Amino acid dipepetide frequency for Streptococcus virus 9871

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.496AlaAla: 3.496 ± 0.678
0.499AlaCys: 0.499 ± 0.182
4.095AlaAsp: 4.095 ± 0.75
3.696AlaGlu: 3.696 ± 0.694
2.697AlaPhe: 2.697 ± 0.561
2.996AlaGly: 2.996 ± 0.769
0.699AlaHis: 0.699 ± 0.274
4.894AlaIle: 4.894 ± 1.193
5.194AlaLys: 5.194 ± 0.572
5.593AlaLeu: 5.593 ± 0.632
1.798AlaMet: 1.798 ± 0.292
4.794AlaAsn: 4.794 ± 0.791
1.698AlaPro: 1.698 ± 0.368
2.297AlaGln: 2.297 ± 0.48
2.097AlaArg: 2.097 ± 0.476
4.195AlaSer: 4.195 ± 0.579
4.195AlaThr: 4.195 ± 0.582
3.895AlaVal: 3.895 ± 0.639
1.398AlaTrp: 1.398 ± 0.394
1.998AlaTyr: 1.998 ± 0.378
0.0AlaXaa: 0.0 ± 0.0
Cys
0.2CysAla: 0.2 ± 0.145
0.0CysCys: 0.0 ± 0.0
0.999CysAsp: 0.999 ± 0.354
1.099CysGlu: 1.099 ± 0.353
0.4CysPhe: 0.4 ± 0.193
0.4CysGly: 0.4 ± 0.197
0.3CysHis: 0.3 ± 0.176
0.3CysIle: 0.3 ± 0.135
0.599CysLys: 0.599 ± 0.225
0.3CysLeu: 0.3 ± 0.153
0.0CysMet: 0.0 ± 0.0
0.2CysAsn: 0.2 ± 0.128
0.0CysPro: 0.0 ± 0.0
0.1CysGln: 0.1 ± 0.084
0.4CysArg: 0.4 ± 0.197
0.899CysSer: 0.899 ± 0.271
0.2CysThr: 0.2 ± 0.125
0.599CysVal: 0.599 ± 0.267
0.2CysTrp: 0.2 ± 0.152
0.3CysTyr: 0.3 ± 0.156
0.0CysXaa: 0.0 ± 0.0
Asp
3.196AspAla: 3.196 ± 0.481
0.499AspCys: 0.499 ± 0.209
5.094AspAsp: 5.094 ± 0.797
4.694AspGlu: 4.694 ± 0.786
3.795AspPhe: 3.795 ± 0.706
5.294AspGly: 5.294 ± 0.809
0.499AspHis: 0.499 ± 0.234
4.495AspIle: 4.495 ± 0.566
4.894AspLys: 4.894 ± 0.675
4.794AspLeu: 4.794 ± 0.548
1.598AspMet: 1.598 ± 0.497
4.095AspAsn: 4.095 ± 0.611
1.199AspPro: 1.199 ± 0.359
1.199AspGln: 1.199 ± 0.296
2.897AspArg: 2.897 ± 0.672
3.496AspSer: 3.496 ± 0.534
3.296AspThr: 3.296 ± 0.447
3.895AspVal: 3.895 ± 0.572
0.799AspTrp: 0.799 ± 0.293
2.297AspTyr: 2.297 ± 0.486
0.0AspXaa: 0.0 ± 0.0
Glu
4.495GluAla: 4.495 ± 0.643
0.3GluCys: 0.3 ± 0.158
3.596GluAsp: 3.596 ± 0.535
6.093GluGlu: 6.093 ± 0.971
2.497GluPhe: 2.497 ± 0.455
3.196GluGly: 3.196 ± 0.548
0.999GluHis: 0.999 ± 0.273
4.594GluIle: 4.594 ± 0.862
6.792GluLys: 6.792 ± 1.205
7.091GluLeu: 7.091 ± 0.834
2.397GluMet: 2.397 ± 0.539
3.895GluAsn: 3.895 ± 0.81
1.698GluPro: 1.698 ± 0.393
3.596GluGln: 3.596 ± 0.782
3.496GluArg: 3.496 ± 0.588
3.396GluSer: 3.396 ± 0.48
4.395GluThr: 4.395 ± 0.633
4.794GluVal: 4.794 ± 0.805
1.498GluTrp: 1.498 ± 0.332
