063 ± 0.042
0.523TyrHis: 0.523 ± 0.018
0.883TyrIle: 0.883 ± 0.028
0.557TyrLys: 0.557 ± 0.021
2.307TyrLeu: 2.307 ± 0.045
0.474TyrMet: 0.474 ± 0.017
0.541TyrAsn: 0.541 ± 0.019
1.096TyrPro: 1.096 ± 0.027
0.684TyrGln: 0.684 ± 0.022
1.598TyrArg: 1.598 ± 0.037
1.094TyrSer: 1.094 ± 0.032
1.079TyrThr: 1.079 ± 0.025
1.521TyrVal: 1.521 ± 0.037
0.362TyrTrp: 0.362 ± 0.016
0.561TyrTyr: 0.561 ± 0.02
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4976 proteins (1570877 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski