Amino acid dipepetide frequency for Burkholderia sp. A9

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.116AlaAla: 19.116 ± 0.255	1.397AlaCys: 1.397 ± 0.047	7.185AlaAsp: 7.185 ± 0.091	5.962AlaGlu: 5.962 ± 0.096	4.57AlaPhe: 4.57 ± 0.073	11.127AlaGly: 11.127 ± 0.139	2.988AlaHis: 2.988 ± 0.065	5.949AlaIle: 5.949 ± 0.088	3.832AlaLys: 3.832 ± 0.094	15.012AlaLeu: 15.012 ± 0.211	3.354AlaMet: 3.354 ± 0.063	3.188AlaAsn: 3.188 ± 0.06	6.209AlaPro: 6.209 ± 0.108	5.341AlaGln: 5.341 ± 0.106	9.59AlaArg: 9.59 ± 0.14	7.025AlaSer: 7.025 ± 0.097	6.698AlaThr: 6.698 ± 0.099	9.153AlaVal: 9.153 ± 0.12	1.776AlaTrp: 1.776 ± 0.05	2.871AlaTyr: 2.871 ± 0.061	0.0AlaXaa: 0.0 ± 0.0
Cys	1.218CysAla: 1.218 ± 0.042	0.123CysCys: 0.123 ± 0.012	0.58CysAsp: 0.58 ± 0.03	0.482CysGlu: 0.482 ± 0.024	0.337CysPhe: 0.337 ± 0.02	0.987CysGly: 0.987 ± 0.034	0.238CysHis: 0.238 ± 0.017	0.399CysIle: 0.399 ± 0.019	0.179CysLys: 0.179 ± 0.014	0.769CysLeu: 0.769 ± 0.03	0.201CysMet: 0.201 ± 0.015	0.221CysAsn: 0.221 ± 0.013	0.439CysPro: 0.439 ± 0.023	0.203CysGln: 0.203 ± 0.014	0.626CysArg: 0.626 ± 0.027	0.495CysSer: 0.495 ± 0.023	0.473CysThr: 0.473 ± 0.026	0.837CysVal: 0.837 ± 0.031	0.105CysTrp: 0.105 ± 0.009	0.231CysTyr: 0.231 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	9.187AspAla: 9.187 ± 0.124	0.469AspCys: 0.469 ± 0.023	3.659AspAsp: 3.659 ± 0.08	3.41AspGlu: 3.41 ± 0.077	1.888AspPhe: 1.888 ± 0.047	5.16AspGly: 5.16 ± 0.081	1.218AspHis: 1.218 ± 0.042	2.358AspIle: 2.358 ± 0.054	1.529AspLys: 1.529 ± 0.039	5.209AspLeu: 5.209 ± 0.088	1.143AspMet: 1.143 ± 0.037	1.219AspAsn: 1.219 ± 0.037	3.106AspPro: 3.106 ± 0.059	1.499AspGln: 1.499 ± 0.05	3.618AspArg: 3.618 ± 0.058	2.301AspSer: 2.301 ± 0.049	3.073AspThr: 3.073 ± 0.055	4.723AspVal: 4.723 ± 0.071	0.916AspTrp: 0.916 ± 0.033	1.51AspTyr: 1.51 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	5.862GluAla: 5.862 ± 0.102	0.375GluCys: 0.375 ± 0.02	1.898GluAsp: 1.898 ± 0.046	2.139GluGlu: 2.139 ± 0.068	1.736GluPhe: 1.736 ± 0.045	3.052GluGly: 3.052 ± 0.065	1.394GluHis: 1.394 ± 0.045	2.758GluIle: 2.758 ± 0.061	1.588GluLys: 1.588 ± 0.05	5.297GluLeu: 5.297 ± 0.093	1.123GluMet: 1.123 ± 0.034	1.217GluAsn: 1.217 ± 0.032	2.464GluPro: 2.464 ± 0.058	2.373GluGln: 2.373 ± 0.054	4.836GluArg: 4.836 ± 0.084	2.364GluSer: 2.364 ± 0.052	2.691GluThr: 2.691 ± 0.057	3.302GluVal: 3.302 ± 0.071	0.738GluTrp: 0.738 ± 0.03	1.225GluTyr: 1.225 ± 0.046	0.0GluXaa: 0.0 ± 0.0
Phe	4.773PheAla: 4.773 ± 0.081	0.371PheCys: 0.371 ± 0.02	2.765PheAsp: 2.765 ± 0.057	2.012PheGlu: 2.012 ± 0.045	1.409PhePhe: 1.409 ± 0.043	3.842PheGly: 3.842 ± 0.075	0.756PheHis: 0.756 ± 0.03	1.497PheIle: 1.497 ± 0.041	0.962PheLys: 0.962 ± 0.032	2.834PheLeu: 2.834 ± 0.065	0.84PheMet: 0.84 ± 0.028	1.118PheAsn: 1.118 ± 0.041	1.587PhePro: 1.587 ± 0.044	0.931PheGln: 0.931 ± 0.033	2.106PheArg: 2.106 ± 0.047	2.216PheSer: 2.216 ± 0.053	1.985PheThr: 1.985 ± 0.046	3.321PheVal: 3.321 ± 0.068	0.491PheTrp: 0.491 ± 0.025	0.965PheTyr: 0.965 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	10.164GlyAla: 10.164 ± 0.115	0.874GlyCys: 0.874 ± 0.041	4.236GlyAsp: 4.236 ± 0.065	4.082GlyGlu: 4.082 ± 0.07	3.499GlyPhe: 3.499 ± 0.07	6.926GlyGly: 6.926 ± 0.119	1.81GlyHis: 1.81 ± 0.049	4.386GlyIle: 4.386 ± 0.073	3.17GlyLys: 3.17 ± 0.056	8.139GlyLeu: 8.139 ± 0.095	2.267GlyMet: 2.267 ± 0.05	2.374GlyAsn: 2.374 ± 0.061	2.875GlyPro: 2.875 ± 0.057	2.744GlyGln: 2.744 ± 0.062	5.54GlyArg: 5.54 ± 0.08	4.369GlySer: 4.369 ± 0.071	4.813GlyThr: 4.813 ± 0.082	6.903GlyVal: 6.903 ± 0.091	1.449GlyTrp: 1.449 ± 0.045	2.52GlyTyr: 2.52 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	3.449HisAla: 3.449 ± 0.069	0.262HisCys: 0.262 ± 0.017	1.523HisAsp: 1.523 ± 0.045	1.132HisGlu: 1.132 ± 0.034	0.925HisPhe: 0.925 ± 0.03	2.251HisGly: 2.251 ± 0.05	0.599HisHis: 0.599 ± 0.027	0.798HisIle: 0.798 ± 0.027	0.469HisLys: 0.469 ± 0.027	2.115HisLeu: 2.115 ± 0.045	0.469HisMet: 0.469 ± 0.024	0.485HisAsn: 0.485 ± 0.025	1.52HisPro: 1.52 ± 0.045	0.614HisGln: 0.614 ± 0.023	1.578HisArg: 1.578 ± 0.043	0.914HisSer: 0.914 ± 0.034	1.082HisThr: 1.082 ± 0.033	1.841HisVal: 1.841 ± 0.048	0.37HisTrp: 0.37 ± 0.021	0.624HisTyr: 0.624 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	7.306IleAla: 7.306 ± 0.1	0.459IleCys: 0.459 ± 0.024	3.527IleAsp: 3.527 ± 0.065	3.005IleGlu: 3.005 ± 0.058	1.397IlePhe: 1.397 ± 0.043	4.867IleGly: 4.867 ± 0.08	0.886IleHis: 0.886 ± 0.034	1.406IleIle: 1.406 ± 0.049	1.25IleLys: 1.25 ± 0.043	3.229IleLeu: 3.229 ± 0.066	0.722IleMet: 0.722 ± 0.024	1.297IleAsn: 1.297 ± 0.04	2.013IlePro: 2.013 ± 0.05	1.154IleGln: 1.154 ± 0.038	2.838IleArg: 2.838 ± 0.053	2.259IleSer: 2.259 ± 0.057	2.236IleThr: 2.236 ± 0.055	4.559IleVal: 4.559 ± 0.076	0.471IleTrp: 0.471 ± 0.024	0.989IleTyr: 0.989 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	3.464LysAla: 3.464 ± 0.076	0.171LysCys: 0.171 ± 0.015	1.432LysAsp: 1.432 ± 0.043	1.367LysGlu: 1.367 ± 0.044	0.872LysPhe: 0.872 ± 0.036	2.018LysGly: 2.018 ± 0.051	0.69LysHis: 0.69 ± 0.028	1.541LysIle: 1.541 ± 0.046	1.236LysLys: 1.236 ± 0.062	3.332LysLeu: 3.332 ± 0.06	0.754LysMet: 0.754 ± 0.032	0.809LysAsn: 0.809 ± 0.031	1.896LysPro: 1.896 ± 0.051	1.289LysGln: 1.289 ± 0.041	2.401LysArg: 2.401 ± 0.053	1.632LysSer: 1.632 ± 0.046	1.822LysThr: 1.822 ± 0.049	2.301LysVal: 2.301 ± 0.061	0.369LysTrp: 0.369 ± 0.019	0.694LysTyr: 0.694 ± 0.028	0.0LysXaa: 0.0 ± 0.0
Leu	14.344LeuAla: 14.344 ± 0.158	0.925LeuCys: 0.925 ± 0.028	6.293LeuAsp: 6.293 ± 0.093	4.761LeuGlu: 4.761 ± 0.08	3.584LeuPhe: 3.584 ± 0.068	8.185LeuGly: 8.185 ± 0.104	2.279LeuHis: 2.279 ± 0.055	4.451LeuIle: 4.451 ± 0.08	3.332LeuLys: 3.332 ± 0.067	9.757LeuLeu: 9.757 ± 0.13	2.26LeuMet: 2.26 ± 0.054	2.685LeuAsn: 2.685 ± 0.055	5.799LeuPro: 5.799 ± 0.093	3.251LeuGln: 3.251 ± 0.062	6.892LeuArg: 6.892 ± 0.101	6.075LeuSer: 6.075 ± 0.092	5.735LeuThr: 5.735 ± 0.129	7.626LeuVal: 7.626 ± 0.113	1.105LeuTrp: 1.105 ± 0.038	2.124LeuTyr: 2.124 ± 0.044	0.0LeuXaa: 0.0 ± 0.0
Met	2.385MetAla: 2.385 ± 0.046	0.189MetCys: 0.189 ± 0.015	0.945MetAsp: 0.945 ± 0.031	0.835MetGlu: 0.835 ± 0.027	0.752MetPhe: 0.752 ± 0.029	1.485MetGly: 1.485 ± 0.044	0.526MetHis: 0.526 ± 0.02	1.075MetIle: 1.075 ± 0.037	1.047MetLys: 1.047 ± 0.034	2.749MetLeu: 2.749 ± 0.061	0.601MetMet: 0.601 ± 0.029	0.903MetAsn: 0.903 ± 0.031	1.544MetPro: 1.544 ± 0.044	1.05MetGln: 1.05 ± 0.031	1.888MetArg: 1.888 ± 0.041	1.678MetSer: 1.678 ± 0.041	1.71MetThr: 1.71 ± 0.043	1.473MetVal: 1.473 ± 0.042	0.221MetTrp: 0.221 ± 0.018	0.4MetTyr: 0.4 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.568AsnAla: 3.568 ± 0.073	0.238AsnCys: 0.238 ± 0.019	1.528AsnAsp: 1.528 ± 0.045	1.19AsnGlu: 1.19 ± 0.037	0.881AsnPhe: 0.881 ± 0.029	2.602AsnGly: 2.602 ± 0.061	0.5AsnHis: 0.5 ± 0.023	1.124AsnIle: 1.124 ± 0.042	0.589AsnLys: 0.589 ± 0.027	2.694AsnLeu: 2.694 ± 0.062	0.529AsnMet: 0.529 ± 0.025	0.762AsnAsn: 0.762 ± 0.034	1.771AsnPro: 1.771 ± 0.041	0.915AsnGln: 0.915 ± 0.035	1.853AsnArg: 1.853 ± 0.047	1.174AsnSer: 1.174 ± 0.048	1.373AsnThr: 1.373 ± 0.048	2.287AsnVal: 2.287 ± 0.072	0.378AsnTrp: 0.378 ± 0.018	0.743AsnTyr: 0.743 ± 0.031	0.0AsnXaa: 0.0 ± 0.0
Pro	7.251ProAla: 7.251 ± 0.117	0.342ProCys: 0.342 ± 0.019	3.517ProAsp: 3.517 ± 0.063	2.723ProGlu: 2.723 ± 0.051	1.987ProPhe: 1.987 ± 0.048	4.308ProGly: 4.308 ± 0.076	1.242ProHis: 1.242 ± 0.036	2.004ProIle: 2.004 ± 0.041	1.452ProLys: 1.452 ± 0.043	5.262ProLeu: 5.262 ± 0.085	1.088ProMet: 1.088 ± 0.034	1.369ProAsn: 1.369 ± 0.04	2.502ProPro: 2.502 ± 0.063	1.716ProGln: 1.716 ± 0.045	3.033ProArg: 3.033 ± 0.061	2.778ProSer: 2.778 ± 0.054	2.517ProThr: 2.517 ± 0.051	4.348ProVal: 4.348 ± 0.073	0.648ProTrp: 0.648 ± 0.028	1.124ProTyr: 1.124 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	4.547GlnAla: 4.547 ± 0.074	0.266GlnCys: 0.266 ± 0.017	1.37GlnAsp: 1.37 ± 0.036	1.271GlnGlu: 1.271 ± 0.044	1.201GlnPhe: 1.201 ± 0.037	2.476GlnGly: 2.476 ± 0.057	0.868GlnHis: 0.868 ± 0.032	1.879GlnIle: 1.879 ± 0.049	1.026GlnLys: 1.026 ± 0.036	3.689GlnLeu: 3.689 ± 0.077	0.97GlnMet: 0.97 ± 0.035	0.9GlnAsn: 0.9 ± 0.04	2.135GlnPro: 2.135 ± 0.052	1.844GlnGln: 1.844 ± 0.052	2.9GlnArg: 2.9 ± 0.059	1.915GlnSer: 1.915 ± 0.048	1.857GlnThr: 1.857 ± 0.049	2.576GlnVal: 2.576 ± 0.094	0.522GlnTrp: 0.522 ± 0.023	0.896GlnTyr: 0.896 ± 0.03	0.0GlnXaa: 0.0 ± 0.0
Arg	8.818ArgAla: 8.818 ± 0.141	0.575ArgCys: 0.575 ± 0.026	4.337ArgAsp: 4.337 ± 0.078	3.87ArgGlu: 3.87 ± 0.076	3.096ArgPhe: 3.096 ± 0.057	4.786ArgGly: 4.786 ± 0.083	2.016ArgHis: 2.016 ± 0.048	3.752ArgIle: 3.752 ± 0.066	1.959ArgLys: 1.959 ± 0.051	7.088ArgLeu: 7.088 ± 0.095	1.883ArgMet: 1.883 ± 0.046	1.913ArgAsn: 1.913 ± 0.052	3.12ArgPro: 3.12 ± 0.073	2.53ArgGln: 2.53 ± 0.061	5.567ArgArg: 5.567 ± 0.119	3.29ArgSer: 3.29 ± 0.062	3.749ArgThr: 3.749 ± 0.061	5.643ArgVal: 5.643 ± 0.086	1.03ArgTrp: 1.03 ± 0.035	2.091ArgTyr: 2.091 ± 0.056	0.0ArgXaa: 0.0 ± 0.0
Ser	6.463SerAla: 6.463 ± 0.093	0.418SerCys: 0.418 ± 0.02	2.778SerAsp: 2.778 ± 0.055	2.237SerGlu: 2.237 ± 0.055	2.086SerPhe: 2.086 ± 0.047	5.101SerGly: 5.101 ± 0.079	1.18SerHis: 1.18 ± 0.036	2.637SerIle: 2.637 ± 0.056	1.544SerLys: 1.544 ± 0.037	5.345SerLeu: 5.345 ± 0.077	1.314SerMet: 1.314 ± 0.036	1.484SerAsn: 1.484 ± 0.044	2.753SerPro: 2.753 ± 0.053	1.703SerGln: 1.703 ± 0.043	3.51SerArg: 3.51 ± 0.07	3.139SerSer: 3.139 ± 0.074	2.994SerThr: 2.994 ± 0.065	4.334SerVal: 4.334 ± 0.079	0.743SerTrp: 0.743 ± 0.032	1.363SerTyr: 1.363 ± 0.04	0.0SerXaa: 0.0 ± 0.0
Thr	6.154ThrAla: 6.154 ± 0.111	0.471ThrCys: 0.471 ± 0.023	2.914ThrAsp: 2.914 ± 0.066	2.224ThrGlu: 2.224 ± 0.057	2.049ThrPhe: 2.049 ± 0.047	4.926ThrGly: 4.926 ± 0.079	1.322ThrHis: 1.322 ± 0.041	2.704ThrIle: 2.704 ± 0.058	1.306ThrLys: 1.306 ± 0.044	6.534ThrLeu: 6.534 ± 0.076	1.17ThrMet: 1.17 ± 0.037	1.462ThrAsn: 1.462 ± 0.051	3.484ThrPro: 3.484 ± 0.063	1.863ThrGln: 1.863 ± 0.056	3.51ThrArg: 3.51 ± 0.068	2.894ThrSer: 2.894 ± 0.061	3.084ThrThr: 3.084 ± 0.131	4.568ThrVal: 4.568 ± 0.077	0.714ThrTrp: 0.714 ± 0.028	1.297ThrTyr: 1.297 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	10.15ValAla: 10.15 ± 0.134	0.833ValCys: 0.833 ± 0.03	4.62ValAsp: 4.62 ± 0.067	4.132ValGlu: 4.132 ± 0.069	2.872ValPhe: 2.872 ± 0.063	5.835ValGly: 5.835 ± 0.093	1.597ValHis: 1.597 ± 0.038	3.716ValIle: 3.716 ± 0.066	2.584ValLys: 2.584 ± 0.064	7.973ValLeu: 7.973 ± 0.102	1.934ValMet: 1.934 ± 0.05	2.23ValAsn: 2.23 ± 0.061	4.119ValPro: 4.119 ± 0.066	2.502ValGln: 2.502 ± 0.05	5.458ValArg: 5.458 ± 0.08	4.609ValSer: 4.609 ± 0.075	4.772ValThr: 4.772 ± 0.081	6.496ValVal: 6.496 ± 0.09	0.965ValTrp: 0.965 ± 0.032	1.767ValTyr: 1.767 ± 0.043	0.0ValXaa: 0.0 ± 0.0
Trp	1.127TrpAla: 1.127 ± 0.036	0.132TrpCys: 0.132 ± 0.012	0.601TrpAsp: 0.601 ± 0.028	0.47TrpGlu: 0.47 ± 0.022	0.582TrpPhe: 0.582 ± 0.029	0.928TrpGly: 0.928 ± 0.032	0.398TrpHis: 0.398 ± 0.021	0.675TrpIle: 0.675 ± 0.029	0.419TrpLys: 0.419 ± 0.022	1.967TrpLeu: 1.967 ± 0.058	0.387TrpMet: 0.387 ± 0.019	0.431TrpAsn: 0.431 ± 0.026	0.633TrpPro: 0.633 ± 0.029	0.69TrpGln: 0.69 ± 0.028	1.239TrpArg: 1.239 ± 0.04	0.788TrpSer: 0.788 ± 0.03	0.709TrpThr: 0.709 ± 0.03	0.909TrpVal: 0.909 ± 0.036	0.219TrpTrp: 0.219 ± 0.014	0.3TrpTyr: 0.3 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.998TyrAla: 2.998 ± 0.052	0.25TyrCys: 0.25 ± 0.018	1.488TyrAsp: 1.488 ± 0.042	1.127TyrGlu: 1.127 ± 0.033	1.06TyrPhe: 1.06 ± 0.036	2.275TyrGly: 2.275 ± 0.044	0.509TyrHis: 0.509 ± 0.022	0.765TyrIle: 0.765 ± 0.029	0.619TyrLys: 0.619 ± 0.025	2.471TyrLeu: 2.471 ± 0.06	0.446TyrMet: 0.446 ± 0.023	0.632TyrAsn: 0.632 ± 0.028	1.241TyrPro: 1.241 ± 0.039	0.898TyrGln: 0.898 ± 0.032	2.13TyrArg: 2.13 ± 0.055	1.212TyrSer: 1.212 ± 0.038	1.278TyrThr: 1.278 ± 0.037	1.963TyrVal: 1.963 ± 0.054	0.374TyrTrp: 0.374 ± 0.019	0.66TyrTyr: 0.66 ± 0.03	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3010 proteins (940337 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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