Amino acid dipepetide frequency for Pyrodictium occultum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
16.647AlaAla: 16.647 ± 0.383
0.906AlaCys: 0.906 ± 0.062
3.26AlaAsp: 3.26 ± 0.086
7.747AlaGlu: 7.747 ± 0.145
2.419AlaPhe: 2.419 ± 0.082
10.692AlaGly: 10.692 ± 0.199
1.358AlaHis: 1.358 ± 0.055
4.156AlaIle: 4.156 ± 0.099
3.497AlaLys: 3.497 ± 0.114
12.969AlaLeu: 12.969 ± 0.226
2.334AlaMet: 2.334 ± 0.074
1.528AlaAsn: 1.528 ± 0.063
4.48AlaPro: 4.48 ± 0.107
1.655AlaGln: 1.655 ± 0.057
11.699AlaArg: 11.699 ± 0.193
6.794AlaSer: 6.794 ± 0.165
4.073AlaThr: 4.073 ± 0.11
10.273AlaVal: 10.273 ± 0.186
1.605AlaTrp: 1.605 ± 0.073
3.357AlaTyr: 3.357 ± 0.096
0.0AlaXaa: 0.0 ± 0.0
Cys
0.431CysAla: 0.431 ± 0.034
0.151CysCys: 0.151 ± 0.018
0.265CysAsp: 0.265 ± 0.026
0.256CysGlu: 0.256 ± 0.025
0.149CysPhe: 0.149 ± 0.018
1.145CysGly: 1.145 ± 0.061
0.149CysHis: 0.149 ± 0.02
0.51CysIle: 0.51 ± 0.034
0.217CysLys: 0.217 ± 0.024
0.666CysLeu: 0.666 ± 0.047
0.245CysMet: 0.245 ± 0.025
0.136CysAsn: 0.136 ± 0.019
0.83CysPro: 0.83 ± 0.051
0.09CysGln: 0.09 ± 0.015
0.961CysArg: 0.961 ± 0.05
0.946CysSer: 0.946 ± 0.056
0.412CysThr: 0.412 ± 0.032
0.501CysVal: 0.501 ± 0.038
0.118CysTrp: 0.118 ± 0.02
0.215CysTyr: 0.215 ± 0.018
0.0CysXaa: 0.0 ± 0.0
Asp
4.193AspAla: 4.193 ± 0.101
0.289AspCys: 0.289 ± 0.028
1.34AspAsp: 1.34 ± 0.059
3.273AspGlu: 3.273 ± 0.087
0.974AspPhe: 0.974 ± 0.047
2.949AspGly: 2.949 ± 0.083
0.628AspHis: 0.628 ± 0.035
2.551AspIle: 2.551 ± 0.088
1.568AspLys: 1.568 ± 0.064
3.996AspLeu: 3.996 ± 0.093
0.942AspMet: 0.942 ± 0.05
0.782AspAsn: 0.782 ± 0.042
3.468AspPro: 3.468 ± 0.084
0.631AspGln: 0.631 ± 0.038
2.938AspArg: 2.938 ± 0.09
1.771AspSer: 1.771 ± 0.059
1.971AspThr: 1.971 ± 0.058
3.755AspVal: 3.755 ± 0.091
0.604AspTrp: 0.604 ± 0.038
1.911AspTyr: 1.911 ± 0.066
0.0AspXaa: 0.0 ± 0.0
Glu
11.585GluAla: 11.585 ± 0.206
0.493GluCys: 0.493 ± 0.038
3.094GluAsp: 3.094 ± 0.087
8.331GluGlu: 8.331 ± 0.193
1.428GluPhe: 1.428 ± 0.059
5.406GluGly: 5.406 ± 0.105
1.366GluHis: 1.366 ± 0.058
3.617GluIle: 3.617 ± 0.108
4.456GluLys: 4.456 ± 0.124
7.972GluLeu: 7.972 ± 0.141
1.399GluMet: 1.399 ± 0.049
1.388GluAsn: 1.388 ± 0.054
4.27GluPro: 4.27 ± 0.097
1.585GluGln: 1.585 ± 0.061
6.788GluArg: 6.788 ± 0.141
2.717GluSer: 2.717 ± 0.079
2.835GluThr: 2.835 ± 0.077
5.638GluVal: 5.638 ± 0.108
0.937GluTrp: 0.937 ± 0.051
2.363GluTyr: 2.363 ± 0.084
0.0GluXaa: 0.0 ± 0.0
Phe
2.014PheAla: 2.014 ± 0.069
0.212PheCys: 0.212 ± 0.022
1.163PheAsp: 1.163 ± 0.054
1.504PheGlu: 1.504 ± 0.056
0.742PhePhe: 0.742 ± 0.039
1.581PheGly: 1.581 ± 0.059
0.578PheHis: 0.578 ± 0.037
1.66PheIle: 1.66 ± 0.065
0.885PheLys: 0.885 ± 0.046
2.411PheLeu: 2.411 ± 0.081
0.596PheMet: 0.596 ± 0.031
0.836PheAsn: 0.836 ± 0.044
0.955PhePro: 0.955 ± 0.051
0.545PheGln: 0.545 ± 0.032
1.725PheArg: 1.725 ± 0.057
1.449PheSer: 1.449 ± 0.061
1.574PheThr: 1.574 ± 0.063
1.603PheVal: 1.603 ± 0.056
0.342PheTrp: 0.342 ± 0.029
1.182PheTyr: 1.182 ± 0.052
0.0PheXaa: 0.0 ± 0.0
Gly
7.963GlyAla: 7.963 ± 0.162
1.114GlyCys: 1.114 ± 0.05
3.678GlyAsp: 3.678 ± 0.093
6.479GlyGlu: 6.479 ± 0.122
2.945GlyPhe: 2.945 ± 0.088
7.753GlyGly: 7.753 ± 0.179
1.449GlyHis: 1.449 ± 0.05
3.965GlyIle: 3.965 ± 0.098
3.135GlyLys: 3.135 ± 0.09
10.759GlyLeu: 10.759 ± 0.203
2.323GlyMet: 2.323 ± 0.058
1.347GlyAsn: 1.347 ± 0.062
3.81GlyPro: 3.81 ± 0.101
1.452GlyGln: 1.452 ± 0.059
7.889GlyArg: 7.889 ± 0.133
5.205GlySer: 5.205 ± 0.125
2.822GlyThr: 2.822 ± 0.078
8.272GlyVal: 8.272 ± 0.141
1.384GlyTrp: 1.384 ± 0.068
3.617GlyTyr: 3.617 ± 0.086
0.0GlyXaa: 0.0 ± 0.0
His
1.738HisAla: 1.738 ± 0.065
0.169HisCys: 0.169 ± 0.019
0.655HisAsp: 0.655 ± 0.037
1.036HisGlu: 1.036 ± 0.052
0.388HisPhe: 0.388 ± 0.034
2.071HisGly: 2.071 ± 0.066
0.394HisHis: 0.394 ± 0.033
0.874HisIle: 0.874 ± 0.042
0.39HisLys: 0.39 ± 0.028
1.644HisLeu: 1.644 ± 0.063
0.339HisMet: 0.339 ± 0.027
0.328HisAsn: 0.328 ± 0.027
1.388HisPro: 1.388 ± 0.054
0.311HisGln: 0.311 ± 0.026
1.546HisArg: 1.546 ± 0.058
0.926HisSer: 0.926 ± 0.048
0.725HisThr: 0.725 ± 0.037
1.763HisVal: 1.763 ± 0.069
0.25HisTrp: 0.25 ± 0.024
0.615HisTyr: 0.615 ± 0.04
0.0HisXaa: 0.0 ± 0.0
Ile
5.778IleAla: 5.778 ± 0.149
0.289IleCys: 0.289 ± 0.023
2.816IleAsp: 2.816 ± 0.085
4.062IleGlu: 4.062 ± 0.114
0.882IlePhe: 0.882 ± 0.044
3.346IleGly: 3.346 ± 0.097
1.044IleHis: 1.044 ± 0.045
2.49IleIle: 2.49 ± 0.083
1.583IleLys: 1.583 ± 0.067
4.762IleLeu: 4.762 ± 0.102
0.992IleMet: 0.992 ± 0.049
1.071IleAsn: 1.071 ± 0.062
2.514IlePro: 2.514 ± 0.086
0.762IleGln: 0.762 ± 0.048
3.554IleArg: 3.554 ± 0.091
2.01IleSer: 2.01 ± 0.077
2.104IleThr: 2.104 ± 0.08
5.38IleVal: 5.38 ± 0.102
0.396IleTrp: 0.396 ± 0.032
1.874IleTyr: 1.874 ± 0.069
0.0IleXaa: 0.0 ± 0.0
Lys
3.858LysAla: 3.858 ± 0.107
0.254LysCys: 0.254 ± 0.025
1.104LysAsp: 1.104 ± 0.054
1.968LysGlu: 1.968 ± 0.083
0.698LysPhe: 0.698 ± 0.044
2.68LysGly: 2.68 ± 0.075
0.628LysHis: 0.628 ± 0.04
1.881LysIle: 1.881 ± 0.077
1.714LysLys: 1.714 ± 0.076
4.642LysLeu: 4.642 ± 0.123
0.731LysMet: 0.731 ± 0.042
0.639LysAsn: 0.639 ± 0.039
2.886LysPro: 2.886 ± 0.072
0.738LysGln: 0.738 ± 0.046
3.035LysArg: 3.035 ± 0.099
1.552LysSer: 1.552 ± 0.074
1.833LysThr: 1.833 ± 0.065
2.54LysVal: 2.54 ± 0.095
0.427LysTrp: 0.427 ± 0.034
1.187LysTyr: 1.187 ± 0.047
0.0LysXaa: 0.0 ± 0.0
Leu
15.121LeuAla: 15.121 ± 0.286
0.683LeuCys: 0.683 ± 0.044
5.459LeuAsp: 5.459 ± 0.114
10.67LeuGlu: 10.67 ± 0.201
2.301LeuPhe: 2.301 ± 0.076
10.475LeuGly: 10.475 ± 0.18
2.341LeuHis: 2.341 ± 0.072
4.07LeuIle: 4.07 ± 0.096
3.258LeuLys: 3.258 ± 0.101
13.888LeuLeu: 13.888 ± 0.232
1.848LeuMet: 1.848 ± 0.07
1.911LeuAsn: 1.911 ± 0.068
5.642LeuPro: 5.642 ± 0.112
2.562LeuGln: 2.562 ± 0.079
11.151LeuArg: 11.151 ± 0.176
6.113LeuSer: 6.113 ± 0.124
3.413LeuThr: 3.413 ± 0.087
10.396LeuVal: 10.396 ± 0.166
1.099LeuTrp: 1.099 ± 0.053
4.097LeuTyr: 4.097 ± 0.111
0.0LeuXaa: 0.0 ± 0.0
Met
2.573MetAla: 2.573 ± 0.073
0.138MetCys: 0.138 ± 0.019
0.852MetAsp: 0.852 ± 0.04
1.682MetGlu: 1.682 ± 0.059
0.425MetPhe: 0.425 ± 0.031
1.787MetGly: 1.787 ± 0.064
0.418MetHis: 0.418 ± 0.032
1.023MetIle: 1.023 ± 0.048
0.957MetLys: 0.957 ± 0.05
2.772MetLeu: 2.772 ± 0.066
0.44MetMet: 0.44 ± 0.031
0.412MetAsn: 0.412 ± 0.024
1.29MetPro: 1.29 ± 0.054
0.44MetGln: 0.44 ± 0.029
1.618MetArg: 1.618 ± 0.059
1.193MetSer: 1.193 ± 0.058
0.86MetThr: 0.86 ± 0.047
1.909MetVal: 1.909 ± 0.065
0.155MetTrp: 0.155 ± 0.021
0.558MetTyr: 0.558 ± 0.033
0.0MetXaa: 0.0 ± 0.0
Asn
1.833AsnAla: 1.833 ± 0.066
0.171AsnCys: 0.171 ± 0.02
0.661AsnAsp: 0.661 ± 0.038
0.906AsnGlu: 0.906 ± 0.053
0.418AsnPhe: 0.418 ± 0.029
1.325AsnGly: 1.325 ± 0.065
0.274AsnHis: 0.274 ± 0.026
1.379AsnIle: 1.379 ± 0.064
0.659AsnLys: 0.659 ± 0.043
1.703AsnLeu: 1.703 ± 0.059
0.528AsnMet: 0.528 ± 0.038
0.451AsnAsn: 0.451 ± 0.032
1.756AsnPro: 1.756 ± 0.064
0.28AsnGln: 0.28 ± 0.025
1.042AsnArg: 1.042 ± 0.053
0.764AsnSer: 0.764 ± 0.043
1.073AsnThr: 1.073 ± 0.053
1.697AsnVal: 1.697 ± 0.072
0.204AsnTrp: 0.204 ± 0.024
0.622AsnTyr: 0.622 ± 0.041
0.0AsnXaa: 0.0 ± 0.0
Pro
4.618ProAla: 4.618 ± 0.109
0.497ProCys: 0.497 ± 0.031
2.214ProAsp: 2.214 ± 0.077
4.309ProGlu: 4.309 ± 0.115
1.287ProPhe: 1.287 ± 0.05
7.059ProGly: 7.059 ± 0.167
0.922ProHis: 0.922 ± 0.047
1.736ProIle: 1.736 ± 0.068
1.235ProLys: 1.235 ± 0.059
5.8ProLeu: 5.8 ± 0.116
0.893ProMet: 0.893 ± 0.04
0.775ProAsn: 0.775 ± 0.043
3.672ProPro: 3.672 ± 0.111
1.023ProGln: 1.023 ± 0.049
5.599ProArg: 5.599 ± 0.117
3.212ProSer: 3.212 ± 0.082
1.76ProThr: 1.76 ± 0.06
5.053ProVal: 5.053 ± 0.115
1.027ProTrp: 1.027 ± 0.045
1.795ProTyr: 1.795 ± 0.066
0.0ProXaa: 0.0 ± 0.0
Gln
2.284GlnAla: 2.284 ± 0.074
0.112GlnCys: 0.112 ± 0.016
0.561GlnAsp: 0.561 ± 0.033
1.231GlnGlu: 1.231 ± 0.051
0.265GlnPhe: 0.265 ± 0.023
1.947GlnGly: 1.947 ± 0.064
0.377GlnHis: 0.377 ± 0.029
0.655GlnIle: 0.655 ± 0.04
0.639GlnLys: 0.639 ± 0.046
2.505GlnLeu: 2.505 ± 0.073
0.348GlnMet: 0.348 ± 0.027
0.28GlnAsn: 0.28 ± 0.02
1.121GlnPro: 1.121 ± 0.054
0.528GlnGln: 0.528 ± 0.037
1.754GlnArg: 1.754 ± 0.066
0.753GlnSer: 0.753 ± 0.046
0.539GlnThr: 0.539 ± 0.041
1.522GlnVal: 1.522 ± 0.061
0.16GlnTrp: 0.16 ± 0.018
0.504GlnTyr: 0.504 ± 0.037
0.0GlnXaa: 0.0 ± 0.0
Arg
7.749ArgAla: 7.749 ± 0.143
0.963ArgCys: 0.963 ± 0.056
3.427ArgAsp: 3.427 ± 0.089
7.232ArgGlu: 7.232 ± 0.139
2.058ArgPhe: 2.058 ± 0.076
8.872ArgGly: 8.872 ± 0.177
1.476ArgHis: 1.476 ± 0.061
4.918ArgIle: 4.918 ± 0.106
2.586ArgLys: 2.586 ± 0.079
13.407ArgLeu: 13.407 ± 0.193
1.925ArgMet: 1.925 ± 0.065
1.195ArgAsn: 1.195 ± 0.058
4.173ArgPro: 4.173 ± 0.112
1.5ArgGln: 1.5 ± 0.059
9.986ArgArg: 9.986 ± 0.202
4.727ArgSer: 4.727 ± 0.126
2.181ArgThr: 2.181 ± 0.068
8.688ArgVal: 8.688 ± 0.173
1.101ArgTrp: 1.101 ± 0.053
2.93ArgTyr: 2.93 ± 0.083
0.0ArgXaa: 0.0 ± 0.0
Ser
4.033SerAla: 4.033 ± 0.116
0.501SerCys: 0.501 ± 0.033
1.837SerAsp: 1.837 ± 0.072
2.77SerGlu: 2.77 ± 0.083
1.53SerPhe: 1.53 ± 0.057
4.644SerGly: 4.644 ± 0.104
1.053SerHis: 1.053 ± 0.052
3.446SerIle: 3.446 ± 0.101
1.741SerLys: 1.741 ± 0.074
6.91SerLeu: 6.91 ± 0.142
1.596SerMet: 1.596 ± 0.064
0.915SerAsn: 0.915 ± 0.048
3.357SerPro: 3.357 ± 0.09
1.125SerGln: 1.125 ± 0.055
5.583SerArg: 5.583 ± 0.114
3.646SerSer: 3.646 ± 0.114
2.323SerThr: 2.323 ± 0.081
3.886SerVal: 3.886 ± 0.091
0.749SerTrp: 0.749 ± 0.041
1.962SerTyr: 1.962 ± 0.067
0.0SerXaa: 0.0 ± 0.0
Thr
3.9ThrAla: 3.9 ± 0.11
0.317ThrCys: 0.317 ± 0.03
1.125ThrAsp: 1.125 ± 0.054
1.703ThrGlu: 1.703 ± 0.06
0.812ThrPhe: 0.812 ± 0.049
4.432ThrGly: 4.432 ± 0.086
0.677ThrHis: 0.677 ± 0.041
2.03ThrIle: 2.03 ± 0.078
0.946ThrLys: 0.946 ± 0.045
4.845ThrLeu: 4.845 ± 0.115
0.876ThrMet: 0.876 ± 0.038
0.67ThrAsn: 0.67 ± 0.041
2.546ThrPro: 2.546 ± 0.08
0.558ThrGln: 0.558 ± 0.04
3.265ThrArg: 3.265 ± 0.08
2.229ThrSer: 2.229 ± 0.077
1.999ThrThr: 1.999 ± 0.139
4.235ThrVal: 4.235 ± 0.103
0.506ThrTrp: 0.506 ± 0.037
1.082ThrTyr: 1.082 ± 0.053
0.0ThrXaa: 0.0 ± 0.0
Val
10.321ValAla: 10.321 ± 0.181
0.672ValCys: 0.672 ± 0.042
5.016ValAsp: 5.016 ± 0.1
9.415ValGlu: 9.415 ± 0.159
2.662ValPhe: 2.662 ± 0.083
5.237ValGly: 5.237 ± 0.125
1.546ValHis: 1.546 ± 0.059
4.064ValIle: 4.064 ± 0.114
3.908ValLys: 3.908 ± 0.097
9.665ValLeu: 9.665 ± 0.163
1.695ValMet: 1.695 ± 0.071
1.931ValAsn: 1.931 ± 0.062
3.998ValPro: 3.998 ± 0.099
1.366ValGln: 1.366 ± 0.059
6.021ValArg: 6.021 ± 0.116
4.565ValSer: 4.565 ± 0.095
3.573ValThr: 3.573 ± 0.103
9.56ValVal: 9.56 ± 0.174
0.885ValTrp: 0.885 ± 0.05
4.305ValTyr: 4.305 ± 0.102
0.0ValXaa: 0.0 ± 0.0
Trp
1.158TrpAla: 1.158 ± 0.051
0.103TrpCys: 0.103 ± 0.016
0.488TrpAsp: 0.488 ± 0.039
0.797TrpGlu: 0.797 ± 0.043
0.339TrpPhe: 0.339 ± 0.03
0.922TrpGly: 0.922 ± 0.052
0.247TrpHis: 0.247 ± 0.024
0.622TrpIle: 0.622 ± 0.036
0.425TrpLys: 0.425 ± 0.035
1.883TrpLeu: 1.883 ± 0.077
0.307TrpMet: 0.307 ± 0.025
0.221TrpAsn: 0.221 ± 0.025
0.569TrpPro: 0.569 ± 0.038
0.236TrpGln: 0.236 ± 0.024
1.511TrpArg: 1.511 ± 0.067
0.871TrpSer: 0.871 ± 0.048
0.368TrpThr: 0.368 ± 0.031
0.952TrpVal: 0.952 ± 0.045
0.221TrpTrp: 0.221 ± 0.022
0.403TrpTyr: 0.403 ± 0.029
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.65TyrAla: 3.65 ± 0.086
0.357TyrCys: 0.357 ± 0.031
1.522TyrAsp: 1.522 ± 0.068
2.297TyrGlu: 2.297 ± 0.073
0.832TyrPhe: 0.832 ± 0.045
3.041TyrGly: 3.041 ± 0.082
0.624TyrHis: 0.624 ± 0.034
2.063TyrIle: 2.063 ± 0.059
1.198TyrLys: 1.198 ± 0.055
3.3TyrLeu: 3.3 ± 0.094
1.143TyrMet: 1.143 ± 0.048
0.928TyrAsn: 0.928 ± 0.051
1.763TyrPro: 1.763 ± 0.066
0.694TyrGln: 0.694 ± 0.03
3.431TyrArg: 3.431 ± 0.091
2.163TyrSer: 2.163 ± 0.075
2.314TyrThr: 2.314 ± 0.076
2.783TyrVal: 2.783 ± 0.072
0.475TyrTrp: 0.475 ± 0.036
1.388TyrTyr: 1.388 ± 0.067
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1602 proteins (456718 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski