Amino acid dipepetide frequency for Strigomonas culicis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.631AlaAla: 14.631 ± 0.13	1.503AlaCys: 1.503 ± 0.021	4.985AlaAsp: 4.985 ± 0.043	6.26AlaGlu: 6.26 ± 0.044	3.181AlaPhe: 3.181 ± 0.03	5.864AlaGly: 5.864 ± 0.055	2.476AlaHis: 2.476 ± 0.028	3.25AlaIle: 3.25 ± 0.032	4.177AlaLys: 4.177 ± 0.042	9.755AlaLeu: 9.755 ± 0.069	2.213AlaMet: 2.213 ± 0.026	2.616AlaAsn: 2.616 ± 0.028	5.606AlaPro: 5.606 ± 0.055	3.845AlaGln: 3.845 ± 0.037	6.182AlaArg: 6.182 ± 0.047	6.313AlaSer: 6.313 ± 0.047	5.531AlaThr: 5.531 ± 0.045	7.224AlaVal: 7.224 ± 0.051	0.887AlaTrp: 0.887 ± 0.017	2.287AlaTyr: 2.287 ± 0.026	0.021AlaXaa: 0.021 ± 0.002
Cys	1.708CysAla: 1.708 ± 0.026	0.593CysCys: 0.593 ± 0.015	0.928CysAsp: 0.928 ± 0.017	0.919CysGlu: 0.919 ± 0.017	0.907CysPhe: 0.907 ± 0.018	1.545CysGly: 1.545 ± 0.023	0.461CysHis: 0.461 ± 0.011	0.896CysIle: 0.896 ± 0.016	0.608CysLys: 0.608 ± 0.011	1.678CysLeu: 1.678 ± 0.023	0.462CysMet: 0.462 ± 0.011	0.523CysAsn: 0.523 ± 0.013	0.793CysPro: 0.793 ± 0.017	0.525CysGln: 0.525 ± 0.012	1.226CysArg: 1.226 ± 0.02	1.382CysSer: 1.382 ± 0.021	1.127CysThr: 1.127 ± 0.018	1.642CysVal: 1.642 ± 0.026	0.199CysTrp: 0.199 ± 0.008	0.557CysTyr: 0.557 ± 0.014	0.003CysXaa: 0.003 ± 0.001
Asp	5.872AspAla: 5.872 ± 0.042	0.795AspCys: 0.795 ± 0.016	3.387AspAsp: 3.387 ± 0.042	3.859AspGlu: 3.859 ± 0.039	1.949AspPhe: 1.949 ± 0.025	3.977AspGly: 3.977 ± 0.039	1.162AspHis: 1.162 ± 0.018	2.326AspIle: 2.326 ± 0.025	2.126AspLys: 2.126 ± 0.027	4.637AspLeu: 4.637 ± 0.042	1.296AspMet: 1.296 ± 0.019	1.574AspAsn: 1.574 ± 0.021	2.641AspPro: 2.641 ± 0.034	1.329AspGln: 1.329 ± 0.021	2.976AspArg: 2.976 ± 0.03	2.932AspSer: 2.932 ± 0.032	2.905AspThr: 2.905 ± 0.029	4.393AspVal: 4.393 ± 0.032	0.515AspTrp: 0.515 ± 0.013	1.55AspTyr: 1.55 ± 0.021	0.006AspXaa: 0.006 ± 0.001
Glu	6.671GluAla: 6.671 ± 0.046	0.86GluCys: 0.86 ± 0.017	3.804GluAsp: 3.804 ± 0.037	6.407GluGlu: 6.407 ± 0.066	1.667GluPhe: 1.667 ± 0.024	4.193GluGly: 4.193 ± 0.038	1.546GluHis: 1.546 ± 0.02	2.237GluIle: 2.237 ± 0.027	3.876GluLys: 3.876 ± 0.047	5.877GluLeu: 5.877 ± 0.046	1.779GluMet: 1.779 ± 0.022	2.092GluAsn: 2.092 ± 0.029	2.294GluPro: 2.294 ± 0.026	2.679GluGln: 2.679 ± 0.031	4.906GluArg: 4.906 ± 0.045	3.344GluSer: 3.344 ± 0.034	2.983GluThr: 2.983 ± 0.027	4.559GluVal: 4.559 ± 0.038	0.66GluTrp: 0.66 ± 0.016	1.624GluTyr: 1.624 ± 0.02	0.006GluXaa: 0.006 ± 0.001
Phe	3.115PheAla: 3.115 ± 0.03	0.847PheCys: 0.847 ± 0.015	2.086PheAsp: 2.086 ± 0.027	2.01PheGlu: 2.01 ± 0.025	2.579PhePhe: 2.579 ± 0.037	2.297PheGly: 2.297 ± 0.029	1.026PheHis: 1.026 ± 0.017	1.811PheIle: 1.811 ± 0.025	1.342PheLys: 1.342 ± 0.022	4.063PheLeu: 4.063 ± 0.041	0.973PheMet: 0.973 ± 0.015	1.424PheAsn: 1.424 ± 0.019	1.762PhePro: 1.762 ± 0.027	1.289PheGln: 1.289 ± 0.019	2.068PheArg: 2.068 ± 0.026	3.038PheSer: 3.038 ± 0.031	2.232PheThr: 2.232 ± 0.029	3.002PheVal: 3.002 ± 0.031	0.418PheTrp: 0.418 ± 0.011	1.389PheTyr: 1.389 ± 0.02	0.006PheXaa: 0.006 ± 0.001
Gly	6.555GlyAla: 6.555 ± 0.052	1.221GlyCys: 1.221 ± 0.022	3.596GlyAsp: 3.596 ± 0.031	3.804GlyGlu: 3.804 ± 0.036	2.137GlyPhe: 2.137 ± 0.026	6.177GlyGly: 6.177 ± 0.069	1.542GlyHis: 1.542 ± 0.026	2.588GlyIle: 2.588 ± 0.03	2.996GlyLys: 2.996 ± 0.034	4.888GlyLeu: 4.888 ± 0.044	1.439GlyMet: 1.439 ± 0.02	1.968GlyAsn: 1.968 ± 0.026	2.494GlyPro: 2.494 ± 0.028	1.923GlyGln: 1.923 ± 0.022	4.307GlyArg: 4.307 ± 0.043	4.561GlySer: 4.561 ± 0.04	3.675GlyThr: 3.675 ± 0.033	4.616GlyVal: 4.616 ± 0.033	0.679GlyTrp: 0.679 ± 0.015	1.677GlyTyr: 1.677 ± 0.023	0.016GlyXaa: 0.016 ± 0.002
His	2.409HisAla: 2.409 ± 0.034	0.523HisCys: 0.523 ± 0.013	1.2HisAsp: 1.2 ± 0.016	1.403HisGlu: 1.403 ± 0.019	1.216HisPhe: 1.216 ± 0.019	1.681HisGly: 1.681 ± 0.025	1.033HisHis: 1.033 ± 0.022	1.166HisIle: 1.166 ± 0.019	1.01HisLys: 1.01 ± 0.018	2.704HisLeu: 2.704 ± 0.026	0.672HisMet: 0.672 ± 0.012	0.899HisAsn: 0.899 ± 0.016	1.592HisPro: 1.592 ± 0.022	0.989HisGln: 0.989 ± 0.015	2.096HisArg: 2.096 ± 0.032	1.625HisSer: 1.625 ± 0.02	1.545HisThr: 1.545 ± 0.022	2.133HisVal: 2.133 ± 0.027	0.274HisTrp: 0.274 ± 0.008	0.911HisTyr: 0.911 ± 0.017	0.006HisXaa: 0.006 ± 0.001
Ile	3.659IleAla: 3.659 ± 0.035	0.764IleCys: 0.764 ± 0.015	2.278IleAsp: 2.278 ± 0.024	2.413IleGlu: 2.413 ± 0.031	1.686IlePhe: 1.686 ± 0.025	2.414IleGly: 2.414 ± 0.032	1.066IleHis: 1.066 ± 0.016	2.019IleIle: 2.019 ± 0.027	1.797IleLys: 1.797 ± 0.024	3.539IleLeu: 3.539 ± 0.033	0.948IleMet: 0.948 ± 0.016	1.534IleAsn: 1.534 ± 0.024	2.049IlePro: 2.049 ± 0.023	1.531IleGln: 1.531 ± 0.021	2.357IleArg: 2.357 ± 0.028	2.683IleSer: 2.683 ± 0.033	2.316IleThr: 2.316 ± 0.029	3.147IleVal: 3.147 ± 0.03	0.348IleTrp: 0.348 ± 0.01	1.164IleTyr: 1.164 ± 0.02	0.004IleXaa: 0.004 ± 0.001
Lys	3.765LysAla: 3.765 ± 0.04	0.672LysCys: 0.672 ± 0.015	2.661LysAsp: 2.661 ± 0.034	3.943LysGlu: 3.943 ± 0.042	1.207LysPhe: 1.207 ± 0.02	2.821LysGly: 2.821 ± 0.031	1.082LysHis: 1.082 ± 0.016	1.771LysIle: 1.771 ± 0.024	3.888LysLys: 3.888 ± 0.05	3.894LysLeu: 3.894 ± 0.035	1.345LysMet: 1.345 ± 0.021	1.824LysAsn: 1.824 ± 0.03	1.804LysPro: 1.804 ± 0.024	1.93LysGln: 1.93 ± 0.026	3.351LysArg: 3.351 ± 0.036	2.752LysSer: 2.752 ± 0.03	2.469LysThr: 2.469 ± 0.027	2.965LysVal: 2.965 ± 0.031	0.476LysTrp: 0.476 ± 0.011	1.372LysTyr: 1.372 ± 0.021	0.01LysXaa: 0.01 ± 0.002
Leu	7.975LeuAla: 7.975 ± 0.06	2.223LeuCys: 2.223 ± 0.029	4.678LeuAsp: 4.678 ± 0.037	5.539LeuGlu: 5.539 ± 0.052	4.33LeuPhe: 4.33 ± 0.045	4.717LeuGly: 4.717 ± 0.032	2.999LeuHis: 2.999 ± 0.034	3.338LeuIle: 3.338 ± 0.034	4.044LeuLys: 4.044 ± 0.043	11.297LeuLeu: 11.297 ± 0.079	2.152LeuMet: 2.152 ± 0.022	3.048LeuAsn: 3.048 ± 0.033	5.231LeuPro: 5.231 ± 0.048	4.865LeuGln: 4.865 ± 0.043	7.653LeuArg: 7.653 ± 0.06	7.226LeuSer: 7.226 ± 0.045	5.052LeuThr: 5.052 ± 0.041	6.37LeuVal: 6.37 ± 0.045	1.078LeuTrp: 1.078 ± 0.018	2.902LeuTyr: 2.902 ± 0.024	0.015LeuXaa: 0.015 ± 0.002
Met	1.965MetAla: 1.965 ± 0.023	0.464MetCys: 0.464 ± 0.011	1.411MetAsp: 1.411 ± 0.021	1.699MetGlu: 1.699 ± 0.02	0.828MetPhe: 0.828 ± 0.015	1.427MetGly: 1.427 ± 0.021	0.621MetHis: 0.621 ± 0.011	0.913MetIle: 0.913 ± 0.021	1.268MetLys: 1.268 ± 0.019	2.357MetLeu: 2.357 ± 0.029	0.701MetMet: 0.701 ± 0.014	0.925MetAsn: 0.925 ± 0.016	1.171MetPro: 1.171 ± 0.018	1.072MetGln: 1.072 ± 0.017	1.755MetArg: 1.755 ± 0.024	1.763MetSer: 1.763 ± 0.02	1.366MetThr: 1.366 ± 0.021	1.509MetVal: 1.509 ± 0.022	0.303MetTrp: 0.303 ± 0.011	0.777MetTyr: 0.777 ± 0.015	0.003MetXaa: 0.003 ± 0.001
Asn	3.048AsnAla: 3.048 ± 0.033	0.578AsnCys: 0.578 ± 0.015	1.683AsnAsp: 1.683 ± 0.023	2.122AsnGlu: 2.122 ± 0.025	1.261AsnPhe: 1.261 ± 0.02	2.084AsnGly: 2.084 ± 0.025	0.76AsnHis: 0.76 ± 0.014	1.612AsnIle: 1.612 ± 0.026	1.659AsnLys: 1.659 ± 0.026	2.66AsnLeu: 2.66 ± 0.029	0.966AsnMet: 0.966 ± 0.016	1.569AsnAsn: 1.569 ± 0.032	1.708AsnPro: 1.708 ± 0.024	0.983AsnGln: 0.983 ± 0.018	1.853AsnArg: 1.853 ± 0.02	2.172AsnSer: 2.172 ± 0.025	2.128AsnThr: 2.128 ± 0.024	2.577AsnVal: 2.577 ± 0.027	0.367AsnTrp: 0.367 ± 0.01	1.169AsnTyr: 1.169 ± 0.017	0.005AsnXaa: 0.005 ± 0.001
Pro	5.2ProAla: 5.2 ± 0.05	0.799ProCys: 0.799 ± 0.017	2.171ProAsp: 2.171 ± 0.025	2.793ProGlu: 2.793 ± 0.027	2.108ProPhe: 2.108 ± 0.026	2.55ProGly: 2.55 ± 0.031	1.549ProHis: 1.549 ± 0.024	1.764ProIle: 1.764 ± 0.021	1.887ProLys: 1.887 ± 0.027	5.218ProLeu: 5.218 ± 0.047	0.953ProMet: 0.953 ± 0.017	1.545ProAsn: 1.545 ± 0.023	4.46ProPro: 4.46 ± 0.066	2.119ProGln: 2.119 ± 0.026	3.304ProArg: 3.304 ± 0.04	4.185ProSer: 4.185 ± 0.042	3.125ProThr: 3.125 ± 0.033	3.364ProVal: 3.364 ± 0.032	0.537ProTrp: 0.537 ± 0.013	1.454ProTyr: 1.454 ± 0.021	0.015ProXaa: 0.015 ± 0.002
Gln	3.027GlnAla: 3.027 ± 0.034	0.72GlnCys: 0.72 ± 0.015	1.594GlnAsp: 1.594 ± 0.02	2.554GlnGlu: 2.554 ± 0.032	1.291GlnPhe: 1.291 ± 0.021	1.894GlnGly: 1.894 ± 0.023	1.31GlnHis: 1.31 ± 0.019	1.431GlnIle: 1.431 ± 0.02	2.099GlnLys: 2.099 ± 0.029	4.522GlnLeu: 4.522 ± 0.037	1.027GlnMet: 1.027 ± 0.017	1.25GlnAsn: 1.25 ± 0.015	1.858GlnPro: 1.858 ± 0.022	2.97GlnGln: 2.97 ± 0.043	3.726GlnArg: 3.726 ± 0.041	2.266GlnSer: 2.266 ± 0.029	1.872GlnThr: 1.872 ± 0.027	2.403GlnVal: 2.403 ± 0.026	0.493GlnTrp: 0.493 ± 0.012	1.223GlnTyr: 1.223 ± 0.02	0.006GlnXaa: 0.006 ± 0.001
Arg	6.523ArgAla: 6.523 ± 0.062	1.41ArgCys: 1.41 ± 0.022	3.459ArgAsp: 3.459 ± 0.031	4.613ArgGlu: 4.613 ± 0.05	2.309ArgPhe: 2.309 ± 0.023	4.419ArgGly: 4.419 ± 0.05	2.24ArgHis: 2.24 ± 0.028	2.618ArgIle: 2.618 ± 0.026	3.04ArgLys: 3.04 ± 0.034	6.488ArgLeu: 6.488 ± 0.051	1.597ArgMet: 1.597 ± 0.018	2.025ArgAsn: 2.025 ± 0.023	3.321ArgPro: 3.321 ± 0.039	3.241ArgGln: 3.241 ± 0.038	7.108ArgArg: 7.108 ± 0.093	4.309ArgSer: 4.309 ± 0.043	3.472ArgThr: 3.472 ± 0.035	4.789ArgVal: 4.789 ± 0.047	0.884ArgTrp: 0.884 ± 0.017	2.003ArgTyr: 2.003 ± 0.025	0.019ArgXaa: 0.019 ± 0.002
Ser	6.51SerAla: 6.51 ± 0.053	1.29SerCys: 1.29 ± 0.019	3.353SerAsp: 3.353 ± 0.031	3.513SerGlu: 3.513 ± 0.034	3.149SerPhe: 3.149 ± 0.035	4.629SerGly: 4.629 ± 0.042	1.655SerHis: 1.655 ± 0.021	3.094SerIle: 3.094 ± 0.032	2.91SerLys: 2.91 ± 0.035	6.534SerLeu: 6.534 ± 0.047	1.654SerMet: 1.654 ± 0.023	2.283SerAsn: 2.283 ± 0.028	3.601SerPro: 3.601 ± 0.039	2.133SerGln: 2.133 ± 0.027	4.037SerArg: 4.037 ± 0.038	6.159SerSer: 6.159 ± 0.065	4.265SerThr: 4.265 ± 0.042	4.908SerVal: 4.908 ± 0.04	0.664SerTrp: 0.664 ± 0.013	1.861SerTyr: 1.861 ± 0.025	0.014SerXaa: 0.014 ± 0.002
Thr	5.865ThrAla: 5.865 ± 0.056	1.011ThrCys: 1.011 ± 0.022	2.708ThrAsp: 2.708 ± 0.025	3.204ThrGlu: 3.204 ± 0.031	2.325ThrPhe: 2.325 ± 0.026	3.39ThrGly: 3.39 ± 0.03	1.428ThrHis: 1.428 ± 0.019	2.47ThrIle: 2.47 ± 0.027	2.424ThrLys: 2.424 ± 0.026	5.293ThrLeu: 5.293 ± 0.033	1.297ThrMet: 1.297 ± 0.02	1.897ThrAsn: 1.897 ± 0.022	3.18ThrPro: 3.18 ± 0.032	1.905ThrGln: 1.905 ± 0.023	3.178ThrArg: 3.178 ± 0.027	4.117ThrSer: 4.117 ± 0.039	3.7ThrThr: 3.7 ± 0.04	4.296ThrVal: 4.296 ± 0.037	0.543ThrTrp: 0.543 ± 0.013	1.652ThrTyr: 1.652 ± 0.019	0.01ThrXaa: 0.01 ± 0.002
Val	7.008ValAla: 7.008 ± 0.051	1.524ValCys: 1.524 ± 0.023	4.08ValAsp: 4.08 ± 0.039	4.689ValGlu: 4.689 ± 0.044	2.853ValPhe: 2.853 ± 0.028	4.302ValGly: 4.302 ± 0.037	2.048ValHis: 2.048 ± 0.028	2.665ValIle: 2.665 ± 0.032	3.044ValLys: 3.044 ± 0.03	7.605ValLeu: 7.605 ± 0.053	1.643ValMet: 1.643 ± 0.023	2.311ValAsn: 2.311 ± 0.025	3.941ValPro: 3.941 ± 0.036	2.858ValGln: 2.858 ± 0.026	4.965ValArg: 4.965 ± 0.044	4.773ValSer: 4.773 ± 0.043	3.752ValThr: 3.752 ± 0.037	6.001ValVal: 6.001 ± 0.051	0.747ValTrp: 0.747 ± 0.016	2.048ValTyr: 2.048 ± 0.026	0.013ValXaa: 0.013 ± 0.002
Trp	0.802TrpAla: 0.802 ± 0.016	0.289TrpCys: 0.289 ± 0.009	0.558TrpAsp: 0.558 ± 0.013	0.632TrpGlu: 0.632 ± 0.014	0.385TrpPhe: 0.385 ± 0.012	0.597TrpGly: 0.597 ± 0.012	0.264TrpHis: 0.264 ± 0.008	0.39TrpIle: 0.39 ± 0.011	0.567TrpLys: 0.567 ± 0.014	0.978TrpLeu: 0.978 ± 0.016	0.374TrpMet: 0.374 ± 0.01	0.426TrpAsn: 0.426 ± 0.012	0.376TrpPro: 0.376 ± 0.011	0.402TrpGln: 0.402 ± 0.011	0.964TrpArg: 0.964 ± 0.019	0.792TrpSer: 0.792 ± 0.016	0.585TrpThr: 0.585 ± 0.014	0.689TrpVal: 0.689 ± 0.014	0.198TrpTrp: 0.198 ± 0.008	0.337TrpTyr: 0.337 ± 0.009	0.002TrpXaa: 0.002 ± 0.001
Tyr	2.476TyrAla: 2.476 ± 0.027	0.591TyrCys: 0.591 ± 0.014	1.581TyrAsp: 1.581 ± 0.021	1.679TyrGlu: 1.679 ± 0.025	1.403TyrPhe: 1.403 ± 0.019	1.866TyrGly: 1.866 ± 0.02	0.814TyrHis: 0.814 ± 0.014	1.355TyrIle: 1.355 ± 0.019	1.231TyrLys: 1.231 ± 0.02	2.736TyrLeu: 2.736 ± 0.031	0.803TyrMet: 0.803 ± 0.016	1.233TyrAsn: 1.233 ± 0.019	1.203TyrPro: 1.203 ± 0.019	0.946TyrGln: 0.946 ± 0.018	1.846TyrArg: 1.846 ± 0.024	1.808TyrSer: 1.808 ± 0.024	1.783TyrThr: 1.783 ± 0.02	2.271TyrVal: 2.271 ± 0.028	0.334TyrTrp: 0.334 ± 0.01	1.19TyrTyr: 1.19 ± 0.021	0.005TyrXaa: 0.005 ± 0.001
Xaa	0.024XaaAla: 0.024 ± 0.003	0.004XaaCys: 0.004 ± 0.001	0.007XaaAsp: 0.007 ± 0.001	0.007XaaGlu: 0.007 ± 0.001	0.007XaaPhe: 0.007 ± 0.001	0.016XaaGly: 0.016 ± 0.002	0.005XaaHis: 0.005 ± 0.001	0.004XaaIle: 0.004 ± 0.001	0.006XaaLys: 0.006 ± 0.001	0.01XaaLeu: 0.01 ± 0.002	0.004XaaMet: 0.004 ± 0.001	0.002XaaAsn: 0.002 ± 0.001	0.013XaaPro: 0.013 ± 0.002	0.005XaaGln: 0.005 ± 0.001	0.028XaaArg: 0.028 ± 0.003	0.019XaaSer: 0.019 ± 0.003	0.01XaaThr: 0.01 ± 0.001	0.011XaaVal: 0.011 ± 0.002	0.001XaaTrp: 0.001 ± 0.001	0.003XaaTyr: 0.003 ± 0.001	0.361XaaXaa: 0.361 ± 0.012

Statistics based on 9986 proteins (3821174 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---