3.596GluTyr: 3.596 ± 0.668
0.0GluXaa: 0.0 ± 0.0
Phe
3.096PheAla: 3.096 ± 0.554
0.4PheCys: 0.4 ± 0.187
3.696PheAsp: 3.696 ± 0.436
4.095PheGlu: 4.095 ± 0.656
2.097PhePhe: 2.097 ± 0.523
2.497PheGly: 2.497 ± 0.537
0.3PheHis: 0.3 ± 0.196
2.497PheIle: 2.497 ± 0.518
5.493PheLys: 5.493 ± 0.73
2.597PheLeu: 2.597 ± 0.519
1.698PheMet: 1.698 ± 0.404
3.696PheAsn: 3.696 ± 0.675
0.3PhePro: 0.3 ± 0.193
2.297PheGln: 2.297 ± 0.386
1.298PheArg: 1.298 ± 0.468
3.696PheSer: 3.696 ± 0.504
2.497PheThr: 2.497 ± 0.466
2.097PheVal: 2.097 ± 0.438
0.799PheTrp: 0.799 ± 0.347
1.398PheTyr: 1.398 ± 0.418
0.0PheXaa: 0.0 ± 0.0
Gly
3.696GlyAla: 3.696 ± 0.78
0.599GlyCys: 0.599 ± 0.191
3.496GlyAsp: 3.496 ± 0.638
2.197GlyGlu: 2.197 ± 0.465
2.797GlyPhe: 2.797 ± 0.454
2.797GlyGly: 2.797 ± 0.72
0.899GlyHis: 0.899 ± 0.307
6.392GlyIle: 6.392 ± 0.987
7.091GlyLys: 7.091 ± 0.879
5.194GlyLeu: 5.194 ± 1.107
1.398GlyMet: 1.398 ± 0.573
3.096GlyAsn: 3.096 ± 0.593
1.298GlyPro: 1.298 ± 0.425
2.397GlyGln: 2.397 ± 0.496
2.697GlyArg: 2.697 ± 0.476
3.096GlySer: 3.096 ± 0.561
4.295GlyThr: 4.295 ± 0.592
3.596GlyVal: 3.596 ± 0.623
0.499GlyTrp: 0.499 ± 0.21
3.696GlyTyr: 3.696 ± 0.563
0.0GlyXaa: 0.0 ± 0.0
His
0.599HisAla: 0.599 ± 0.213
0.2HisCys: 0.2 ± 0.129
0.599HisAsp: 0.599 ± 0.231
0.499HisGlu: 0.499 ± 0.25
0.3HisPhe: 0.3 ± 0.183
1.199HisGly: 1.199 ± 0.309
0.1HisHis: 0.1 ± 0.093
0.4HisIle: 0.4 ± 0.214
1.298HisLys: 1.298 ± 0.321
1.298HisLeu: 1.298 ± 0.308
0.0HisMet: 0.0 ± 0.0
0.499HisAsn: 0.499 ± 0.182
0.4HisPro: 0.4 ± 0.181
0.3HisGln: 0.3 ± 0.181
0.499HisArg: 0.499 ± 0.247
0.699HisSer: 0.699 ± 0.269
0.899HisThr: 0.899 ± 0.287
0.899HisVal: 0.899 ± 0.274
0.2HisTrp: 0.2 ± 0.164
0.4HisTyr: 0.4 ± 0.153
0.0HisXaa: 0.0 ± 0.0
Ile
3.795IleAla: 3.795 ± 0.601
0.699IleCys: 0.699 ± 0.308
4.095IleAsp: 4.095 ± 0.705
6.193IleGlu: 6.193 ± 0.956
2.097IlePhe: 2.097 ± 0.499
4.594IleGly: 4.594 ± 0.761
0.699IleHis: 0.699 ± 0.274
4.994IleIle: 4.994 ± 0.901
7.191IleLys: 7.191 ± 0.798
4.295IleLeu: 4.295 ± 0.571
1.298IleMet: 1.298 ± 0.31
5.094IleAsn: 5.094 ± 0.609
2.497IlePro: 2.497 ± 0.44
3.396IleGln: 3.396 ± 0.518
1.798IleArg: 1.798 ± 0.392
4.095IleSer: 4.095 ± 0.786
4.395IleThr: 4.395 ± 0.666
3.795IleVal: 3.795 ± 0.65
0.999IleTrp: 0.999 ± 0.287
1.998IleTyr: 1.998 ± 0.436
0.0IleXaa: 0.0 ± 0.0
Lys
7.191LysAla: 7.191 ± 1.014
0.4LysCys: 0.4 ± 0.226
4.894LysAsp: 4.894 ± 0.678
7.891LysGlu: 7.891 ± 1.279
2.996LysPhe: 2.996 ± 0.638
5.394LysGly: 5.394 ± 0.751
1.099LysHis: 1.099 ± 0.357
5.893LysIle: 5.893 ± 0.927
7.291LysLys: 7.291 ± 1.173
7.591LysLeu: 7.591 ± 0.95
2.297LysMet: 2.297 ± 0.419
6.093LysAsn: 6.093 ± 0.855
3.496LysPro: 3.496 ± 0.554
4.594LysGln: 4.594 ± 0.654
4.495LysArg: 4.495 ± 1.057
5.593LysSer: 5.593 ± 0.812
5.493LysThr: 5.493 ± 0.682
3.396LysVal: 3.396 ± 0.509
0.799LysTrp: 0.799 ± 0.343
4.095LysTyr: 4.095 ± 0.825
0.0LysXaa: 0.0 ± 0.0
Leu
4.594LeuAla: 4.594 ± 0.708
0.799LeuCys: 0.799 ± 0.333
5.294LeuAsp: 5.294 ± 0.622
5.493LeuGlu: 5.493 ± 1.041
3.596LeuPhe: 3.596 ± 0.733
5.194LeuGly: 5.194 ± 0.586
0.899LeuHis: 0.899 ± 0.243
3.895LeuIle: 3.895 ± 0.639
6.892LeuLys: 6.892 ± 0.789
5.793LeuLeu: 5.793 ± 0.8
2.197LeuMet: 2.197 ± 0.387
4.594LeuAsn: 4.594 ± 0.548
2.797LeuPro: 2.797 ± 0.426
2.897LeuGln: 2.897 ± 0.5
2.797LeuArg: 2.797 ± 0.699
6.692LeuSer: 6.692 ± 0.627
5.194LeuThr: 5.194 ± 0.823
4.495LeuVal: 4.495 ± 0.647
1.298LeuTrp: 1.298 ± 0.575
2.497LeuTyr: 2.497 ± 0.431
0.0LeuXaa: 0.0 ± 0.0
Met
1.498MetAla: 1.498 ± 0.392
0.1MetCys: 0.1 ± 0.1
1.998MetAsp: 1.998 ± 0.399
1.298MetGlu: 1.298 ± 0.375
0.899MetPhe: 0.899 ± 0.245
1.298MetGly: 1.298 ± 0.278
0.3MetHis: 0.3 ± 0.193
1.099MetIle: 1.099 ± 0.316
2.597MetLys: 2.597 ± 0.616
1.898MetLeu: 1.898 ± 0.431
0.599MetMet: 0.599 ± 0.292
1.598MetAsn: 1.598 ± 0.337
0.499MetPro: 0.499 ± 0.257
1.199MetGln: 1.199 ± 0.335
1.598MetArg: 1.598 ± 0.443
1.998MetSer: 1.998 ± 0.538
2.797MetThr: 2.797 ± 0.51
1.199MetVal: 1.199 ± 0.332
0.0MetTrp: 0.0 ± 0.0
0.599MetTyr: 0.599 ± 0.262
0.0MetXaa: 0.0 ± 0.0
Asn
4.495AsnAla: 4.495 ± 0.739
0.599AsnCys: 0.599 ± 0.245
2.597AsnAsp: 2.597 ± 0.481
3.396AsnGlu: 3.396 ± 0.622
3.096AsnPhe: 3.096 ± 0.525
6.592AsnGly: 6.592 ± 0.981
0.699AsnHis: 0.699 ± 0.305
4.594AsnIle: 4.594 ± 0.534
5.693AsnLys: 5.693 ± 0.728
4.994AsnLeu: 4.994 ± 0.553
1.698AsnMet: 1.698 ± 0.406
4.095AsnAsn: 4.095 ± 0.802
1.998AsnPro: 1.998 ± 0.466
2.497AsnGln: 2.497 ± 0.488
1.998AsnArg: 1.998 ± 0.351
4.195AsnSer: 4.195 ± 0.931
2.897AsnThr: 2.897 ± 0.503
4.095AsnVal: 4.095 ± 0.789
0.899AsnTrp: 0.899 ± 0.28
2.996AsnTyr: 2.996 ± 0.692
0.0AsnXaa: 0.0 ± 0.0
Pro
0.999ProAla: 0.999 ± 0.326
0.2ProCys: 0.2 ± 0.137
2.197ProAsp: 2.197 ± 0.467
1.698ProGlu: 1.698 ± 0.323
1.598ProPhe: 1.598 ± 0.339
0.599ProGly: 0.599 ± 0.236
0.499ProHis: 0.499 ± 0.239
2.097ProIle: 2.097 ± 0.508
2.797ProLys: 2.797 ± 0.533
1.798ProLeu: 1.798 ± 0.431
0.3ProMet: 0.3 ± 0.167
1.598ProAsn: 1.598 ± 0.369
0.899ProPro: 0.899 ± 0.22
0.899ProGln: 0.899 ± 0.36
1.099ProArg: 1.099 ± 0.344
1.798ProSer: 1.798 ± 0.393
1.798ProThr: 1.798 ± 0.419
1.598ProVal: 1.598 ± 0.491
0.4ProTrp: 0.4 ± 0.166
1.199ProTyr: 1.199 ± 0.27
0.0ProXaa: 0.0 ± 0.0
Gln
4.095GlnAla: 4.095 ± 0.754
0.3GlnCys: 0.3 ± 0.155
1.798GlnAsp: 1.798 ± 0.418
3.196GlnGlu: 3.196 ± 0.52
1.698GlnPhe: 1.698 ± 0.467
2.996GlnGly: 2.996 ± 0.573
0.3GlnHis: 0.3 ± 0.158
2.097GlnIle: 2.097 ± 0.483
3.396GlnLys: 3.396 ± 0.689
3.296GlnLeu: 3.296 ± 0.528
1.398GlnMet: 1.398 ± 0.315
1.498GlnAsn: 1.498 ± 0.292
1.398GlnPro: 1.398 ± 0.45
2.097GlnGln: 2.097 ± 0.619
1.298GlnArg: 1.298 ± 0.371
2.297GlnSer: 2.297 ± 0.454
2.797GlnThr: 2.797 ± 0.439
2.597GlnVal: 2.597 ± 0.635
0.699GlnTrp: 0.699 ± 0.306
1.298GlnTyr: 1.298 ± 0.263
0.0GlnXaa: 0.0 ± 0.0
Arg
2.297ArgAla: 2.297 ± 0.502
0.2ArgCys: 0.2 ± 0.133
2.497ArgAsp: 2.497 ± 0.679
3.096ArgGlu: 3.096 ± 0.631
2.197ArgPhe: 2.197 ± 0.425
1.698ArgGly: 1.698 ± 0.469
0.499ArgHis: 0.499 ± 0.212
2.597ArgIle: 2.597 ± 0.538
3.396ArgLys: 3.396 ± 0.523
5.294ArgLeu: 5.294 ± 0.821
0.699ArgMet: 0.699 ± 0.335
2.697ArgAsn: 2.697 ± 0.447
0.699ArgPro: 0.699 ± 0.33
1.498ArgGln: 1.498 ± 0.452
1.099ArgArg: 1.099 ± 0.32
2.996ArgSer: 2.996 ± 0.464
1.898ArgThr: 1.898 ± 0.44
2.397ArgVal: 2.397 ± 0.47
0.4ArgTrp: 0.4 ± 0.17
1.798ArgTyr: 1.798 ± 0.702
0.0ArgXaa: 0.0 ± 0.0
Ser
4.495SerAla: 4.495 ± 0.786
0.3SerCys: 0.3 ± 0.174
5.294SerAsp: 5.294 ± 0.441
4.295SerGlu: 4.295 ± 0.624
3.895SerPhe: 3.895 ± 0.702
3.496SerGly: 3.496 ± 0.677
0.699SerHis: 0.699 ± 0.216
5.294SerIle: 5.294 ± 0.871
4.295SerLys: 4.295 ± 0.666
4.794SerLeu: 4.794 ± 0.624
1.398SerMet: 1.398 ± 0.404
4.794SerAsn: 4.794 ± 0.968
0.999SerPro: 0.999 ± 0.259
2.697SerGln: 2.697 ± 0.52
2.597SerArg: 2.597 ± 0.446
3.196SerSer: 3.196 ± 0.618
4.295SerThr: 4.295 ± 0.89
4.495SerVal: 4.495 ± 0.644
0.799SerTrp: 0.799 ± 0.267
2.897SerTyr: 2.897 ± 0.542
0.0SerXaa: 0.0 ± 0.0
Thr
3.895ThrAla: 3.895 ± 0.556
0.3ThrCys: 0.3 ± 0.168
3.396ThrAsp: 3.396 ± 0.6
4.295ThrGlu: 4.295 ± 0.651
3.895ThrPhe: 3.895 ± 0.756
4.095ThrGly: 4.095 ± 0.618
0.699ThrHis: 0.699 ± 0.234
4.794ThrIle: 4.794 ± 0.873
6.392ThrLys: 6.392 ± 0.747
4.395ThrLeu: 4.395 ± 0.689
1.398ThrMet: 1.398 ± 0.387
2.996ThrAsn: 2.996 ± 0.55
0.999ThrPro: 0.999 ± 0.431
2.197ThrGln: 2.197 ± 0.469
2.897ThrArg: 2.897 ± 0.54
3.496ThrSer: 3.496 ± 0.504
4.694ThrThr: 4.694 ± 0.568
5.394ThrVal: 5.394 ± 0.81
0.799ThrTrp: 0.799 ± 0.361
2.797ThrTyr: 2.797 ± 0.608
0.0ThrXaa: 0.0 ± 0.0
Val
3.096ValAla: 3.096 ± 0.741
0.499ValCys: 0.499 ± 0.206
3.196ValAsp: 3.196 ± 0.824
4.894ValGlu: 4.894 ± 0.601
2.797ValPhe: 2.797 ± 0.546
2.996ValGly: 2.996 ± 0.516
0.599ValHis: 0.599 ± 0.372
3.496ValIle: 3.496 ± 0.556
6.292ValLys: 6.292 ± 0.847
3.995ValLeu: 3.995 ± 0.553
0.999ValMet: 0.999 ± 0.334
5.194ValAsn: 5.194 ± 0.839
1.498ValPro: 1.498 ± 0.385
1.798ValGln: 1.798 ± 0.516
1.698ValArg: 1.698 ± 0.489
4.994ValSer: 4.994 ± 0.701
5.194ValThr: 5.194 ± 0.976
3.696ValVal: 3.696 ± 0.846
1.398ValTrp: 1.398 ± 0.357
2.097ValTyr: 2.097 ± 0.398
0.0ValXaa: 0.0 ± 0.0
Trp
1.398TrpAla: 1.398 ± 0.347
0.0TrpCys: 0.0 ± 0.0
0.899TrpAsp: 0.899 ± 0.272
1.199TrpGlu: 1.199 ± 0.407
0.699TrpPhe: 0.699 ± 0.24
0.999TrpGly: 0.999 ± 0.337
0.1TrpHis: 0.1 ± 0.1
0.999TrpIle: 0.999 ± 0.249
0.799TrpLys: 0.799 ± 0.313
0.599TrpLeu: 0.599 ± 0.235
0.2TrpMet: 0.2 ± 0.137
1.498TrpAsn: 1.498 ± 0.587
0.1TrpPro: 0.1 ± 0.095
0.799TrpGln: 0.799 ± 0.374
0.999TrpArg: 0.999 ± 0.258
0.599TrpSer: 0.599 ± 0.236
0.999TrpThr: 0.999 ± 0.319
1.298TrpVal: 1.298 ± 0.336
0.2TrpTrp: 0.2 ± 0.139
0.3TrpTyr: 0.3 ± 0.165
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.598TyrAla: 1.598 ± 0.457
0.599TyrCys: 0.599 ± 0.259
2.397TyrAsp: 2.397 ± 0.52
3.096TyrGlu: 3.096 ± 0.622
2.497TyrPhe: 2.497 ± 0.522
2.897TyrGly: 2.897 ± 0.707
0.4TyrHis: 0.4 ± 0.2
2.597TyrIle: 2.597 ± 0.706
2.597TyrLys: 2.597 ± 0.57
2.297TyrLeu: 2.297 ± 0.556
1.598TyrMet: 1.598 ± 0.429
2.097TyrAsn: 2.097 ± 0.584
1.598TyrPro: 1.598 ± 0.48
1.798TyrGln: 1.798 ± 0.451
2.197TyrArg: 2.197 ± 0.443
3.596TyrSer: 3.596 ± 0.526
1.598TyrThr: 1.598 ± 0.373
2.197TyrVal: 2.197 ± 0.407
0.599TyrTrp: 0.599 ± 0.217
1.898TyrTyr: 1.898 ± 0.594
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 49 proteins (10013 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski